정신분열병에 대한 리스페리돈의 효과 및 안정성

이민수,김용구,김영훈,연병길,오병훈,윤도준,윤진상,이철,정희연,강병조,김광수,김동언,김명정,김상훈,김희철,나철,노승호,민경준,박기창,박두병,백기청,백인호,손봉기,손진욱,양병환,양창국,우행원,이정호,이종범,이홍식,임기영,전태연,정영조,정영철,정인과,정인원,지익성,채정호,한상익,한선호,한진희,서광윤 大韓神經精神醫學會 1998 신경정신의학 Vol.37 No.1

연구목적 : 본 시험의 목적은 임상시험 시작전에 연구자들을 대상으로 PANSS Workshop을 통하여 PANSS, ESRS에 대한 국내에서의 표준화 작업을 구축하고 새로운 정신병 치료제인 리스페리돈의 효과와 안정성을 재확인하여 리스페리돈 사용에 대한 적정화를 이루는데 있다. 연구방법 : 1996년 4월부터 1996년 9월까지 국내 39개 대학병원 정신과에 입원중인 혹은 증상이 악화되어 입원하는 정신분열병 환자 377명을 대상으로 다시설 개방 연구를 시행하였다. 1주일간의 약물 배설기간을 가진후, 리스페리돈을 8주간 투여하였고, 기준점, 1주, 2주, 4주, 그리고 8주후에 평가되었다. 용량은 제1일에는 리스페리돈 1mg씩 1일 2회, 제2일에는 2mg씩 1일 2회, 제3∼7일에는 3mg씩 1일 2회 투여하였다. 이후 환자의 임상상태에 따라 임의로 증량할 수 있으며, 최대 일일 16mg을 초과하지 않도록 하였다. 추체외로 증상을 조절하기 위한 투약을 허용하였다. 임상증상 및 부작용의 평가는 PANSS(Positive and Negative Syndrome Scale), CGI(Clinical Global Impression) 그리고 ESRS(Extrapyramidal Symptom Rating Scale)을 사용하였다. 연구결과 : 377명중 343명(91%)이 8주간의 연구를 완결하였다. 치료 종결시점인 8주후 PANSS 총점수가 20% 이상 호전된 경우를 약물 반응군으로 정의할때, 약물반응군은 81.3%였다. 리스페리돈에 반응하는 예측인자로는 발병연령, 이전의 입원 횟수, 유병기간이 관련 있었다. 리스페리돈은 1주후부터 PANSS양성, 음성, 및 일반정신병리 점수상에 유의한 호전을 보여 효과가 빨랐다. CGI의 경우도 기준점에 비해 1주후부터 유의한 감소를 나타내었다. ESRS의 경우, 파킨슨 평가점수는 기준점과 비교해 투여 1주, 2주, 4주후 유의하게 증가되었다가 8주후 기준점과 차이가 없었다. Dystonia 평가점수는 1주후만 유의한 증가를 보였으며, dyskinesia 평가점수는 유의한 차이가 없었다. 혈압, 맥박수의 생명징후 및 일반 혈액학 검사, 생화학적 검사, 심전도 검사에서 유의한 변화는 없었다. 결 론 : 이상의 다시설 개방 임상 연구를 통해 리스페리돈은 정신분열병 환자에서 양성증상뿐만 아니라 음성증상 및 전반적인 증상에도 효과적인 것으로 사료된다. 보다 명확한 평가를 위해서는 다른 항정신병약물과의 이중맹검 연구가 필요할 것으로 생각되며, 또한 장기적 치료에 대한 평가도 함께 이루어져야 하겠다. Objective : The purpose of this study was to investigate the efficacy and safety of risperidone in the treatment of Korean schizophrenic patients. Method : This multicenter open study included 377 schizophrenic patients drawn from 39 university hospitals. After a wash-out period of 1 week, the schizophrenic patients were treated with risperidone for 8 weeks and evaluated at 5 points ; at baseline, and 1, 2, 4 and 8 weeks of treatment. The dose was increased from 2mg/day(1mg twice daily) to 6mg/day(3mg twice daily) during the first week and adjusted to a maximum of 16mg/day over the next 7 weeks according to the patient's clinical response. Medication to control extrapyramidal symptoms was permitted. The psychiatric and neurological status of the patients was assessed by PANSS, CGI, and ESRS scales. Results : 343(91%) of 377 patients completed the 8-week trial period. Clinical improvement, as defined by a 20% or more reduction in total PANSS score at end point, was shown by 81.3% of patients. The predictors of response to risperidone were associated older age, shorter duration of illness, fewer previous hospitalization. Risperidone had rapid onset of action ; a significant decrease of the total PANSS and three PANSS factor(positive, negative, general), and CGI was already noticed at the end of first week. For the ESRS, parkinsonism rating scores were significantly increased until week 4 comparing with baseline. Dystonia rating scores were significantly increased until week 1, and dyskinesia rating scores were not significantly changed during the study. Laboratory parameters including vital sign, EKG, hematological, and biochemical values showed no significant changes during the trial. Conclusions : This study suggests that risperidone is generally safe and effective against both the positive and negative symptoms in our group of patients.

LC-MS/MS를 이용한 S.D. Rat 혈장 중 Arctiin 분석법 개발

송병정,채정우,백현문,권광일 충남대학교 약학대학 의약품개발연구소 2014 藥學論文集 Vol.29 No.-

KIOM-MA128 is a novel oriental herbal medicine which is for atopic dermatitis and asthma. The purpose of this study was to develop on analytical method of arctiin in rat plasma after oral administration of KIOM-MA128. Analyte was separated on a Atlantis dC18 reverse phase column, using gradient mobile phase (A:B = acetonitrile: 0.1% formic acid in water) at a flow rate of 0.3 mL/min. Detection was performed by electrospray positive ionization mass spectrometry using multiple reaction monitoring of the transitions of arctiin at m/z 552.4 → 372.8 and internal standard (carbamazepine) at m/z 237.0 → 194.5. The limit of quantification was 1 ng/mL for arctiin. The precisions were lower than 15% and the accuracy was between – 12.21 and 3.2%. The maximum concentration found in plasma samples was 4.1 ng/mL. The present method was successfully developed for detecting arctiin in plasma and this results would be utilized to the further study.

골격성 Ⅲ급 부정교합자에서 상악골 전진술을 동반한 양악 수술 시 중안면 연조직 형태의 변화

정종현,김성식,손우성,박수병 대한치과교정학회 2008 대한치과교정학회지 Vol.38 No.2

본 연구는 중안면 함몰이 있는 골격성 III급 부정교합자의 중안면의 형태를 정상 표본과 비교하고, 악교정수술에 의하여 연조직이 어떤 변화를 보이는지를 알아보기 위하여 시행하였다. 골격성 III급 부정교합으로 진단받고 상악 전진술과 하악 후퇴술을 시행받은 환자 34명 (남자:15명, 여자:19명)을 대상으로 수술 전후 측모 두부방사선 계측사진을 분석하였다. 골격성 III급 부정교합자의 중안면의 경조직 계측치 S'-Or, Or⊥NA, S'Or/SN, ∠SNOr에서 남녀 모두에서 정상 교합자와 큰 차이가 있었다. 상악골이 평균 5.03 mm 전방이동 될 때 연조직 Orbitale는 2.26 mm 전방으로 이동하였으며 상관계수는 0.599였다(p < 0.05). 상악 평면각의 변화(시계방향으로 회전)와 상악골의 수직 이동은 연조직 Orbitale의 전방이동과 유의성있는 상관관계가 없었다. 상악골 전방이동에 대한 연조직 Orbitale와 Subnasale의 전방이동 비율은 각각 43.57%, 81.54%였다. 이상의 결과에서 중안면 함몰이 있는 환자는 상악골 전방이동시 상순과 비부 외에도 연조직 Orbitale를 포함한 중안면 연조직이 전방으로 이동하지만, 상악골의 회전이동 및 수직이동에 대해서는 연조직의 변화량이 적었다는 것을 알 수 있었다. 이는 상악골의 수술에 따른 중안면 함몰의 해소를 예측하는 데 도움이 될 것이다. Purpose: The first objective of this study was to compare the upper midface morpholgy, focusing on the soft tissues, between skeletal Class III maloccusion patients with midfacial depression and the norm. The second objective was to estimate and analyze the change in the upper midface soft tissues following surgical correction with maxillary advancement by Lefort I osteotomy and mandibular setback by bilateral sagittal split osteotomy (BSSRO). Methods: The samples consisted of 34 adult patients (15 males and 12 females) with an average age of 21 years, who had severe anteroposterior discrepancy with midfacial depression. These patients had received presurgical orthodontic treatment and surgical treatment which consisted of simultaneous Lefort I osteotomy and BSSRO. Results: The correlation coefficient between changes in maxillary advancement and changes in Or' (soft tissue orbitale) was 0.599 (P < 0.05). Change in maxillary plane angle and vertical change of the maxilla were not correlated with the change in Or' (P < 0.05). The ratio of soft tissue change in Or' to maxillary advancement was 43.57 %, and 81.54 % in Sn. Regression equations between maxillary movement and Or' were devised. The r² value was 0.476. Conclusions: The majority of measurements in the upper midface in skeletal Class III maloccusions when compared to the norm, showed significant differences. In Class III malocclusion with midfacial depression, maxillary advancement produces soft tissue change in the upper midface.

Pullulanase를 생산하는 Bacillus 속 세균의 분리와 효소의 최적 생산조건 및 특성

정희경,김병우 동의대학교 기초과학연구소 1997 基礎科學硏究論文集 Vol.7 No.1

A bacterium producing pullulanase was isolated from soil, and was identified Bacillus cereus and named as Bacillus cereus JK36. The optimal culture conditions for the efficient production of pullulanase from B. cereus JK36 was obtained by cultivating with the medium composed of 1% pullulan, 1% yeast extract, 1% bactopeptone, 0.1% NaH₂PO₄· 2H₂O, 0.02% MgSO₄· 7H₂O at 40℃, intial pH 6.5 for 70 hours. Using the culture supernatant as crude enzyme, the optimal pH and temperature of the pullulanase of this strain were 6.5 and 50℃. In effect of pH and temperature on the stability of the enzyme, the enzyme was stable in the range of pH 6.0~9.5 and up to 40℃, respectively. The hydrolysis product on pullulan was mainly maltotriose.

다중체 낙하법에 의한 상대밀도 재현에 관한 연구

주재우,곽정민,오병현 순천대학교 공업기술연구소 1994 工業技術硏究所論文集 Vol.8 No.-

The relative density seems to be important as a factor of controlling the physical properties in the case of cohesionless soil ground as sand. Therefore, the study is more important about the method for reappearing he same relative density when the specimen of shearing test is to be produce or the model test of ground is to made. In this study, the apparatus making use of the multiple sieving pluviation method-one of the reappearance of relative density-could be made. Using this apparatus, tests were practiced varying the factors such as the size of sieve mesh and the number of sieve, the amount of falling discharge, the falling height etc. about the standard sand in Jumunjin and Hadong sand. When laboratory test is perfomed by the cohesionless soil, it presents the method for reappearing of the relative density in field.

XML/RDF와 SMIL에 기반한 멀티미디어 교육 컨텐츠 검색

최병욱,류정우,조정원 한국컴퓨터교육학회 2002 컴퓨터교육학회 논문지 Vol.5 No.3

대량의 멀티미디어 교육 컨텐츠의 재사용과 그 효과적인 관리를 위해서는 원하는 컨텐츠를 빠르고 정확하게 검색하는 방법을 제공할 수 있어야 한다. 본 논문에서는 대량의 멀티미디어 교육 컨텐츠에 대한 새로운 검색 방법을 제안한다. 교육 컨텐츠의 호환성을 확보하기 위해, XML을 기반으로 한 멀티미디어 동기화 표준언어인 SMIL을 이용하여 교육 컨텐츠에 사용되는 멀티미디어 요소의 통합과 동기화를 표준화된 방법으로 구현하였다. 또한 SMIL 교육 컨텐츠에 교육용 메타데이터인 IEEE LOM을 XML 기반의 RDF 형태로 부여하였다. 본 논문에서는 2단계의 검색 방법을 통해 보다 정확한 검색 기법을 제시한다. 1단계에서는 메타데이터를 이용한 검색으로서 원하는 컨텐츠를 검색하고, 2단계에서는 1단계에서 찾은 컨텐츠에 대해 SMIL의 시간 정보를 이용하여 컨텐츠의 세부적인 내용을 검색하도록 설계하였다. 또한 사용자가 각각의 검색 결과들을 이용하여 새로운 교육 컨텐츠로 재구성하고, 이를 학습에 이용하도록 함으로써 사용자 주도적인 학습이 가능하도록 하였다. In this paper, we propose the new approach with which user is able to retrieve the massive volume of learning contents in the multimedia learning system. In order to secure the compatibility of learning contents, we apply the SMIL on the basis of XML, so that the integration and the synchronization of multimedia components can be available to realize in the mode of standardization. We also implement the multimedia learning contents represented by the RDF on the IEEE LOM. We present the two step-retrieval method to get precise results. In the first step, user can find with high speed and ease whatever contents user wants to take a look through metadata in the system. The second step is followed that by using the time information of SMIL, user can retrieve the interest synchronous parts in the result of the first step. This innovative retrieval approach applied in the multimedia learning system is highly expected to make a meaningful contribution to implement the principles of self-directed learning in the learning environments, where user can use and revise the retrieval results for their own learning purpose and make further the active knowledge-reconstruction.

남성 근로자의 건강관련 행태와 건강수준과의 관련성

함정오,김화성,이성수,우극현,안규동,이병국 순천향대학교 산업의학연구소 2001 순천향산업의학 Vol.7 No.1

This study was conducted to evaluate the health related behaviors associated with blood pressure, results of liver function and renal function, and anemia indices. Study subjects were 499 male workers who visited to General Health Screening Center of A hospital located in Chonan. Data were collected from March to December 1996. By the questionnaire, the informations of health related behaviors such as, age, smoking and drinking habits, food intake habit, sleeping time, stress were obtained. Height, weight and blood pressure were measured by a trained nurse. The level of total Cholesterol, HDL Cholesterol, triglyceride, fasting blood sugar, glutamate oxaloacetate transaminase(GOT), glutamate pyruvate transaminase (GPT), r-glutamyl transferase(rGTP), blood urea nitrogen(BUN), serum creatinine(Cr), hemoglobin(Hb), hematocrit(Hct), hepatitis B surface antigen were selected as biometric test variables. Statistical analysis, such as t-test, Chi square-test, stepwise multiple regression, multiple logistic regression were performed using SAS package program. There were significant differences in age, systolic blood pressure, total cholesterol, GOT, GGT, BUN, Hb, and Hct between drinkers and non-drinkers, and significant differences in age, body mass index(BMI), systolic blood pressure, diastolic blood pressure, rGTP, BUN, and Hb between smokers and non-smokers . Triglyceride, age, BMI, and HDL cholesterol were found to be positivc independent predictors of blood pressure, but drinking habit(mild drinking group vs. non-drinking group) and pack-year of smoking were negative predictors of blood pressure. Logistic analysis of systolic hypertensive related condition indicated that triglyceride(OR=1.003, 95% CI; 1.000-1.006), total cholesterol(OR=1.008, 95% CI; 1.000-1.016), and pack-years of smoking (OR=0.972, 95% CI; 0.952-0.994) were significantly contribution to dependent variable, Logistic analysis of diastolic hypertensive related condition revealed that age3(≥50 years vs. <40 years) (OR=4.702 (95% CI; 1.919-11.521), age2(40-49 years vs. <40 years) (OR=4.702 (955 CI; 1.919-11.521), triglyceride (OR=1.005, 95% CI; 1.002-1.008), pack-years of smoking(OR=0.972, 95% CI; 0.951-0.993), and meal regularity (yes vs. no) (OR=0.618, 95% CI; 0.383-0.991) were significantly contribution to dependent variable. Triglyceride, total cholesterol, fasting blood sugar, and animal food intake(yea vs. no) were found to be positive independent predictors to BMI, but HDL and stress(yes vs. no) were negative predictors. Logistic analysis of abnormal BMI condition indicated that total cholesterol(OR= 1.013, 95% CI; 1.007-1.020) and HDL cholesterol (OR=0.943, 95% CI; 0.916-0.972) were significantly contribution to dependent variable. BMI, HBs Ag, and the frequency of drinking were found to be positive independent predictors to GOT, but meal regularity(yes vs. no) were negative predictors. Logistic analysis of abnormal GOT condition indicated that HBs Ag(yes vs. no)(OR-6.666, 95% CI; 1.724-25.779), BMI(OR=1.199, 95% CI;1.015-1.416), and meal regularity(yes vs. no)(OR=0.248, 95% CI; 0.096-0.639) were significantly contribution to dependent variable. BMI, and HBs Ag were found to be positive independent predictors to GPT, but meal regularity(yes vs. no) were negative predictors. Logistic analysis of abnormal GPT condition showed that only BMI (OR=1.301, 95% CI; 1.301(1.176-1.440) was significantly contribution to dependent variable. BMI and the frequency of drinking were found to be positive independent predictors to rGTP, but meal regularity(yes vs. no) were negative predictors. Logistic analysis of abnormal rGTP conditionindicated that BMI(OR=1.340, 95% CI; 1.197-1.499), Alc5(abovc 5 times/week vs. non-drinking) (OR=21.733, 95% CI; 3.671-128.684), Alc4(3-4 times/week vs. non-drinking) (OR=4.533, 95% CI; 1.463-14.049), Alc3(1-2 times/week vs. non-drinking) (OR=3.918, 95% CI; 1.406-10.916), and meal regularity(yes vs. no) (OR=0.405, 95% CI; 0.221-0.740) were significantly contribution to dependent variable. BMI and age were found to be positive independent predictors to BUN, but stress(yes vs. no) and pack-year of smoking were negative predictors. Logistic analysis of abnormal BUN condition indicated that only age3(≥50 years vs. <40 years) (OR=4.808 (95% CI; 1.307-17.676) was significantly contribution to dependent variable. BMI was found to be positive independent predictors to Hb and Hct, respectively, but regular exercise(yes vs. no) was negative predictors to Hb and Hct, respectively. With above results, it was found that age, BMI, level of serum triglyceride, and level of serum total cholesterol were significantly associated with hypertension and that BMI was significantly associated with abnormal results of liver function tests and especially the frequency of drinking was associated with abnormal rGTP. Also the workers with meal regularity habits, compared to those with meal irregularity habits, were lower prevalence of hypertension and abnormal liver function tests, therefore the meal regularity habits seem to be reflected good health related behaviors.

等電點 電氣泳動에 의한 배추와 양배추 育成系統에서의 自家不和合性 關聯 glycoproteins의 比較分析

이정명,최근원,민병훈,이태진,백남권,이철우 경희대학교 부설 식량자원개발연구소 1994 硏究論文集 Vol.15 No.-

等電點 電氣泳動을 이용하여 배추의 몇 개의 5-allele 造成과 그들의 F₁에서 自家不和合性의 발현과 관련된 glycoprotein의 band 樣相을 비교 분석한 결과는 다음과 같다. 1. 배추의 內婚系와 이들 간의 에서 柱頭內 glycoprotein의 band pattern을 分析한 결과 兩親의 band pattern이 F₁으로 그대로 遺傳되므로 써 명확한 同定 및 區分이 가능하였다. 2. 공시된 배추의 계통 중에서 8개의 等電點을 발견하였는데 대부분의 系統에서 pl 7.0 또는 8.6에서 major band를 보이고 있었다. 따라서 major band만으로는 S-allele genotype의 명확한 동정이 불가능한 경우도 상당히 있었다. 3. 상기 bands (pI 6.8 and 7.7)에서의 glycoprotein의 分子量은 pI 7.0에서 49,000-50,000이었고 pI 8.6에서 59,000으로 推定되었다. 4. 양배추는 배추에 비해서 glycoprotein의 major bands와 minor bands수가 많고 매우 다양하게 나타나므로써 S-allele 동정이 배추보다 매우 용이할 것임을 보여 주었다. Band patterns of glycoproteins associated with the expression of self-incompatibility were examined in the stigmatic extracts of self-incompatible Chinese cabbage inbred lines and the hybrids. Clear relationship in the band pattern could be confirmed in the parents and their hybrid, indicating the inheritance of S-alleles to the progeny. Total of 8 isoelectric points were indentified in the inbreds, with the major bands at pI 7.0 and 8.6. Thereforne, in some genotypes, identification of cultivars or S-allele genotypes were impossible with the major bands only. The molecular weights of the glycoproteins were estimated to be 49,000-50,000 for pI 7.0 and 59,000 for pI 8.6 bands. The stigmatic extracts from cabbages showed numerous major and minor bands so that identification of S-allele genotype will be much easier as compared to chinese cabbage.

곰쓸개 복용 후 발생한 육안적 혈뇨와 신유두부 괴사증 1예

김우진,한민석,김수항,박인형,박진석,선제형,홍세인,박옥영,신정현,이숭,신병철 朝鮮大學校 附設 醫學硏究所 2006 The Medical Journal of Chosun University Vol.31 No.3

Renal papillary necrosis occurs most commonly in association with urinary tract infection, diabetes mellitus, sickle cell disease, vascular disease, and analgesic nephropathy. Clinical presentation may be related to symptoms of pyelonephritis such as flank pain, renal colic, hematuria, Proteinuria, recurrent fever. The necrotic tissue may be sloughed off, and the diagnosis can sometimes be made by finding piece of renal medullary tissue in the urine. Pyelography may demonstrate cavities and sinuses in the resion of papillae. Anuria & oliguria can lead to the acute renal failure, and especially prognosis and progress may be affect influenced by urinary infection. We report a case of renal papillary necrosis with ingestion of bear gallbladder. On pyelography, Persistent contrast is diagnostic clue of renal papillary necrosis. This case is not be related to urinary tract infection, but occurred acute renal failure. Expectant treatment was gone.

후두개와에 발생한 신경장관난종 : 증례보고 Case Report

최우진,유헌,정희원,최기영,조병규 대한신경외과학회 1999 Journal of Korean neurosurgical society Vol.28 No.6