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Duc Dat Le,Duc Hung Nguyen,Bing Tian Zhao,민병선,송시환,우미희 한국생약학회 2019 Natural Product Sciences Vol.25 No.2
The roots of Phlomis umbrosa (Turcz.) (Phlomidis Radix) have been traditionally used to treat cold, reduce swelling and staunch bleeding. Four iridoids (1 - 3 and 5) and six phenylethanoid derivatives (4, and 6 -10) were isolated from the roots of P. umbrosa. A simple, sensitive, and reliable analytical HPLC/PDA method was developed, validated, and applied to determine 10 marker compounds in Phlomidis Radix. Furthermore, the isolates were evaluated for cytotoxic and anti-oxidant activities as well as DPPH-HPLC method. Among them, compounds 4 and 6 – 9 displayed potent anti-oxidant capacities using DPPH assay with IC50 values of 27.7 ± 2.4, 10.2 ± 1.1, 18.0 ± 0.8, 19.1 ± 0.3, and 19.9 ± 0.6 μM, and compounds 6, 8, and 9 displayed significant cytotoxic activity against HL-60 with IC50 values of 35.4 ± 3.1, 18.6 ± 2.0, and 42.9 ± 3.0 μM, respectively.
Duc Dat Le,Duc Hung Nguyen,Bing Tian Zhao,민병선,우미희 한국생약학회 2019 Natural Product Sciences Vol.25 No.3
In this study, we described the new developed method to simultaneously discriminate two herbal drugs of Artemisiae Argyi Folium and Artemisiae Iwayomogii Herba using eight marker compounds (1 - 8) on an HPLC-PDA system. The developed method was applied to quantify the major components of two herbal drugs. The pattern analysis successfully discriminated and evaluated different components between Artemisiae Argyi Folium and Artemisiae Iwayomogii Herba. Results were used for classification of different species from collected samples.
Anti-inflammatory Triterpenes and Glyceryl Glycosides from Kandelia candel (L.) Druce
Le Duc Dat,NGUYEN PHUONG THAO,BUIHUU TAI,Bui Thi Thuy Luyen,양서영,김소현,구정은,고영상,Nguyen The Cuong,Nguyen Hoai Nam,Nguyen Van Thanh,Phan Van Kiem,Chau Van Minh,김영호 한국생약학회 2015 Natural Product Sciences Vol.21 No.3
Phytochemical investigation of Kandelia candel resulted in the isolation of six triterpenes (1 - 5) and two glyceryl glycosides (6 and 7) and their structures were determined by comparing the spectroscopic data with those of reported values. In present study, we described the inhibitory effects of fractions and isolated compounds from K. candel on pro-inflammatory cytokines (IL-12 p40, IL-6, and TNF-a) production in lipopolysaccharide (LPS) stimulated bone marrow-derived dendritic cells (BMDCs). Results indicated that compounds 3, 6, and 7 showed potent inhibition on IL-6 production (IC50 values at less than 0.5 mM, respectively). Meanwhile, compounds 6 and 7 exhibited strong inhibitory effects on the production of TNF-a (IC50 values of 1.7 ? 0.1 and 5.5 ? 0.2 mM). Compounds 1 and 3 were also showed the inhibitory effects on IL-12 p40 production (IC50 values of 8.9 ? 0.4 and 3.3 ? 0.1 mM, respectively).
Duc Hung Nguyen,Duc Dat Le,마은숙,민병선,우미희 한국생약학회 2020 Natural Product Sciences Vol.26 No.4
The aerial parts of Eclipta prostrata is used as a traditional medicine and vegetable. In traditional folk medicine, it is used for treatment of hemorrhages, hepatic, disease, renal injuries, hair loss, tooth mobility, and viper bites. In this study, ten compounds (1 ‒ 10) were isolated from the aerial parts of E. prostrata. A reliable high performance liquid chromatography equipped with photometric diode array detector (HPLC-PDA) method was developed to simultaneously quantitate 10 marker compounds [chlorogenic acid (1), paratensein 7-O-β-ᴅ-glucoside (2), quercetin 7-O-β-ᴅ-glucoside (3), luteolin 7-O-β-ᴅ-glucoside (4), apigenin 7-O-β-ᴅ-glucoside (5), apigenin 4'-O-β-ᴅ-glucoside (6), apigenin (7), luteolin (8), wedelolactone (9), and paratensein (10)]. In addition, compounds 5 and 6 showed considerable inhibitory effects against protein-tyrosine phosphatase 1B (PTP1B) enzyme. Moreover, compounds 6 ‒ 8, and 10 exhibited potent α-glucosidase inhibitory effects with IC50 values of 24.5 ± 1.9, 33.0 ± 0.5, 45.5 ± 0.1, and 23.8 ± 1.0 µM, respectively. All compounds (1 ‒ 10) showed considerable acetylcholinesterase (AChE) inhibitory effects with IC50 ranging from 30.1 to 75.2 µM.
Antioxidant Compounds Isolated from the Roots of Phlomis umbrosa Turcz.
Duc Hung Nguyen,Duc Dat Le,Bing Tian Zhao,마은숙,민병선,우미희 한국생약학회 2018 Natural Product Sciences Vol.24 No.2
Two triterpenoids, arjunolic acid (1), belleric acid (2), five phenylethanoids, martynoside (3), orobanchoside (4), 3,4-dihydroxyphenethylalcohol-6-O-caffeoyl-b-D-glucoside (5), leucosceptoside B (6), lunarii- folioside (7), four phenolic acids, ferulic acid (8), syringic acid (9), vanillic acid (10), 4-hydroxybenzoic acid (11), and one lignan, (+)-syringaresinol-b-D-glucoside (12), were isolated from the roots of P. umbrosa. All isolated compounds were explored for their antioxidant potential in the DPPH and ABTS assays. In DPPH assay, compound 5 showed high antioxidant capacity. Compounds 3, 4, 6, and 7 displayed considerable antioxidant activities. In addition, compounds 5-7 exhibited potential antioxidant capacities in the ABTS assay.
Phenolic Constituents and Their Anti-inflammatory Activity from Echinochloa utilis Grains
Duc Hung Nguyen,Bing Tian Zhao,Duc Dat Le,Ki Yun Kim,김영호,윤영호,고지연,우관식,우미희 한국생약학회 2016 Natural Product Sciences Vol.22 No.2
Seven phenolic compounds including p-coumaric acid (1), 4-hydroxybenzoic acid (2), 4-hydroxy-benzaldehyde (3), vanillic acid (4), luteolin (5), acacetin (6), and tricin (7), were isolated from the methylene chloride and ethyl acetate fractions of Echinochloa utilis grains. Compounds (1 - 4, 6) were isolated for the first time from this plant. These compounds were tested for inhibitory activities against LPS-induced NO production in RAW 264.7 cells. Compounds 5 and 6 displayed significant inhibitory effects, with IC50 values of 27.9 ? 2.6 and 14.0 ? 1.1 ?M, respectively. The results suggested that E. utilis ethanolic extract may be used as a potential source of anti-inflammatory agents and functional foods for the treatment of allergic diseases.
Duc Hung Nguyen,Bing Tian Zhao,Duc Dat Le,마은숙,민병선,우미희 한국생약학회 2019 Natural Product Sciences Vol.25 No.4
Cuscuta chinensis Lam. and Cuscuta japonica Choisy are parasitic plants. C. chinensis seeds were traditionally used for treatment of kidney and liver deficiencies. C. japonica seeds were used as tonic medicine to improve liver function and strengthen kidneys, treatment of high blood pressure, chronic diarrhea, and sore eyes. Cuscutae Semen are seeds of only C. chinensis in Korean Herbal Pharmacopoeia (K.H.P.). The developed HPLC-PDA method easily, accurately, and sensitively quantified using eight marker compounds [hyperoside (1), astragalin, (2), quercetin (3), kaempferol (4), chlorogenic acid (5), 3,4-di-O-caffeoylquinic acid (6), 1,5-di-O-caffeoylquinic acid (7), and 4,5-di-O-caffeoylquinic acid (8)]. In addition, the method may be used to distinguish seeds between C. chinensis Lam. and C. japonica Choisy. Furthermore, the result from the current study was applied to clarify samples between steam processed and unprocessed samples of C. chinensis by pattern analysis.
Hai Le Xuan,Quoc-Dong Hoang,Soon Geul Lee,Dat Pham Xuan,Hoang Tran Viet,Minh Pham Van,Hung Pham Van,Hung Pham Viet,PHAM DUC TUAN,Duc Anh Nguyen 대한기계학회 2022 JOURNAL OF MECHANICAL SCIENCE AND TECHNOLOGY Vol.36 No.2
Ballbots, which have been studied for over ten years, are under-actuated mobile robots that operate using the inverted pendulum paradigm. Controlling a ballbot poses a number of challenges, including maintaining the stable upright posture from the ground in all directions and making sure it follows the desired trajectory. External factors such as a minor change in contact surface properties or fabrication errors can affect the system's stabilization and transfer capabilities. In this study, an adaptive hierarchical sliding mode control algorithm based on an artificial neural network is developed to make the ballbot robust to external factors. The use of the proposed controller ensures system stability despite uncertainties including friction, accidental centrifugal forces and gravity that occur when the ballbot follows the reference trajectory. The system stability is guaranteed on the basis of Lyapunov theory. Control efficiency and robot stability under system uncertainties are demonstrated by numerical simulation.
Mi Hee Woo,Duc Hung Nguyen,Jae Sue CHOI,Se Eun Park,Phuong Thien Thuong,민병선,Duc Dat Le 대한약학회 2020 Archives of Pharmacal Research Vol.43 No.2
Kadsura coccinea (Lem.) A. C. Smith has beenused as a tonic, decongestant, and digestive agent. The rootsare also employed in traditional medicine to treat chronicenteritis, acute gastritis, duodenal ulcers, rheumatic pain inbone, and traumatic injuries. In the present study, we havedescribed the biological evaluation of constituents fromthe roots of K. coccinea with PTP1B and AChE inhibitoryactivities for the first time in literature. A new compound (1),kadcoccilactone T, and 24 known ones (2‒25) were isolatedand identified using spectroscopic methods. All the isolateswere examined for PTP1B and AChE inhibitory activities. Compounds 4 and 8 expressed strong PTP1B inhibitionwith IC50values of 1.57 ± 0.11 and 3.99 ± 1.08 μM, respectively. Apparently, these compounds were further studied forPTP1B enzyme kinetic analysis. The result indicated thatcompounds 4 and 8 exhibited mixed-type inhibition with theΚi values of 4.97 and 3.26 μM, respectively.
Protein tyrosine phosphatase 1B inhibitors from natural sources
Bing Tian Zhao,Duc Hung Nguyen,Duc Dat Le,최재수,민병선,우미희 대한약학회 2018 Archives of Pharmacal Research Vol.41 No.2
Since PTP1B enzyme was discovered in 1988, ithas captured the research community’s attention. Thislandmark discovery has stimulated numerous researchstudies on a variety of human diseases, including cancer,inflammation, and diabetes. Tremendous progress has beenmade in finding PTP1B inhibitors and exploring PTP1Bregulatory mechanisms. This review investigates for thenatural PTP1B inhibitors, and focuses on the commoncharacteristics of the discovered structures and structure–activity relationships. To facilitate understanding, all thenatural compounds are here divided into five differentclasses (fatty acids, phenolics, terpenoids, steroids, andalkaloids), according to their skeletons. These PTP1Binhibitors of scaffold structures could serve as a theoreticalbasis for new concept drug discovery and design.