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난소 Krukenberg종양 30 예의 임상통계적 관찰
현병규(BK Hyun),이충훈(CH Lee),이종건(CK Lee),김수평(SP Kim),이헌영(HY Lee) 대한산부인과학회 1986 Obstetrics & Gynecology Science Vol.29 No.3
1. 발생빈도는 악성 종양증 11.3%이었으나 연령분포에 따른 발생빈도는 30~49세이었다. 2. 임상적 주소는 종괴촉지, 하복부 팽만감, 소화불량, 복통 및 복수월경이상 순위였다. 3. 임상증상 출현후 Krukenberg 종양 확진시까지의 평균시간은 6.5개월이었다. 34. 일반 외과적 개복수술시 확진된 예가 40%(12예)이었다. 5. 병변이 양측성인 경우가 18예(60%)였으며 일측성이 9예(30%)였다. 6. 원발부위는 위, 대장 순위였으며 위 병소가 76%(23)를 차지했다. 7. 원발병소 확진후 Krukenberg 종양으로 진단내릴때까지의 기간은 13.6개월이었다. 8. 원발성 Krukenberg 종양은 6.6%(2예)이었다. 9. 17예에서 chemotherapy를 시행했으며 regimen은 CCNU, 5-FU, adriamycin, mitomycin 등이었으며 이중 radiation therapy는 1예에서 있었다. 그후 가능했던 추적검사 2예에서 15개월 이상의 생존율을 보였다. A high incidence of stomach carcinoma revealed in Korea led to the general impression that there are large number of Krukenberg tumors. We have observed 30 cases of Krukenberg tumor among 958 cases of ovarian tumor who were admitted, operated and diagnosed at Department of Obstetrics and Gynecology, Catholic Medical Hospital from January, 1975 to June, 1985. The following results were obtained: 1. The incidence of Krukenberg tumor was 3.1% and 11.3% respectively among ovarian tumors(958 cases) and malignant ovarian tumors(265 cases). 2. The highest incidence was shown in the group of 30~49 year of age. 3. Clinical symptoms and signs were palpable abdominal mass, abdominal pain and distension, ascites, menstual irregularity and other gastrointestinal symptoms in order. 4. Mean duration from appearance of clinical symptoms and signs until confirmation of Krukenberg tumor was 6.5 months. 5. Krukenberg tumor was confirmed in 12 cases(40%) by surgical exploratory laparotomy in General Surgery Department. 6. Bilateral involvements were shown in 18 patients(60%) and unilateral confinements were shown in 9 patients(30%). 7. Primary site of carcinoma was found as stomach in 23 cases and colon in 2 cases. 8. Mean duration from confirmation of primary site until confirmation of Krukenberg tumor was 13.6 months. 9. Primary Krukenberg tumor was found in 2 cases(6.6%). 10. Chemotherapy was performed in 17 cases and regimens were CCNU, 5-Fu, Adriamycin and Mitomycin. Among these, radiotherapy was done in 1 case. 11. Survival rate of more than 15 months was shown in 2 cases in which follow-up was possible.
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부인과 악성종양의 진단에 있어서 Gynaegnost 검사
고광덕(KD Ko),현병규(BK Hyun),김장흡(JH Kim),안웅식(WS An),남궁성은(SE Namkoog) 대한산부인과학회 1985 Obstetrics & Gynecology Science Vol.28 No.12
생화학적으로 처리된 Gynaegnost라는 탐폰을 이용하여, 분비물내의 LDH 농도를 반정량적으로 측정함으로써 부인과 악성종양을 진단하는데 있어서 검사의 진단적 가치를 병리학적으로 확진된 양성종양환자(대조군) 65명, 악성종양환자(검사군) 49명을 대상으로 검사한 결과, 대조군 65명중에서 음성이 60명(92.3%), borderline이 2명(3.0%), 양성이 3명(4.6%)이었으며, 검사군 49명중에서는 양성이 38명(77.6%), borderline이 5명 (10.2%), 음성이 6명(12.2%)으로 borderline까지 포함하여 전체적으로 87.8%의 양성으로 높은 감수성과 특이성을 보여 악성종양을 확진하긴 어려우나 screening 목적으로 사용하는데 유용한 검사가 될 것으로 사료된다. Gynaegnost is a clinically applicable new diagnostic agent supplied in the from of a specially prepared customary tampon By means of a colour change to blue as a function of the individual concentration it can be serve to detect the free lactate dehydrogenase present in vaginal secretion The latter exhibits markedly increased levels in the case of pathological change such as tumors and/or infection and yielded a highly significant correlation with Gynaegnost test result at early and stage . The purpose of this study was to test whether Gynaegnost can serve as an indicator for early detection or exclusion of grnecological malignancy In 49 patients diagnosed to malignancy pathologically there was obtained with Gynaegnost 38 positive(77.65) 5 (10.2%) borderline 6(12.2%) negative results in 65 patients diagnosed to benign 60(92.3%) negative 2(3.0%) borderline 3(4.6%) positive results The results of this study show that high sensitivity and specificity permit the conclusion in case of suspected carcinoma Gynagenost can be recommended for early diagnosis in gynecological cancer screening.
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