악교정 수술후 골격성 Ⅲ급 부정교합 환자의 하악운동 변화에 관한 연구

남동석,양원식,서정훈,장영일 대한치과교정학회 1997 대한치과교정학회지 Vol.27 No.2

본 연구는 골격성 III급 부정교합 환자에서 악교정 수술 전후의 하악운동 양상을 관찰하여 수술에 의한 하악운동의 변화를 평가하기 위하여 시행되었다. 서울대학교병원 교정과에서 골격성 III급 부정교합으로 진단받고 수술 전 교정치료를 받은 후, 동 병원 악안면구강외과에서 악교정 수술을 시행한 20명(남;9명, 여;11명)을 대상으로 수술 직전과 수술 2-7개월 후에 Sirognathograph와 BioPak EGN을 이용하여 최대 개폐구 운동과 시상면, 전두면, 수평면에서의 하악한계운동을 기록하고 21개의 항목을 계측하여 다음과 같은 결과를 얻었다. 1. 수술 후에 가장 큰 변화를 보인 항목은 시상면상 전방 운동각도로서, 수술 전 17.4°에서 수술 후 38.8°로 증가하였다. 또한 전치 유도가 형성됨에 따라 전방운동 궤적도 일직선에서 상악 절치의 형태에 따른 곡선으로 변하였다. 2. 수술 전후를 비교할 때 p<0.01 수준에서 유의성을 보인 항목들은 최대 개폐구 운동시 최대 개구량과 최대 전후방 운동량, 시상면상 최대 개구량, 전두면상 좌측방 운동각도의 4항목이었다. 3. 수술 전후를 비교할 때 p<0.05 수준에서 유의성을 보인 항목들은 전두면상 최대 좌우 운동폭, 수평면상 최대 우측방 운동거리, 최대 좌측방 운동각의 3항목이었다. 4. 최대 개폐구 운동시 최대 개구량과 최대 전후방 운동량은 수술 후 측정시간에 따른 차이를 보였다(p<0.05). 즉 2, 3개월군에서보다 5, 6, 7개월군에서 더 많은 운동량 회복을 나타내었다. 5. 수술 전 불규칙하던 개폐구시 운동 궤적은 수술 후 개구로와 폐구로가 일치하며 부드러운 곡선을 이루었는데, 이는 악교정 수술에 의해 교합장애가 제거되었기 때문인 것으로 생각된다. The purpose of this study was to evaluate changes in mandibular movement patterns after orthognathic surgery in skeletal Class III patients. The sample consisted of 20 Class III malocclusion patients(9 males, 11 females). Just before and after(2-7months) surgery, maximum opening & closing movement, mandibular border movement on sagittal, frontal and horizontal planes were recorded using Sirognathograph & BioPak EGN. On each record, 21 items were measured and statistically analyzed. The results were as follows: 1. Angle of protrusive movement on sagittal plane showed greatest change after surgery. Also, as the incisal guidance was established by surgery, straight path of protrusive movement became curved line. 2. Maximum opening distance and maximum antero-posterior distance on maximum opening & closing movement, maximum opening distance on sagittal plane, angle of left lateral excursion on frontal plane were statistically significant after surgery(p<0.01). 3. Maximum width of lateral excursion on frontal plane, distane of right lateral excursion and angle of maximum left lateral excursion on horizontal plane were statistically significant after surgery(p<0.05). 4. Maximum opening distance and maximum antero-posterior distance on maximum opening % closing movement showed significant differences according to post-surgical time(p<0.05). More recovery of range of movement occured in 5-7month group than in 2-3month group. 5. As the occlusal interferences were removed by orthognathic surgery, irregular opening & closing path became smooth curve.

Effect of epidural corticosteroid injection on magnetic resonance imaging findings

( Min Soo Kim ),( Tae Yoon Jeong ),( Yu Seon Cheong ),( Young Wook Jeon ),( So Young Lim ),( Seong Sik Kang ),( In Nam Kim ),( Tsong Bin Chang ),( Hyun Ho Seong ),( Byeong Mun Hwang ) 대한통증학회 2017 The Korean Journal of Pain Vol.30 No.4

Background: Magnetic resonance imaging (MRI) of the spine is the preferred diagnostic tool for pathologic conditions affecting the spine. However, in patients receiving epidural corticosteroid injection (ESI) for treatment of spinal diseases, there is a possibility of misreading of MR images because of air or fluid in the epidural space after the injection. Therefore, we defined the characteristics of abnormal changes in MRI findings following an ESI in patients with low back pain. Methods: We reviewed the medical records of 133 patients who underwent MRI of the lumbar spine within 7 days after ESI between 2006 and 2015.All patients were administered an ESI using a 22-gauge Tuohy needle at the lumbar spine through the interlaminar approach. The epidural space was identified by the loss of resistance technique with air. Results: The incidences of abnormal changes in MRI findings because of ESI were 54%, 31%, and 25% in patients who underwent MRI at approximately 24 h, and 2 and 3 days after ESI, respectively. Abnormal MRI findings included epidural air or fluid, needle tracks, and soft tissue changes. Epidural air, the most frequent abnormal finding (82%), was observed in 41% of patients who underwent MRI within 3 days after injection. Abnormal findings due to an ESI were not observed in MR images acquired 4 days after ESI or later. Conclusions: Pain physicians should consider the possibility of abnormal findings in MR images acquired after epidural injection using the interlaminar approach and the loss of resistance technique with air at the lumbar spine. (Korean J Pain 2017; 30: 281-6)

시판 청량음료 시음 후의 마뇨산 배설에 관한 실험적 연구

장성훈,김청식,김준식 건국대학교 의과학연구소 1999 건국의과학학술지 Vol.9 No.-

In this study, we measured the urinary excretion of the hippuric acid after ingestion of several kinds of common soft drinks. The urinary hippuric acid has been known as a sensitive and specific biomarker of toluene exposure in workplace. But it has not been known exactly that drinking some kinds of soft drinks can increase urinary hippuric acid significantly even in usual dosage. These phenomena surely can invoke problems in interpretation of urinary hippuric acid at the regular health check up of the workers exposed to toluene. We recruited 140 healthy volunteers(medical school students) and surveyed their diet history, medication, smoking and drinking habit before experiment. The persons who had eaten some kinds of food or drinks which were including benzoic acid were excluded and the rest 122 were divided into 2 groups. The Experimental group(n=88) drank the soft drinks which contained benzoic acid, and the control group(n=34) drank the soft drinks which contained not. We checked the excretion of urinary hippuric acid in 1.5hr and 3hr after ingestion of the drinks in each group. The measurement of urinary hippuric acid was performed by using high performance liquid chromatography(HPLC). The results were as follows: 1. The mean age(year) was 23.3±1.4 in experimental group, and 23.5±2.4 in control group; the number of female was 13(14.8%) and 4(11.8%) in each group. 2. The geometric mean of urinary hippuric acid before drinking soft drinks was 0.24, and 0.21g/l in experimental and control group(p=0.426). In 1.5 hour after ingestion of the drinks, the geometric mean increased 1.14g/l in experimental group, and 0.17g/l in control group, which was significantly different after adjusting the urinary hippuric acid before drinking(p<0.01). By addition some other covariates(sex, smoking in amount) in the model, the result was not changed(p<0.01). In 3.0 hour after ingestion, the geometric mean was 0.32 and 0.16g/l in each group, even the difference was much smaller than that of 1.5 hour after drinking, which was statistically different after adjusting the urinary hippuric acid of before drinking(p<0.01), sex and smoking additionally(p<0.01). 3. The mean increasement of urinary hippuric acid after 1.5 hour(Diff 1) after ingestion was 0.83 in experimental group, which was significantly different from that of control group(-0.06, p<0.01). Diff 2(the increasement after 3.0 hour) was also different from each other(p<0.01). 4. We used 7 different kinds of soft drinks in experimental group. The increasement after drinking them was different from 0.57 to 1.05g/l after 1.5 hour, from -0.08 to 0.08g/l after 3.0 hour, but statistically not significant in each other(p=0.146, p=0.849 in sequence). We concluded that the soft drinks which contain benzoic acid could increase the urinary hippuric acid excretion significantly, even over 1.0g/l without toluene exposure. It seems to be needed that check the diet and drink(at least 3.0 hour before collect the urine) history is essential in interpretation of urinary hippuric acid concentration.

교정 치료 환자에 있어 항균 varnish 처치 전후의 타액 내 Streptococcus mutans 균주의 변화에 관한 연구

남동석,양원식,장영일,서정훈,정종평,김태우 대한치과교정학회 1994 대한치과교정학회지 Vol.24 No.3

Dental caries is one of the most prevalent dental diseases in Korea and its prevention is very important in orthodontic therapy. For the cleansing action of saliva itself and/or tooth-brushing is lowered in patient with fixed orthodontic appliance, oral hygiene of the patient becomes worse, which provides more favorable environment for micro-organisms. Chlorexidine, one of the series of bisguanide, has been reported to be strong antimicrobial agent and very effective on Streptococcus mutans. The purpose of this study is to evaluate the possibility of chlorhexidine as a anticariogenic agent in fixed orthodontic therapy. We used the varnish containing chlorhexidine as a main ingredient for the chemical control of salivary S.mutans in patients with fixed appliance therapy. We applied the varnish containing chlorhexidine on the labial and interproximal surface of the teeth before bonding and banding teeth of our patients(N=20) and compared to control group patients(N=20). Before the application of chlorhexidine varnish and four times periodically after the completion of fixed appliance set-up, we sampled saliva of both group patients and incuvate S.mutans for 24 hours. In the culture study of sampled saliva, counting the number of S.mutans colonies, we founded as follows : 1. In patients with fixed appliance therapy, the risk of dental caries increase when it compared to that of preorthodontic treatment ; The number of salivary S.mutans increase in patient's oral cavity. 2. The experimental agent that contain chlorhexidine is effective to reduce the number of salivary S.mutans. 3. For the effect of this agent is not ever-lasting, periodical application is needed, and additional study for economical interval and number of application is needed.

교정환자의 관리, 진단, 성장과 치료결과 분석을 위한 software 개발에 관한 연구

장영일,김태우,양원식,김근만,남동석,서정훈 대한치과교정학회 1992 대한치과교정학회지 Vol.22 No.4

It is prerequisite of orthodontists to diagnose malocclusion correctly and make treatment plans accurately for treating maloccluded patients efficiently and earning more stable and better results. Recently computers were introduced in orthodontic diagnosis steps, which enabled orthodontists to get more precise diagnosis, to make more accurate treatment planning and to provide better orthodontic cares for more patients. The authors studied on the diagnostic analysis methods which have been used frequently in Korea and made a diagnostic computer program including the horizontal and/or vertical measurement of length, degrees and proportions in lateral cephalometric radiographs, the analysis of the skeletal and soft-tissue features and the evaluation of the treatment results. We also made a scheduling program for arrangement and management of patients. 40 skeletal and 24 soft-tissue landmarks were selected in a lateral cephalometric radiographs. The available analysis methods in this program are Angular analysis, Linear analysis, Ricketts analysis, Profilogram, Steiner analysis, Tweed analysis, MacNamara analysis, Open bite analysis, Kim's diagnosis, Skeleto-dental cephalometric analysis and Height& weight analysis. We suggested that this diagnostic computer program make it possible for orthodontists to get more rapid and accurate diagnostic analysis and treatment planning and for patient to earn better and more efficient orthodontic service.

韓國人 兒童의 顔面輪廓에 關한 頭部放射線學的 硏究

張英一,南東錫,梁源植,徐廷勳 대한치과교정학회 1976 대한치과교정학회지 Vol.6 No.1

This study was undertaken to investigate the values of the cephalometric standards of Korean children which consisted of 57 boys and 61 girls with normal occlusion and harmony of the facial musculature. The following conclusions were obtained. 1) The relatively vertical inclination of nasal bone and flat contour of the frontal bone contribute to the flattening of the upper face. 2) Slight lack of chin prominence characterizes the lower face while procumbent incisors and their alveolar bone dominate the middle face. 3) A caudal skull base inclination is probably the most specific feature for Korean.

思春期前 兒童의 正常 鼻腔 通氣度에 관한 硏究

서정훈,장영일,양원식,남동석 대한치과교정학회 1992 대한치과교정학회지 Vol.22 No.1

This study was designed to analyze normal nasal respiratory resistance in prepubertal children. The subjects consisted of 30 prepubertal children(male:15, female:15).The mean age was 11.4 years in male children and 11.5 years in female children. The results were as follows: 1.The normal nasal respiratory patency was lower than the normal values from RION corp. 2.The normal nasal respiratory airflow rates showed no sexual differences. And there were no differences between inspiration and expiration. 3.Before and after use of nasal decongestants, there were no significant differences of normal nasal respiratory airflow rates and after the administration of nasal decongestants, nasal respiratory patency manifested lower variability. 4.The normal nasal respiratory resistance without nasal decongestants at 150 Pascal in inspiration was 0.30 Pa/cm³/sec(±0.07) and peak nasal inspiratory airflow rate was 1016.83cm³/sec(±223.89). 5.The normal nasal respiratory resistance with nasal decongestant at 150 Pascal in inspiration was 0.25 Pa/cm³/sec(±0.05) and peak nasal inspiratory airflow rate was 1148.33 cm³/sec(±234.29).

산부식시간이 법랑질 표면 부식형태와 교정장치의 전단접착강도에 미치는 영향에 관한 연구

서정훈,장영일,양원식,남동석 대한치과교정학회 1997 대한치과교정학회지 Vol.27 No.5

본 연구의 목적은 법랑질 표면에 대한 산부식시간의 차이가 법랑질 표면의 부식형태, 교정장치의 전단접착강도 및 탈락 양상에 미치는 영향을 알아보는 것이다. 교정치료를 위해 발거된 하악 소구치의 법랑질을 37%의 인산 용액을 이용하여 동일한 방법으로 각각 5, 10, 15, 30, 45, 60, 90, 120초동안 부식시킨후 법랑질 표면을 주사전자현미경으로 관찰하고, 교정장치를 접착한 후 Instron universal testing machine을 이용하여 전단접착강도를 측정하고 교정장치의 탈락양상을 관찰하여 다음과 같은 결론을 얻었다. 1. 산부식시간을 5-120초 범위에서 변화시켜도 교정장치의 전단접착강도는 통계학적으로 유의성 있는 차이가 없었다(p<0.05). 2. 산부식시간에 따른 교정장치의 탈락양상은 15초이하 부식군에서는 접착제/법랑질 경계부 탈락이 상대적으로 많았으나, 30초 이상 부식군에서는 접착제/교정장치 경계부 탈락이 많았다. 3. 법랑질 표면의 부식형태는 매우 다양하였으며 동일한 법랑질 표면에서도 여러 가지 형태의 부식 소견이 관찰되었다. 또한 법랑질 부식형태와 교정장치의 접착강도 사이에 연관성을 발견할 수 없었다. 4. 본 연구의 결과는 실험적 조건에서는 부식시간을 5초로 단축하여도 임상적으로 유용한 접착강도를 얻을 수 있음을 보여주고 있다. 그러나, 15초 이하 부식군에서 나타난 탈락양상에 대해서는 더 많은 연구가 이루어져야 할 것으로 여겨진다. The purpose of this in vitro study was to evaluate the effects of different acid etching times on th enamel surface morphology, shear bond strength and debonding failure mode of orthodontic attachment. Ninety six extracted human mandibular premolars were divided into eight groups of twelve teeth. The buccal surfaces were etched with 37% phosphoric acid for 5, 10, 15, 30, 45, 60, 90 and 120 seconds, respectively. Two teeth from each group were used for scanning electron microscope examination. On the etched buccal surfaces of remaining teeth, orthodontic attachments(lingual buttons)were bonded with light cured orthodontic adhesive. Twenty four hours after bonding, a Instron universal testing machine was used to determine shear bond strength of orthodontic attachment to enamel. After debonding, bases of orthodontic attachments and enamel surfaces were examined under stereoscopic microscope to determine failure mode. Statistical analysis of the data was carried out with on way ANOVA and Duncan's multiple range test. The results were as follows; 1. There was no statistically significant difference in shear bond strengths between the various etching times(p<0.05). 2. The failure modes of orthodontic attachments had some differences. In 5, 10 and 15 seconds etching groups, the percentage of adhesive/enamel interface failure was higher than that of adhesive/attachment interface failure. On the contrary, in 30, 45, 60, 90 and 120 seconds etching groups, the results were reversed. 3. The etching patterns of enamel surfaces had a great variation. So, we could not find any correlation between etching pattern and bond strength. 4. The findings in this study indicate that in vitro reduction of the etching time to 5 seconds maintains clinically acceptable bond strength. However, further study is required to determine the cause of failure mode in 5, 10 and 15 seconds groups.

Gene profile of fibroblasts identify relation of CCL8 with idiopathic pulmonary fibrosis

Lee, Jong-Uk,Cheong, Hyun Sub,Shim, Eun-Young,Bae, Da-Jeong,Chang, Hun Soo,Uh, Soo-Taek,Kim, Young Hoon,Park, Jong-Sook,Lee, Bora,Shin, Hyoung Doo,Park, Choon-Sik BioMed Central 2017 Respiratory research Vol.18 No.-

<P><B>Background</B></P><P>Idiopathic pulmonary fibrosis (IPF) is characterized by the complex interaction of cells involved in chronic inflammation and fibrosis. Global gene expression of a homogenous cell population will identify novel candidate genes.</P><P><B>Methods</B></P><P>Gene expression of fibroblasts derived from lung tissues (8 IPF and 4 controls) was profiled, and ontology and functional pathway were analyzed in the genes exhibiting >2 absolute fold changes with <I>p</I>-values < 0.05. <I>CCL8</I> mRNA and protein levels were quantified using real-time PCR and ELISA. <I>CCL8</I> localization was evaluated by immunofluorescence staining.</P><P><B>Results</B></P><P>One hundred seventy eight genes differentially expressed and 15 genes exhibited >10-fold change. Among them, 13 were novel in relation with IPF. <I>CCL8</I> expression was 22.8-fold higher in IPF fibroblasts. The levels of <I>CCL8</I> mRNA and protein were 3 and 9-fold higher in 14 IPF fibroblasts than those in 10 control fibroblasts by real-time PCR and ELISA (<I>p</I> = 0.022 and <I>p</I> = 0.026, respectively). The <I>CCL8</I> concentrations in BAL fluid was significantly higher in 86 patients with IPF than those in 41 controls, and other interstitial lung diseases including non-specific interstitial pneumonia (<I>n</I> = 22), hypersensitivity pneumonitis (<I>n</I> = 20) and sarcoidosis (<I>n</I> = 19) (<I>p</I> < 0.005, respectively). Cut-off values of 2.29 pg/mL and 0.43 pg/mL possessed 80.2 and 70.7% accuracy for the discrimination of IPF from NC and the other lung diseases, respectively. IPF subjects with <I>CCL8</I> levels >28.61 pg/mL showed shorter survival compared to those with lower levels (<I>p</I> = 0.012). <I>CCL8</I> was expressed by α-SMA-positive cells in the interstitium of IPF.</P><P><B>Conclusions</B></P><P>Transcriptome analysis identified several novel IPF-related genes. Among them, <I>CCL8</I> is a candidate molecule for the differential diagnosis and prediction of survival.</P><P><B>Electronic supplementary material</B></P><P>The online version of this article (doi:10.1186/s12931-016-0493-6) contains supplementary material, which is available to authorized users.</P>

일부 농약 취급 근로자들의 성호르몬 상태

이원진,김청식,김형수,이창훈,김진석 대한산업의학회 2000 대한직업환경의학회지 Vol.12 No.2

Objective : This study was carried out to determine the effects of occupational pesticides exposure on the level of serum Luteinizing Hormone (LH), Follicle Stimulating Hormone (FSH), testosterone in male workers. Methods : Twenty-two male workers exposed to pesticides were compared with twenty-eight male workers at same factory who were not exposed to pesticides. The selected variables for studying reproductive hormones were LH, FSH and testosterone. As part of the baseline health status, subjects were asked medical history. Results : There were no statistically significant differences on the level of LH, FSH, testosterone between the exposed and non-exposed group. Also the level of sex hormones were not significant difference with each department in exposed group. And the level of LH, FSH positively correlated with age. Conclusions : These results indicate that there are no alterations in LH, FSH, testosterone at workers exposed to pesticides. But our findings are highly preliminary because of a small sample size. Thus it calls for furthur investigation of the hormonal effects at workers exposed to pesticides.