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- 저자 : ( Dharma Lindarto ) (검색결과 1 건)
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( Sari Harahap ),( Dharma Lindarto ) 대한내과학회 2014 대한내과학회 추계학술대회 Vol.2014 No.1
Background: Obesity, accumulation of excessive adipose tissue, is a risk factor of cardiovascular diseases. Human adipocytes produce asymmetrical dimethyl arginine (ADMA) an inhibitor nitric oxide synthase which has important role in endothel dysfunction, and express the full enzymatic machinery responsible for ADMA metabolism (biosynthesis and degradation). Life style modifi cation and metformin have lowering body weight and ADMA level effects. This study intends to fi nd out whether life style modifi cation with metformin in obese subjects can make the improvement of ADMA level better. Methods: This was a randomized double blind clinical trial held in 12 weeks on 40 obese subjects which divided into 2 group, life style modification plus metformin group and life style modifi cation plus placebo group. Antropometric parametre and ADMA level were measured before and after intervention. Results: After intervention, there were decreament in ADMA level, body weight, waist circumfrence and body mass index in both group. Mean of ADMA reduction in metformin versus placebo group was 0,0235 ± 0,12 ug/l vs 0,03 ± 0,1ug/l (p=0,726). Mean of weight reduction in metformin versus placebo group was 3,88 ± 1,23 kg vs 2,36 ± 1,12 kg (p=0,0001). Mean of waist circumfrence reduction in metformin versus placebo group was 6,39 ± 0,99 cm vs 5,75 ± 1,71 cm (p=0,0001). Mean of body mass index reduction in metformin and placebo group was 1,76 ± 0,85 kg/m2 vs 1,08 ± 0,61 kg/m2 (p=0,0001). Conclusions: Implementation of lifestyle modification in 12 weeks could improve some antropometric parametres but addition of metformin did not improve the ADMA level signifi cantly in obese subjects.
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