C-반응성단백과 가장 관련 있는 대사증후군 대사이상 항목

손중천,김범택,이득주,최현국,정현주,김광민 대한비만학회 2003 The Korean journal of obesity Vol.12 No.1

연구배경: C-반응성단백 (이하 CRP)은 심혈관질환의 예후인자 및 독립적 위험인자이다. 대사증후군은 복부비만, 고혈압. 당대사이상 및, 지질대사이상과 같은 관상동맥질환 위험인자들이 동시에 나타나는 증후군을 말한다. 저자들은 18세 이상의 성인 남녀에서 CRP와 대사증후군 대사이상 항목과의 상관관계를 연구하였다. 방법: 2002년 4월부터 10월까지 일개 대학병원 건강증진센터에 내원한 수진자 2772명 중 염증성질환이 의심되는 577명을 제외한 총 2195명을 대상으로 하였다. 신체계측과 혈압측정, 혈액검사를 실시하였다. 통계적 분석은 남녀를 구분하여 대사증루군의 대사이상 항목의 군집성에 따른 CRP값에 대해 ANOVA 검정을 시행하였고, 각 대사이상 항목들과 연령을 독립변수로 하여 회귀분석을 실시하였다. 결과: CRP는 남성에서 0.10 (±0.004) mg/dL, 여성에서 0.08 (±0.003) mg/dL로 남성이 여성보다 유의하게 높았다(p<0.001). 남녀 모두에서 CRP가 대사증후군 군에서 대사증후군이 없는 군보다 유의하게 높았다. 대사증후군의 대사이상 항목 수가 증가할수록 CRP값이 증가하는 양상을 보였다(P for trend<0.001). 남녀 모두에서 허리둘레 (남성 R²=0.132, 여성 R²=0.166)가 가장 높은 설명력을 보였다. 결론: 18세 이상의 성인 남녀 모두에서 CRP는 대사증후군 대사이상 항목들과 유의한 상관관계를 보였다. 대사이상 항목중 허리둘레가 CRP 수치와 상관관계가 가장 높았다 Background: C-reactive protein has been known as an independent risk factor and prognostic factor for cardiovascular diseases. Metabolic syndrome is a sum of coronary risk factors such as abdominal obesity, elevated blood pressure, hypertension, glucose intolerance and abnormalities in lipid level. The previous studies showed limited relationships between CRP and the risk factors in metabolic syndrome. We investigated the relationships between CRP and the risk factors in metabolic syndrome in adult men and women over 18 years old. Methods: This study included 2772 people. 577 people of them found to have inflammatory disease excluded. The anthropometry and blood pressure were measured. High sensitive CRP, Lipid profiles, WBC, and ESR were assessed. Results: CRP in Men (0.10 (±0.004) mg/dL) was significantly higher than that in women (0.08 (±0.003) mg/dL)(P<0.001). In both genders, CRP was significantly higher in people who have metabolic syndrome than in people who don't. As the number of risk factors increased, CRP was significantly increased (P for trend < 0.001). Waist circumference showed the greatest correlation with CRP in men and women (men; R²=0.132, women; R²=0.166) Conclusion: CRP was correlated with risk factors in metabolic syndrome in men and women over 18 years old. Of the risk factors waist circumference was most correlated with CRP.

Carcinoembryonic Antigen Level Can be Overestimated in Metabolic Syndrome

Kim, Kyu-Nam,Joo, Nam-Seok,Je, Sang-Yeon,Kim, Kwang-Min,Kim, Bom-Taeck,Park, Sat-Byul,Cho, Doo-Yeoun,Park, Rae-Woong,Lee, Duck-Joo The Korean Academy of Medical Sciences 2011 JOURNAL OF KOREAN MEDICAL SCIENCE Vol.26 No.6

<P>Carcinoembryonic antigen (CEA) levels can be affected by many factors and metabolic syndrome is also a candidate. This study examined the relationship between CEA levels and metabolic syndrome using the data of 32,897 healthy Koreans. Fecal occult blood tests were also performed. Subjects with colorectal carcinoma were excluded. Subjects were classified by their smoking status, metabolic syndrome and its components. Prevalence of metabolic syndrome and its all components showed a significant increase according to the quartile of serum CEA concentration (<I>P</I> < 0.001). Increased numbers of metabolic syndrome components showed a positive association with CEA levels (<I>P</I>-trend < 0.001). The odds ratios for the highest CEA quartile vs the lowest serum CEA quartile significantly increased in the presence of metabolic syndrome and its components. After adjusting for age, gender and smoking status, metabolic syndrome, low high density lipoprotein cholesterol and elevated blood pressure had higher odds ratios (OR) of the highest CEA quartile compared with the lowest serum CEA quartile (OR = 1.125, 95% CI = 1.030 to 1.222, <I>P</I> = 0.009; OR = 1.296, 95% CI = 1.195 to 1.405, <I>P</I> < 0.001; OR = 1.334, 95% CI = 1.229 to 1.448, <I>P</I> < 0.001, respectively). These results indicate that metabolic syndrome is associated with CEA value, which may lead to a misunderstanding of the CEA levels.</P>

Women with Fibromyalgia Have Lower Levels of Calcium, Magnesium, Iron and Manganese in Hair Mineral Analysis

Kim, Young-Sang,Kim, Kwang-Min,Lee, Duck-Joo,Kim, Bom-Taeck,Park, Sat-Byul,Cho, Doo-Yeoun,Suh, Chang-Hee,Kim, Hyoun-Ah,Park, Rae-Woong,Joo, Nam-Seok The Korean Academy of Medical Sciences 2011 JOURNAL OF KOREAN MEDICAL SCIENCE Vol.26 No.10

<P>Little is known about hair mineral status in fibromyalgia patients. This study evaluated the characteristics of hair minerals in female patients with fibromyalgia compared with a healthy reference group. Forty-four female patients diagnosed with fibromyalgia according to the American College of Rheumatology criteria were enrolled as the case group. Ageand body mass index-matched data were obtained from 122 control subjects enrolled during visit for a regular health check-up. Hair minerals were analyzed and compared between the two groups. The mean age was 43.7 yr. General characteristics were not different between the two groups. Fibromyalgia patients showed a significantly lower level of calcium (775 µg/g vs 1,093 µg/g), magnesium (52 µg/g vs 72 µg/g), iron (5.9 µg/g vs 7.1 µg/g), copper (28.3 µg/g vs 40.2 µg/g) and manganese (140 ng/g vs 190 ng/g). Calcium, magnesium, iron, and manganese were loaded in the same factor using factor analysis; the mean of this factor was significantly lower in fibromyalgia group in multivariate analysis with adjustment for potential confounders. In conclusion, the concentrations of calcium, magnesium, iron, and manganese in the hair of female patients with fibromyalgia are lower than of controls, even after adjustment of potential confounders.</P>

폐경 후 여성에서 혈중 호모시스테인농도와 골밀도 및 골전환율과의 연관성

김범택 ( Bom Taeck Kim ),안병훈 ( Byung Hoon Ahn ),김광민 ( Kwang Min Kim ),주남석 ( Nam Seok Joo ),김찬원 ( Chan Won Kim ),권도승 ( Do Seung Kwon ),이득주 ( Duck Joo Lee ) 대한폐경학회 2010 대한폐경학회지 Vol.16 No.1

연구목적: 유전성 고호모시스테인뇨증 환자에서 골다공증이 발생한다는 것이 알려진 후, 혈중 호모시스테인 농도의 증가가 뼈에 부정적인 영향을 끼쳐 골절의 유병률을 증가시키는 기전이 연구되고 있지만, 아직 정확히 알려져 있지는 않다. 이 연구는 고호모시스테인혈증과 골절의 위험인자인 골밀도, 골전환율 및 골의 구조적인 특성들의 관계를 조사하였다. 연구재료 및 방법: 이 연구는 2002년 1월부터 2003년 12월 동안 모대학병원의 건강검진센터에 내원한 2,670명의 폐경 후 여성을 대상으로 하였다. 혈중 호모시스테인, bone turnover marker와 골밀도 검사를 시행하여 상관관계를 조사하였다. 결과: 폐경 후 여성에서 혈중 호모시스테인 농도는 연령, osteocalcin, 25-Vit D농도, L1-4골밀도, 총대퇴골밀도 및 L3의BMC, vBMD, aBMD와 유의한 상관관계관련이 있었다. 그러나, 연령과 체질량 지수를 보정한 후, 척추 전체, 대퇴부의 골밀도는 혈중 호모시스테인 농도와 관련이 없었지만, osteocalcin은 여전히 관련이 있었다. L3의 BMC, vBMD, aBMD와 유의한 상관관계관련이 있었지만, 골의 크기나 부피와는 관련이 없었다. 연령을 보정하고 난 후에도, L3의 골밀도는 작지만 유의한 상관관계가 있었다. 결론: 혈중 호모시스테인의 증가는 골밀도와는 관련이 적지만, 골교체율의 증가와 관련이 있었다. Objectives: Hyperhomocysteinemia is related to fractures in the elderlies. We assessed the relationship between serum homocysteine and bone mass, size, and bone turnover rate. Methods: This study included 2,670 postmenopausal women who underwent periodic health examinations in Ajou University Health Promotion Center, between January 2002 and December 2003. Serum homocysteine, bone turnover markers and bone mineral density were measured. Results: Patient age, osteocalcin, 25-vit D, total lumbar BMD, total lumbar T-score, the lowest lumbar BMD, the lowest lumbar T-score, femur neck BMD, femur neck T-score, femur trochanteric BMD and femur trochanteric T-score showed a significant correlation with the serum total homocysteine. However, after adjusting for age, the only osteocalcin was significantly correlated with the serum total homocysteine, At the 3rd lumbar vertebra, the BMC, volumetric BMD and areal BMD had a significant correlation with the serum total homocysteine but the bony size and the volume were not significant. After adjusting for age, the 3rd lumbar BMD was significantly correlated with the serum total homocysteine. Conclusion: Serum homocysteine level is correlated significantly with bone turnover rate, less with bone mass but not with bone size. (J Korean Soc Menopause 2010;16:23-28)

Review : 2014 Clinical Practice Guidelines for Overweight and Obesity in Korea

( Mee Kyoung Kim ),( Won Young Lee ),( Jae Heon Kang ),( Jee Hyun Kang ),( Bom Taeck Kim ),( Seon Mee Kim ),( Eun Mi Kim ),( Sang Hoon Suh ),( Hye Jung Shin ),( Kyu Rae Lee ),( Ki Young Lee ),( Sang Y 대한비만학회 2014 The Korean journal of obesity Vol.23 No.4

The dramatic increase in the prevalence of obesity and its accompanying comorbidities are major health concerns in Korea. Obesity is defined as a body mass index (BMI) ≥25 kg/m2 in Korea. Current estimates are that 32.8% of adults are obese: 36.1% of men and 29.7% of women. The prevalence of being overweight and obese in national surveys is increasing steadily. Early detection and the proper management of obesity are urgently needed. Weight loss of 5-10% is the standard goal. In obese patients, control of cardiovascular risk factors deserves the same emphasis as weight-loss therapy. Since obesity is multifactorial, proper care of obesity requires a coordinated multidisciplinary treatment team, as a single intervention is unlikely to modify the incidence or natural history of obesity.

원저 : 제2형 당뇨병 환자에서 Voglibose와 Glimepiride의 체중에 대한 효과

정선혜 ( Sun Hye Jung ),김대중 ( Dae Jung Kim ),이관우 ( Kwan Woo Lee ),김범택 ( Bom Taeck Kim ),김성수 ( Sung Soo Kim ),김은숙 ( Eun Sook Kim ),목지오 ( Ji Oh Mok ),안철우 ( Chul Woo Ahn ),윤현대 ( Hyun Dae Yoon ),이상엽 ( Sang Y 대한비만학회 2005 The Korean journal of obesity Vol.14 No.2

연구배경: 당뇨병 환자에서 설폰요소제나 인슐린은 체중 증가를 가져올 수 있는 반면, 메트포민은 체중 감소 효과가 있으며, 알파 글루코시다제 억제제는 체중 증가를 억제하는 효과가 있다고 보고된 바 있다. 본 연구는 초기 제2형 당뇨병 환자를 대상으로 혈당조절의 방법으로 voglibose, glimepiride, 식이요법을 사용하였을 때 각각의 체중 및 혈당조절에 미치는 영향을 비교해 보았다. 방법: 연구 대상은 제2형 당뇨병 환자로 나이는 30~75세이며, 공복혈당은 200 ㎎/dL 미만, 체질량 지수는 23.0 ㎏/㎡ 이상, 최근 2주 이내 혈당 강하제나 인슐린, 체중에 영향을 줄 수 있는 약제를 사용하지 않은 경우로 하였다. Voglibose (Basen(R)), glimepiride(Amaryl(R)), 식이요법 세 군으로 무작위 배정하였고, 신체계측 및 혈당, 당화혈색소, 혈압, 지질 등을 시작 시점과 12주 후에 측정하였다. 결과: 총 448명의 제2형 당뇨병 환자가 연구에 포함되었고, 이 중에 voglibose 군은 223명, glimepiride 군은 176명, 식이요법 군은 49명이었다. 12주 후의 체중은 voglibose 군과 식이요법 군에서 glimepiride 군보다 체중이 유의하게 더 감소하였으며 (voglibose vs glimepiride, P=0.001; diet vs glimepiride, P=0.016), voglibose 군과 식이요법 군 간에는 차이가 없었다. 반면, 당화혈색소는 glimepiride 군에서 voglibose 군이나 식이요법 군보다 유의하게 감소하였으며 (glimepiride vs voglibose, P=0.001; glimepiride vs diet, P=0.004), voglibose 군과 식이요법 군 간에는 차이가 없었다. 결론: Voglibose는 glimepiride에 비해 혈당조절 능력은 다소 떨어지지만, 상대적으로 체중감소의 효과가 있다. Background: Obesity is a major risk factor for type 2 diabetes. Improvement in glycemic control using insulin, sulfonylurea and meglitinide is often accompanied by weight gain. But metformin and α-glucosidase inhibitor have a positive effect(decrease) on weight. In this study, we compared the effect of voglibose, glimepiride, and diet alone on body weight and glycemic control after a period of 12 weeks. Methods: The patients with type 2 diabetes were randomly assigned to one of the following three treatment groups: Patients treated for 12 weeks with voglibose, those treated with glimepiride and those with diet alone. Anthropometric parameters and metabolic parameters were measured at the initial stage and after 12 weeks. The study consisted of 448 patients with type 2 diabetes. There were 223 patients in the voglibose group, 176 in the glimepiride group, and 49 in the diet alone group. Results: The patients treated with voglibose and diet alone showed higher decreased body weight compared with glimepiride group (voglibose vs glimepiride, P=0.001; diet vs glimepiride, P=0.016). In contrast, glimepiride group showed more decreased HbA1C compared with voglibose and diet alone groups (glimepiride vs voglibose, P=0.001; glimepiride vs diet, P=0.004). Conclusion: Voglibose showed more effective on body weight reduction despite the relatively weak glycemic control compared with glimepiride.

Discordance in Secular Trends of Bone Mineral Density Measurements in Different Ages of Postmenopausal Women

Kim Kwang Yoon,Park Jaesun,Yang Sungwon,Shin Junghwa,Park Ji Hyun,Park Bumhee,Kim Bom Taeck 대한의학회 2023 Journal of Korean medical science Vol.38 No.42

Background: Age-adjusted bone mineral density (BMD) in postmenopausal women decreases in developed countries whereas incidence of osteoporotic fracture decreases or remains stable. We investigated secular trends of bone density from 2008 to 2017 among different age groups of postmenopausal women. Methods: We analyzed BMD data obtained from health check-ups of 4,905 postmenopausal women during three survey cycles from 2008 to 2017. We divided them into 3 groups by age (50–59 years, 60–69 years, and 70 years or more) and observed the transition of lumbar and femoral BMD in each group, before and after adjusting for variables that may affect BMD. Results: Age-adjusted BMD, bone mineral content (BMC), and T-score demonstrated a declining trend over the survey period at lumbar spine (−2.8%), femur neck (−3.5%) and total femur (−4.3%), respectively. In the analysis for the age groups, the BMD, BMC, and T-score presented linear declining trend (−6.1%) in younger postmenopausal women while women aged over 70 or more showed linear increasing trends (+6.3%) at lumbar spine during the survey period. Femoral neck and total femur BMD demonstrated a declining linear trend only in the 50–59 and 60–69 years groups (−5.5%, −5.2%, respectively), but not in the 70 years or more group. Conclusion: BMD in younger postmenopausal women has decreased considerably but has increased or plateaued in elderly women. This discordance of BMD trends among different age groups may contribute to decreased incidence of osteoporotic fracture despite a recent declining BMD trend in postmenopausal women.

Application of the transtheoretical model: exercise behavior in Korean adults with metabolic syndrome.

Kim, Chun-Ja,Kim, Bom-Taeck,Chae, Sun-Mi Aspen Publishers 2010 JOURNAL OF CARDIOVASCULAR NURSING Vol.25 No.4

<P>BACKGROUND: Although regular exercise has been recommended to reduce the risk of cardiovascular disease (CVD) among people with metabolic syndrome, little information is available about psychobehavioral strategies in this population. OBJECTIVE: The purpose of this study was to identify the stages, processes of change, decisional balance, and self-efficacy of exercise behavior and to determine the significant predictors explaining regular exercise behavior in adults with metabolic syndrome. METHODS: This descriptive, cross-sectional survey design enrolled a convenience sample of 210 people with metabolic syndrome at a university hospital in South Korea. Descriptive statistics were used to analyze demographic characteristics, metabolic syndrome risk factors, and transtheoretical model-related variables. A multivariate logistic regression analysis was used to determine the most important predictors of regular exercise stages. RESULTS: Action and maintenance stages comprised 51.9% of regular exercise stages, whereas 48.1% of non-regular exercise stages were precontemplation, contemplation, and preparation stages. Adults with regular exercise stages displayed increased high-density lipoprotein cholesterol level, were more likely to use consciousness raising, self-reevaluation, and self-liberation strategies, and were less likely to evaluate the merits/disadvantages of exercise, compared with those in non-regular exercise stages. CONCLUSIONS: In this study of regular exercise behavior and transtheoretical model-related variables, consciousness raising, self-reevaluation, and self-liberation were associated with a positive effect on regular exercise behavior in adults with metabolic syndrome. Our findings could be used to develop strategies and interventions to maintain regular exercise behavior directed at Korean adults with metabolic syndrome to reduce CVD risk. Further prospective intervention studies are needed to investigate the effect of regular exercise program on the prevention and/or reduction of CVD risk among this population. Health care providers, especially nurses, are optimally positioned to help their clients initiate and maintain regular exercise behavior in clinical and community settings.</P>

Identification of a novel susceptibility gene for postmenopausal osteoporosis

Jeonghyun Kim,Eunkuk Park,Mi Ran Jo,Jeong-soo Lee,Yong-Jun Choi,Bom-Taeck Kim,Hyung-Min Ji,Ye-Yeon Won,Yoon-Sok Chung,Hyun-Seok Jin,Seon-Yong Jeong 한국실험동물학회 2018 한국실험동물학회 학술발표대회 논문집 Vol.2018 No.7

UBAP2: A novel susceptibility gene for osteoporosis in korean women

Jeonghyun Kim,Bom-Taeck Kim,Yong Jun Choi,Ye-Yeon Won,Eunkuk Park,Eunguk Lim,Seokjin Hwang,Sunghee Yoon,Yoon-Sok Chung,Seon-Yong Jeong 한국실험동물학회 2020 한국실험동물학회 학술발표대회 논문집 Vol.2020 No.7