Monochloroacetaldehyde의 합성에 관한 연구

홍성엽 서경대학교 산업기술연구소 2000 産業技術硏究所論文集 Vol.8 No.-

Monochloroacetaldehyde is a very useful compound as a raw material for the synthesis of medicinal and agricultural chemicals. Because of the unstability of the monochloroacetaldehyde, many new synthetic method for the compound were proposed such as the chloroacetaldehyde's concentration in water and chloroacetaldehyde trimer. In this report, some new factors were proposed to improve the yield to synthesize and the purity of monochloroacetaldehyde. The synthetic method of monochloroacetaldehyde in organic solvent instead of in water have shown good result in the point of the yield and the purity.

급성흉통의 진단적 프로토콜에 대한 전향적 연구

홍성엽,김갑득,강명희 대한응급의학회 2003 대한응급의학회지 Vol.14 No.3

Purpose: For appropriate triage of chest pain patients in the emergency room (ER), We verified whether or not a new chest pain protocol, which is a combination of Goldman algorithm Cardiac STATus® adequately reflects the risk of a major cardiac event in patients with acute chest pain. Methods: All patients arriving at the ER were divided into 4 risk group based on the Goldman Ml probability and on the result of cardiac STATus®. one month later, we collected information on whether the patients had undergone major cardiac event or death. We analyzed relative risk (RR) of cardiac event by using a logistic regression and we com pare the event-free survival rates and survival lengths. RR=2 mean that the risk of cardiac events is high by two folds than control group. Results: There were 31 major cardiac events. the relative risk of major events of each group compared to group 4 were 40.1 for group 1, 51.9 for group 2 and 27.4 for group 3. Group 4 patients experienced one cardiac event and no deaths. The survival time without a cardiac event of group 4 patients approach 30 days within experimental error. The survival rate without a cardiac event is 0.98±0.02. Therefore, the patients in group 4 had life expectancies similar to those of normal persons. Conclusion: This chest pain protocol adequately reflects the chances of cardiac event, so patients who show a negative result in cardiac STATus® and a low Goldman MI probability can be safely discharged from ER and followed up in outpatient clinic.

기상현상이 기흉 발생에 미치는 영향

홍성엽,양희범,양영모 대한응급의학회 2005 대한응급의학회지 Vol.16 No.4

프린터용 도료인 aniline계 yellow dye의 새로운 합성법에 대한 연구

홍성엽 서경대학교 산업기술연구소 2008 産業技術硏究所論文集 Vol.21 No.-

A known yellow dye was synthesized by a new synthetic method. The dye, an aniline derivative, was synthesized by a five step. The first was O-alkylation, and then N-alkylation, followed by formylation. The last step was the formation of double bond by reaction of malononitrile.

A Study on the Application of Nano-material Focused on CNT and Graphene as Textile Fire Retardant

홍성엽 한국전시산업융합연구원 2017 한국과학예술융합학회 Vol.31 No.-

One of the main reason of the disastrous fire is polymer which is used in livelihood. Because polymers are organic materials combined carbon, hydrogen and oxygen, polymers are vulnerable to heat. To decrease the disastrous polymers are necessary flame retardant which are additives not to burn by improving the inflammability of a polymer. The research method is as follows. Firstly, introduction of the fire retardant which are used in textile is variously used as not only household clothing but also all sorts of livelihood items. Development of fire retardant facilitates not only reinforcing fire retarding but also producing fabric with various functions such as sterilization, deodorization, and water repellent, so makes the use in the present restricted fields spread to new uses. Production of this multifunctional fabric facilitates combining existing fabric field with the field of engineering related to disaster prevention. Secondly, presentation of Kinds of fire retardants which are divided into addition fire retardant and responsive fire retardant. Addition fire retardant is a method mixing it simply by putting it as additive during compounding process, and responsive fire retardant gives fire retarding by producing a fire retarding polymer by introducing a monomer giving fire retarding to main chain of a polymer, or by combining fire retarding substance chemically in the end or side chain of a polymer by introducing reactive groups into a polymer. Thirdly, the introduction of nanocomposite fire retardants such as CNT or graphene fire retardants emerging from a limit of existing fire retardants reduces true character of fabric. Carbon nanotube CNT) is an allotrope of carbon with cylindroid nanostructure. Graphene is also one of carbon allotropes and has a structure that carbon atoms gather become 2D plane. Finally, CNT and graphene are overviewed as the promising materials for the flame retardant. The various results of CNT and graphene as nanofiller to retard the fire are mentioned. By the understanding of the retardation properties of those material, textile industry in the areas of clothing and household items will be more easily convergence with the nanotechnology.

Research in Emergency Medicine : How to make collaboration and commission of molecular research in emergency medicine

홍성엽 대한응급의학회 2013 대한응급의학회 학술대회초록집 Vol.2013 No.1

An antimicrobial peptide-mimicking methacrylate polymer with pH-responsive activity for the treatment of methicillin resistant staphylococcal skin infection

홍성엽,정시경,김인수,조별님희 대한응급의학회 2015 대한응급의학회 학술대회초록집 Vol.2015 No.2

Background: Acid mantle in skin protects from bacterial skin infection. The pH of skin changes from acidic pH to neutral pH at infection. Antimicrobial polymers employ their bactericidal effect by targeting bacterial cell walls and/or membranes. Objectives: We developed poly(aminobutyl methacrylate-ethyl methacrylate) copolymer (poly (ABMAEMA)) which active in infected skin (pH=7.5) and inactive in acid mantle on the normal human skin pH (pH=5.5). Anti-MRSA function of the polymer was evaluated at different pH (5.5, 6.5 and 7.5) conditions. Methods: Antimicrobial susceptibility testing for twelve methicillin resistant staphylococcus aureus (MRSA) origin from clinic patient with sepsis was performed according to Clinical and Laboratory Standards Institute (CLSI). Polymer toxicity testing against human RBCs and dermal fibroblasts was conducted to predict the degree Toxicity of the polymer to human body. Results: MIC for the polymer were 10~15 ?g/ml in pH 7.5 and 6.5 MHB but the MIC values are above 200 ?g/ml in acidic condition with pH 5.5. MIC, MIC50, MIC90 and MBC values was not influenced by bacterial zeta potential and hydrophobicity. Conclusion: Poly (ABMA-EMA)) have strong anti-MRSA properties in physiologic skin pH but it is attenuated at acidic skin pH. This fact reflects the pH sensitive antimicrobial polymer can cure the norsocomial cutaneous infection but not toxic to skin cells in acidic skin condition.

심포지엄 1 : 응급의학 영역에서 융합연구의 실제와 미래

홍성엽 대한응급의학회 2015 대한응급의학회 학술대회초록집 Vol.2015 No.1

Quantitative lateral-flow immunoassay for the assessment of the cartilage oligomeric matrix protein as a marker of osteoarthritis

홍성엽,박유민,장요한,민병현,윤현철 한국바이오칩학회 2012 BioChip Journal Vol.6 No.3

This study reports a simple and quantita-tive analytical method for detecting cartilage oligome-ric matrix protein(COMP) using a lateral-flow immu-noassay(LFI) format. An immuno-chromatographic assay was developed using a gold nanoparticle(AuNP)-conjugated monoclonal antibody(Ab) probe for the quantitative detection of COMP in human synovial fluid(SF). The detection antibody was conjugated with the AuNP(~30nm) to enable detection, and the cap-ture antibody was immobilized within a multi-spot pattern in the test zone of a membrane strip. COMP in the human SF binds to the AuNP-conjugated detection antibody, and the COMP-Ab complex then binds to the capture antibody. The immunoassay test can be analyzed by visualizing the test strip with a commer-cial scanner and an imaging software program. The color density of the multi-spot pattern at the test zone increased in proportion to the concentration of COMP. The developed immunoassay exhibited a dynamic de-tection range from 0.6 to 20μg/mL of COMP. The detection limit of the proposed LFI system was approx-imately 0.2μg/mL. The test results showed good cor-relation with those obtained using a conventional en-zyme-linked immunosorbent assay(ELISA) to detect COMP. We expect that the proposed immunoassay method, based on the quantification of COMP, is sui-table for osteoarthritis diagnosis using SF samples.

암로디핀의 합성 및 분석법에 대한 고찰

홍성엽 서경대학교 산업기술연구소 2010 産業技術硏究所論文集 Vol.24 No.-

Amlodipine besylate is a hypotensive drug. Amlodipine besylate was synthesized from N-(2-hydroxyethyl)phthalimide by 3 steps. 4-(2-chlorophenyl)-3-ethoxycarbonyl-5-methoxycabonyl-6-methyl-2(2-phtalimide ethoxymethyl)-1, 4-dihydropyridine is a second intermediate for the amlodipine besylate. After amlodipine besylate was synthesized, the spectroscopic analysis of amlodipine besylate was underwent to take HPLC assay data.