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홍일기,은영규,정대한,권기환,김덕윤 대한이비인후과학회 2011 Clinical and Experimental Otorhinolaryngology Vol.4 No.4
Objectives. To investigate the association between papillary thyroid cancer (PTC) and single nucleotide polymorphisms (SNPs) of oncostatin M receptor (OSMR) in the Korean population. Methods. Retrospective case-control study was done. Eighty-five patients with PTC and 287 controls were studied. One missense SNP (rs2278329, Asp553Asn) and one promoter SNP (rs2292016, -100 G/T) of the OSMR gene were genotyped by direct sequencing. Genetic data were analyzed using the SNPStats, Helixtree, and SNPAnalyzer Pro. PTC patients were dichotomized and compared with respect to the clinicopathologic characteristics. Results. There was no association between genotypes and allele frequencies of OSMR SNPs (rs2278329 and rs2292016)and PTC susceptibility. SNP rs2278329 was significantly associated with tumor size (dominant model; P=0.028;odds ratio [OR], 2.71; 95% confidence interval [CI], 1.12 to 6.57). The A allele was higher in sizes large than 1 cm (32.5% vs. 16.7%; P=0.018; OR, 2.41; 95% CI, 1.17 to 4.98). Regarding the number of tumors, we found no significant association with genotype, however, the A allele was higher in patients with multifocaltiy (33.3% vs. 19.1%;P=0.040; OR, 2.12; 95% CI, 1.03 to 4.34). Conclusion. The results suggest that OSMR polymorphism rs2278329 is associated with clinicopathologic characteristics of the tumor growth and multifocality development.
PET의 최신지견: F-18 FP-CIT를 이용한 도파민 운반체 영상
홍일기 ( Il Ki Hong ),김덕윤 ( Deog Yoon Kim ) 경희대학교 경희의료원 2010 慶熙醫學 Vol.26 No.1
Dopamine transporter imaging provides a marker for the integrity of presynaptic nigrostriatal dopaminergic system and is useful in the diagnosis of Parkinson`s disease. Several radiopharmaceuticals including I-123 FP-CIT, Tc-99m TRODAT for single photon emission computed tomography (SPECT) have been approved for the clinical use in Europe and Taiwan, respectively. F-18 FP-CIT is a radiopharmaceutical for positron emission tomography (PET) which provides images with higher resolution than SPECT and now available for the routine clinical use in Korea. This review summarized clinical usefulness of dopamine transporter imaging including F-18 FP-CIT PET.