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흰쥐 해마 절편에서 저산소증에 의한 [$^3H$-5-Hydroxytrytamine의 유리 변동에 미치는 superoxide dismutase/catalase의 영향
이경은,박월미,배영숙 한국독성학회 1997 Toxicological Research Vol.13 No.4
Many factors are known to be responsible for cerebral ischemic injury, such as excitatory neurotransmitters, increased intraneuronal calcium, or disturbance of cellular energy metabolism. Recently, oxygen free radicals, formed during ischemia/reperfusion, have been proposed as one of the main causes of ischemia/reperfusion injury. Therefore, to investigate the role of oxygen free radical during ischemia/reperfusion, in the present study the effect of endogenous oxygen free radical scavenger, superoxide dismutase / catalase(SOD / catalase) on the release of [$^3$H]-5-hydroxytryptamine([$^3$H]-5-HT) during hypoxia/reoxygenation in rat hippocampal slices was measured. The hippocampus was obtained from the rat brain and sliced 400 gm thickness with manual chopper. After 30 min's preincubation in the normal buffer, the slices were incubated for 20 min in a buffer containing [$^3$H]-5-HT(0.1 $\mu$M, 74 $\mu$Ci) for uptake, and washed. To measure the release of [$^3$H]-5-HT into the buffer, the incubation medium was drained off and refilled every ten minutes through a sequence of 14 tubes. Induction of hypoxia for 20 min (gassing it with 95% N$_2$/5% CO$_2$) was done in the 6th and 7th tube, and oxygen free radical scavenger, SOD / catalase was added 10 minutes prior to induction of hypoxia. The radioactivity in each buffer and the tissue were counted using liquid scintillation counter and the results were expressed as a percentage of the total activity. When slices were exposed to hypoxia for 20 min, [$^3$H]-5-HT release was markedly decreased and a rebound release of [$^3$H]-5-HT was observed on the post-hypoxic reoxygenation period. SOD / catalase did not changed the release of [$^3$H]-5-HT in control group, but inhibited the decrease of [$^3$H]-5-HT release in hypoxic period and rebound increase of [$^3$H]-5-HT in reoxygenation period. This result suggest that superoxide anion may play a role in the hypoxic-, and reoxygenation-induced change of [$^3$H]-5-HT release in rat hippocampal slices.
이경은,이미희,최선아 梨花女子大學校 藥學硏究所 1979 梨花藥學硏究 Vol.- No.19
O-aminophenol can be synthesized by reduction of O-nitrophenol. By the reduction, the difference of yield are followed by sort of reducing agent, reaction time, and reaction temperature etc. In this experiment, it will be proposed that compared with the yield according to reducing agent, Na_2S and Zn.
교합안정장치가 비호흡에 미치는 영향 : 공기역학적 분석
이경은,서봉직 대한안면통증∙구강내과학회 2004 Journal of Oral Medicine and Pain Vol.29 No.3
교합안정장치가 비호흡에 미치는 영향을 평가하고자, 측두하악장애 및 호흡기질환이 없는 17명의 건강한 20대 성인을 대상으로 앙와위(仰臥位)에서 Aerophone II Voice Function Analzyer (KAY elemetrics, USA)를 이용하여 교합안정장치 장착 전후의 공기역학적 검사를 시행하여 다음과 같은 결과를 얻었다. 1. 최대기류량은 교합안정장치를 장착한 후 유의한 차이는 없었다. 2. 폐활량은 교합안정장치를 장착한 후 유의한 차이는 없었다. 3. 교합안정장치를 장착한 후 1회호흡의 지속시간은 유의하게 증가하였다 (P < 0.05). To evaluate the effect of occlusal stabilizing appliance on nasal respiration in supine position, this study was examined. Subjects were composed of dental students without any signs and symptoms of temporomandibular disorders and respiratory diseases. The age of subjects was limited to be between 22 and 28 years. Maximum flow rate, vital capacity and duration of a respiration were measured, analyzed and evaluated without and with appliance in supine position by Aerophone II. The obtained results were as follows : 1. The maximum flow rate of a respiration with occlusal stabilizing appliance was no significant difference compared to that without occlusal stabilizing appliance. 2. The vital capacity of a respiratoion with occlusal stabilizing appliance was no significant difference compared to that without occlusal stabilizing appliance. 3. The duration of a respiration with occlusal appliance was significantly increased compared to that without occlusal appliance (P < 0.05).