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수종의 생약이 Bovine Adrenal Tyrosine Hydroxylase 및 Dopamine ${\beta}-Hydroxylase$ 활성에 미치는 영향 (II)
황윤정,이승호,김학성,이경순,노재섭,이명구,Hwang, Yoon-Jeong,Lee, Seung-Ho,Kim, Hack-Seang,Lee, Kyong-Soon,Ro, Jai-Seup,Lee, Myung-Koo 한국생약학회 1994 생약학회지 Vol.25 No.2
MeOH extracts of sixteen herbal drugs were tested for the effects on bovine adrenal tyrosine hydroxylase and dopamine ${\beta}-hydroxylase$. The MeOH extracts of Paeoniae Radix and Pinelliae Tuber showed 65% inhibition on the tyrosine hydroxylase activity at the concentration of 100 $\mu$g in the enzyme reaction mixture. Those of Paeoniae Radix, Pinelliae Tuber and Evodiae Fructus showed 87, 84 and 62%, respectively, on the dopamine ${\beta}-hydroxylase$ activity.
황윤정(Yoon Jeong Hwang),이승호(Seung Ho Lee),유시용(Shi Yong Ryu),안종웅(Jong Woong Ahn),김은주(Eun Joo Kim),노재섭(Jai Seup Ro),이경순(Kyong soon Lee) 한국생약학회 1994 생약학회지 Vol.25 No.1
Gleditsia japonica var. koraiensis NAKAI(Leguminosae) is commonly distributed in Korea and has been used as a folk. medicine in the treatment of bronchitis, neoplasm and blennorrhgia in the Orient. The aqueous acetone extract of the leaves of G. japonica was subjected to a combination of Sephadex LH-20, Cosmosil 75C<sub>18</sub>-OPN, TSK-gel Toyopearl HW 40F, Avicel cellulose, and MCI-gel CHP 20P chromatographies with various solvent systems. Twelve compounds were isolated and confirmed to be vitexin(1), isovitexin(2), orientin(3), isoorientin(4), 4-caffeoyl quinic acid(5), 5-caffeoyl quinic acid(6), 3, 5-dicaffeoyl quinic acid(7), 4, 5-dicaffeoyl quinic acid(8), caffeic acid(9), quercetin(10), isoquercitrin(11) and luteolin-7-O-glucoside(12), on the basis of chemical and spectroscopic evidences.
정보 활용 능력 함양을 위한 소프트 지식 기반 사회과 교재의 개발과 적용
황윤정(Hwang Yoon Jeong),박기범(Park Kee Burm) 한국사회과수업학회 2020 사회과수업연구 Vol.8 No.2
디지털 시대에 지식의 생성, 유통, 소멸의 주기는 단축되고 있다. 이러한 시대를 살아가는 학습자들에게 필요한 능력은 지식을 기억하는 능력이 아니라 지식․정보를 연결하는 능력이다. 소프트 지식의 관점에서 보았을 때, 학습은 끊임없이 정보를 연결하여 지식을 조직․확장․활용하는 것이다. 본 연구의 목적은 소프트 지식 관련 학습이론을 탐구하여 소프트 지식 기반 사회과 교재를 개발․적용함으로써 학습자의 정보 활용 능력을 함양시키는 데 있다. 이를 위해 소프트 지식 관련 학습이론인 커넥티비즘(connectivism)과 인지적 융통성 이론(cognitive flexibility theory)을 탐색하여 교재 구성 전략을 수립하고 교재를 개발하였다. 교재 적용 결과, 다음과 같이 유의미한 결론을 도출하였다. 첫째, 소프트 지식 기반 사회과 교재의 적용을 통해 학습자의 정보 생산 능력의 하위 요소 중 ‘대안 탐색하기’ 능력이 향상되었다. 공유와 연결의 확장을 통해 학습자는 다양한 대안을 탐색하는 모습을 보였다. 둘째, 연구 대상자 중 학업 성취도가 높은 일부 학생들에게서 정보를 면밀히 정리․해석하고, 연결하여 구체적인 계획을 수립하는 모습을 확인할 수 있었다. 셋째, 과업을 완수하기 위한 실행력에 효과적으로 작용했다. 동일한 과제에 대해 비교반은 중단한 경우가 비교적 많았으나 연구반은 모두 과제를 완성하였다. 본 연구는 소프트 지식의 관점에서 사회과 교재를 개발하고 실제 수업에 적용했다는 점에서 의의를 지닌다. The purpose of this thesis is to study the learning theory of Soft Knowledge and apply the findings in creating a Social Studies textbook, that will nurture information literacy to learners To do so, the researcher has conducted thorough studies on the ‘connectivism’ and ‘cognitive flexibility theory’, both of which are deeply related to ‘soft knowledge’. Afterwards, the researcher created a structure plan to create a Social Studies textbook based on the findings, and conclusively developed a textbook. The research was concluded as significant through the findings from the classes conducted to increase information literacy. Firstly, through classes taught with the Social Studies textbook based on ‘Soft knowledge’, learner abilities to ‘search for solutions’ (a subelement of information literacy) increased. Secondly, among the studied learners, it was observed that those with high levels of education were able to organize and interpret information in great detail, and make connections to create specific plans. Thirdly, it has increased abilities to make efficient executions to finish classwork. Through a comparative experiment done with another class assigned with the same classwork, it has been observed that while many learners in the comparative class gave up midway, all learners in the studied class finished the assignment. The thesis shows significance in that a textbook based on the theory was developed, and was used as material in an actual teaching/learning environment.
TRIP-16 화합물의 베타세포 당지질독성 해독 기전 분석
박선미(Sun mi Park),정대연(Dae youn Jeong),구진모(Jin mo Ku),황윤정(Yoon Jung Hwang),최성이(Sung E Choi),강엽(Yup Kang),정귀완(Kwi wan Jeong) 대한약학회 2016 약학회지 Vol.60 No.6
Gradual deterioration of pancreatic beta cells is a conundrum still to be resolved in the diabetes field. The toxicity manifested by high level of glucose and saturated fatty acid (SFA), which is collectively termed as glucolipotoxicity, has been accepted as a predominant factor of beta cell dysfunction or failure. In this study, we examined the effect of TRIP (Triazolo[ 3,4-a]phthalazine)-16, a compound derivatized from TRIP which had been identified in a high throughput screening to discover chemicals protecting INS-1 cells from glucolipotoxicity. We also investigated its mode of action to reduce glucolipotoxicity, especially regarding modulation of lipid metabolism. From a series of cell-based experiments, we observed that TRIP-16 reduced fatty acid-induced triglyceride (TG) accumulation, whereas it increased oxidation rate of glucose or palmitate. The compound also reduced reactive oxygen species generated by palmitate and upregulated expression levels of carnitine palmitoyltransferase-1a (CPT-1a), peroxisome proliferator-activated receptor gamma coactivator 1-alpha (PGC- 1α) and uncoupling protein 2 (UCP-2), implicating that it can facilitate mitochondrial energy metabolism to oxidize palmitate. In terms of beta cell functioning, TRIP-16 augmented glucose-stimulated insulin secretion (GSIS) per se. Taken together, our data strongly suggest that TRIP-16 can be a potential drug candidate for prevention of type 2 diabetes through beta cell protection.