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Tropolone has been used as preserved agent in food. However, utilization of tropolone as preserved agent has been limited because of expensive cost and short half-life. To overcome these obstacle, tropolone was encapsulated to chitosan-graft stearic acid micelle (CSA), which may lead to sustained release of tropolone. The chemical structure of CSA was analyzed by <sup>1</sup>H-NMR. Moreover, tropolone loaded CSA nanoparticles (CSAT) were prepared by evaporation method. The contents, encapsulation efficiency and release behavior of tropolone from CSAT were confirmed by UV-vis spectrophotometer. Its particle size and morphological property of CSA and CSAT were confirmed by DLS and TEM. Moreover, cytotoxicity of CSA and CSAT were confirmed by MTT assay in human embryo kidney (HEK 293) cell line. These results suggest that CSA micelle is exceptional drug carrier for sustained release of tropolone. (No. NRF-2016H1D5A1910499).
Coal-fired power plants use coal as the main raw material, and when a coal is moved, a dust generation and spontaneous ignition of coal occur. To prevent this, water is sprayed. As a result, wastewater called “coal-dust water” flows out of coal dust and water mixed together, causing environmental pollution. In this study, in order to solve this problem, we developed a natural flocculant that can purify water by aggregating fine dust using chitosan and tried to prove its applicability. It was found that the optimum flocculation concentration was 4 ppm by adding various concentrations of flocculant to the coal-dust water, and it was confirmed that the developed material had very good coal-dust flocculation capacity through permeability and coal-dust removal efficiency. In addition, the cytotoxicity of the flocculant was evaluated through the MTT assay and it was found that there is no toxicity at all. We believe that the flocculant developed in this study can effectively adsorb coal-dust without affecting human and natural ecosystems. 석탄 화력발전소는 석탄을 주원료로 사용하고 있으며, 석탄 이동 시에 석탄의 분진 및 자연 발화가 발생하게 되는데, 이를 방지하기 위해 물을 분사하는 작업을 수행한다. 이로 인해 석탄의 분진과 물이 함께 섞여 흘러나오는 일명 ‘탄진수(coal-dust water)’라고 불리는 폐수가 흘러나와 환경오염을 초래한다. 본 연구에서는 이러한 문제점을 해결하기 위해미세한 분진까지 응집하여 물을 정화할 수 있는 키토산 기반의 천연 응집제를 개발하고, 그 응용성을 입증하고자 하였다. 탄진수에 다양한 농도의 응집제를 투여하여 최적의 흡착농도가 4 ppm임을 규명하였고, 투과도 및 탄진 제거효율을 통해 개발된 물질의 탄진 응집능이 매우 우수함을 확인하였다. 또한, MTT assay를 통해 응집제의 세포독성을 평가하여 독성이 전혀 없음을 입증함으로써, 본 연구에서 개발된 응집제가 인간 및 자연 생태계에 영향을 주지 않고 효과적으로 탄진을 응집할 수 있는 물질임을 규명하였다.
Reactive oxygen species (ROS) have been caused to life-span due to many diseases and aging. The anti-oxidant (AO) used for the removal of ROS has a potential such as Anti-allergic, anti-oxide, anti-cancer effective and Low toxic. However, the disadvantages of AO is that it has a low bioavailability in the body. Therefore, we developed to natural anti-oxidant-encapsulated chitosan microsphere by spray dry method. Its chemical structure was analyzed by <sup>1</sup>H-NMR and FT-IR. In addition, morphological property of anti-oxidant agent-encapsulated chitosan microsphere (AECM) was analyzed by SEM and It showed to spherical shape. Beside, particle size of AECM was confirmed to 2 ~ 5 ㎛. Moreover, its cytotoxicity was accomplished by MTT assay. Additionally, encapsulation of anti-oxidant from AECM was confirmed by UV-vis spectrophotometer. These results suggest that AECM can be effectively removed ROS as an antioxidant with low toxicity and improved bioavailability. (NRF-2016H1D5A1910499).
Branched polyethyleneimine(PEI) was well known as high gene transfection agent, However, utilization of PEI as gene carrier was limited because of high cytotoxicity. To solve this problem, PEI was introduced to chitosan(CS) back bone by using coupling reaction. Also, hyaluronic acid(HA) was introduced for targeted CD44-receptor in breast cancer cell. Its structural analysis of PEI-grafted chitosan(CSPEI) was confirmed by <sup>1</sup>H-NMR. In addition, ternary complex of pDNA/CSPEI/HA was prepared by electrostatic charge interaction. Its gel retardation assay showed that pDNA was completely condensed by CSPEI and HA. Moreover, pDNA was protected from DNase and released by heparin. Also, transfection assay showed that ternary complexes was effectively transfected more than binary complexes by targeting effect of HA. <sup>**</sup>These results suggest that ternary complexes can enhance transfection efficiency by targeted CD44-receptor in breast cancer cell. (NRF-2014R1A2A1A10053027).