음성 인식 헬스케어 시스템

신진우,조우승,조성빈,김재훈,정지은,사예지,백경동,박동규 순천향대학교 부설 산업기술연구소 2021 순천향 산업기술연구소논문집 Vol.27 No.2

As modern people's interest in health grows, wearable healthcare-related technologies that can collect biometric information and receive health-related services regardless of time and place are developing. This paper proposes the healthcare system based on voice recognition function. Unlike conventional wearable healthcare systems, the proposed system provides real-time telemedicine and diagnosis and the direct connection with doctors is possible through it. And almost all functions of the application in it are operated with voice commands to lower user access barriers. Because it deals with personal information including medical information, encryption algorithms have been applied between all data movements. Finally, the healthcare system proposed in this paper is expected to increase convenience in health care and reduce the medical gap.

운동유발성 아나필락시스 환자에서 혈 중 tryptase 측정 1례

예영민,임선교,서유진,최정희,서창희,남동호,박해심 대한천식 및 알레르기학회 2004 천식 및 알레르기 Vol.24 No.1

Exercise-induced anaphylaxis(EIA) is a medical emergency in that it derives from a physical allergy. We reported a case of food-independent EIA based on history and laboratory data. A 40-year-old male patient was presented with generalized urticaria, angioedema, and syncope after jogging. He had suffered from allergic rhinitis for 25 years. Increased level of serum tryptase was noted. Mast cell activation might be suggested in the pathophysiologic mechanism of EIA. (J Asthma Allergy Clin Immunol 24 : 152-5, 2004)

울산 지역에서 대기중 벤젠으로 인한 암 사망 손실비용 추정 모형에 관한 연구

이용진,김예신,신동천,신영철 한국환경경제학회 한국자원경제학회 2004 자원·환경경제연구 Vol.13 No.1

울산 지역에서 대기중 벤젠으로 인한 발암 인체영향에 대한 경제성 평가를 위해서, 건강 위해성 평가를 수행하여 대상 지역의 이론적 암 사망지수를 추정하고, 대상 지역 주민을 대상으로 가상 가치평가법을 통한 위해도 감소의 지불의사금액을 추정하여 1인의 통계적 생명가치액을 유도하여 이론적 암 사망지수에 대한 사망 손실비용을 유도하였다. 대상 지역의 대기중 벤젠의 평균 농도는 7.88㎍/㎥(min : 1.16∼max : 23.32㎍/㎥)로 조사되어 US EPA IRIS의 벤젠 단위 위해도 2.2×10^(-6)∼7.8∼10^(-6)을 사용하고, 30세 이상의 노출인구수 51만 6,641명에 대한 인구 집단 위해도를 추정한 결과 10년간 발생 가능한 발암 사망지수는 2.90명(5 percentile : 0.32명∼95 percentile : 9.11명)으로 조사되었다. 1인의 통계적 생명가치액을 추정하기 위하여, 공단 지역의 지불의사금약 모형을 추정한 결과, 응답자의 암 치료경험 유·무와 기대 여명, 가족수, 교육수즌이 유의한 영향 요인으로 조사되었고, 연간 1만 평당 5명의 위해도 감소에 대한 지불의사금액은 월1만 4,852원(95% C.I : 1만3,135원∼1만6,794)으로 산출되었으며, 위해도 감소치를 고려한 1인의 통계적 생명가치액은 약 3억6,000만원(95% C.I:3억2,000만원∼4억원)으로 추정되었다. 대기중 벤젠의 발암 영향으로 인한 건강 손실비용은 발암 위해성 평가로 추정된 이론적 사망지수에 1인의 통계적 생명가치액을 곱하여 추정하였다. 추정 결과, 현 수준의 벤젠의 발암 영향이 10년간 지속될 경우 약 10억원(5 percentile: 1억원∼95 percentile: 33억원)의 건강 손실이 있는 것으로 추정되었다. 본 연구 결과, 대기중 벤젠의 노출로 인한 위해도를 줄이기 위해서는 벤젠 단독물질에 대해서 이론적으로 10년간 약 10억원에 대응하는 감소 대책에 투자하여햐 한다. 그러나 벤젠 한 물질만을 감소시키기 위한 대안은 현실적이지 못하므로, 이 연구를 모델로 하여 차후 벤젠을 포함한 휘발성 유기오염물질에 대한 총합 적용이 필요하고, 손실비용을 재추정해야 할 것이다. This study aimed to evaluate cancer damage cost due to risk from benzene inhalation. We performed health risk assessment based on US EPA guideline to estimate annual population risk in Ulsan metropolitan city. Also, we estimated a willingness-to-pay amount for reducing a cancer mortality rate to evaluate a value of statistical life. We combined the annual population risk and the value of statistical life to calculate the cancer damage cost. In the health risk assessment, we applied the benzene unit risk (2.2×10^(-6)~7.8×10^(-6)) in the US EPA's Integrated Risk Information System to assess the annual population risk. Average concentration of benzene in ambient air is 7.88 ㎍/㎥(min: 1.16~ max: 23.32 ㎍/㎥). We targeted an exposure population of 516,641 persons who aged over 30 years old. Using a Monte-Carlo simulation for uncertainty analysis, we evaluated that the population risk of benzene during ten years in Ulsan city is 2.90 persons (5 percentile: 0.32 ~ 95 percentile: 9.11 persons). And the monthly averagc WTP for 5/1,000 cancer mortality reduction during ten years is 14,852 Won(95% C.I: 13,135 ~ 16,794 Won) and the implied VSL is 36 million Won(95% C.I: 32~40 million Won). Cancer damage cost due to risk from benzene inhalation during 10 years in Ulsan city is about 104 million Won(5 percentile: 13 ~95 percentile: 328 million Won). Health benefit cost to reduce a cancer mortality risk of benzene is about 50 million Won in Ulsan metropolitan city. But, it is very important that this cost is not for all health damage cost of cancer mortality in some area. We just recommended a model for evaluating a cancer risk reduction, so we must re-evaluate all integrated application of total VOCs damage cost including benzene.

소화성 궤양에서 삼제 병합 요법의 저용량에 의한 Helicobacter pylori 제균률과 궤양 치유효과

김예리,박봉안,이재동,이종혁,김인숙,박형석,진춘조,김상윤,박의우 건국대학교 의과학연구소 2000 건국의과학학술지 Vol.10 No.-

Helicobacter pylori is the major cause of histologic chronic gastritis and is strongly associated with peptic ulcer disease, gastric cancer and lymphoma. Several recommendations for the management of the Helicobacter pylori infection have been developed. However, there has been no clear therapeutic regimen for the optimal treatment of Helicobacter pylori infection. This study was desinged to evaluate the eradication rate and the ulcer healing rate of the triple regimen with low-dose clarithromycin(0.5g/day) in peptic ulcer patients. Forty three patients with gastric ulcer(n=15) and duodenal ulcer(n=28) were enrolled. The patients were treated either with omeprazole 20mg b.i.d. amoxicillin 0.5g b.i.d. and clarithromycin 250mg b.i.d. (low-dose regimen group, n=29) or with omeprazole 20mg b.i.d., amoxicillin 1.0g b.i.d. and clarithromycin 0.5g b.i.d.(high-dose regimen group, n= 14) for 2 weeks. After 4 weeks, the patients were evaluated for the eradication of Helicobacter pylori and the healing of ulcer. And gastritis scores according to the Sydney system were evaluated before and after 4 weeks from the end of the triple regimen. There was no significant difference in the eradication rate and the ulcer healing rate between the low-dose regimen group, group and the high-does regimen group. In the low-does regimen group, the mean initial scores of chronic inflammation and activity were decreased after the eradication of Helicobacter pylori. In conclusion, the low-dose triple regimen is as effective as the high-dose triple regimen on the eradication of Helicobacter pylori and the ulcer healing rate in peptic ulcer disease.

한국인 혼합치열기 아동의 두부방사선계측학적 연구

손동수,김진태,이상훈,한세현,김종철,선예경 大韓小兒齒科學會 1993 大韓小兒齒科學會誌 Vol.20 No.2

The purpose of this study was to obtain roentgenocephalmetric norms of the Korean mixed dentition children which are used in the occlusal guidance treatment. The 121 subjects(57 males and 64 females) were consisted of mixed dentition children who showed up in Department of Pediatric Dentistry Seoul National University Hospital from June 1990 till February 1993 and contestants of the Heathy Dentition Contest in 1992 and 1993. The subjects had normal profiles and occlusions without severe carious lesions or missing teeth. Following results were obtained from Sassouni, Ricketts and McNamara analysis; 1. Norms and standard deviations of the children were obtained. 2. ANS, upper incisor, pogonion, upper 1st molar and gonion were located posterior to their reference arcs and B was located anterior to its reference arc. 3. Lower anterior facial height was longer than upper anterior facial height and upper posterior facial height was longer than lower posterior facial height. Mandibular corpus length was longer than anterior cranial base length. 4. Anterior cranial length was longer in male(p<0.05) and mandibular corpus length was longer in male than in those of female(p<0.01). Porion was located more posterior in male than in those of female(p<0.05) 5. Effective mandibular length and lower anterior facial height were longer in male than in those of female(p<0.005). Effective midfacial length was longer in male than in those of female(p<0.05).

성인 엉덩관절을 이루는 구조에 대한 형태학적 연구

원예연,장준섭,정인혁,한대용,한창동,서진석 아주대학교 의과학연구소 1999 아주의학 Vol.4 No.1

With 77 hip joints of Korean adults available, anatomical study was carried out to clarify morphological variations of the acetabular labrum, the acetabular articular cartilage, the penetrating sites, the purchasing lengths of transacetabular screws including dangerous neurovascular structures, and the theoretical safe space of the acetabular fossa. The results were as follows; 1. The posterior superior region of the acetabulum through which the screw could be inserted more than 50 ㎜ in length was the safest region. However, depending on the insertion angle, the screw could penetrate the psoas muscle with an average 30 ㎜ of intervening space. 2. The average purchasing length of the screws penetrating the mid point (B) of the articular surface which was located on the inferior portion of the line (AB) connecting the anterior superior iliac spine and the center of the acetabulum: the mid points (C and D) of the articular surface which was located on the anterior and posterior portion of the line (CD) perpendicular to the line AB; and the mid point (G) of the articular surface which was located on the posterior inferior portion of the acetabular articular surface, was more than 20 ㎜. The screws penetrating the point "C" had a risk to damage the bladder and the screws penetrating the points "D" and "G" had a risk to endanger gluteal neurovascular bundles. 3. The screw placed in the anterior superior region of the acetabulum could be directed toward the external iliac vessels. The perpendicular bony thickness of this region averaged 13 ㎜. The topographical relationship of the external iliac artery and vein was variable and classified into 6 types. 4. At the center of the acetabulum, the most vulnerable structure was the obturator neurovascular bundle and the average thickness of bone at this point was measured as 6.5 ㎜. 5. The thickness of the compact bone became wider from the inner side to the outer side of the lunate surface. 6. The posterior inferior portion of the acetabular fossa would be a danger area when we used the screws for infernal fixation of the acetabular fracture through the acetabular fossa. 7. The morphological variations of the acetabular labrum which were measured differently at different locations should be considered during reading magnetic resonance images. 8. The anterior, anterosuperior and posterosuperior portion of the acetabular labrum might be easily torn because the labrum was attached to the bone-like "seating on a flat bony surface." 9. The shape of the articular cartilage was classified into 5 types according to the position of both ends. The above data in this study revealed new findings which should be considered at the times of diagnosis and operation of the hip joint together with morphological characteristics of Korean adult hips.

지하수 중 자연방사성물질의 위해성 관리에 대한 고찰

신동천,김예신,문지영,박화성,김진용,박선구 한국환경독성학회 2002 환경독성보건학회지 Vol.17 No.4

At present, the health risks associated with the natural radionuclides of ground water have become a concern as potential social problems. However, there are no regulatory actions or control strategies for such risks. Therefore, we have investigated and discussed the risks and associated management strategies for radionuclides in other countries. US EPA has proposed MCL (300 pCi/L) and AMCL (4,000 pCi/L) for radon, and 30 ppb for uranium, 15 pCi/L for gross-alpha and 5 pCi/L for radium as final MCLs. Also, Canada, WHO and European countries have their inherent management levels. Finally, we suggested several criteria for setting guidelines in our countries including exposure related criteria such as geological distribution, occurrence, exposure probability distribution, exposure population and multimedia exposure assessment, acceptable risk, and cost-benefit analysis. The national-scale exposure and risk assessment, and economic analysis should be conducted for producing and aggregating the representative information on these criteria.

사람의 혈장 아포지단백질 A-I에 대한 단일클론항체 A-I4-18의 생성 및 특성 분석

장예진,이상한,김동연,조만희,우기민 순천향의학연구소 1998 Journal of Soonchunhyang Medical Science Vol.4 No.1

본 연구는 사람의 고밀도 지단백질을 구성하는 아포지단백질 A-I에 특이적인 single-chain Fv를 클로닝하여 대장균 세포에서 발현시킬 목적으로, 먼저 단일클론항체 A-I4-18을 제조하였으며 이항체의 특성을 분석하였다. 아포지단백질 A-I을 BALB/c 생쥐에 면역한후 얻어진 비장세포를 Sp2/O myeloma세포주와 융합한 후 융합세포를 생쥐의 복강내에 주입하였으며, 복수를 채취하여 protein A Sepharose CL-4B크로마토그래피법으로 단일클론항체를 분리하였다. Isotyping결과 heavy chain은 subgroup IIa이며 κ형의 light chain을 나타내었으며 항원과의 결합특이성은 ELISA와 Western blotting법으로 확인하였다. Indirect ELISA법으로 얻어진 해리상수 (Kd)값은 8.33x10의 마이너스8승이었다.

서울 대기 중 미세 먼지 노출로 인한 위해도에 근거한 우선 관리 지역 선정 : 이론적 사망 위해도 및 손실비용을 근거로

김예신,이용진,신동천 한국환경독성학회 2004 환경독성보건학회지 Vol.19 No.1

It is important to select a risk based priority area for environmental policy formation and decision-making. We estimated the health risks and associated damage costs from exposure to fine particles and assigned priority areas for twenty-five districts in Seoul. In order to estimate the theoretical mortality incidence of the health risk, baseline risks were estimated from mortality rates in two low level areas of fine particles, Seocho Gu and Cheju city. To estimate the damage cost from the risk estimates, we investigated and estimated the willingness to pay(WTP) for specific risk reduction. We assumed two different locations as the reference area, Cheju city as Scenario I and Seocho gu as Scenariao Ⅱ. From the results, the five districts, Kwangjin, Chungnang, Kangbuk, Nowon, and Kangnam, ranked high in the categories of both health risk and economic risk. Damage costs were over twenty billion won in each of these districts. As there are uncertainties in these results, the parameter values such as PM_(2.5) level, dose-response slope factor, baseline risk, exposure population and WTP should be continuously validated and refined.

메트암페타민 정맥주사 남용후 발생한 뇌경색 2예

김종환,김동선,김상진,예종수,김성은,김응규,허경 대한신경과학회 1998 대한신경과학회지 Vol.16 No.5