음핵에 발생한 신경섬유종증 1례

화정석,최봉석,이 현,정병하 大韓泌尿器科學會 1994 Korean Journal of Urology Vol.35 No.11

산화스트레스에 노출된 정자의 생존성 및 운동성에 있어서 커큐민의 이중효과

화정석,김은진,Adrian S. Siregar,박창윤,최창용,강다원 한국수정란이식학회 2016 한국동물생명공학회지 Vol.31 No.3

Although cryopreservation of sperm is routinely used for clinical requirement, it has some problems, such as high generation of reactive oxygen species (ROS) and cold-shock. To reduce the detrimental damage in sperm, anti-oxidants were added to cryoprotectant for sperm. Curcumin is one of anti-oxidants, which are added in cryoprotectants. However, recent studies have demonstrated that curcumin decreases sperm viability and motility. This study was performed to identify the effect of curcumin on hydrogen peroxide (H2O2)-exposed bovine sperm, which were cryopreserved-thawed. In H2O2-exposed bovine sperm, reactive oxygen species (ROS) were significantly reduced by treatment with curcumin in a dose-dependent manner (p < 0.05). Among tested concentrations of curcumin (1 to 50 μM), 30 and 50 μM curcumin showed anti-oxidant effect on H2O2-induced ROS generation. On the other hand, combination of 30 or 50 μM curcumin with anti-oxidant H2O2 increased the percentage of apoptotic sperm compared to only H2O2 treatment. Sperm viability was also decreased in the combination of 30 or 50 μM curcumin with H2O2 as judged by FDA/PI staining. H2O2–induced decrease in sperm progressive motility was recovered by treatment with 1 μM curcumin. These results show that high concentration of curcumin has anti-oxidant effect, but it has also cytotoxic effect on bovine sperm. Sperm viability and motility might be more affected by cytotoxic signals of curcumin compared to antioxidant signals.

Identification of Proteins Differentially Expressed in the Conventional Renal Cell Carcinoma by Proteomic Analysis

화정석,Park Hyo Jin,정재훈,감성철,Park Hyung Chul,김충원,강기련,현재석,정기현 대한의학회 2005 Journal of Korean medical science Vol.20 No.3

Renal cell carcinoma (RCC) is one of the most malignant tumors in urology, and due to its insidious onset patients frequently have advanced disease at the time of clinical presentation. Thus, early detection is crucial in management of RCC. To identify tumor specific proteins of RCC, we employed proteomic analysis. We prepared proteins from conventional RCC and the corresponding normal kidney tissues from seven patients with conventional RCC. The expression of proteins was determined by silver stain after two-dimensional polyacrylamide gel electrophoresis (2D-PAGE). The overall protein expression patterns in the RCC and the normal kidney tissues were quite similar except some areas. Of 66 differentially expressed protein spots (p<0.05 by Student t-test), 8 different proteins from 11 spots were identified by MALDI-TOF-MS. The expression of the following proteins was repressed (p<0.05); aminoacylase-1, enoyl-CoA hydratase, aldehyde reductase, tropomyosin -4 chain, agmatinase and ketohexokinase. Two proteins, vimentin and -1 antitrypsin precursor, were dominantly expressed in RCC (p<0.05).

방광요관역류와 신반흔

화정석,정기현 大韓泌尿器科學會 1996 Korean Journal of Urology Vol.37 No.5

Effects of Tamsulosin on Premature Ejaculation in Men with Benign Prostatic Hyperplasia

최재휘,화정석,감성철,제성욱,현재석 대한남성과학회 2014 The World Journal of Men's Health Vol.32 No.2

Purpose: Previous studies have revealed that tamsulosin is effective in improving lower urinary tract symptoms (LUTS) and erectile functioning but has some inhibitory effects on ejaculation, including decreased ejaculatory volume. However, these inhibitory effects on ejaculation can be beneficial to patients with premature ejaculation (PE). Therefore, this study was conducted to understand the effect of tamsulosin on PE in men with benign prostatic hyperplasia.Materials and Methods: Twenty-nine patients who visited with LUTS were categorized into 2 groups of LUTS-only patients (n=12) and LUTS combined with PE (LUTS+PE) patients (n=17), and 0.4 mg of tamsulosin was administered to the patients of both groups for 12 weeks. Comparative analyses of before and after the treatment were conducted for calculating the International Prostate Symptom Score (IPSS), International Index of Erectile Function-5 (IIEF-5), intravaginal ejaculatory latency time (IELT), premature ejaculation diagnostic tool (PEDT), and premature ejaculation profile (PEP). The patients with an IPSS score of 8 or higher were determined as LUTS patients, and the patients with IELT of less than 2 minutess and a PEDT score of 9 or higher were determined as PE patients.Results: After treatment, the IPSS score significantly decreased in both groups. There was no statistically significant change in the PEDT for the LUTS group, but there was a significant decrease in PEDT (p=0.012; from 12.1±3.31 to 8.4±4.49) in the LUTS+PE group.Conclusions: Tamsulosin not only has a treatment effect for LUTS but also improves the PE of LUTS+PE patients. Therefore, further studies are needed to confirm the effects of tamsulosin on PE.

만성 신부전 환자의 투석이 혈중 전립선특이항원 수치에 미치는 영향

박진수,화정석,정기현 大韓泌尿器科學會 2001 Korean Journal of Urology Vol.42 No.7

임상실습 1년차의 임상실습적응에 미치는 영향 요인

제남주,화정석,박미라 한국산학기술학회 2019 한국산학기술학회논문지 Vol.20 No.11

This study examined the factors affecting clinical practice adaptation to provide basic data for the improvement of clinical practice adaptation for the first year of clinical practice. The subjects were 153 nursing students and medical students in G-do. Data were collected from April 1 to April 30, 2019, and analyzed using a t-test, ANOVA, Pearson correlation coefficient, and multiple regression using IBM SPSS WIN/21.0. The mean of college adjustment, character, interpersonal competence, communicative competence, and clinical practice adaptation was 3.37 points, 3.82, 3.61, 3.56, and 3.54, respectively. Clinical practice adaptation was related to college adjustment, character, interpersonal competence, and communicative competence (p<.001). The most influential factor in clinical practice was interpersonal competence (β=.502, p<.001), followed by department adaptation (β=-.215, p<.001) and college adjustment (β=.174, p=.010), respectively. The explanatory power was 41.1% (F=34.11, p<.001). Therefore, a way to improve interpersonal competence is needed to advance clinical practice adaptation. In the character building program for adjustment to college life, systematic education is needed, including the opportunity to think about and understand oneself, continuous meeting to understand and accept others. In addition, repeated communication training to improve interpersonal competence is needed. 본 연구는 임상실습 1년차 학생을 대상으로 임상실습적응에 영향을 미치는 요인을 파악하여 임상실습적응을 높이기 위한 대책 마련의 기초자료를 마련하고자 시도되었다. 연구대상자는 G도의 간호대학생과 의과대학생 153명을 대상으로 하였다. 자료수집은 2019년 4월 1일부터 4월 30일까지였고, 자료분석은 IBM SPSS WIN/21.0을 이용하여 t-test, ANOVA, Pearson correlation coefficient, Multiple regression 을 사용하였다. 대학적응은 평균 3.37점, 인성은 평균 3.82점. 대인관계 유능성은 평균 3.61점, 의사소통은 평균 3.56점, 임상실습적응은 평균 3.54점이었다. 임상실습적응은 대학적응, 인성, 대인관계 유능성, 의사소통과 순상관관계가 있었다(p<.001). 임상실습에 가장 영향을 미치는 요인은 대인관계 유능성(β=.502, p<.001)이었고, 그 다음으로 학과적응(β=-.215, p<.001), 대학적응(β=.174, p=.010) 순으로 나타났다. 설명력은 41.1%이었다(F=34.11, p<.001). 따라서 임상실습적응의 향상을 위해 대인관계 유능성을 높여줄 수 있는 방안이 필요하며, 대학생활적응을 위한 인성교육 프로그램에는 자신에 대해 생각해보고 이해할 수 있는 계기마련과 지속적인 만남을 통한 타인의 이해와 타인수용이 필요하다. 또한, 반복적인 의사소통 훈련을 통한 대인관계능력을 향상을 시킬 수 있는 내용의 체계적인 교육을 제공하는 것이 필요하다.

남성 척수장애자의 성 실태 조사 및 성재활 교육의 효과

정행기,화정석,현재석 대한비뇨의학회 2005 Investigative and Clinical Urology Vol.46 No.10

Purpose: This questionnaire study was conducted to examine sexual problems and assess the effect of sexual rehabilitation education on the marital intimacy in patients with spinal cord injuries. Materials and Methods: 45 male patients with spinal cord injuries were evaluated for sexual problems using a questionnaire. The patients were divided into two groups: control group(n=16) and trial group(n=16). Sexual rehabilitation education for patients, using manual and video tapes, was provided. The effect of sexual rehabilitation education on marital intimacy was assessed in the two groups. Using Student's t-test(paired), Student's t-test the scores of marital intimacy measured before and after the sexual rehabilitation education were compared. Results: After one year, 80%(36/45) of the subjects recovered normal sexual desire, and 51%(23/45) recovered normal erectile function, most of who had been proved to have sustained a spinal cord injury at the cervical or thoracic level. Normal erectile function was more frequently seen in patients with incomplete spinal cord injury than in those with complete spinal cord injury. 31%(14/45) were able to ejaculate and 29% (13/45) experienced orgasm. After sustaining a spinal cord injury, 87% (39/45) were aware of sexual rehabilitation education. However, only 13% (5/45) were informed by their healthcare professionals. After sexual rehabilitation education, a significant increase in marital intimacy was found in the trial compared to the control group. Conclusions: In conclusion, our results indicate that sexual rehabilitation education is effective at increasing the marital intimacy of patients with a spinal cord injury. Moreover, these patients must receive relevant care and education from their healthcare professionals, which must also be in a persistent manner.

신장 세포 암종으로 오인된 신장전이 갑상선 여포암

조기주,화정석,고경혁,박정제 대한이비인후과학회 2017 대한이비인후과학회지 두경부외과학 Vol.60 No.1

Follicular thyroid carcinoma is the second most common form of thyroid cancer. It accounts for 10 percent of all thyroid cancer, and is found three times more frequently in men than in woman. It is well known that follicular thyroid carcinoma usually occurs in regions where it is hard for people to intake iodine. Most follicular thyroid carcinomas occur asymptomatically but occasionally reveal as masses in the thyroid nodules. The occurence of metastasis of follicular thyroid cancer in the lymph node is less than 10%, which is relatively low compared to that of papillary cancer. Follicular carcinomas are metastasized hematogenously and are common in the bone, liver, lung and brain. It is especially rare for metastatic follicular thyroid cancer to be diagnosed as renal tumor. We recently experienced and further investigated a case of follicular thyroid carcinoma that metastasised to the kidney in a 57-year-old woman, who had had abdominal distension. We report this case with a review of the reference. Korean J Otorhinolaryngol-Head Neck Surg 2017;60(1):30-3

상급종합병원근무자의 연명치료중단에 미치는 영향요인 -장기기증·이식의 지식 및 태도, 죽음에 대한 인식, 호스피스완화의료에 대한 지식 및 인식-

제남주,화정석,Je, Nam Joo,Hwa, Jeong Seok 한국호스피스완화의료학회 2018 한국호스피스.완화의료학회지 Vol.21 No.3

목적: 본 연구는 병원 근무자의 연명치료 중단에 영향을 미치는 장기기증, 장기이식, 죽음, 호스피스 완화의료의 지식, 태도 및 인식을 알아본 서술적 조사연구이다. 방법: K도 J시에 위치한 일개 상급종합병원에 근무하는 228명의 대학병원 근무자를 대상으로 자가 보고식 설문지를 이용하여 자료를 수집하였다. 자료는 SPSS WIN 21.0 프로그램으로 t-test, ANOVA, and Pearson's correlation coefficient를 이용하여 분석하였다. 결과: 대상자의 생명의료윤리 의식관련 지식은 연령, 학력, 직종, 근무부서, 생명의료윤리 교육유무에 따라 차이를 보였다. 뇌사 장기기증 장기이식에 대한 지식은 인체조직기증 및 이식에 대한 태도, 호스피스 완화의료에 대한 지식, 호스피스 완화의료의 인식에서 유의한 양의 상관관계가 있었다. 인체조직기증 및 이식에 관한 태도는 호스피스 완화의료에 대한 지식, 호스피스 완화의료의 인식, 연명치료 중단에서 유의한 상관관계가 있었고, 죽음에 대한 인식은 호스피스 완화의료에 대한 지식, 호스피스 완화의료의 인식, 연명치료 중단에서 유의한 상관관계가 있었다. 호스피스 완화의료의 인식은 연명치료 중단에서 유의한 상관관계가 있었다. 연명치료 중단 태도에 영향을 주는 요인은 호스피스 병동 근무와 인체조직기증 및 이식에 관한 태도, 호스피스 완화의료의 인식으로 연명치료 중단 태도를 32.5% 설명하였다. 결론: 연명치료 중단 태도에 호스피스 병동 근무와 인체조직기증 및 이식에 관한 태도, 호스피스 완화의료 인식이 관련이 있었으며, 생명의료윤리에 기반을 둔 다양한 교육과정의 개발 및 적용에 대한 연구가 필요함을 제언한다. Purpose: This descriptive study was conducted to examine factors that affect hospital workers in their decision to withdraw from life-sustaining treatment, such as knowledge, attitude, and perception of organ donation, transplantation, death and hospice palliative care. Methods: A questionnaire was completed by 228 workers of a tertiary general hospital, and data were analyzed using t-test, ANOVA, and Pearson's correlation by using SPSS 21.0. Results: The subjects' knowledge of biomedical ethics awareness differed by age, education level, occupation, affiliated department, and biomedical ethics education. Their knowledge of brain death, organ donation and transplantation was positively correlated with attitudes toward tissue donation and transplantation, knowledge of hospice palliative care, and perception of hospice palliative care. Their attitudes toward tissue donation and transplantation were significantly correlated with knowledge of hospice palliative care, perception of hospice palliative care, and withdrawal of life-sustaining treatment. Their awareness of death was significantly correlated with knowledge of hospice palliative care, perception of hospice palliative care and withdrawal of life-sustaining treatment. The perception of hospice palliative care was significantly correlated with withdrawal of life-sustaining treatment. Factors associated with their withdrawal of life-sustaining treatment were work at the hospice ward (32.5%), attitudes toward tissue donation and transplantation and perception of hospice palliative care. Conclusion: This study has shown that work at the hospice ward, attitudes toward tissue donation and transplantation and perception of hospice palliative care were related to attitudes toward withdrawal of life-sustaining treatment. More research is needed to further develop various curriculums based on biomedical methods.