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Triamcinolone acetonide 국소도포가 햄스터 협낭 비만세포의 분포에 미치는 영향
황성명,고재승,김종배,손영익 대한구강생물학회 1988 International Journal of Oral Biology Vol.12 No.1
Steroidal ointments possess mainly anti-inflammatory actions and decrease the mast cell number in tissues, but exhibit atrophogenic tendency to the skin and mucosa as a side effect. To know the redistribution of mast cells in hamster cheek pouch by triamcinolone topical application, which is prednisolone derivative, 0.01% triamcinolone acetonide paste was applicated to the hamster cheek pouch once a day for 5 weeks and the pouches were observed after 3rd and 5th week each. The excised pouches from hamsters were fixed with 10% neutral buffered formalin, embedded in paraffin, stained with toluidine blue solution, and observed with light microscope. The results were as follows. 1. The mast cell number was decreased noticeably in 3rd week experimental group, but not in control groups. 2. Necrotic change in 5th week experimental group could be seen, the necrotic tissues were denuded and the mast cells were not present in that area. 3. Adjacent the necrotic center, epithelial thickening and inflammatory changes could be seen, but only a few mast cells were present. In some area, many mast cells were aggregated densely and, also, many small, round mast cells were aggregated around the blood vessel.
劉東洙,張完稙,黃聖明 大韓顎顔面 放射線學會 1976 Imaging Science in Dentistry Vol.6 No.1
The authors has observed the effect of X-ray irradiation on the dentin matrix formation of the albino rat fetuses. The lower abdomen of the pregnant ratswere exposed to X-ray on the 9 1/2th day of gestation, respectively 150, 250 and 350 rads. The fetuses of the right sides of the same pregnant rats which were not exposed to X-ray were as controls. The results were as follows: 1) In the 150 rads irradiated fetuses, predentin formation was identicalwith control groups, but the arrangement of odontoblasts was distorted, subodontoblastic layer was condesed with pulp cells and blood capillaries were enlarged. 2) In the 250 rads irradiation, dentin matrix was imperfact or osteodentin was occured. Short columnar or cuboidal odontoblasts were presented and pulp cells were dispersed. Blood capillaries were cogested. 3) 350 rads irradiated fetuses showed osteodentin matrix and numerous degenerated odontoblasts. Their dental papilla showed reticular atrophy and enlarged capillary.