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- 저자 : ( Berrin Belcik Inal ) (검색결과 1 건)
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( Hanife Usta Atmaca ),( Feray Akbas ),( Ilker Nihat Okten ),( Eda Nuhoglu Kantarci ),( Berrin Belcik Inal ),( Mustafa Boz ) 대한내과학회 2014 대한내과학회 추계학술대회 Vol.2014 No.1
Background: Obesity is a disease known to stimulate low grade infl ammation. N/L ratio has been started to be used as an indicator of systemic infl ammation. This study aims to examine the relationship between obesity and N/L ratio over anthropometric measurements, obesity grade, and some biochemical parameters. Methods: 96 obese patients (mild-moderate and severe) who are being monitored in obesity outpatient clinic, who have no concomitant disease, and who do not have a history of smoking and drug use, and as the control group, 20 patients of normal weight with the same characteristics were included in the study. Anthropometric measurements were recorded, and BMI was calculated. Biochemical tests and total blood counts were performed. N/L ratio was obtained by dividing neutrophil count by lymphocyte count. The results were evaluated using SPSS statistical analysis program. Results: A signifi cant increase was present in neutrophils and lymphocyte counts of morbid obese group compared to control groups. Due to both increased neutrophil and lymphocyte counts, even though L/N ratio increased, it was not found statistically signifi cant. The increase in total leucocyte count of morbid obese was statistically signifi cant compared to mild obese. While N/L ratio demonstrated a strongly positive correlation with total leucocyte count and neutrophil count, it demonstrated a weakly positive correlation with waist circumference and with hip circumference. Conclusions: N/L ratio increases by obesity grade and reveals that concomitant infl ammatory response increases. High count of circulating neutrophil in obese patients might be considered as an acute infl ammatory response to a chronic infl ammatory state. Therefore, N/L ratio might be used as an infl ammatory marker in obese patients, and might be helpful in the prediction of cardiovascular and metabolic risks for the patient.
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