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        • β-용혈성 연쇄상구균 C, G 및 F 혈청군의 균종별 분리 빈도

          황규열 ( Gyu Yul Hwang ),어영 ( Young Uh ),장인호 ( In Ho Jang ),이관수 ( Kan Su Lee ) 대한임상검사과학회 2006 대한임상검사과학회지(KJCLS) Vol.38 No.1

          Beta-hemolytic streptococci (BHS) are frequently isolated pathogens in clinical microbiology laboratories. Among them, Group C, G and F streptococci infrequently cause respiratory infections, but they often invade other sites. Patients with underlying diseases are prone to be infected by the organisms and some of them can be fatal. Therefore, combination tests of serological and biochemical tests are needed to correct the identification of non-A, B streptococci because to various species belong to this species. The aim of this study was to investigate the isolation rates of strains and distribution of serogroup C, G and F streptococci at Wonju Hospital during the period of 2003-2004. 133 clinical isolates of group C, G and F streptococci were examined. Of them, 13 (9.8%) were group C, 41 (31.8%) were group F, 79 (59.4%) were group G. The prevalent isolation of the strains by serogroup were: group C, Streptococcus constellatus (38.5%); group F, Streptococcus anginosus (56.1%), Streptococcus constellatus (26.9%); group G, Streptococcus anginosus (54.4%), Streptococcus dysgalatiae subsp. equisimilis (26.5%). Overall, the most frequently isolated BHS was Streptococcus anginosus (51.2%).

        • KCI등재

          흉막액 배양에서 누출액과 삼출액에 따른 세균학적 특성

          이현교,황규열,박순덕,어영,김주원,윤갑준,리원연 대한임상미생물학회 2015 Annals of clinical microbiology Vol.18 No.2

          A total of 1,132 pleural fluid culture results obtained from October 2012 to July 2014 were analyzed to elucidate the microbiological characteristics according to transudative and exudative pleural fluid. The pleural fluid cultures were performed using aerobic and anaerobic blood culture bottles. The blood and pleural fluid for total protein, lactate dehydrogenase, and glucose measurement were submitted to laboratory at the same time with pleural fluid cultures. The rates for culture positivity, anaerobes isolation, and polymicrobials between transudative and exudative pleural fluid were 5.2% vs. 10.4%, 14.8% vs. 7.8%, and 14.8% vs. 10.9%. (Ann Clin Microbiol 2015;18:-55) 흉막의 누출액과 삼출액에 따른 흉막액 배양에서의 세균학적 특성을 규명하기 위해 2012년 10월부터 2014년 6월까지 혈액배양용 호기성과 무산소성 배지를 이용한 흉막액 배양 검사와 함께 혈청과 체액에서 총단백, 젖산탈수소효소와 당 검사를 의뢰한 1,132검체에서의 결과를 분석하였다. 흉수 누출액과 삼출액의 배양 양성률, 미호기세균 분리율과 다균증 빈도는 각각 5.2%와 10.4%, 14.8%와 7.8% 및 14.8%와 10.9%였다. [Ann Clin Microbiol 2015;18:52-55]

        • KCI등재

          Nosocomial Outbreak Caused by NDM-5 and OXA-181 Carbapenemase Co-producing Escherichia coli

          안광진,황규열,김영근,김효열,정혜란,홍준성,어영 대한감염학회 2019 Infection and Chemotherapy Vol.51 No.2

          Carbapenemase-producing Enterobacteriaceae (CPE) is an important and increasing threat to global health. From July to September 2017, 20 inpatients at a tertiary care hospital in Korea were either colonized or infected with carbapenem-resistant Escherichia coli strains. All of E. coli isolates co-produced blaNDM-5 and blaOXA-181 carbapenemase genes and shared ≥88% clonal relatedness on the basis of a cladistic calculation of the distribution of pulsed-field gel electrophoresis patterns. Rapid detection of CPE is one of the most important factors to prevent CPE dissemination because it takes long time for CPE to become negative.

        • KCI등재

          Macrolide Resistance Trends in β-Hemolytic Streptococci in a Tertiary Korean Hospital

          어영,황규열,장인호,조현미,노송미,김효열,권오건,윤갑준 연세대학교의과대학 2007 Yonsei medical journal Vol.48 No.5

          Purpose: Erythromycin-resistant β-hemolytic streptococci (BHS) has recently emerged and quickly spread between and within countries throughout the world. In this study, we evaluate the antimicrobial susceptibility patterns and erythromycin resistance mechanisms of BHS during 2003-2004. Materials and Methods: The MICs of seven antimicrobials were determined for 204 clinical isolates of BHS from 2003 to 2004. Resistance mechanisms of erythromycin-resistant BHS were studied by the double disk test as well as by polymerase chain reaction (PCR). Results: Compared with our previous study, resistance among Streptococcus pyogenes isolates to a variety of drugs decreased strikingly: from 25.7% to 4.8% in erythromycin; 15.8% to 0% in clindamycin; and 47.1% to 19.0% in tetracycline. The prevalent phenotypes and genotypes of macrolide-lincosamide- streptograminB (MLSB) resistance in Streptococcus pyogenes isolates have been changed from the constitutive MLSB phenotype carrying erm(B) to the M phenotype with mef(A) gene. In contrast with Streptococcus pyogenes, resistance rates to erythromycin (36.7%), clindamycin (43.1%), and tetracycline (95.4%) in Streptococcus agalactiae isolates did not show decreasing trends. Among the Streptococcus dysgalactiae subsp. equisimilis isolates (Lancefield group C, G), resistance rates to erythromycin, clindamycin, tetracycline and chloramphenicol were observed to be 9.4%, 3.1%, 68.8%, and 9.4%, respectively. Conclusion: Continual monitoring of antimicrobial resistance among large-colony-forming BHS is needed to provide the medical community with current data regarding the resistance mechanisms that are most common to their local or regional environments.

        • KCI등재후보

          임상분리균주에 대한 은이온(Ag+) 거즈의 생체외 항균력 시험

          어영,황규열,윤갑준,김효열,어홍선,권오갑 대한임상미생물학회 2007 Annals of clinical microbiology Vol.10 No.1

          Background: It is well-known that silver ions and silver compounds are broad-spectrum antimicrobial agents effective against gram-positive and gram-negative bacteria, and yeasts. Thus, silver ions, as an antibacterial agent, have been used in the components of materials used in medical devices or coatings. Recently, advances in nanotechnology have enabled manufacturers to develop silver particles of a nanometer size with a safer and more effective antimicrobial activity. So, we evaluate the antimicrobial activity of nanoSilver-coated gauze against clinical isolates. Methods: Three kinds of nanoSilver-coated gauzes (100Å, 800Å, and 1,500Å) were tested for antimicrobial activity by the disk diffusion method. The organisms tested included clinical isolates of nonfermentative gram-negative bacilli (143 isolates), aerobic gram-negative bacteria (188), aerobic gram-positive bacteria (397), anaerobic bacteria (46), and yeasts (161), and three reference ATCC strains. Results: The susceptible rates to NanoSilver of nonfermentative gram-negative bacilli (NFB), aerobic gram-negative bacteria and aerobic gram-positive bacteria were 87%, 87% and 78%, respectively. Antimicrobial activity of NanoSilver against imipenem-resistant NFB, extended spectrum β-lactamase (ESBL) producing Enterobacteriaceae, and methicillin-resistant Staphylcoccus aureus (MRSA) was similar to that against imipenem-sensitive NFB, ESBL non-producing Enterobacteriaceae, and methicillin-susceptible S. aureus. Conclusion: NanoSilver-coated gauze exhibits broad spectrum antimicrobial activities to a large number of gram-negative and gram-positive bacteria including imipenem-resistant NFB, ESBL producing Enterobacteriaceae, and MRSA. 배경: 은이온(Ag+)과 은화합물은 그람양성과 그람음성 세균 및 효모균에 효력이 있는 광범위 항균제로 잘 알려져 있으며, 은이온은 항균제 용도로 의료기구나 의료용품의 코팅제로 사용되고 있다. 최근에는 나노기술의 발달로 더 안전하며 항균력이 증가된 은나노 입자를 생산할 수 있게 되었다. 이에 본 연구에서는 임상분리주를 대상으로 은나노를 코팅한 은이온(Ag+) 거즈의 항균력을 평가하였다. 방법: 임상검체에서 분리된 143주의 포도당비발효그람음성간균, 18 주의 통성 혐기성 그람음성세균 , 397주의 통성 혐기성 그람양성세균, 46주의 혐기성세균과 161주의 효모균 및 3주의 정도관리 균주를 대상으로 세 종류의 은이온 (Ag+) 거즈(10, 800, 1,500)의 항균력을 디스크확산법으로 시험하였다. 결과: 포도당비발효그람음성간균, 통성 혐기성 그람음성세균과 통성 혐기성 그람양성세균의 은이온 (Ag+) 거즈의 감수성률은 각각 87%, 87%, 78% 였으며, imipenem 내성 포도당비발효그람음성간균, extended spectrum β-lactamase (ESBL) 생성 장내세균, methicillin 내성 포도알균에 대한 은이온 (Ag+) 거즈의 항균력은 imipenem 감수성 포도당비발효그람음성간균, ESBL을 생성하지 않는 장내세균, methicillin 감수성 포도알균과 유사하였다. 결론: 은이온(Ag+) 거즈는 imipenem 내성 포도당비발효그람음성간균, ESBL 생성 그람음성간균, methicillin 내성 포도알균을 포함한 다수의 통성 혐기성 그람양성과 그람음성 세균에 광범위 항균력을 보였다.

        • KCI등재

          최근 20년 동안 단일 3차 의료기관의 칸디다혈증 환자에서 분리된 Candida 균종별 분리 빈도와 항진균제 내성률의 변화 추이

          김동균,황규열,유길성,김주원,어영 대한임상미생물학회 2017 Annals of clinical microbiology Vol.20 No.3

          Background: Candidemia has increased with an increasing number of people in the high risk group and so has become more important. This study was conducted to investigate the isolation rate of Candida species from candidemia patients and the change in rate of antifungal resistance. Methods: At a single tertiary care hospital, 1,120 blood cultures positive for Candida species from 1997 to 2016 were investigated according to date of culture, gender, age, and hospital department. Results: During the investigation period, the number of candidemia patients increased from 14 in 1997 to 84 in 2016. The most common organism identified during the two decades was Candida albicans (40.8%), followed by Candida parapsilosis (24.1%), Candida tropicalis (13.2%), and Candida glabrata (12.8%). C. glabrata was relatively common in females (45.5%) compared to males. The age group 40-89 years was more frequently infected than other age groups, and the most frequent isolates according to age group were C. albicans in neonate (66.7%), C. parapsilosis in 1-9-year-olds (41.7%), and C. glabrata in those aged ≥60 years (range; 13.3%-20.0%). According to the visited departments, C. albicans, C. glabrata, and Candida haemulonii were more common in medical departments, while C. parapsilosis was more common in surgical departments. In the antifungal susceptibility test, a rising trend of azole resistance among C. albicans and C. glabrata was observed in recent years. Conclusion: In this study, it was confirmed that the isolation rate of Candida species in blood is different by age, gender, and hospital department, and the distribution of isolated Candida species changed over time. The resistance patterns of antifungal agents are also changing, and continuous monitoring and proper selection of antifungal agents are necessary. (Ann Clin Microbiol 2017;20:-62) 배경: 칸디다혈증은 전세계적으로 고위험군 증가에 따라 발생이 증가하고 있어 임상적으로 더욱 중요해지고 있다. 이번 연구를 통해 칸디다혈증 환자에서 분리되는 칸디다 균종별 분리 빈도와 항진균제 내성률의 변화를 조사하였다. 방법: 1997년부터 2016년까지 국내 단일 3차 의료기관의 혈액배양에서 분리된 1,120 칸디다 균주를 대상으로 배양 연도, 성별, 나이, 진료과에 따라 분석하였다. 결과: 전체 기간 중 칸디다혈증 환자의 수는 1997년의 14명에서 2016년에는 84명으로 증가하였다. 20년 동안 칸디다의 균종별 분리 빈도는 Candida albicans 40.8%, Candida parapsilosis 24.1%, Candida tropicalis 13.2%와 Candida glabrata 12.8%의 순이었다. C. glabrata는 다른 균종에 비해 여성(45.5%)에서 상대적으로 높은 비율로 분리되었다. 연령별로 칸디다 균종이 많이 분리되는 연령군은 40세-89세군이었고 C. albicans는 신생아(66.7%), C. parapsilosis는 1-9세(41.7%), C. glabrata는 60세 이상(13.3%-20.0%)에서 상대적으로 흔히 분리되었다. 비수술과에서는 C. albicans, C. glabrata, C. haemulonii가 많이 분리되었고 수술과에서는 C. parapsilosis가 흔히 분리되었다. 항진균제 감수성 검사에서 최근 들어 azole 계열에 내성을 나타내는 C. albicans와 C. glabrata가 증가하는 경향을 보였다. 결론: 이번 연구를 통해 혈액에서 분리되는 칸디다의 균종별 분리 빈도는 연령, 성별과 진료과목에 따라 다르며 시기 변화에 따라 균종별 분리 빈도가 변화하는 것을 확인할 수 있었다. 항진균제에 대한 내성 양상 또한 변화하고 있어 이에 대한 지속적인 감시와 적합한 항진균제 선택이 요구된다. [Ann Clin Microbiol 2017;20:53-62]

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