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Tbc1d15-17 Regulates Synaptic Development at the Drosophila Neuromuscular Junction
이민정,이승복,장수연,남민엽,윤진호 한국분자세포생물학회 2013 Molecules and cells Vol.36 No.2
Members of the Tre-2/Bub2/Cdc16 (TBC) family of pro-teins are believed to function as GTPase-activating pro-teins (GAPs) for Rab GTPases, which play pivotal roles in intracellular membrane trafficking. Although membrane trafficking is fundamental to neuronal morphogenesis and function, the roles of TBC-family Rab GAPs have been poorly characterized in the nervous system. In this paper, we provide genetic evidence that Tbc1d15-17, the Drosophila homolog of mammalian Rab7-GAP TBC1d15, is required for normal presynaptic growth and postsynaptic organization at the neuromuscular junction (NMJ). A loss-of-function mutation in tbc1d15-17 or its presynaptic knock- down leads to an increase in synaptic bouton number and NMJ length. tbc1d15-17 mutants are also defective in the distribution of the postsynaptic scaffold Discs-large (Dlg) and in the level of the postsynaptic glutamate subunit GluRIIA. These postsynaptic phenotypes are recapitulated by postsynaptic knockdown of Tbc1d15-17. We also show that presynaptic overexpression of a constitutively active Rab7 mutant in a wild-type background causes a synaptic overgrowth phenotype resembling that of tbc1d15-17 mutants, while a dominant-negative form of Rab7 has the opposite effect. Together, our findings establish a novel role for Tbc1d15-17 and its potential substrate Rab7 in regulating synaptic development.
미술교육에서 스토리텔링을 통한 “미”에 대한 미학적 접근방법
이민정 한국국제미술교육학회 2018 미술과 교육 Vol.19 No.4
본 논문은 미학 영역의 주된 주제이자 미술교육의 기초개념의 하나라고 할 수 있는 아름다움에 대한 정의를 스토리텔링을 통한 미학적 탐구방법을 통해 시도함으로써 미술교육에서 접근할 수 있는 미학적 접근 방법을 마련하고 그 의의와 가치를 제공하는 데 목적이 있다. 아름다움에 대한 스토리텔링을 통한 미학적 접근 방법은 철학적인 사유를 촉진시키고 우리의 구체적인 삶 속에서 다양하게 전개되는 미의 의미와 가치를 짚어내고 되새기게 하며 나아가 서로의 다름을 존중하고 확인하는 과정 속에서 인성교육의 함양까지 기대해 볼 수 있게 한다. 또한 이러한 접근 방식은 학생들로 하여금 이론적 지식을 통한 앎의 방식과는 다른, 예술에서의 감성적 통로를 통한 앎의 방식이라는 측면에서의 인식론적인 가치도 함께 배울 수 있게 한다. The purpose of this study is to prepare aesthetic approaches in art education to access the idea of “what is beauty?” through storytelling as beauty has long been the main subject of aesthetics and a fundamental concept of art education. Aesthetic approaches put us in the position of meta, which means being awakened by investigating the main themes of aesthetics. The aesthetic approaches to beauty through storytelling promote our philosophical thinking and ruminate the meanings and values of the beauty that has spread out variously in our concrete lives. Furthermore it makes us expect holistic education in the process, where we enjoy the differences between people and then respect and accept the differences of one another. This approach enables us to learn epistemological values in aesthetics that differ from those in theoretical approaches.
이민정,안소연,배창범,손영배,정윤석 대한내분비학회 2012 Endocrinology and metabolism Vol.27 No.2
CATCH 22 is a medical acronym for cardiac defects, abnormal faces, thymic hypoplasia, cleft palate, and hypocalcemia, and a variable deletion on chromosome 22. It includes DiGeorge syndrome, conotruncal anomaly face syndrome, and velo-cardio-facial syndrome. It has a prevalence estimated at 1:3,000-1:6,000. Most deletions occur at de novo, but autosomal dominant inheritance is observed in 6-10% of cases. Hormonal disorders are common in patients with CATCH22 syndrome. While hypoparathyroidism was the predominant endocrine disturbance that has been documented in the DiGeorge syndrome, other hormonal defects, such as growth hormone deficiency, hypothyroidism, and hyperthyroidism have been occurred in patients with CATCH22 syndrome. The spectrum of parathyroid gland dysfunction in this syndrome ranges from severe neonatal hypocalcemia to normal parathyroid function. Most patients are usually diagnosed in young age, but a few patients with mild abnormality are presented later in life. We report a case of CATCH22 syndrome with normal parathyroid hormone and calcium level in an adult. The diagnosis of CATCH22syndrome was confirmed by fluorescence in situ hybridization analysis.
국가연구개발사업에서 종이영수증은 왜 폐지되지 않는가? - 신제도주의적 관점을 중심으로 -
이민정,이삼열 한국정책학회 2021 韓國政策學會報 Vol.30 No.1
국가연구개발 사업의 효율성을 높이기 위한 방안 중 대표적인 정책은 ‘종이영수증 폐지정책’이다. 연구자 행정부담 완화를 위한 정책토론이 벌어질 때마다 단골로 등장하는 이 주제는, 연구비 정산을 위해 영수증을 A4 종이에 풀로 붙이는 낭비적 관행을 철폐해 달라는 것으로 넓은 공감을 얻고 있다. 하지만 이의 개선을 위해 정부가 규정 개정, 시스템 개선 등 다각도로 제도변화를 추진하고 있음에도 연구현장에서는 종이영수증이 버젓이 존재하고 있다. 왜 종이영수증은 없어지지 않는 것인가? 본 연구는 제도를 복합체로 이해하는 신제도주의 관점에서 종이영수증 폐지 정책과 관련된 정책자료 및 인터뷰를 기반으로 다섯 가지 인과기제를 분석한다. 제도특성과 행위자의 전략적 행위를 고려한 분석 결과 1) 제도의 상호보완성 및 강제집행 부재에 따른 인과기제, 2) 제도의 지속성과 집행수단 한계에 따른 인과기제, 3) 제도의 모호성에 따른 인과기제, 4) 부분설계에 따른 인과기제, 5) 권력관계에 따른 인과기제를 파악할 수 있었다. 본 논문의 분석 결과는 종이영수증 폐지와 같이 겉보기에 간단해 보이는 정책문제도 이를 둘러싼 제도의 복합성을 이해하지 못할 경우 의도한 목적을 이룰 수 없음을 보여 준다. 정책의 효과성을 제고하기 위해서는 정책 기획 시 반드시 정책문제를 둘러싼 제도의 복합적인 특성을 고려해야 한다.
스마트 눈물점마개 삽입 후 발생한 눈물소관염의 임상양상과 치료
이민정,이경욱,김남주,정호경,곽상인 대한안과학회 2009 대한안과학회지 Vol.50 No.6
목적: 스마트 눈물점마개(SmartPlug™) 삽입 후 발생한 눈물소관염 환자의 임상 양상과 치료 결과를 보고하고자 한다. 대상과 방법: 2006년 1월부터 2008년 10월까지 서울대병원 안과에서 눈물소관염을 진단받은 환자 중, 눈물점마개 삽입의 병력이 있고, 그 종류가 스마트 눈물점마개임을 확인한 환자 6명 8안을 대상으로 하여 후향적 분석을 시행하였다. 결과: 대상 환자는 평균나이 34.3±8.6세, 여자가 5명, 남자가 1명이었다. 눈물점마개 삽입부터 증상 발현까지의 기간은 평균27.0± 27.0개월(범위: 4~77개월)이었다. 내원 시 호소한 흔한 증상은 결막의 점성 분비물(6안), 결막 충혈(2안)이었다. 모든 환자에게 onesnip 눈물점성형술 후, 눈물소관소파술 혹은 눈물소관압박술로 눈물점마개를 제거하였다. 시술 후 모든 환자에서 증상이 소실되었음을 확인하였다. 결론: 스마트 눈물점마개를 삽입받은 환자에서 결막 분비물, 충혈 등의 증상을 호소할 때 눈물소관염을 의심해야 하며, 눈물점마개의 제거로 효과적으로 치료할 수 있다. 눈물점마개의 제거는 눈물점성형술 후 눈물소관압박술을 우선 시도해 보는 것이 좋겠다. Purpose: To report the clinical features and treatment of canaliculitis associated with SmartPlug punctal plug insertion. Methods: Case selection criteria included patients with canaliculitis, who were managed at Seoul National University Hospital from January 2006 to October 2008, presenting with a history of punctal plug insertion. The operation reports were reviewed to identify patients in whom SmartPlug was discovered during the operation. Six patients (8 eyes) were identified, and a retrospective chart review was performed for all the patients. Results: The mean age of the patients was 34.3±8.6 years, and there were 1 men and 5 women. Common symptoms were mucous discharge (6 eyes) and conjunctival injection (2 eyes). The mean time from insertion of the plug to onset of symptoms was 27.0±27.0 months (range 4 to 77 months). All patients underwent surgical removal of the punctal plug by one-snip punctoplasty, canalicular retrograde compression using 2 cotton-tipped applications (2 eyes), or canalicular curettage (6 eyes). All patients had resolution of symptoms after the procedure. Conclusions: Canaliculitis should be considered when there is conjunctival discharge or injection in patients with SmartPlug. One-snip punctoplasty and retrograde compression of canaliculus can be attempted preferentially as a minimally-invasive treatment option.
5개월 추적연구를 통한말 늦은 아동의 표현어휘 발달 예측 요인
이민정,임동선 이화여자대학교 특수교육연구소 2020 특수교육 Vol.19 No.1
Purpose: The purpose of this study was to examine the differences between late talkers(LT) and late bloomers in internal factors(family history of language problems, quick incidental learning) and external factors(mother's years of education, quantity of maternal language) that impact the expressive vocabulary development, and which factor significantly predicts the expressive vocabulary development in LT after five months. Method: Thirty-one children age 18-31 months participated in this study. The children's quick incidental learning was assessed QUIL, mother years of education and family history of language problem were collected from KBPR and Child Background Information. Spontaneous speech samples collected in mother-child free play situations were analyzed to assess the quantity of maternal language(MLU-w, TTR, NDW per minute). Based on the expressive vocabulary measured after five months, thirty-on LTs were classified into the 14 ‘late bloomer’ group and 17 continuous late talker group, Differences in internal and external factors between the two groups and the factors that significantly predict LT’s expressive vocabulary development after five months were analyzed. Results: There were significant differences between the two groups in the quick incidental learning. MLU-w was the best predictor of LT’s expressive vocabulary ability after five months. Conclusion: The clinical significance of this study is that it provided basic data for early selection of LRs as a study of factors impaccting the expressive vocabulary development. 연구목적: 표현어휘 발달에 영향을 미치는 내적 요인(가계력, 빠른우연학습) 및 외적 요인(어머니 교육년수, 어머니의 발화 양)에서 말 늦은 아동과 늦게 말이 트인 아동 간 차이를 살펴보고, 말 늦은 아동의 5개월 후 표현어휘 능력을 유의미하게 예측하는 요인이 무엇인지 알아보고자 한다. 연구방법: 18-31개월 말 늦은 아동 31명이 본 연구에 참여하였다. 아동의 빠른 우연학습을 알아보기 위해 QUIL을 실시하였고, 언어장애의 가계력과 어머니 교육년수는 KBPR와 아동 배경정보지를 통해 수집하였으며, 어머니의 발화 양(MLU-w, TTR, 분당 NDW)을 알아보기 위해 어머니-아동의 자유놀이 상황에서 수집한 자발화를 분석하였다. 5개월 후 측정한 표현어휘를 기준으로 전체 말 늦은 아동 31명을 정상수준도달집단 14명과 정상수준미달집단 17명을 구분하여, 두 집단 간 내적 및 외적 요인의 차이와 말 늦은 아동의 5개월 후 표현어휘 능력을 유의미하게 예측하는 요인을 분석하였다. 연구결과: 두 집단 간 빠른우연학습에서 유의한 차이가 나타났다. 말 늦은 아동의 5개월 후 표현어휘 능력을 가장 잘 예측하는 요인은 MLU-w였다. 결론: 본 연구는 말늦은 아동의 표현어휘 발달에 영향을 미치는 요인에 대한 연구로 말 늦은 아동의 조기선별을 위한 기초자료를 제공하였다는 데에 임상적 의의가 있다.
Anaphylaxis caused by latex surgical gloves immediately after starting surgery -A case report-
이민정,도상환,나효석,김미현,전영태,황정원 대한마취통증의학회 2010 Korean Journal of Anesthesiology Vol.59 No.-
Anaphylaxis is an acute and fatal systemic allergic reaction to an allergen, and it can be an unpredictable and lifethreatening cause during anesthesia. Latex is the second most common cause of anaphylaxis following the use of neuromuscular blocking agents during general anesthesia or surgery. We report on a 67-year-old male who had undergone surgery under general anesthesia without any problem but who presented with severe intraoperative anaphylaxis to latex surgical gloves. This case emphasizes the need for anesthesiologists to quickly diagnose and properly manage an allergic reaction in patients under general anesthesia.
A Case of Traumatic Bilateral Adrenal Hemorrhage Mimicking Bilateral Adrenal Adenomas
이민정,김기애,장정은,최효인,이서현,고광범,김가희,김민선 영남대학교 의과대학 2012 Yeungnam University Journal of Medicine Vol.29 No.1
Adrenal hemorrhages caused by blunt abdominal trauma have been frequently reported, and most of the lesions are unilateral. In contrast, bilateral hemorrhage of the adrenal glands after trauma rarely occurs in subjects with predisposing conditions such as coagulopathy, thromboembolism, and sepsis. Furthermore, bilateral hemorrhage of the adrenal glands is potentially fatal by inducing acute adrenal insufficiency. Here,a case of a 40-year-old man who developed traumatic bilateral adrenal hemorrhage after a car accident, without any predisposing condition, is reported. The spontaneous shrinkage of the bilateral lesions revealed in the follow-up abdominal computed tomography (CT) scansupported the aforementioned diagnosis. Fortunately, the patient had no clinical or biochemical evidence suggesting acute adrenal insufficiency. To these authors’ knowledge, this is the first South Korean report of traumatic bilateral adrenal hemorrhage in a subject with no predisposing factors.
이민정 한복문화학회 2020 韓服文化 Vol.23 No.3
Black clothes in the late Joseon Dynasty disappeared due to the strong driving force of the momentum of modernity. This study investigated the meaning of black clothes in the late Joseon Dynasty, which is closest to when you perceive it as a tradition and accounts for most relics. To overcome the preconceived notion and inductive or empirical research method applied when studying the traditional costume, 'the Virtual' and the deductive study was conducted to understand the potential value and meaning of black clothes in the Korean tradition. The color of black in black clothes in the late Joseon Dynasty was not a simple black but with a slight cast of red, blue, green, and achromatic gray colors. The color of black symbolized a governance system by ritual ceremonies, a dynamism through the energy of yin and yang, and a social order. The reflection of black color in the ceremonial rituals of the Neo-Confucianism can be divided into five categories: clothes for ancestral rites and wedding, clothes for diplomatic events, clothes for a public official, headdress for the Seonbi, and black trimming for a scholar. Danryeong and military uniforms were black color, which was integrated the yin yang and five elements. Lastly, crown prince and princess clothes, hapi, fur headdress and boots, and servant clothes used black color to indicate the social status. As a result, black clothes in the late Joseon Dynasty had a spiritual meaning. Since the opening of ports, especially after the Gabo reform in 1894, the movement to abolish the caste system to build an equal society reduced the solemn and rigid attitudes enforced by Neo-Confucian rituals, abolished gat and pelangi, and dressed all classes in black, which meant the best and lowest colors in Joseon society at the same time.