재발성군날개 치료에 있어 항혈관내피성장인자 항체 베바시주맙을 적용한 임상효과

이종욱,박영정,김인택,이규원,Jong Wook Lee,Young Jeung Park,In Taek Kim,Kyoo Won Lee 대한안과학회 2008 대한안과학회지 Vol.49 No.12

Purpose: To clinically establish the effectiveness and safety of bevacizumab on recurrent pterygium. Methods: Twenty patients with recurrent pterygium were given a subconjunctival injection of 0.3 cc bevacizumab, and were evaluated for periodic clinical results at 1 week, 2 weeks, 4 weeks, and every month thereafter. The patients were also evaluated for clinical results and complications. Results: Of recurrent pterygium patients with bevacizumab injection, the conjunctival injection decreased maximally after 1 to 2 weeks, but significantly increased at 4 weeks (above the lowest level measured at 1 to 2 weeks), and no patient presented conjunctival injection above the pre-injection level at 3 months, except in 2 cases. Two weeks after the injection, ICG anterior segment angiography revealed a significant decrease (30.14+17.69%) in vessel thickness of the pterygium 2 weeks after the bevacizumab injection compared to before the injection. There had been no cases of progression of pterygium, and no ocular or systemic complications due to bevacizumab. Conclusions: As shown above in the results, subconjunctival injection of 0.3 cc bevacizumab decreased the conjunctival injection and effectively suppressed any further progression of pterygium. Thus, bevacizumab subconjunctival injection appears to be effective in recurrent pterygium treatment instead of surgical methods.

지각(枳穀) 약침이 고지방 식이 급여 흰쥐의 혈액 내 지질구성과 $TNF-{\alpha}$ 및 IL-6농도에 미치는 영향

이종욱,이지향,이은,이준무,Lee, Jong-Wook,Lee, Ji-Hyang,Lee, Eun,Lee, Joon-Moo 경락경혈학회 2006 Korean Journal of Acupuncture Vol.23 No.1

Objective : To investigate the effects of Poncirus trifoliata Pharmacopuncture on lowering lipid and contents of serum tumor necrosis $factor-{\alpha}$ $(TNF-{\alpha})$ and interleukin-6 (IL-6) in hyperlipidemic rats. Methods : Triglyceride, total cholesterol, $TNF-{\alpha}$, and IL-6 levels in Poncirus trifoliata Pharmacopuncture groups were compared with those in the control group. Results : Concentration of triglyceride and total cholesterol in plasma was decreased in the Poncirus trifoliata Pharmacopuncture groups. In Poncirus trifoliata Pharmacopuncre groups, plasma LDL-cholesterol showed a lower value and HDL-cholesterol showed a higher value than those of the control group. Contents of $TNF-{\alpha}$ was decreased in the Poncirus trifoliata Pharmacopuncture groups. Contents of IL-6, however, were not significantly different. Conclusions : The results suggest that Poncirus trifoliata Pharmacopuncture may have an impact on lipid metabolism to potentially prevent development of diabetes mellitus and accompanying cerebrovascular diseases.

눈꺼풀속말림이 동반된 두줄속눈썹이나 속눈썹증의 치료

이종욱,신동수,이규원,Jong Wook Lee,Dong Su Shin,Kyoo Won Lee 대한안과학회 2007 대한안과학회지 Vol.48 No.10

Purpose: To evaluate the clinical efficacy of a reverse eyelid splitting technique that we performed in cases of trichiasis or distichiasis combined with entropion. Methods: The study comprised 43 eyes of 31 patients with trichiasis or distichiasis combined with entropion treated from November 2004 to December 2005. After skin incision, the muscular layer and tarsus were reversely dissected to find abnormal follicles. The abnormal hair follicle was cauterized under the muscular layer, and 23 rotating sutures were done with Ethilon 6-0 to fix the tarsus and skin. Success was defined as having the meibomian gland located in front of the junction of skin and mucosa, without an abnormal hair protruding into the eye for at least three months. Results: Fifteen patients were male and sixteen patients were female. The mean age was 62.115.2 years. The patients were followed up for an average of 12.42.0 months after surgery. Surgery was successful in 74.4% (32 of the 43 eyelids) of the cases, and the recurrence rate was 25.6% (11 of the 43 eyelids). No severe complications occurred, such as infection, hemorrhage, wound dehiscence, or granuloma. However, foreign body sensation (1 eye) and eyelid notch (l eye) did occur. Conclusions: This reverse eyelid splitting technique produced satisfactory results in both cosmetic and functional aspects. Moreover, it resulted in a low recurrence rate and low complication rate in patients with trichiasis or distichiasis combined with entropion.

원발성 콩다래끼 환자에서 병소 내 트리암시놀론 주사요법과 절개배농술의 치료 효과 비교

이종욱,김성진,Jong Wook Lee,Sung Jin Kim 대한안과학회 2013 대한안과학회지 Vol.54 No.10

Purpose: To evaluate the effectiveness of intralesional triamcinolone acetonide injection, and incision and curettage for primary chalazia. Methods: In order to compare the effectiveness of treatment modality, 103 patients who were diagnosed with primary chalazia were divided into 2 groups. The patients in group A underwent intralesional triamcinolone acetonide injection and the patients in group B underwent incision and curettage. The patients were followed up 1 week and 3 weeks after the procedures to identify the regression of the lesion and the procedure complications. A decision regarding success or failure was made at 3 and 6 weeks after the treatment. Successful treatment was defined as the infallibility in the functional and esthetic aspects as well as the size of regressed lesion. Results: This study included 82 out of 103 patients, who satisfied the inclusion criteria. Forty-four patients underwent intralesional triamcinolone acetonide injection and the remaining 38 patients underwent incision and curettage. The success rate of the initial treatment, which was identified 3 weeks after the procedure, was 81.8% in group A and 86.8% in group B. The cumulative success rate of treatment after 6 weeks was 86.8% in group A and 92.1% in group B. No complications were observed with both treatment modalities. Conclusions: Intralesional triamcinolone acetonide injection is as effective and safe as incision and curettage for the treatment of primary chalazia.

소안구증 환자에서 piggyback 방법을 이용한 백내장 수술

이종욱,최원석,박영정,이규원.Jong Wook Lee. MD. Won Suk Choi. MD. Young Jeung Park. MD. PhD. Kyoo Won Lee. MD. PhD 대한안과학회 2010 대한안과학회지 Vol.51 No.7

Purpose: To report a case of cataract surgery using a piggyback method in a patient with pure nanophthalmos with an axial length under 16.00 mm in both eyes. Case summary: The authors performed cataract surgery using a piggyback method inserting two intraocular lenses (IOLs) in a 44-year-old male with nanophthalmos with axial lengths of OD 15.36 mm, and OS 15.59 mm. Primary implantation of two IOLs of +53.0D as calculated by the SRK/T and Holladay formula was performed in the right eye using a piggyback method. In the left eye, two IOLs of +60.0D calculated by the Hoffer Q formula were implanted. Postoperative hyperopic refractive errors occurred in both eyes. The differences between the preoperative target spherical equivalent (SE) and the postoperative one year four month SE were 9.68D in the right eye and 1.63D in the left eye. Conclusions: Due to high diopter IOL requirements in nanophthalmic patients (less than 16.00 mm) during cataract surgery, the refractive errors were well corrected, without complications, by using a piggyback method. In the present case study, the Hoffer Q formula produced better results than did the SRK/T or Holladay formula in reducing the difference in preoperative and postoperative SEs, but more surgical cases and research are required to establish the most appropriate formula for cataract surgery in nanophthalmos.

지각과민 처치제 도포 후 칫솔질에 의한 마모가 상아질 투과도에 미치는 영향

이종욱,심준성,이근우,Lee Jong-Wook,Shim June-Sung,Lee Keun-Woo 대한치과보철학회 2001 대한치과보철학회지 Vol.39 No.2

To study the effect of dentin permeability on a tooth with wear from tooth brushing after application of desensitizing agent, extracted teeth free from caries were chosen. Coronal dentin discs with thickness of 1mm were prepared. Using the split chamber device developed by Pashely, hydraulic conductance, scanning electron microscope images(SEM) and atomic force microscope images(AFM) were compared and contrasted before and immediately after the application of desensitizing agent and after equivalent tooth brushing of 1 week, 2 weeks, and 6 weeks. Four commercially available desensitizing agents were used in this study ; they were Gluma, Seal & Protect, All-Bond 2 and MS Coat. The results of this study are as follows. 1. On all specimens, the hydraulic conductance decreased after the application of tooth desensitizing agent. 2. Except the specimens treated with MS Coat, the remaining specimens had an increase in dentin permeability after tooth brushing for 1 and 2 weeks but a decrease after 6 weeks. 3. The specimens treated with MS Coat had statistically significant increase in the dentin permeability regardless with the duration of tooth brushing. 4. On examination of SEM and AFM, the dentinal tubule diameter had decreased after treatment of desensitizing agents. The specimens other than those treated with MS Coat, smear layers were noted after tooth brushing. It is not always consistant but the hydraulic conductance correlated with the images from SEM and AFM.

한국과학기술인용 DB를 반영한 JCR 분석연구

이종욱,양기덕,김병규,류범종,Lee, Jong-Wook,Yang, Ki-Duk,Kim, Byung-Kyu,You, Beom-Jong 한국과학기술정보연구원 과학기술정보센터 2012 Journal of Information Science Theory and Practice Vol.43 No.3

전 세계적으로 이용되는 인용색인 서비스인 Web of Science(WoS)는 데이터 수록 범위에 한계가 있음이 인용색인 연구에서 지적되어 왔다. 또한 국내 학술논문이 인용하는 해외 문헌의 비율이 전체의 약 75%를 차지한다는 것이 인용패턴 분석연구에서 밝혀진 바 있다. 본 연구에서는 WoS DB의 데이터 수록 범위를 검증하기 위한 첫 번째 단계로써 WoS DB에 포함되어 있지 않은 국내 연구자의 인용문헌 즉, 한국과학기술인용 DB(Korea Science Citation Database: KSCD)에 수록된 참고문헌 데이터 일부를 JCR 학술지 영향력지수 산출과정에 포함시켜 학술지 영향력 지수(Impact Factor: IF)의 변화 및 그에 따른 학술지 순위변동 여부를 조사하였다. 구체적으로 국내 문헌정보학 분야 학술지에 수록된 참고문헌을 JCR 2009 문헌정보학 분야 학술지 IF 산출과정에 포함하였다. 하지만 학술지 IF의 변화와 그에 따른 순위 차이가 통계적으로 유의하지 않았고, 이에 데이터 범위를 넓혀 컴퓨터 공학 및 전자공학 분야 학술지 45종에 수록된 참고문헌을 추가로 분석하여 JCR 2010 전자공학 분야 학술지 IF 산출과정에 포함하였다. 그 결과, 부분적으로 통계적으로 유의한 학술지 순위 변화가 일어났다. 본 연구는 한정된 데이터를 사용하였음에도 불구하고 미미하지만 통계적으로 유의한 JCR 학술지 순위 변동을 보여줌으로써 WoS DB에 포함되지 않은 인용 데이터의 잠재적 가치를 제시하였다. Citation analysis studies have reported many problems associated with data coverage problems common to popular citation databases such as Web of Science(WoS). In addition, the studies that analyzed citation patterns of Korean publications found that up to 75% of references in Korean publications were to international publications. As a first step in investigating the international coverage of WoS database, the study investigated the effect of adding citation data from Korea Science Citation Database(KSCD) to the impact factors and journal rankings of the journals listed in Journal Citation Reports. Specifically, the study mined the reference data from top 5 Korean Library and Information Science(KLIS) journals to recompute the impact factors reported in JCR 2009. Since the resulting journal rankings did not significantly differ from JCR 2009 rankings except for minor ranking changes, we analyzed additional citation data from 45 computer science and electrical engineering journals. Although the overall ranking difference was not statistically significant, one of the ranking partitions showed significant change. Such study findings despite its limited data sample suggest the potential impact of non-Western citation databases such as KSCD to bibliometric indicators provided by popular citation databases like WoS.

문헌정보학 분야 국제 학술지 논문 계량분석을 통한 국내 연구자 특성 연구

이종욱,박혜린,Lee, Jong-Wook,Bak, Hye-Rin 한국도서관정보학회 2016 한국도서관정보학회지 Vol.47 No.1

본 연구는 문헌정보학 분야 국제 학술지에 논문을 게재한 연구자의 소속기관 유형 및 전공분야를 파악하고 이를 연도 및 학술지 유형에 따라 분석하여 이들의 연구행태 및 국내 문헌정보학 연구의 동향을 부분적으로 제시하는데 목적이 있다. 이를 위해 2005년부터 2014년까지 문헌정보학 국제 학술지 31종에 게재한 논문 384편에 나타난 국내 연구자 정보 819건을 식별 및 분석하였다. 소속기관, 전공분야, 학술지 유형을 분석하는데 있어 선행연구에서 제시된 범주를 사용하여 향후 연구에서 과거와 현재 그리고 국내와 세계 연구자의 연구행태를 비교가능케 하였다. 공동연구의 경우 공저자 기여도 산정법을 적용하여 개별 연구자의 기여도를 정확하게 측정하였다. 분석 결과, 총 384편 가운데 국내 연구자의 기여도는 342.6편이었으며, 국내 문헌정보학 분야 연구의 국제화와 더불어 연구의 질적수준이 높아지고 있음을 알 수 있었다. 구체적으로 국내 대학기관 소속 연구자들의 주도에 의한 문헌정보학 분야 연구 증가 추세를 제시하였으며 소속기관 유형에 따라 연구의 성격이 다를 수 있음을 제시하였다. 또한 연구자의 전공분야 분석을 토대로 문헌정보학 연구가 타 학문분야 즉, 컴퓨터공학, 경영학, 커뮤니케이션학 등과 연관되어 있음을 알 수 있었다. To investigate the characteristics of Korean researchers who have published journal articles in the international Library and Information Science (LIS) journals, we analyzed the types of institutions of the authors and their disciplines by publication year and journal type. Specifically, we analyzed 819 pieces of author information from 384 articles published between 2005 and 2014 in 31 journals using the existing categories, allowing comparisons of research trends between past and current and between Korean and international researchers. In addition, we used a co-authorship credit allocation method to calculate the credits of individual authors in an accurate manner, and found that 342.6 of 384 papers were contributed by solely Korean researchers. We demonstrated that the internationality and quality of Korean LIS research has increased during this time. In particular, authors who were affiliated with universities took the lead in publishing papers, and we presented that the nature of research might be related to the type of author affiliation. Based on the disciplinary backgrounds of the researchers, we also suggest that LIS research is associated with such disciplines, computer science, management, and communications.

Co계 자성합금 나노와이어의 특성에 영향을 미치는 전기화학적 변수

이종욱,박호동,이관희,김긍호,정원용,Lee, Jong-Wook,Park, Ho-Dong,Lee, Kwan-Hyi,Kim, Gyeung-Ho,Jeung, Won-Young 한국전기화학회 2005 한국전기화학회지 Vol.8 No.3

본 연구에서는 고순도 알루미늄 호일$(t=300{\mu}m)$양극산화 공정을 통해 AAO 나노템플레이트를 자체 제조하였고, 이렇게 제조된 형틀을 가지고 교류 나노전주법에 의해 경자성 합금인 CoP와 연자성 합금인 CoFe를 나노와이어로 제조하였다. 대표적인 Co계 자성합금인 CoP와 CoFe나노와이어는 각기 독특한 자기적 성질을 나타내었다. 경자성 CoP 합금 나노와이어의 경우 교류 인가전압에 따라 hcp와 fcc가 혼재된 구조가 형성되어 자기적 특성에 영향을 미쳤다. 또한 높은 포화자화 값을 갖는 CoFe연자성 합금 나노와이어는 박막 도금 시와는 달리 이상합금도금현상이 거의 나타나지 않았으며 $Co_{30}Fe_{70}$에서 가장 좋은 238emu/g의 포화자화 값을 나타내었다. We have investigated the electrochemical factors affecting the magnetic properties of hard magnetic CoP nanowires and soft magnetic CoFe nanowires fabricated by ac electrodeposition into self-made AAO(anodic aluminum oxide) nano-templates. AAO template having nano scale pores of high aspect ratio has been prepared through 2-step anodizing of aluminum foil in sulfuric acid. Hard Magnetic properties of CoP nanowires were highly conditional on the applied ac potential which could be a decisive factor to make CoP nanowires made up of either pure hcp crystals or a mixture of hop crystals and fcc crystals. On the contrary to CoFe films, there was no anomalous codeposition in the electrodeposition of soft magnetic CoFe nanowires which exhibited their best saturation magnetization of 238 emu/g at the composition of $Co_{30}Fe_{70}$.

상부 180도 및 하부 180도 선택적 레이저 섬유주성형술의 효과 및 안정성 비교

이종욱,김은주,이태윤,이규원,Jong Wook Lee,MD,Eun Joo Kim,MD,Tae Yoon Lee,MD,Kyoo Won Lee,MD 대한안과학회 2012 대한안과학회지 Vol.53 No.11

Purpose: To compare the intraocular pressure (IOP)-lowering effect and safety between superior 180 degree and inferior 180 degree selective laser trabeculoplasty (SLT). Methods: Forty patients with primary open-angle glaucoma and normal tension glaucoma were treated with superior 180-degree SLT, and 28 patients with the same diagnosis were treated with inferior 180-degree SLT. IOP was checked at 1 day, and 1, 2, 3, and 6 months after SLT. Anterior chamber reaction and ocular pain was evaluated at postoperative 1 day. Peripheral anterior synechia was examined at 6 months postoperatively. Results: At the postoperative 6-month follow-up, the superior treatment group had a mean IOP of 15.53 ± 3.49 mm Hg with a mean reduction of 24.6%, while the inferior treatment group had a mean IOP of 17.18 ± 3.29 mm Hg with a mean reduction of 21.9%. There were no significant differences in IOP reduction between the 2 groups. There was a slightly higher anterior chamber reaction rate in the inferior treatment group. Conclusions: The site of SLT application is not important for IOP reduction. Both superior 180 degree and inferior 180 degree SLT are safe and effective procedures for glaucoma treatment because of successful IOP reduction and low complication risks.