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Background: The patch test is widely used for diagnosis of allergic contact dermatitis. However, nearly half of positive reactions can be observed only on day 2 or day 4 and it is difficult to interpret these reactions. Objective: The purpose of this study is to assess the frequency of transient and delayed reactions in TRUE-test and detect common antigens that provoke these reactions. Methods: A total of 311 patients with allergic contact dermatitis were evaluated by TRUE-test between Jan 2007 and December 2011. Records of patch test results of day 2 and day 4 were reviewed and analyzed. Results: A total 311 cases of T.R.U.E. TEST^(R) records (male 79, female 232) were analyzed. Persistent reactions were observed in 80.1% patients tested, transient reactions were observed in 18.3%, and delayed reaction in 5%. Frequent allergens which showed transient reactions were cobalt dichloride (2.9%), nickel sulfate (2.2%), thiomersal (1.9%), and carba mix (1.6%), in order of frequency. Allergens which showed delayed reactions were nickel sulfate (0.3%), fragrance mix (0.3%), p-tert-butylphenol formaldehyde resin (0.43). Conclusion: Our results showed a relatively high frequency of transient reaction in T.R.U.E. TEST^(R). This suggests that additional reading at day 4 in the patch test would be of value. (Korean J Dermatol 2013;51(2):87∼93)
Washboard nail is a dystrophy that presents as a series of ridges that extends across the nail. It is often accompanied by a central depression that extends from the cuticle to the free edge. Washboard nail is often a result of frequently repeated trauma, but sometimes predisposing factors cannot be found. When habitual tic is the cause of the lesions, restraining the habit is the most important treatment. Here, we report a case of a 6-year-old male with washboard nails on both thumbnails and was treated with topical 0.1% tacrolimus ointment. Significant improvement was observed after 4 months of application. This case suggests that topical tacrolimus can be considered as a primary therapy in the treatment of washboard nails in the absence of trauma. (Korean J Dermatol 2012;50(12):1054∼1056)
Scedosporium apiospermum, an asexual state of Pseudallescheria boydii, is a widely distributed mould that can be found in the soil, manure, stagnant water and decaying vegetation. It has become an emerging pathogen among immunosuppressed patients but it can also cause infections in immunocompetent patients by penetrating trauma. This fungus is a classical cause of mycetoma and the localized skin infections caused by this mould are much rarer than mycetoma. We report a case of cutaneous S. apiospermum infection in a 79-year-old woman. She had erythematous plaque with crust and violaceous supprative nodules on the right forearm. The culture from pus showed typical white to gray colored cottony colonies of S. apiospermum. Treatment was started with voriconazole effectively. Skin lesions completely cured with no reccurence. Thus, voriconazole shows to be an effective treatment for Scedosporium infection. (Korean J Dermatol 2013;51(2):135∼139)
갈화해정탕은 역대로 酒傷病에 쓰여진 대표적인 처방이다. 이 연구에서는 알콜 투여 후 자연회복군, 알콜 투여 후 갈화해정탕 투여군, 알콜 투여 후 운동 적용군, 알콜 투여 후 갈화해정탕 투여 운동 병행군으로 나누어 각각의 혈청 지질과 BUN, Creatinine의 함량 변화를 알아 보았다. 1. Total cholesterol 함량은 2주 후에는 갈화해정탕 투여 및 운동 병행군에서 감소하였고, 4주 후에는 갈화해정탕 투여 및 운동 병행군에서 유의성 있게 감소하였다. 2. HDL-cholesterol 함량은 2주 후에는 운동 적용군에서 유의성 있게 증가하였고, 4주 후에는 자연회복군, 갈화해정탕 투여군에서 유의성 있게 증가하였다. 3. Triglyceride 함량은 2주 후에는 운동 적용군에서 유의성 있게 감소하였고, 4주 후에는 갈화해정탕 투여군에서 유의성 있게 감소하였다. 4. Free fatty 함량은 2주 후에는 갈화해정탕 투여군에서 유의성 있게 감소하였고, 4주 후에는 갈화해정탕 투여군, 갈화해정탕 투여 및 운동 병행군에서 유의성 있게 감소하였다. 5. BUN 함량은 2주 후에는 갈화해정탕 투여 및 운동 병행군에서 유의성 있게 감소하였고, 4주 후에는 운동 적용군에서 유의성 있게 감소하였다. 6. Creatinine 함량은 2주 후에는 갈화해정탕 투여 및 운동 병행군에서 유의성 있게 감소하였고, 4주 후에는 운동 적용군, 갈화해정탕 투여 및 운동 병행군에서 유의성 있게 감소하였다. 이상의 결과로 갈화해정탕 투여 및 운동부하는 알콜 대사량 증가의 효과가 있을 것으로 생각된다. Galwhahaejungtang has beer? used to alcoholic disease. Object of This study is examining the effect of Galwhahaejungtang and exercise on variation of total cholesterol, HDL-cholesterol, triglyceride. free fatty acid, BUN, Creatinine in rat with alcohol administration. METHODS AND MATERIALS Fifty four rats were divided into four groups. 1. The group of rat with alcohol administration and no treatment 2. The group of rat with alcohol and Galwhahaejungtang administration 3. The group of rat with alcohol administation and exercise 4. The group of rat with alcohol, Galwhahaejungtang administration and exercise Serum of rat were obtained after 2 weeks and 4 weeks. RESULTS 1. The level of total cholesterol was decreased in the group of rat with Ckluhahaejungtang administration and exercise after 2 weeks. After 4 weeks, the level of total cholesterol Lvas significantly decreased in the group of rat with Galwhahaejungtang administration and exercise. 2. The level of HDL-cholesterol was significantly increased in the group of rat with exercise after 2 weeks. After 4 weeks, the level of HDL-cholesterol was significantly increased in the group of rat with no treatment and with Gulwhahaejungtang administration. 3. The level of tryglyceride was significantly decreased in the group of rat with exercise after 2 weeks, After 4 weeks, the level of tryglyceride was significantly decreased in the group of rat with Galwhahaeiungtang administration. 4. The level of free fatty acid was significantly decreased in the group of rat with Galwhahaejungtang administration after 2 weeks. After 4 weeks, the level of free fatty acid waas significantly decreased in the group of rat with Galuhbejungtang administration and with Galuhahaejungtang administration and exercise. 5. The level of BUN was significantly decreased in the group of rat with Galwhahaejungtang administration and exercise after 2 weeks. After 4 weeks, the level of BUN was significantly decreased in the group of rat with exercise. 6. The level of creatinine was significantly decreased in the group of rat with Galwhhaejungtang administration and exercise. After 4 weeks, the level of creatinine was significantly decreased in the group of rat with exercise and with Galhahaejungtang administration and exercise. CONCLUSION Based on these results, it is considered that Galwhahaejungtang administration and exercise has an accelerating effect on alcohol metabolism Key words : Galwhahaejungtang, lipid, total cholesterol, HDL-cholesterol, triglyceride, free fatty acid, exercise, BUN, creatinine, alcohol metabolism
Color is basically important in our life because it not only plays a role as a visual media but also provokes the human being into emotional action. That is, we can recognize, classify and utilize much information around us by using our color sense. In order to properly apply color so that we can get the upmost effect of color, we must pursue reasonable color arrangement by means of understanding functions of color. According as the improvement of product functional quality due to the technical development consumer requests for satisfactory design for goods as much as functional one. Color has worth for being as an esthetic factor and also as an essential part in our life. Nowadays importance of design has been increased among elements which are deciding factors in ranking product quality. Especially the role of design in electronics holds 60% of purchase motive factors. Besides the role of color holds the majority in design factors. Color is considerable for the fuctional side and it stimulates consumers to buy goods, color contributes enterprise to make up its good image and most of all it makes a distinction with other company's goods. The color plan of a product should be based on scientific research for being fitted our focus and turning to advantage. And it should be planned by a completely strategic progress with all goods' condition which surrounds us as well as fully expressed by their own distinction. We believe the color plan of a product sets up a co-operation between products and consumers, and increases more competitive power than others in electronics market. Therefore We hope this study will help to establish systematic and actual color plan methods and carry out color application.
Infantile hemangioma is a self-resolving benign tumor that commonly requires no intervention. Despite its distinctive, self-limiting course, infantile hemangiomas may result in ulcerations that cause pain, potential scarring, bleeding, and infection. Active treatment is usually required to manage these lesions. The discovery of propranolol in the treatment of infantile hemangioma was described in 2008 by L?aut?-Labr?ze, et al. Since then, its effectiveness and safety have been confirmed by several cases, and replacing systemic corticosteroids as a first-line therapy. Herein, we report the successful treatment of children with ulcerated perianal infantile hemangioma with propranolol. (Korean J Dermatol 2013;51(2):155∼157)