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Survival and migration of transplanted neural stem cells (NSCs) are prerequisites for therapeutic benefits in spinal cord injury. We have shown that survival of NSC grafts declines after transplantation into the injured spinal cord, and that combining treadmill training (TMT) enhances NSC survival via insulin-like growth factor-1 (IGF-1). Here, we aimed to obtain genetic evidence that IGF-1 signaling in the transplanted NSCs determines the beneficial effects of TMT. We transplanted NSCs heterozygous (+/-) for Igf1r, the gene encoding IGF-1 receptor, into the mouse spinal cord after injury, with or without combining TMT. We analyzed the influence of genotype and TMT on locomotor recovery and survival and migration of NSC grafts. In vitro experiments were performed to examine the potential roles of IGF-1 signaling in the migratory ability of NSCs. Mice receiving +/- NSC grafts showed impaired locomotor recovery compared with those receiving wild-type (+/+) NSCs. Locomotor improvement by TMT was more pronounced with +/+ grafts. Deficiency of one allele of Igf1r significantly reduced survival and migration of the transplanted NSCs. Although TMT did not significantly influence NSC survival, it substantially enhanced the extent of migration for only +/+ NSCs. Cultured neurospheres exhibited dynamic motility with cytoplasmic protrusions, which was regulated by IGF-1 signaling. IGF-1 signaling in transplanted NSCs may be essential in regulating their survival and migration. Furthermore, TMT may promote NSC graft-mediated locomotor recovery via activation of IGF-1 signaling in transplanted NSCs. Dynamic NSC motility via IGF-1 signaling may be the cellular basis for the TMT-induced enhancement of migration.
저자들은 본원 산부인과에서 소화기 증상 및 증세를 볼 수 없었던 직장내 자궁내막증이 있었던 1예를 경험하였기에 간단한 문헌고찰과 함께 보고하는 바이다. Endometriosis of the rectum is one of the rare conditions of intrapelvic endometriosis Endometriosis occurs in about 8∼15% of reproductive women, of whom 3∼34% show intestinal invasion of the rectosigmoid colon, appendix, ileum, and cecum, in order of decreasing fequency. Symptoms related to bowel involvement manifest as no symptoms at all to complete obstruction of the bowel and depend on the degree of invasion of the endometriosis. Therefore differentiation between cancer and endometriosis of the sigmoid colon and rectum is important, and unnecessary major operations may be avoided. The authors at this hospital, Department of Obstetrics and Gynecology, report a recent case which presented itself as a intraabdominal mass who was admitted, and who was found to have endometriosis of the rectum and left endometrial cyst who didn`t have any gastrointestinal symptoms of sign.