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RISS 인기검색어
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- 저자 : 황치성 ( Chi Sung Hwang ) (검색결과 2 건)
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Statin 치료시 LDL 콜레스테롤의 직접 측정값과 계산값의 비교
김현진 ( Hyeon Jin Kim ),석지혜 ( Ji Hye Suk ),강지현 ( Ji Hyun Kang ),권혁용 ( Hyuk Yong Kwon ),황치성 ( Chi Sung Hwang ),김명준 ( Myoung Joon Kim ),김미경 ( Mi Kyung Kim ),김태익 ( Tae Ik Kim ),김인주 ( In Joo Kim ) 대한내과학회 2010 대한내과학회지 Vol.79 No.3
Background/Aims: Lowering low-density lipoprotein cholesterol (LDL-C) is the primary target for the prevention of cardiovascular disease. Previous studies have shown that estimated LDL-C levels calculated using Friedewald`s formula (FLDL-C) are closely correlated with directly measured LDL-C levels (DLDL-C). However, because statins not only reduce LDL-C, but also alter the levels of parameters used to calculate FLDL-C (i.e., total cholesterol, triglycerides, and high-density lipoprotein cholesterol), whether calculated LDL-C levels remain a reliable estimate of actual levels after statin treatment is unclear. Methods: Subjects included 985 patients at high risk of cardiovascular disease who had taken statins for more than 6 months. FLDL-C data were compared to DLDL-C data. Results: A strong correlation was observed between DLDL-C and FLDL-C data (R2=0.879). However, the absolute values for FLDL-C and DLDL-C differed significantly according to a paired t-test, and 42.3% of patients showed a difference of greater than 10% between these two values. Among patients with diabetes, the percentage of patients deemed to have achieved target LDL-C levels differed significantly according to the method of LDL-C determination (p=0.007). Conclusions: FLDL-C and DLDL-C data remained well correlated after statin treatment, although the absolute values differed significantly according to the LDL-C determination method. Furthermore, the percentage of subjects deemed to achieve target LDL-C levels differed significantly according to the method of determination among patients with diabetes. (Korean J Med 79:277-284, 2010)
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강지현 ( Ji Hyun Kang ),이지현 ( Ji Hyun Lee ),조경임 ( Kyoung Im Cho ),김태익 ( Tae Ik Kim ),권혁용 ( Hyuk Yong Kwon ),김현진 ( Hyeon Jin Kim ),김명준 ( Myoung Joon Kim ),황치성 ( Chi Sung Hwang ) 대한류마티스학회 2009 대한류마티스학회지 Vol.16 No.3
Background: Aberrations of cardiovascular regulation have been reported in patients who suffer with fibromyalgia (FM). Abnormalities of the cardiovascular autonomic regulation, as well as the correlation between coronary heart disease and depression, have been considered to be the causative factors. The clinical features of transient left apical ballooning syndrome with the patients under acute stress have been clearly described, but the effect of chronic stress such as FM on the myocardium is unknown. We investigated the cardiac strain in FM patients by strain imaging with using the 2D grayscale images, and we quantified the regional myocardial deformation properties. Methods: We investigated 30 consecutive postmenopausal women (mean age: 48±8 years) who satisfied the criteria for fibromyalgia with atypical chest pain by performing standard and 2-dimensional strain echocardiography (2DS). Those patients with hypertension, coronary heart disease or diabetes were excluded. The global and segmental longitudinal deformation parameters of the LV from 3 apical views were analyzed, and the patients underwent a manual tender point survey for determining the number of tender points and tender point counts, and the patients completed the fibromyalgia impact questionnaire (FIQ), the brief fatigue inventory (BFI), and Beck depression inventory (BDI). Results: The global longitudinal LV strain was significantly reduced in the FM patients with a high FIQ score (>40) as compared to the patients with a low FIQ score (-18.61%vs.-22.72%). Also, both the global and segmental longitudinal LV strains were negatively associated with fatigue or the tender point counts. However, there was no significant association between depression and the LV strain. Conclusion: This study showed the reduced myocardial longitudinal deformation in FM patients. This suggested that strain imaging is a feasible approach to assess the regional ventricular function in FM patients.
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