Biofilter modeling integrated with Lim’s adsorption model

Eun Ju LEE,Wui Sook JEON,Hye Min YOON,Hye Jin SONG,Byeung Soo KIM,Hee Jeong KIM,Eun Jeong OH,Kwang-Hee LIM 한국생물공학회 2011 한국생물공학회 학술대회 Vol.2011 No.10

코우크로스로의 방출물에 노출된 근로자에서 발생한 폐암 증례

임현술,최정근,권은혜,김헌 大韓産業醫學會 2002 대한직업환경의학회지 Vol.14 No.1

목 적 : 소세포성 폐암으로 진단받은 56세 남자에대하여 과거 21년간 코우크스로에서 근무한 작업력과 폐암과의 관련성을 파악하고자 하였다. 방 법 : 증례에 대한 의무기록가 흉부컴퓨터단층촬영 및 조직검사, 세포검사를 검토하였다. 증례의 작업 내역, 공것 작업환경 측정 결과를 파악하였고 작업환경 측정과 동료근로자에 대한 역학조사를 실시하였다. 작업환경측정은 산업안전보건연구원에서 모든 근로자를 대상으로 2회 반복 측정하였으며, 측정시간은 근로자의 작업시간 전체를 포함한 1일 8시간으로 하였다. 시료채취 및 분석방법은 미국 국립산업안전보건연구소의 공정시험법과 미국 노동부 산업 안전보건청의 공정시험법을 이용하였다. 측정결과의 정확도를 높이소 오차를 줄이기 위하여 측정 전후에 적적한 보정을 실시하고 현장 공시료를 포함하였다. 동료 근로자 40명에 대하여 역학조사를 실시하였고 COEs의 노출정도를 평가하기 위하여 PAHs의 대사산물인 1-OHP와 2-naphthol을 소변에서 분석하였다. 결 과 : P제철 부속의원에서 1996년부터 1999년까지 COEs에 대하여 측정한 결과는 0.01-0.39 ㎎/㎥ 범위로 후발성 콜타르피치물질에 대한 노동부의 노출기준인 0.2 ㎎/㎥르 적용할 때 초과하는 경우가 있었다. 1999년 산업안전보건연구원에서 작업환경을 직접 측정한 결과 전체 측정 건수 136건 중 45건 (33.1 %)이 노출기준을 초과하였다. 동료 근로자 40명에 대한 역학조사에서 특별한 COEs에 의한 건강장해를 발견하지 못하였다. K업체와 S업체의 근로자에 대하여 충북대학교 의과대학 예방의학교실에서 측정한 요중 1-OHP와 2-naphthol은 대조군인 대학생에 비하여 유의하게 높았다(P<0.01). 결 론 : 중례는 21년간 코우크스 제조공정에서 COEs에 노출되었으며, 현재 작업환경측정 결과로 판단할 때 노출기준을 초과하여 노출되는 경우도 있다고 추정되며, 흡연은 COEs가 폐암 발생을 가중시키는 요인으로 작용하였다고 추정된다. 그러므로 증례의 폐암은 코우크스 제조공정에서 노출된 COEs와 관련이 있다고 생각하여 직업성암으로 판단하였다. Objectives : We report a case of lung cancer (small cell carcinoma) occurring in a worker exposed to coke oven emissions. Methods : We examined the chest CT and pathologic findings of the patient. We reviewed previous environmental measurements for coke oven emissions at the workers place of employment. Also we measured the airborne concentrations for coke oven emissions and total polycuclic aromatic hydrocarbons in the work area. Finally, we analyzed the 1-hydroxypyrene and 2-naphthol concentrations in the subjects urine and compared this with student controls. Results : This case was a 56-year-old male who had worked in a coke oven plant within a steel manufacturing factory for 21 years (1977-1998). The airborne concentrations of coke oven emissions at the worksite were above the permissible exposure level (0.2 ㎎/㎥) in 45 cases (33.1%) among 136 workers. The concentrations of 1-hydroxypyrene and 2-naphthol in the subjects urine were statistically significantly elevated as compared with those of controls (P<0.01). Conclusions : We confirmed that the lung cancer occurring in this patient was as an occupational disease due to exposure to coke oven emissions. To prevent occupational cancer in coke oven plant workers, we must remodel the engineering procedure, begin comprehensive medical surveillance, educate workers on risks and the benefits of smoking cessation, and increase awareness of safety regulations in the workplace.

갑상선기능저하증 이환견에 대한 치료 증례

김혜원,이선희,임수정,박형진,김태신,송은식,송근호 忠南大學校 獸醫科大學 附設 動物醫科學硏究所 2009 動物醫科學硏究誌 Vol.16 No.1

A 10-year-old, male, poodle dog was referred to the Veterinary Medical Teaching Hospital of Chungnam National University because of continuous cough and cardiomegaly. Weight gain, lethargy, unwillingness to exercise and decreased activity was revealed on history. Obesty and alopecia was also observed on physical examination. Hypercholesterolemia and increased ALP was revealed on blood exam. So, evaluation of thyroid gland function was performed and cTSH concentration was increased. tT4 and fT4 concentrations was decreased. Results of a history, physical examination, blood exam, and thyroid gland fuction test support a diagnosis of hypothyroidism. Initial therapy with sodium levothyroxine was indicated. On 32 days after treatment of hypothyroidism, clinical signs was relieved and cTSH concentration was decreased, tT4 and fT4 concenctrations was increased.

초등교사의 열정에 대한 인식: 의미연결망 분석의 활용

임효진 ( Hyo Jin¸ Lim ),최은혜 ( Eun Hye¸ Choi ),박호익 ( Ho Ik¸ Park ),이지현 ( Ji Hyun¸ Lee ) 한국초등교육학회 2021 초등교육연구 Vol.34 No.3

본 연구에서는 초등교사가 가지고 있는 열정에 대한 인식구조를 파악하기 위해 현직 초등교사 131명을 대상으로 설문조사를 실시하였다, 연구에서는 열정, 열정의 장단점, 교사열정에 대한 인식구조를 알아보기 위해 의미연결망 분석을 활용하여 근접 중심성, 연결중심성, 매개중심성, 아이겐벡터 중심성을 위주로 살펴보았다. 연구결과 첫째, 열정에서는 ‘힘’,‘강렬’과 같은 높은 강도나 에너지를 나타내는 단어들이 중요한 역할을 하였으며 커뮤니티 분석 결과 열정의 행동, 정서, 동기 특성에 대한 주제가 분류되었다. 둘째, 열정의 장점에서는 ‘삶’,‘원동력’,‘에너지’등이, 열정의 단점에서는 ‘타인’,‘피로’,‘살피지 못함’등이 중요한 역할을 하는 것으로 보아 기존 이론에 나타난 열정의 특성을 설명하고 있었다. 셋째, 교사열정에서는 ‘학생’,‘수업’과 같은 교수활동의 실천을 나타내는 단어들이 중요한 역할을 하였으며 커뮤니티 분석 결과 교육활동 전반, 학생과 수업, 전문성 개발에 대한 주제가 분류되었다. The purpose of this study was to explore the meaning of passion perceived by elementary school teachers. In order to understand the structure of perception of passion, we surveyed 131 in-service elementary school teachers. Responses to passion, the positive and negative role of passion, and teacher passion were analyzed using a semantic network analysis. We focused on closeness centrality, degree centrality, betweenness centrality and eigenvector centrality. Results showed that first, in passion, words indicating high strength and energy such as‘power’and‘intensity’played an important role in the structure of perception. Themes on behavioral, emotional, and motivational characteristics of passion were classified as sub-factors of passion as a result of community analysis. Secondly,‘life’,‘motivation’, and‘energy’appeared in key-word analysis in the positive role of passion while‘others’,‘fatigue’, and‘not caring for’appeared in the negative role of passion, reflecting the theory on the dualistic model of harmonious and obsessive passion. Third, in teacher passion, words indicating teaching activities and their practices such as‘student’and‘instruction’played an important role in the structure of perception. Themes related to educational activities in general, students and instruction, and professional development were classified as sub-factors of teacher passion.

KS H ISO 1242 표준의 평가 : 라반딘 정유의 산값 측정

전혜림,이은지,장혜진,손현화,김건,김남선,전명숙,이동선 서울여자대학교 2010 자연과학연구논문집 Vol.22 No.-

The acid value (AV) as well as the ester value of essential oil is an important index to evaluate quality of essential oil. The official standard analytical method of KS H ISO 1242 dealing with “Essential oils - Determination of acid value” was assessed experimentally using two lavandin essential oils obtained in France as an example. One French lavandin oil sample showed the results of AV= 0.9 by both indicator method and potentiometry. Another sample showed AV = 1.9 by indicator method and AV = 1.6 by potentiometry. Latter lavandin oil sample exhibited significantly higher acid value than maximum value of 1 described in the standard. This result suggests that latter lavandin oil was contaminated, because this oil was contained in an orange juice bottle. Results of this study proved that KS H ISO 1242 could be used as a suitable scientific standard for the determination of acid value of essential oils.

복수과 진료 환자의 중복 처방에 대한 분석 및 평가

이지은,장혜경,오지영,유윤경,김현지,임숙인,연숙희,강진숙,최귀령 한국병원약사회 2003 병원약사회지 Vol.20 No.1

In an aging society, there is an increasing possibility of the duplication of the drugs given to patients because they take many kinds of drugs. Among the prescriptions given to the patients who was treated at multiple ambulatory clinics in St. Mary's hospital for one month of September, 2002, in which drugs that has identical or similar effects are prescribed, we analysed and evaluated them by patients' characteristics, kinds of medication, severity of side effects on a case by case basis. More, we assessed the potential additional costs. As a result of this study, the duplication rate turned out to be 6.69% and it was shown that the proportion of the elderly patients over 60 was high. The gastro-intestinal medications took up a large part and most of the cases showed that the danger caused by double taking of medicine was slight, but there were some examples in which the serious side effects were predicted. Expected additional costs were the average 11.349 won and it ranges from the minimum of 56 won to the maximum of 135,720 won. In conclusion, the management of drug histories of the patients who need the plural treatments is very important and the necessity of the individual and professional guidance of taking medicines for the elderly patients is emerged, too.

영도지역 남녀 중ㆍ고교 학생들의 성지식에 관한 연구

강혜숙,남은우,박성빈,최재임 고신대학교 영도발전연구소 2000 영도연구 Vol.2 No.-

The purpose of this study was to grasp the sex knowledge in middle and high school students in Youngdo-Gu, Busan, and to provide some basic data for the needs and the direction of sex education for the teenagers. The survey was conducted by using questionnaires in two middle schools and two high schools in Youngdo-Gu. The questionnaires were took back after record by the respondents. The survey was conducted at September 15∼17, 2000 and a total of 791 were completed. The respondents were 200 (25.3%) males and 199 (25.2%) females in middle schools and 196 (24.8%) males and 196 (24.8%) females in high schools. For the statistical analysis, χ2-test, t-test and one-way ANOVA were used by using SPSS/PC+ WIN 8.0 program. The conclusions based on the results obtained from this study are as follows: 1) An attitude of the sexual matters showed that boys, students and non-christians were more progressive than girls, parents and christians, respectively (p<0.01). 2) The sexual agonies of students were in order of having a date 36.2%, sexual drive 11.1%, sexual intercourse 8.8%, masturbation 8.6% and sexual abuse 6.7%. 3) The points for sexual knowledges appeared 40.6 points out of 100 points from boys and 42.3 points from girls in middle schools, and 57.3 points from boys and 66.1 points from girls in high schools. Therefore, the girls had much knowledges on sexuality than those of the boys. There were a significant differences of knowledge on sexuality between boys and girls (p<0.001). Over 60% of both boys and girls had not enough knowledges on sexually transmitted diseases (STDs). 4) Satisfaction of sex education was common or unsatisfied as over 90% of respondents. The reasons were a textbook-like general information (50%) and nothing practically to help (29%). 5) The students wanted sex education for the practice in future life such as male and female relationship with etiquette(23%); and pregnancy and delivery (17%) in middle school students, and contraceptive and abortion (34%) and preventive STDs (18%). There was not enough to understand whole adolescent in Youngdo area because the study subjects were only public middle and hight school students in Youngdo-Gu, Busan. Conclusively, it is necessary to educate to give right information of sexuality to the adolescents in Youngdo, and to have systematically sex education from the kindergartens to the high schools by long range sex educational program. Also, a proper program for integrated sex education is necessary to build healthful sexual consciousness and worth in cooperation with sex educators, universities and health centers.

Whole-genome resequencing analysis of 20 Micro-pigs

Da‑Hye Son,Nam‑Hyun Hwang,Won‑Hyong Chung,Ha‑Seung Seong,Hyungbum Lim,Eun‑Seok Cho,Jung‑Woo Choi,Kyung‑Soo Kang,Yong‑Min Kim 한국유전학회 2020 Genes & Genomics Vol.42 No.3

Background Miniature pigs have been increasingly used as mammalian model animals for biomedical research because of their similarity to human beings in terms of their metabolic features and proportional organ sizes. However, despite their importance, there is a severe lack of genome-wide studies on miniature pigs. Objective In this study, we performed whole-genome sequencing analysis of 20 Micro-pigs obtained from Medi Kinetics to elucidate their genomic characteristics. Results Approximately 595 gigabase pairs (Gb) of sequence reads were generated to be mapped to the swine reference genome assembly (Sus scrofa 10.2); on average, the sequence reads covered 99.15% of the reference genome at an average of 9.6-fold coverage. We detected a total of 19,518,548 SNPs, of which 8.7% were found to be novel. With further annotation of all of the SNPs, we retrieved 144,507 nonsynonymous SNPs (nsSNPs); of these, 5968 were found in all 20 individuals used in this study. SIFT prediction for these SNPs identified that 812 nsSNPs in 402 genes were deleterious. Among these 402 genes, we identified some genes that could potentially affect traits of interest in Micro-pigs, such as RHEB and FRAS1. Furthermore, we performed runs of homozygosity analysis to locate potential selection signatures in the genome, detecting several loci that might be involved in phenotypic characteristics in Micro-pigs, such as MSTN, GDF5, and GDF11. Conclusion In this study, we identified numerous nsSNPs that could be used as candidate genetic markers with involvement in traits of interest. Furthermore, we detected putative selection footprints that might be associated with recent selection applied to miniature pigs.

사업장 근로자의 건강위험 평가도구 개발

홍윤철,임현술,하은희,정규철,조희숙,박혜숙,이용애 大韓産業醫學會 1998 대한직업환경의학회지 Vol.10 No.4

Health Risk Appraisal(HRA) is usually defined as a process by which we expect of individual's chances of death or acquiring specific diseases within a defined period of time. The concept of worksite as an area of health maintenance and promotion is newly developing. Our movement for health promotion of employees has been increasingly known in the worksite. The aim of this study is to develop health risk appraisal tools about health promotion at the worksite for employees. We performed this study by two steps; one step was to develop a HRA questionnaire of worksites in Korea, another was to evaluate the reliability of the questionnaire. For developing HRA questionnaire, we reviewed scientific examples at first, and then weighted the score by delphi. To evaluate the reliability of developed questionnaire, we carried out survey by test-retest method. A total of 131 employees completed HRA questionnaire on two times. The results are as follows. The total score of health risk in unhealthy workers was higher than that of healthy workers. The range of test-retest reliability of responses to the questionnaire was 0.57-0.94. Therefore it seems that this questionnaire was very suitable to assess the health behavior of workers. In conclusion, the developed HRA questionnaire can be used as a tool for evaluating health behavior and for providing health counseling materials.

Celecoxib 유도체인 PCX-계열 화합물의 항염증 및 혈관신생 억제 작용

소지현,안은경,전혜진,임은주,박은희 숙명여자대학교 약학연구소 2005 약학논문집-숙명여자대학교 Vol.22 No.-

This study aimed to evaluate the pharmacological efficacies of PCX-series compounds, which were synthesized as prodrugs of celecoxib, a COX-2 selective inhibitor. Celecoxib, PCX-1, PCX-2, PCX-3, PCX-7, PCX-15 and PCX-16 provide potent anti-angiogenic activity in chorioallantoic membrane (CAM) assay. In addition, celecoxib, PCX-2, and PCX-16 showed anti-angiogenic activity in a dose-dependent manner. PCX-2 inhibited swelling in the carrageenan-induced rat paw edema test 24 hours after the administration. In the acetic acid-induced writhing test, PCX-7 and PCX-15 were verified to provide more potent analgesic effect than celecoxib 12 hours after the administration, and PCX-2 showed potent analgesic effect 24 hours after the administration. In the carrageenan-induced rat air pouch model, PCX-2 significantly decreased exudate volume, number of leukocyte and NO level. In the ulcerogenic activity test, PCX-2, PCX-7, PCX-15, and PCX-16 showed significantly less ulcer formation than indomethacin. Especially, PCX-7 showed the highest safety in the GI safety test. These findings provide novel pharmacological knowledge on pharmacological actions of celecoxib and its PCX-series compouds.