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위암의 Fas-associated Death Domain Protein 단백질의 발현
이석형,이종우,박원상,이정용,유남진,Lee, Sug-Hyung,Lee, Jong-Woo,Park, Won-Sang,Lee, Jung-Young,Yoo, Nam-Jin 대한위암학회 2003 대한위암학회지 Vol.3 No.2
Purpose: Evidence exists that dysregulation of apoptosis is involved in the pathogenesis of cancer development. Fasassociated death domain (FADD) protein, an adaptor protein of death receptors, is a critical regulatory component of the extrinsic cell- death pathway that exerts its pro-apoptotic effect upon binding with death receptors. Expression of the FADD protein has not been reported in stomach cancer. The aim of this study was to explore the expression status of the FADD protein in stomach cancers. Materials and Methods: In the current study, we analyzed the expression of the FADD protein in 60 advanced stomach cancer by using immunohistochemistry and a tissue microarray approach. Results: Immunopositivity (defined as $\geq\30\%$) was observed for the FADD protein in 23 ($38\%$) of the 60 cancers. Normal gastric mucosal cells showed expression of the FADD protein. Conclusion: Taken together, these results indicate that decreased expression of the FADD protein is a frequent event in stomach cancers and suggest that to avoid apoptosis, stomach cancer cells in vivo may need loss of FADD expression, which might contribute to tumor development.
이석형 중앙대학교 외국학연구소 2012 외국학연구 Vol.- No.22
本論文旨於通過分析柳宗元由永州歸京至長安, 再由長安赴任到柳州的途中所創作的詩歌來闡釋作者當時的行蹤及創作心態。在永州度過十年之久貶謫生活的柳宗元在接到朝廷召回詔書時雖半信半疑但同時又感到無比欣喜,與此同時對自身未來的命運感到忐忑不安。就在這樣的不安與惶恐之中柳氏離開了永州,初離永州柳宗元的心中充滿了對過去自身生活的悔恨,漸近長安則逐步恢複了內心的平靜,充滿了對未來的憧憬與期待。可朝中的輿論依然於自身不利,最終柳氏作爲刺史重新被貶謫到了更爲遙遠的柳州。由於朝中無人爲自身辯護,在孤立無援的情況下柳氏內心充滿了孤淒之情。踏上了赴任柳州之途的柳宗元內心懷著何時才能重新還京的絕望之情重新又登上了上京時的所經之途,而出發向更爲遙遠的柳州。途中柳宗元與好友劉禹錫依依惜別,也曾深深感歎界圍巖瀑布的美景,而得以暫時忘卻現實的煩惱。但面對與柳州相鄰的嶺南地區陌生的環境柳氏不禁又因對前途的憂慮而發出了近於挫折的歎息。柳宗元的詩真切如實的描繪了曆史書籍所未曾記載的歸京赴柳的旅程,由此柳氏的歸京赴柳詩亦可以視爲一種詩史。
위암의 Phosphorylated Akt 단백질의 발현
이석형,이종우,박원상,이정용,유남진,김수영,Lee Sug Hyung,Lee Jong Woo,Park Won Sang,Lee Jung Young,Yoo Nam Jin,Kim Su Young 대한위암학회 2003 대한위암학회지 Vol.3 No.2
Purpose: Mounting evidence suggests that alterations of Akt/protein kinase B (PKB) play an important role in tumorigenesis. Phosphorylated Akt regulates many of the key effector molecules involved in apoptosis, angiogenesis, and cell-cycle progression during tumorigenesis. The expression of phosphorylated Akt has been described in some human malignancies, but not in primary human gastric cancer. The purpose of this study was to explore the expression status of phosphorylated Akt protein in gastric carcinomas. Materials and Methods: In the current study, we analyzed the expression of phosphorylated Akt protein in 60 advanced gastric adenocarcinomas by using immunohistochemistry and a tissue microarray approach. Results: Immunopositivity (defined as $\geq\30\%$) was observed for the phosphorylated Akt in 42 ($70\%$) of the 60 cancers. Normal gastric mucosal cells showed no or weak expression of phosphorylated Akt protein. Conclusion: Taken together, these results indicate that Akt is frequently activated in gastric adenocarcinoma cells and suggest that phosphorylayed Akt may play a role in the development of human gastric adenocarcinomas.
국내 학술논문 저자명 전거데이터 구축 방안에 관한 연구
이석형,곽승진,Lee, Seok-Hyoung,Kwak, Seung-Jin 한국비블리아학회 2010 한국비블리아학회지 Vol.21 No.1
본 연구의 목적은 국내 학술지, 회의자료 등 학술논문에 나타나는 저자명을 중심으로 저자명 전거데이터를 구축하기 위한 방안과 이를 적용한 전거데이터 구축시스템을 제시하는데 있다. 학술논문 저자명 전거데이터를 구축하기 위해 저자명 식별 요소를 분석하고 이를 토대로 저자 식별방법을 제안하였으며, 국내 학술논문의 저자명을 대상으로 실제 저자명 전거레코드를 구성하였다. 또한, 학술논문의 입수주기 및 규모를 고려하여 학술정보 데이터베이스구축과 동시에 전거데이터가 구축, 관리되고 학술정보 서비스와 연계될 수 있도록 학술논문 관리시스템과 서비스시스템과 본 연구의 제안 시스템이 상호 연계성을 가질 수 있도록 설계되었다. In this paper, we proposed the effectively method for constructing of name authority data in korean academic papers and designed the authority database system that is applied the method. For these, we analyze the requisite for identifying the author name and suggest the author identification method. Because construction of name authority record costs time and effort, and considering frequently period of large-scale acquisitions of academic papers, our suggestion includes the system that be able to manage and construct the name authority database, and that is tightly connected with the academic paper management and service systems.