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이정석 충남대학교 산업대학원 2007 국내석사
In-Service Inspection is one of the most important processes to ensure the integrity of facilities of operational nuclear power plants. These inspection processes must comply with applicable codes, standards and regulatory requirements such as ASME Boiler and Pressure Vessel Code, Section XI, etc. Inspection plan must be established to identify examination areas, examination method, and examination schedule in accordance with those requirements. Examination must be implemented based on the approved examination plan and by qualified examiner using calibrated equipments as ASME Code. Indications detected as a result of examination must be evaluated for acceptance and indications exceeding allowable limits must be removed and/or corrected. Inspection processes generates a large amounts of examination report, evaluation report, etc., which must be controlled in an acceptable manner. The results of this study are as follows. 1. iSIMS can fulfil functionalities for planning of inspection, reporting of examination results, calibration of inspection equipments, management of resources including appropriate status reporting in communication with isometric drawings and 3 dimensional component layout models 2. This program can take advantage of information technology supporting inspection processes, archival of data generated and the fracture mechanics analysis of flaws detected during ISI. 3. Control of examination resources such as codes & standards, examination equipments and material, calibration blocks, examiners, procedures, references, etc. 4. Nuclear power plant is able to reduce the cost and establish systematic management through ISI database.
인산염과 가스흡수제 첨가를 통한 된장의 褐變進行 抑制에 대한 硏究
李政石 忠南大學校 産業大學院 2005 국내석사
Browning of commercial Doenjang product during storage and marketing is a main concern in the industry. There have been many studies on the improvement on the quality of Doenjang. In this study, phosphate and gas absorber treatments ware introduced in manufacturing of Doenjang to improve the color of commercial Doenjang. Doenjang treated with phosphate and gas absorber(sample C), Doenjang treated with phosphate only (sample B), and the control were prepared and their physicochemical and sensory properties were determined during storage at 30℃ for 28 days. Sample C was the best in terms of color as well as sensory evaluation according to panel test, resulting in preventing browning of Doenjang during storage. Sample B was also better than control. These results suggest that commercial production of Doenjang should introduce phosphate and gas absorber treatment to improve the quality of Doenjang and prevent undesirable browning reaction during storage and marketing.
해사 빅데이터를 활용한 공간분석 알고리즘 기반의 해상교통망 프레임워크에 관한 연구
이정석 한국해양대학교 대학원 2023 국내박사
최근 세계적으로 해운 물동량의 증가와 선박의 거대화의 추세는 해사 산업 분야에 많은 변화를 가져오고 있다. 유럽 국가와 여러 선진 국가들의 경우에는 해상교통의 흐름을 보존하고 안전한 선박의 운항을 위해 최우선으로 항행구역을 고려하고 있다. 이러한 요구들은 여러 국가의 해양공간 계획에서 잘 구분되고 있으며 대용량의 해상교통 데이터와 최신 분석 방법을 활용하여 해상교통로 또는 해상교통망으로 분석하고 공공에 제공한다. 하지만 우리나라의 경우 최근 해상풍력발전단지의 육상입지 대체, 해양관광 활성화 등으로 연안해역을 운항하는 선박들의 관습적 해상교통 흐름에 변화를 유발하고 있지만, 해상교통 보존 연구는 미비한 상황이다. 이에 따라 선박들의 관습적인 통항로를 구축하여 해역이용 수요 증가 및 해상교통 여건의 악화에 대비한 해상교통로의 보존 및 관리 체계가 필요하다. 또한 항만과 항만을 아우르는 해상교통망을 구축하기 위해 해사 빅데이터, 인공지능, 공간분석 알고리즘을 활용하여 실제 선박에 적용이 가능할 방법을 고안할 필요성이 있다. 본 연구에서는 해사 빅데이터를 활용하여 다양한 데이터 분석에 사용하였다. 최근 해운산업에도 비정형, 정형 데이터를 수집하고 처리하는 기술이 발달하였고 선박 운항 기술에 데이터 분석 결과를 접목하는 다양한 연구가 진행되고 있다. 또한 AIS 데이터, 해양공간 정보, 전자해도 등 다양한 형태의 데이터를 해사 분야와 접목하여 안전한 선박 운항과 해양 환경 보호에 도움을 줄 수 있다. 한편 해사 산업에 데이터가 폭발적으로 증가하고 있어 이를 분석하기 위한 기술의 한 가지를 인공지능 알고리즘 개념에 통합하였다. 인공지능 알고리즘이란 대용량의 데이터를 활용하여 학습하고 인간의 의사결정을 모방하는 것을 목적으로 한다. 컴퓨터 기술의 발달에 따라 인공지능 알고리즘은 해양산업의 전통적인 운영 과정을 점진적으로 변화시키고 있다. 또한, 지리정보시스템을 활용하여 해사 공간 빅데이터를 효과적으로 분석하고 시각화 한다. 이러한 추세에 따라 해상교통로와 해상교통망을 구축할 수 있으며 실제 선박 운항에 적용 가능성이 존재하는 것을 의미한다. 본 연구의 구성인 해상교통로의 추출, 해상교통망 탐지, 지리정보 시스템의 네트워크 기반 항해계획 내용은 해사 빅데이터 활용, 인공지능 적용, 공간분석 알고리즘을 통합한 프레임워크를 기반으로 제안하였다.
High performance nanocarbon field emitter
By taking advantage of the superior material properties and high aspect ratio geometry of nanocarbon materials, many researchers have been able to devote their efforts toward the development of nanocarbon emitters, which are capable of providing low turn-on voltage, high emission current density and long-term emission stability. Electron beams of field emitter are widely employed in various applications, including X-ray photography and computed tomography (CT) scans in hospitals, fault detection of semiconductor devices, airport security, and terahertz generation. Moreover, electron beam generators are progressively becoming more miniaturized, light-weighted, and low-powered so that they can be applied to diverse areas. For a high performance field emitter, new concept of field emitter is needed to overcome the previous research. In this thesis, four novel approaches are developed in terms of fabricating the multidimensional field emitters. 1) CNT point emitter with graphene interfacial layer: we report graphene as an interfacial layer between the metal and CNTs to improve the interfacial contact. The interfacial graphene layer results in a dramatic decrease of the electrical contact resistance by an order of 2 and an increase of the interfacial thermal conductivity by 16%. Such a high improvement in the electrical and thermal interface leads to superior field emission performance with a very low turn-on field of 1.49 V μm−1 at 10 μA cm−2 and a threshold field of 2.00 V μm−1 at 10 mA cm−2, as well as the maximum current of 16 mA (current density of 2300 A cm−2). 2) CNT line emitter using clamping process: we report a robust and scalable method to fabricate high-performance carbon nanotube (CNT) line emitters by using a macroscopic mechanical clamping process. The process utilizes a handheld, metallic tongs (which also serves as an electrode for field emission) to pick up vertically aligned, super-grown CNTs from a substrate. By applying mechanical compression to a CNT forest in the uniaxial direction, the hemicylindrical shape of CNT structure strongly held with the tongs electrode is fabricated. With robust mechanical, thermal, and electrical contact characteristics created by mechanical clamping of CNTs, the CNT line emitter shows superior field emission performance with an emission current of 43 mA, a current density of 2700 mAcm-2, and stable operation over 10 hours. Furthermore, an extremely high emission current of 103 mA is achieved by clamping multiple CNT forests in a single tongs, showing prompt applicability of the present emitter for high-power electron beam sources. 3) Holey graphene film as a planar field emitter: we introduce an emitter in the shape of a hole, or hole emitter. An array of holes in graphene film can serve as a planar emitter, in which each circular hole is an emitter. Because of the nature of the sidewall emission through the edge of graphene film, the present planar emitter does not need any cumbersome process of leveling off emitter height and contriving to obtain the desirable inter-distance between emitters. Therefore, the screening effect and the field emission uniformity considered as obstacles in developing high efficiency planar emitters are easily resolved by an optimal design of the circular hole array. Moreover, the graphene film emitter is so flexible that it can be wrapped around a cylindrically shaped anode. This flexibility allows the present emitter to be used as a high power electron beam source because of the focusing of the emitted electron beams rendered by the concavely curved surface. 4) Carbonized cork emitter for multi-dimensional field emission: to broaden the range of application of electron beams, low power field emitters are needed that are miniature and light. We introduce here carbonized cork as a material for field emitters. The light natural cork becomes graphitic honeycomb upon carbonization, with the honeycomb cell walls 100-200 nm thick and the aspect ratio larger than 100, providing an ideal structure for the field electron emission. Compared to nanocarbon field emitters, the cork emitter produces a high current density and long-term stability with a low turn-on field. The nature of cork material makes it quite simple to fabricate the emitter. Furthermore, any desired shape of emitter tailored for the final application can easily be prepared for point, line, or planar emission.
Objectives : The aims of this study was to find appropriate models to predict Body Image disturbance Severity with T-Score of SCL-90-R Subscales in a young Korean adults. Methods : Three hundreds and seventeen young healthy normal subjects ,who were university student, asked to fill out administered the Body Dysmorphic Disorder Examination-Self Report (Korean version of BDDE-SR ; K-BDDE-SR), Symptom checklist 90-Revision(Korean version of SCL 90-R). We calculated T-scores of SCL-90-R subscales standardized by sex and age. We log transformed K-BDDE-SR Total score with Natural logarithm. Stepwise multiple regression analysis was used. Dependent variable was log-transformed K-BDDE-SR and independent variables were T-scores of SCL-90-R subscales. We analysed data four times, for total subjects, male subjects, female subjects, and subjects who seem to have relatively severe body image disturbance, respectively. The statistics are carried out by SPSS 22.0. Results : Out of the 317 subjects, 123 were male and 194 were female. In analysis of total subjects, T-score of Interpersonal Sensitivity subscale was selected as statistically significant variable that increased log-transformed K-BDDE-SR total score. In analysis of male subjects, T-score of Depression subscale was selected as statistically significant variable and increased log-transformed K-BDDE-SR total score. In analysis of female subjects, T-scores of Interpersonal Sensitivity and Somatization subscales were selected as statistically significant and increased log-transformed K-BDDE-SR total score. In analysis of subjects having relatively severe body image disturbance, T-scores of Paranoid was selected as statistically significant and increasd log-tranformed K-BDDE-SR socres. Conclusions : Our study shows that increased T-score Interpersonal Sensitivity of SCL-90-R may be a risk factor of increased body image disturbance. But for male people increased depression subscale may be a risk factor and for female people increased Interpersonal Sensitivity and Somatization subscales may be risk factors. For people having relatively severe body image disturbance, increased paranoid subscale may be a risk factor. This result suggested that psychopathological mechanisms for increased body image disturbance may be different according to sex and severity of body image disturbance.
Role of HLA-DP polymorphism in the pathogenesis of systemic sclerosis
Objectives: To identify common characteristics of amino acid sequences in the risk HLA-DPB1 alleles in systemic sclerosis (SSc) and to predict pathogenic peptide sequence of topoisomerase I. Methods: A total of 127 Korean patients diagnosed with SSc and 548 healthy Korean controls were enrolled. Amino acid sequences of the risk HLA-DPB1 alleles were analyzed, with a focus on known HLA-DP binding motifs. The affinity of all possible 15 amino acid peptide fragments from topoisomerase I against HLA-DP risk alleles compared to protective alleles was examined by NetMHCIIpan-3.0. Results: HLA-DPB1*0901, *1301, and *030101 were revealed as risk alleles for anti-topoisomerase I antibody (ATA)-positive SSc. In contrast, HLA-DPB1*020102 and *0501 were protective against ATA-positive SSc. HLA-DP6 had higher risk than any other supertype of HLA-DP. At amino acid positions 55-57, 67-69, and 82, 84-85 of HLA-DPB1, the number of negatively-charged triplets (NCTs) of amino acids (D, aspartic acid, and E, glutamic acid) were proportional to the odds ratio of ATA-positive SSc. The positions of the NCTs were also important and beta-82,84, and 85 at P1 of HLA-DP binding pocket has a key role. The pathogenic peptides with high affinity to HLA-DP risk alleles had partial concordance with those towards the risk allele of HLA-DQ but no concordance with known risk alleles of HLA-DR. Conclusion: ATA-positive SSc-susceptible HLA-DPB1 alleles share NCTs at critical positions in the peptide binding groove. The peptide fragments of topoisomerase I with high affinity to HLA-DPB1 risk alleles were also favored by risk alleles of HLA-DQB1, suggesting that they may play a role in the pathogenesis of SSc. Key word: Systemic sclerosis, HLA, Topoisomerase-I, Epitope 목표: 전신성 경화증의 위험이 높은 인간 백혈구 항원(HLA)-DPB1 대립인자 유형들을 비교하여 아미노산 서열의 공통적인 특징을 규명하고, 자가항원으로 의심되는 토포아이소머레이스-I의 아미노산 서열 중 병원성 펩티드로 작용할 수 있는 부분을 예측하는 것을 이 연구의 목표로 하였다. 방법: 127명의 한국인 전신성 경화증 환자와 548명의 건강한 한국인 대조군을 연구의 대상으로 하였다. 전신성 경화증 위험이 높은 HLA-DPB1 대립인자들의 아미노산 서열에서, 펩티드 결합부위를 중심으로 공통점을 분석하였다. 또한 토포아이소머레이스-I의 전체 아미노산 서열을 15개 아미노산 단위로 나눈 조각들을 대상으로, HLA-DP 각 대립인자 유형들과의 결합친화력을 NetMHCIIpan-3.0 프로그램을 통해 계산하였다. 이러한 기법을 이용하여, 전신성 경화증에 보호 효과를 갖는 HLA-DPB1 대립인자 대비 위험이 높은 대립인자에 대한 결합친화력 간의 비율을 산출하였고, 이 비율이 높은 토포아이소머레이스 조각을 병원성 펩티드로 작용할 수 있을 것으로 예측하였다. 결과: HLA-DPB1*0901, *1301, *030101 대립인자들이 항-토포아이소머레이스-I 항체(ATA) 양성을 보이는 전신성 경화증에서 고위험 대립인자들이었다. 대조적으로, HLA-DPB1*020102, *0501 대립인자들은 전신성 경화증에 대하여 보호 효과를 갖는 것으로 나타났다. HLA-DP의 슈퍼타입을 기준으로 재분석 했을 때, HLA-DP6가 고위험 슈퍼타입이었다. HLA-DPB1의 아미노산 서열 중 55-57, 67-69, 82, 84-85번째 위치에서 음전하를 띄는 아미노산(아스파르트산, 글루탐산)이 연속하여 세 개씩 나타나는(이하 음전하 트리플렛) 대립인자들이 발견되었는데, 이러한 음전하 트리플렛이 많이 나타날수록 ATA양성 전신성 경화증의 위험이 증가하는 것으로 보였다. 음전하 트리플렛의 위치도 중요했으며, 특히 HLA-DPB1 아미노산 서열의 82, 84, 85번째 위치에 나타나는 음전하 트리플렛이 전신성 경화증 위험과의 연관성이 깊었다. HLA-DP의 고위험 대립인자들과 강한 친화도를 보이는 병인성 펩티드 조각들은 과거 알려졌던 HLA-DQ의 고위험 대립인자들과도 일부 강한 친화도를 보였으나 HLA-DR의 고위험 대립인자들과는 관련이 없었다. 결론: ATA양성 전신성 경화증의 위험이 높은 HLA-DPB1 대립인자들은 펩티드와 결합하는 부위에 음전하 트리플렛을 공유하고 있었다. 토포아이소머-레이스-I의 펩티드 조각들 중 HLA-DPB1과 관련하여 병인성을 가진다고 알려진 것들은 HLA-DQB1와도 관련이 있었으며, 이 펩티드들은 전신성 경화증의 발병과정에 일정한 역할을 할 것으로 보인다. 주요어: 전신성 경화증, 인간 백혈구 항원, 토포아이소머레이스-I, 항원 결정기