Feasibility Study of a Simple Approximation Algorithm for In-vivo Dose Reconstruction by Using the Transit Dose Measured Using an EPID

황의중,송미희,백태성,정은지,윤명근 한국물리학회 2015 THE JOURNAL OF THE KOREAN PHYSICAL SOCIETY Vol.66 No.4

The purpose of this study is to verify the accuracy of the dose delivered to the patient duringintensity-modulated radiation therapy (IMRT) by using in-vivo dosimetry and to avoid accidentalexposure to healthy tissues and organs close to tumors. The in-vivo dose was reconstructed byback projection of the transit dose with a simple approximation that considered only the percentdepth dose and inverse square law. While the average gamma index for comparisons of dose distributionsbetween the calculated dose map and the film measurement was less than the one for96.3% of all pixels with the homogeneous phantom, the passing rate was reduced to 92.8% with theinhomogeneous phantom, suggesting that the reduction was apparently due to the inaccuracy of thereconstruction algorithm for inhomogeneity. The proposed method of calculating the dose insidea phantom was of comparable or better accuracy than the treatment planning system, suggestingthat it can be used to verify the accuracy of the dose delivered to the patient during treatment.

Depth Dose Measurement using a Scintillating Fiber Optic Dosimeter for Proton Therapy Beam of the Passive-Scattering Mode Having Range Modulator Wheel

황의중,신동호,이세병,임영경,정종휘,김학수,김기환 한국물리학회 2018 THE JOURNAL OF THE KOREAN PHYSICAL SOCIETY Vol.72 No.9

To apply a scintillating fiber dosimetry system to measure the range of a proton therapy beam, a new method was proposed to correct for the quenching effect on measuring an spread out Bragg peak (SOBP) proton beam whose range is modulated by a range modulator wheel. The scintillating fiber dosimetry system was composed of a plastic scintillating fiber (BCF-12), optical fiber (SH 2001), photo multiplier tube (H7546), and data acquisition system (PXI6221 and SCC68). The proton beam was generated by a cyclotron (Proteus-235) in the National Cancer Center in Korea. It operated in the double-scattering mode and the spread out of the Bragg peak was achieved by a spinning range modulation wheel. Bragg peak beams and SOBP beams of various ranges were measured, corrected, and compared to the ion chamber data. For the Bragg peak beam, quenching equation was used to correct the quenching effect. On the proposed process of correcting SOBP beams, the measured data using a scintillating fiber were separated by the Bragg peaks that the SOBP beam contained, and then recomposed again to reconstruct an SOBP after correcting for each Bragg peak. The measured depth-dose curve for the single Bragg peak beam was well corrected by using a simple quenching equation. Correction for SOBP beam was conducted with a newly proposed method. The corrected SOBP signal was in accordance with the results measured with an ion chamber. We propose a new method to correct for the SOBP beam from the quenching effect in a scintillating fiber dosimetry system. This method can be applied to other scintillator dosimetry for radiation beams in which the quenching effect is shown in the scintillator.

전신 피부 전자선 치료(TSET)에서 EBT2 필름을 사용한 선량측정

황의중,라정은,정호진,안성환,김동욱,이상엽,임영경,윤명근,신동호,이세병,박성용,표홍렬,정원규,Hwang, Ui-Jung,Rah, Jeong-Eun,Jeong, Ho-Jin,Ahn, Sung-Hwan,Kim, Dong-Wook,Lee, Sang-Yeob,Lim, Young-Gyung,Yoon, Myong-Geun,Shin, Dong-Ho,Lee, Se-Bye 한국의학물리학회 2010 의학물리 Vol.21 No.1

전신 피부 전자선 치료(total skin electron beam therapy, TSET)를 위해서는 흔히 행해지는 일반적인 방사선 치료와 달리 치료 전 다양한 조건에서의 선량 측정과 더불어, 치료 중 지속적인 환자 신체부위별 선량 측정이 요구된다. 본 연구에서는 선형 가속기에 기반한 modified Stanford Technique으로 전신 피부 전자선 치료를 할 때 치료에 필요한 치료 전자선의 에너지와 선량의 공간적 분포 및 치료 중 환자의 각 부위별 조사선량을 EBT2 필름을 이용하여 측정 하였다. 전자선의 에너지는 이온전리함으로 측정한 값과 비교하였을 때 잘 일치하였고, 선량의 공간 분포 및 환자 각 신체부위에서의 선량 분포는 EBT2 필름을 이용하여 편리하게 측정할 수 있었다. 또한 TSET 치료중 EBT2 필름을 사용하여 in-vivo로 측정된 환자 신체 부위별 선량분포의 변화는 열형광선량계(thermoluminescent dosimeter, TLD)로 동시에 측정한 값과 비교하였을 때 잘 일치함을 알 수 있었다. 이로써 EBT2 필름의 전신 피부 전자선 치료를 위한 선량계로서의 가능성을 확인하였다. For treatment of Total Skin Electron beam Therapy (TSET), measurement of dose at various conditions is need on the contrary to usual radiotherapy. When treating TSET with modified Stanford technique based on linear accelerator, the energy of treatment electron beam, the spatial dose distribution and the actual doses deposited on the surface of the patient were measured by using EBT2. The measured energy of the electron beam was agreed with the value that measured by ionization chamber, and the spatial dose distribution at the patient position and the doses at several point on the patient's skin could be easily measured by EBT2 film. The dose on the patient that was measured by EBT2 film showed good agreement with the data measured simultaneously by TLD. With the results of this study, it was proven that the EBT2 film can be one of the useful dosimeter for TSET.

방사선치료에서 투과선량을 이용한 체내선량 검증프로그램 개발

황의중,백태성,윤명근,Hwang, Ui-Jung,Baek, Tae Seong,Yoon, Myonggeun 한국의학물리학회 2014 의학물리 Vol.25 No.1

방사선치료에서는 환자 체내에 전달된 선량이 원래 의도한 데로 분포되는 지 확인하기 위하여 균질한 팬텀을 이용한 정도 관리를 치료 전에 주로 시행하고 있다. 하지만 균질한 팬텀을 이용한 정도 관리는 표면이 불규칙적이고 불균질한 인체에 대한 선량분포를 완전히 보증해 주지는 못하고 있다. 본 연구에서는 환자를 투과하는 선량의 분포를 측정하여 역으로 환자체내 선량 분포를 계산하는 투과선량 기반 체내선량 검증프로그램을 개발하였다. 투과선량은 주방사선과 산란방사선으로 이루어져 있는데, 본 연구에서는 전자포탈영상장치로 측정한 선량분포로부터 주방사선만을 이용한 간단한 식으로 환자체내선량분포를 계산하는 프로그램과 감마값 분포를 평가하여 두 선량분포를 서로 비교할 수 있는 프로그램을 개발하였다. 개발된 프로그램을 이용하여 계산한 팬텀의 등중심점을 지나는 관상면의 체내선량 분포는 치료계획시스템에서 제공하는 동일 평면의 선량분포와의 비교결과 균질팬텀에서 평균 95%, 비균질팬텀에서 81.8%의 감마통과율을 보였다. The purpose of this study is to evaluate the developed dose verification program for in vivo dosimetry based on transit dose in radiotherapy. Five intensity modulated radiotherapy (IMRT) plans of lung cancer patients were used in the irradiation of a homogeneous solid water phantom and anthropomorphic phantom. Transit dose distribution was measured using electronic portal imaging device (EPID) and used for the calculation of in vivo dose in patient. The average passing rate compared with treatment planning system based on a gamma index with a 3% dose and a 3 mm distance-to-dose agreement tolerance limit was 95% for the in vivo dose with the homogeneous phantom, but was reduced to 81.8% for the in vivo dose with the anthropomorphic phantom. This feasibility study suggested that transit dose-based in vivo dosimetry can provide information about the actual dose delivery to patients in the treatment room.

방사선치료분야에서 의학물리사의 적정인력 분석

황의중,임영경,김동욱,신동오,김성규,정해조,지영훈,Hwang, Ui-Jung,Lim, Young Gyung,Kim, Dong Wook,Shin, Dong Oh,Kim, Sung Kyu,Jung, Haijo,Ji, Young Hoon 한국의학물리학회 2012 의학물리 Vol.23 No.4

최근 방사선치료기기 및 방사선치료기술이 빠르게 발전하고 복잡해짐에 따라 방사선치료의 신뢰성을 높이고 정확한 환자 치료와 환자 및 치료관련 종사자의 방사선안전을 확보하기 위하여 자격있는 의학물리사 적정 인원에 대한 재평가가 이루어지고 있다. 방사선치료분야에서 의학물리사의 적정한 인원수준에 대하여 외국의 연구사례 및 결과에 대해 미국과 유럽을 중심으로 분석하였다. 또한 외국연구결과를 토대로 국내에 필요한 의학물리사의 적정 인원을 간접적으로 계산해 보았다. 국내 중대형 6개 병원의 현재 의학물리사 적정 인원은 국제적 적정 권고 인원의 50% 이하였다. 더욱 더 객관적인 의학물리사의 필요 인원수를 예측하기 위하여는 국내 여건에 적합한 추가적인 연구가 요구되며, 특히 지속적으로 증가되고 있는 입자방사선치료를 고려한 인원수 예측이 필요하다. Recently, an adequate number of qualified medical physicist is needed for achieving effective treatment and securing safety to the patient, staff and the public on the course of radiation therapy, since the equipment and the technique of radiation therapy are being developed fast and becoming complex. The studies on medical physics staffing level in United State and European countries were investigated. These results were applied to the domestic situation in order to anticipate indirectly the adequate number of medical physicist in Korea. The current number of medical physicists of 6 (middle to large sized) hospitals in Korea was less than 50% of number recommended in the study. Further detailed research specified on the domestic situation is needed in order to expect adequate number of medical physicist more accurately, and particle beam therapy has to be also considered in the research since the facility site is increasing gradually.

Image Guided Radiation Therapy

황의중,민병준,김미영,김기환 한국의학물리학회 2022 의학물리 Vol.33 No.4

Over the past decades, radiation therapy combined with imaging modalities that ensure optimal image guidance has revolutionized cancer treatment. The two major purposes of using imaging modalities in radiotherapy are to clearly delineate the target prior to treatment and set up the patient during radiation delivery. Image guidance secures target position prior to and during the treatment. High quality images provide an accurate definition of the treatment target and the possibility to reduce the treatment margin of the target volume, further lowering radiation toxicity and improving the quality of life of cancer patients. In this review, the various types of image guidance modalities used in radiation therapy are distinguished into ionized (kilovoltage and megavoltage image) and nonionized imaging (magnetic resonance image, ultrasound, surface imaging, and radiofrequency). The functional aspects, advantages, and limitation of imaging using these modalities are described as a subsection of each category. This review only focuses on the technological viewpoint of these modalities and any clinical aspects are omitted. Image guidance is essential, and its importance is rapidly increasing in modern radiotherapy. The most important aspect of using image guidance in clinical settings is to monitor the performance of image quality, which must be checked during the periodic quality assurance process.

Photoinduced Birefringence in an Azo Polymer Film

황의중,오차환,G. J. Lee,J. . Kim,P. . Kim,. H. ong,. Y. You,Y. K. Han,이영백 한국물리학회 2005 THE JOURNAL OF THE KOREAN PHYSICAL SOCIETY Vol.46 No.2

Photoinduced anisotropy and birefringence in an azobenzene polymer film were investigated by pumping beams with various wavelengths. Azobenzene-type polymer whose and n transition bands are far enough from each other to be distinguished was used in this experiment. The vertical and the parallel polarization components of the absorbance and also the birefringence on the polymer film were measured simultaneously during pumping with a linearly polarized beam at various wavelengths. We observed abnormal behavior of the birefringence for the pumping beam at specific wavelength. For explaining the photoinduced birefringence change with the illumination time, rate equations for angular distribution of trans fraction in the azobenzene polymer were introduced. By comparing the experimental results with the theoretical simulations by using the rate equations, it was found that the abnormal behavior of the birefringence is due to the incomplete cycle of the photoisomerization process.

[역사나눔 1-3] 〈에다가와 재판사건〉의 의의와 가능성

황의중 전남대학교 글로벌디아스포라연구소 2005 전남대학교 세계한상문화연구단 국제학술회의 Vol.2005 No.11

외부광궤환에 의한 레이저 다이오드의 출력특성

이세영,오차환,김필수,황의중 漢陽大學校 自然科學硏究所 1997 自然科學論文集 Vol.16 No.-

외부 광궤환 반도체 레이저의 출력 특성을 비율방정식의 수치해를 이용하여 분석하였다. 출력의 세기와 위상과 전자밀도를 시간에 대한 함수로 알아보았다. 또한 bifurcation diagram과 phase diagram을 통하여 궤환비율 k에 따른 레이저의 동작 특성을 조사하였다. 궤환광이 없을때는 이완발진이 감쇄한 후 안정한 출력특성이 나타나지만 되먹임 비율이 증가하면서 안정한 해의 갯수가 증가하다가 ??????이상의 매우 강한 광궤환에서는 출력특성이 극도로 불규칙해지고 무수히 많은 해를 갖는 혼돈현상이 나타남을 알 수 있었다. The output characteristics of a laser diode with external optical feedback were analyzed by numerical solutions of rate equations. The output power, phase and carrier density were plotted as a function of time. Dynamics of external cavity laser were investigated by the bifurcation diagram and the phase diagram with respect to the feedback rate k. If there was no feedback, relaxation oscillation reduced and laser showed stable output. For increasing feed back level, the number of stable state was increased. In very strong feedback rate above ??????, laser output showed extremely unstable and chaotic behavior.

FOCRS (Fiber-Optic Cerenkov Radiation Sensor)을 이용한 치료 양성자 빔의 dosimetry system 개발

손재만,김미영,황의중,황의중,윤명근,이세병,임영경,박정훈 대한방사선방어학회 2014 대한방사선방어학회 학술발표회 논문요약집 Vol.2014 No.11