운동수행에 매실음료의 스포츠음료 대처효과

민범일,배철웅,최연수 한국스포츠리서치 2003 한국 스포츠 리서치 Vol.14 No.2

The purpose of this study is to compare the differences in the effect of ion drink and plum drink, the Korea traditional drink, on the human body during treadmill training. For the purpose, this study sample 6male basketball players of university: The subjects were made to drink 500㎖, of the plum drink and the ion drink in each 20minutes before they began Treadmill training. The findings are as follows; 1. The ion drink and the plum drink had the biggest effets on the pressure, myocardial oxygen demand, and lactate right after the training was ended the effets gradually diminish. In the particular, there was a significant difference in the effects of the ion drink and the plum drink on the blood pressure, myocadial oxygen demand and lactate(P<.05), when they were measured at the above-mentioned measureing times. However, there was no significent difference in the effects of the two drinks on the blood pressure at the measuring times. 2. The effects of the ion drink and the plum drink on experied gas volume was the hightes 1minute before the all-out training was ended, and then gradually dismised. there was a significent differance in the effects of the two drinks at the measuring times(P<05), bur there was no difference in the two drinks. 3. The effects of the ion drink and the plum drink on the heart rate were the heighest after the training was finished and then gradually diminished. There was a significant(P<.05) in the effects at the measuring times, but there was no difference in the two drinks. The results showed that the effects of the plum drink and the ion drink on the body during the treadmill training were same and that the natural plum drink was considered to be more helpful comparing to the artifical ion drink from the viewpoint of nutrition.

Angiotensin-converting enzyme inhibitors versus angiotensin II receptor blockers in acute ST-segment elevation myocardial infarction patients with diabetes mellitus undergoing percutaneous coronary intervention

Choi, Se Yeon,Choi, Byoung Geol,Rha, Seung-Woon,Byun, Jae Kyeong,Shim, Min suk,Li, Hu,Mashaly, Ahmed,Choi, Cheol Ung,Park, Chang Gyu,Seo, Hong Seog,Oh, Dong Joo,Jeong, Myung Ho Elsevier 2017 INTERNATIONAL JOURNAL OF CARDIOLOGY Vol.249 No.-

<P><B>Abstract</B></P> <P><B>Background</B></P> <P>Diabetes Mellitus (DM) is an important factor of adverse cardiovascular events in acute ST-segment elevation myocardial infarction (STEMI) patients. Renin-angiotensin-aldosterone system (RAAS) inhibitors is associated with improved clinical outcomes, however, there are limited data comparing the effectiveness of two different RAAS inhibitors in STEMI patients with DM undergoing percutaneous coronary intervention (PCI) with drug-eluting stents (DES).</P> <P><B>Methods</B></P> <P>A total of 3811 eligible STEMI patients with DM were enrolled in Korea Acute Myocardial Infarction Registry (KAMIR). They were stratified into two groups: Angiotensin converting enzyme inhibitors (ACEI) group (n=2691) and angiotensin receptor blockers (ARB) group (n=1120). To adjust baseline confounding factors, we performed propensity score matching (PSM) analysis and evaluated individual and composite major clinical outcomes between the two groups up to 2years.</P> <P><B>Results</B></P> <P>After PSM, a total of 1049 well-matched pairs were generated. Baseline clinical, angiographic and procedural characteristics were well-balanced between the two groups. The incidence of death, recurrent myocardial infarction (MI), revascularization and major adverse cardiac events (MACE) were not significantly different between the two groups up to 2years,</P> <P><B>Conclusion</B></P> <P>In the present study, ACEI and ARB showed comparable effectiveness and safety on individual and composite clinical outcomes in STEMI patients with DM who underwent successful PCI with DES at least up to 2years.</P>

Effect of Pitavastatin Compared with Atorvastatin andRosuvastatin on New-Onset Diabetes Mellitus in PatientsWith Acute Myocardial Infarction

Choi, Jah Yeon,Choi, Cheol Ung,Hwang, Soon-Young,Choi, Byoung Geol,Jang, Won Young,Kim, Do Young,Kim, Woohyeun,Park, Eun Jin,Lee, Sunki,Na, Jin Oh,Kim, Jin Won,Kim, Eung Ju,Rha, Seung-Woon,Park, Chang Elsevier 2018 The American Journal of Cardiology Vol.122 No.6

<P>Although statin use in patients with acute myocardial infarction (AMI) is mandatory, it has been suggested to be associated with new-onset diabetes mellitus (NODM). In real world practice, moderate-intensity statin therapy is more commonly used than high-intensity statin therapy. In this study, we investigated the impact of moderate-intensity pitavastatin (2 to 4 mg) compared with moderate-intensity atorvastatin (10 to 20 mg) and rosuvastatin (5 to 10 mg) on the development of NODM during a follow-up period of up to 3years. Between November 2011 and May 2015, 2001 patients with AMI who did not have diabetes mellitus were investigated. The cumulative incidence of NODM was evaluated in all groups. To adjust for potential confounders, multinomial propensity scores were used. Cox proportional hazard models were used to assess the hazard ratio of NODM in the atorvastatin and rosuvastatin groups compared with pitavastatin group. The cumulative incidence of NODM was significantly lower in pitavastatin group compared with the atorvastatin and rosuvastatin groups (3.0% vs 8.4% vs 10.4%, respectively; Log-rank p value = 0.001). After weighting the baseline characteristics of the 3 statin groups by multinomial propensity scores, atorvastatin (hazard ratio: 2.615, 95% confidence interval: 1.163 to 5.879) and rosuvastatin (hazard ratio: 3.906, 95% confidence interval: 1.756 to 8.688) were found to be associated with a higher incidence of NODM compared with pitavastatin therapy on multivariable analysis. Moderate-intensity pitavastatin therapy is associated with a lower incidence of NODM in patients with AMI andhas similar clinical outcomes to moderate-intensity atorvastatin and rosuvastatin therapy.</P>

Can mean platelet volume predict coronary vasospasm??

Choi, Cheol Ung,Seo, Hong Seog,Kim, Yun Kyung,Na, Jin Oh,Lim, Hong Euy,Kim, Jin Won,Kim, Eung Ju,Rha, Seung-Woon,Park, Chang Gyu,Oh, Dong Joo Informa UK, Ltd. 2011 Platelets Vol.22 No.3

<P>Mean platelet volume (MPV) is an index of platelet function that reflects platelet production rate and sensitivity to activation. The relationship between MPV and coronary vasospasm has not been previously studied. In this study, we aimed to evaluate this relationship. A total of 696 patients (age 55.20 ??±짹 ??12.26, male 46.4%%, female 53.6%%) with typical or atypical angina who underwent diagnostic coronary angiography (CAG) and an acetylcholine (Ach)-provocation test were enrolled. Each patient was assigned to either an Ach-induced coronary vasospasm group (<I>n</I> ??== ??183) or a control group (<I>n</I> ??== ??513). We compared MPV between the two groups. MPV and the platelet count showed a negative correlation (<I>r</I> ??== ??−??0.289, <I>p</I> ??< ??0.001). MPV was higher in the Ach-induced coronary vasospasm group than in the control group (9.03 ??±짹 ??1.37 ??fl and 8.69 ??±짹 ??1.25 ??fl, respectively, <I>p</I> ??== ??0.002). In multivariate analysis, MPV independently predicted Ach-induced coronary vasospasm (OR ??== ??1.188, <I>p</I> ??== ??0.018). This study identified high MPV as an independent risk factor for Ach-induced coronary vasospasm.</P>

The Reproductive Cycle of the Humbug Damselfish Dascyllus aruanus According to the Changes in Lunar Phase in Micronesia

Choi, Ji Yong,Kim, Na Na,Lee, Dae-Won,Choi, Young-Ung,Choi, Cheol Young Korean Ocean Research & Development Institute and 2017 OCEAN SCIENCE JOURNAL Vol.52 No.3

Mid-term angiographic benefit of sirolimus-eluting stents compared with paclitaxel-eluting stents in patients with acute myocardial infarction

Choi, Cheol Ung,Rha, Seung-Woon,Chen, Kang-Yin,Jin, Zhe,Minami, Yoshiyasu,Shin, Seung Yong,Na, Jin Oh,Suh, Soon Yong,Lim, Hong Euy,Kim, Jin Won,Kim, Eung Ju,Park, Chang Gyu,Seo, Hong Seog,Oh, Dong Joo Elsevier 2009 Journal of cardiology Vol.54 No.1

<P><B>Summary</B></P><P><B>Background</B></P><P>We compared angiographic and clinical outcomes among different drug-eluting stents (DESs) in Korean acute myocardial infarction (AMI) patients.</P><P><B>Methods</B></P><P>A total of 109 consecutive AMI patients who underwent percutaneous coronary intervention (PCI) with either sirolimus-eluting (SES, <I>n</I>=56 pts) or paclitaxel-eluting stents (PES, <I>n</I>=53 pts) were enrolled from August 2004 to December 2006. The angiographic outcomes at 6 months and clinical outcomes at 1 year were compared between the two groups.</P><P><B>Results</B></P><P>Baseline clinical and procedural characteristics were similar between the two groups. At 6 months, the rate of binary restenosis was 17.0% in the PES group compared with 3.6% in the SES group (<I>p</I>=0.026). Percent restenosis was 24.9±28.6% in the PES group compared with 11.2±17.6% in the SES group (<I>p</I>=0.004). Length of restenosis segment was 3.21±9.02mm in the PES group compared with 0.89±2.38mm in the SES group (<I>p</I>=0.048). Late loss was 0.73±0.89mm in the PES group compared with 0.28±0.37mm in the SES group (<I>p</I>=0.001). However, there were no differences in clinical outcomes at 1 year including mortality, myocardial infarction, repeat PCI, and major cardiac adverse events between two groups.</P><P><B>Conclusion</B></P><P>SES implantation in patients with AMI was associated with reduction in angiographic restenosis at 6 months compared with PES, however, these angiographic benefits were not translated into better clinical outcomes in real world clinical practice.</P>

혈압측정 트렌드의 변화: 중심 동맥압과 대동맥 경직도, 맥파 분석

최철웅 ( Cheol Ung Choi ),박창규 ( Chang Gyu Park ) 대한내과학회 2009 대한내과학회지 Vol.76 No.4

중심 대동맥압은 말초동맥압에 비해, 직접적으로 심장의 후부하를 나타내는 표지자임으로, 좌심실 심근, 관상동맥과 뇌혈관의 부하에 대해 보다 더 정확하게 반영을 하고, 표적장기손상 및 심혈관 질환의 발생과 더 밀접하게 관련이 있는 것으로 알려져 있다. 대규모의 연구에서도 파형증가 지수 등 맥파 분석과 중심 대동맥압이 심혈관 질환의 발생과 연관이 있다고 보고하였고, 이런 요소들을 비침습적으로 측정하는 방법들이 소개되었다. 따라서 중심 대동맥압과 맥파 속도 및 파형증가 지수 측정이 실제 환자를 치료하는데 있어서 중요할 것으로 생각되고 있다. 혈관경직도를 개선시키는 방안은 혈관경직도에 관여하는 요인이 다양하므로 비약물 요법과 함께 다양한 약제를 복합하는 치료로 발전할 것으로 생각된다. 아직 해결해야 될 제한점들(각 지표들의 측정부위 및 방법의 표준화, 다양한 환자군에서 사용가능하고 적용할 수 있는 참고치 확정 등)이 남아있기는 하지만 향후 중심 대동맥압과 이와 연관된 지수들(대동맥 경직도; 맥파 속도, 맥파분석; 파형증가 지수)이 실제 임상에서 사용될 수 있을 것으로 기대가 된다. The 2007 European Society of Hypertension/European Society of Cardiology guidelines acknowledged that the central (aortic) blood pressure (BP), which is the pressure exerted on the heart and brain, may differ from the pressure that is measured at the arm. They also recognized that central pressure may predict outcome in specific populations and is affected differently by antihypertensive drugs. These guidelines also regarded an increased carotid-femoral pulse wave velocity as subclinical organ damage and classified increased arterial stiffness into high/very-high risk. Clinical studies have indicated that the central BP and central hemodynamics (aortic stiffness, augmentation index) are important components in the determination of cardiovascular risk in some patients. More importantly, recent large-scale trials have shown that central hemodynamics may constitute a worthwhile treatment target. In addition, central hemodynamics can now be assessed reliably noninvasively with a number of devices. Accordingly, because arterial stiffness and central hemodynamics are markers and manifestations of organ damage, they independently predict future cardiovascular events. (Korean J Med 76:389-397, 2009)

아세틸 콜린 유발 검사시 허혈성 심전도 변화와 흉통의 발생이 내피세포 기능장애에 미치는 영향

최철웅(Cheol Ung Choi),나승운(Seung-Woon Rha),김선원(Sun Won Kim),나진오(Jin Oh Na),임홍의(Hong Euy Lim),김진원(Jin Won Kim),김응주(Eung Ju Kim),한성우(Seong Woo Han),박창규(Chang Gyu Park),서홍석(Hong Seog Seo),오동주(Dong Joo Oh) 대한임상노인의학회 2010 대한임상노인의학회지 Vol.11 No.4

연구배경: 아세틸 콜린 유발 검사시 발생하는 흉통과 허혈성 심전도 변화가 아세틸 콜린에 의해 발생하는 관상동맥의 내피세포 기능에 어떤 영향을 주는지 알아보고자 했다. 방법: 흉통으로 내원하여 관상동맥 조영술과 아세틸 콜린 유발검사를 시행받은 1,085명의 환자를 대상으로 하였다. 아세틸 콜린 유발 검사를 하는 동안 허혈성 심전도 변화 및 흉통의 발생 유무에 따른 관상동맥 내피세포 기능의 특징을 비교하였다. 결과: 539명의 환자에서 아세틸 콜린 검사시 내피세포 기능 장애가 발생 하였다. 허혈성 심전도 변화가 있었던 그룹이 심전도 변화가 없었던 그룹보다 흉통이 더 많았고(78.1% vs. 60.8%, P=0.007), 관상동맥 조영술상 다발성 관상동맥 경련이 빈번하였고(59.4% vs. 40.6%, P=0.004), 관상동맥의 경련 정도도 더 심하였다(64.1% vs. 46.5%, P=0.006). 흉통이 있었던 그룹이 흉통이 없었던 그룹보다 허혈성 심전도 변화의 빈도가 더 높았다(14.7% vs. 7.5%, P=0.007). 또한 흉통이 있었던 그룹이 관상동맥 경련이 다발성으로 발생하는 경우가 많았고 (50.7% vs. 29.5%, P<0.001), 미만성으로 발생하는 경우가 많았고(87.1% vs. 75%, P<0.001), 관상동맥의 경련의 정도도 더 심하였다(51.6% vs. 43.5%, P=0.041). 결론: 아세틸 콜린 유발검사시 발생하는 허혈성 심전도 변화와 흉통은 관상동맥 경련의 정도와 경련이 발생하는 관상동맥 개수와 연관이 있다. Background: ECG changes and chest pain during acetylcholine (Ach) provocation tests may constitute important clinical parameters for Ach-induced endothelial dysfunction. We investigated the association between ischemic ECG changes and chest pain during the Ach-provocation test and angiographic characteristics of Ach-induced endothelial dysfunction. Methods: A total of 1,085 patients with anginal symptoms underwent diagnostic coronary angiography (CAG) and Ach-provocation tests. We compared angiographic characteristics of Ach-induced endothelial dysfunction according to the presence of ECG change and chest pain. Results: A total of 539 patients experienced Ach-induced endothelial dysfunction. Patients who experienced ECG change group suffered more frequent chest pain (78.1% vs. 60.8%, P=0.007), angiographically more frequent multiple coronary artery spasm (59.4% vs. 40.6%, P=0.004), and more severe coronary artery spasm (64.1% vs. 46.5%, P=0.006) than patients without ECG change. However, there was no difference in the length of endothelial dysfunction between the groups. The incidence of ischemic ECG changes in patients with chest pain was higher than in patients without chest pain (14.7% vs. 7.5%, P=0.007). Patients who experienced chest pain more often experienced multiple (50.7% vs. 29.5%, P<0.001), diffuse (87.1% vs. 75%, P<0.001), and severe coronary artery spasm (51.6% vs. 43.5%, P=0.041) than patients without chest pain. Conclusion: Ischemic ECG changes and chest pain during the Ach-provocation test are associated with multi-vessel involvement and severe coronary artery spasm. Chest pain is associated with the length of endothelial dysfunction, but ischemic ECG change is not.

The impact of myocardial bridge on coronary artery spasm and long-term clinical outcomes in patients without significant atherosclerotic stenosis

Nam, Purumeh,Choi, Byoung Geol,Choi, Se Yeon,Byun, Jae Kyeong,Mashaly, Ahmed,Park, Yoonjee,Jang, Won Young,Kim, Woohyeun,Choi, Jah Yeon,Park, Eun Jin,Na, Jin Oh,Choi, Cheol Ung,Lim, Hong Euy,Kim, Eung Elsevier 2018 Atherosclerosis Vol.270 No.-

<P><B>Abstract</B></P> <P><B>Background and aims</B></P> <P>Myocardial bridge (MB) and coronary artery spasm (CAS) can induce a sustained chest pain, acute coronary syndrome (ACS) and even sudden cardiac death. The aim of this study is to evaluate the relationship between MB and CAS and its impact on long-term clinical outcomes.</P> <P><B>Methods</B></P> <P>A total of 812 patients with MB without significant coronary artery disease (CAD), who underwent acetylcholine (ACH) provocation test, were enrolled. Significant CAS was defined as ≥70% temporary narrowing by ACH test, and MB was defined as the characteristic phasic systolic compression of the coronary artery with a decrease of more than 30% in diameter on the angiogram after intracoronary nitroglycerin infusion. To adjust baseline confounders, logistic regression analysis was performed. The primary endpoint was incidence of CAS, and secondary endpoints were major adverse cardiac events (MACE) and recurrent angina requiring repeat coronary angiography (CAG) at 5 years.</P> <P><B>Results</B></P> <P>MB is closely implicated in a high incidence of CAS, spontaneous spasm, ischemic ECG change and chest pain during ACH provocation test. In addition, MB of various severity and reference vessel size was substantially implicated in CAS incidence, and severe MB was a strong risk factor of CAS. MB patients with CAS were shown to have a higher rate of recurrent angina compared with MB patients without CAS, up to a 5-year follow-up. However, there were no differences regarding the incidence of MACE.</P> <P><B>Conclusions</B></P> <P>Severe MB was associated with high incidence of CAS, and MB patients with CAS were likely to have a higher incidence of recurrent angina. Intensive medical therapy and close clinical follow-up are needed for better clinical outcomes in MB patients with CAS.</P> <P><B>Highlights</B></P> <P> <UL> <LI> The aim of this study is to evaluate the relationship between myocardial bridge (MB) and coronary artery spasm (CAS). </LI> <LI> A total of 812 patients with MB without significant coronary artery disease who underwent acetylcholine test were enrolled. </LI> <LI> Severe MB was associated with high incidence of CAS, and MB patients with CAS had a higher incidence of recurrent angina. </LI> </UL> </P>

Impact of Cigarette Smoking: a 3-Year Clinical Outcome of Vasospastic Angina Patients

Byoung Geol Choi,Seung-Woon Rha,Taeshik Park,Se Yeon Choi,Jae Kyeong Byun,Min Suk Shim,Shaopeng Xu,Hu Li,Sang-Ho Park,Ji Young Park,Woong Gil Choi,Yun-Hyeong Cho,이선기,Jin Oh Na,Cheol Ung Choi,Hong Euy 대한심장학회 2016 Korean Circulation Journal Vol.46 No.5

However, it is largely unknown whether smoking adds to any long-term clinical risk in VSA patients. Subjects and Methods: A total of 2797 patients without significant CAD underwent acetylcholine (Ach) provocation test between November 2004 and October 2010. Patients were divided into three groups, based on the presence of coronary artery spasm (CAS) and smoking habits (non-CAS group: n=1188, non-smoking CAS group: n=1214, smoking CAS group: n=395). All CAS patients were prescribed with anti-anginal medications for at least 6 months. The incidence of major clinical outcomes and recurrent angina of these groups were compared up to 3 years. Results: There were considerable differences in the baseline clinical and angiographic characteristics among the three groups, but there was no difference in the endpoints among the three groups (including individual and composite hard endpoints) such as death, myocardial infarction, de novo percutaneous coronary intervention, cerebrovascular accident, and major adverse cardiac events. However, there was a higher incidence of recurrent angina in both the non-smoking CAS group and smoking CAS group, as compared to the nonCAS group. In multivariable adjusted Cox-proportional hazards regression analysis, smoking CAS group exhibited a higher incidence of recurrent angina compared with the non-CAS group (hazard ratio [HR]; 2.46, 95% confidence interval [CI]; 1.46-4.14, p=0.001) and nonsmoking CAS group (HR; 1.76, 95% CI; 1.08-2.87, p=0.021). Conclusion: Cigarette smoking CAS group exhibited higher incidence of recurrent angina during the 3-year clinical follow-up compared with both the non-CAS group and non-smoking CAS group. Quitting of smoking, paired with intensive medical therapy and close clinical follow-up, can help to prevent recurrent angina.