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      • SCOPUSKCI등재
      • KCI등재

        Protective Effects of Gabapentin on Allodynia and α2δ1-Subunit of Voltage-dependent Calcium Channel in Spinal Nerve-Ligated Rats

        함태수,안현주,배창대,임승운,조현성,이상민,심우석,김지애,곽미숙,최수주,김한섭 대한의학회 2009 Journal of Korean medical science Vol.24 No.1

        This study was designed to determine whether early gabapentin treatment has a protective analgesic effect on neuropathic pain and compared its effect to the late treatment in a rat neuropathic model, and as the potential mechanism of protective action, the α2δ1-subunit of the voltage-dependent calcium channel (α2δ1-subunit) was evaluated in both sides of the L5 dorsal root ganglia (DRG). Neuropathic pain was induced in male Sprague-Dawley rats by a surgical ligation of left L5 nerve. For the early treatment group, rats were injected with gabapentin (100 ㎎/㎏) intraperitoneally 15 min prior to surgery and then every 24 hr during postoperative day (POD) 1-4. For the late treatment group, the same dose of gabapentin was injected every 24 hr during POD 8-12. For the control group, L5 nerve was ligated but no gabapentin was administered. In the early treatment group, the development of allodynia was delayed up to POD 10, whereas allodynia was developed on POD 2 in the control and the late treatment group (p<0.05). The α2δ1-subunit was up-regulated in all groups, however, there was no difference in the level of the α2δ1-subunit among the three groups. These results suggest that early treatment with gabapentin offers some protection against neuropathic pain but it is unlikely that this action is mediated through modulation of the α2δ1-subunit in DRG.

      • Fe-dextran의 投與가 哺乳仔豚의 成長과 血液値에 미치는 影響

        咸泰守,安鍾鎬 영남대학교 자원문제연구소 1985 資源問題硏究 Vol.4 No.-

        These studies were conducted to determine the effects of Fe treatment on body weight and hematologic values in suckling pigs, and also to clarify the effect of a single injection of Fe as iron dextran on weight gain and hematologic values for the subsequent 4 weeks. One hundred and ninety two suckling pjgs of Landrace, Yorkshire, Duroc Jersey and Crosses of those breeds were used for the experiment. At 7 day of age, piglets were divided into treated and untreated groups. Body weight, organ weight and hematologic values following treatment were measured weekly for 4 weeks. The results obtained in these experiments were summarized as follows: 1. The average daily gain of suckling pigs treated with Fe-dextran were significantly higher (p<0.05) than those of control, but no significant differences between 50 and 100mg treated groups were observed. 2. Hemoglgbin concentrations of suckling pigs treated with Fe-dextran were significantly higher (p<0.05) than those of control and the same was true between suckling pigs treated with 100mg and 50mg Fe dextran, respectively. 3. Hematocrit values of suckling pigs treated with Fe-dextran was significantly higher(p<0.05) than those of control, but no significant difference between suckling pigs trested with 50 and 100mg Fe-dextran, respectively, were observed. 4. Erythrocytes and leukocytes count were significantly (p<0.05) increased by the administration of Fe-dextran but no significant changes in the number of RBC and WBC between suckling pigs treated with 50 and 100 mg Fe-dextran were observed. 5. Serum Fe concentration of sucklings pigs treated with 100mg Fe-dextran were significantly higher (p<0.05) than either those of control or those of pigs administered 50mg of Fe-dextran. 6. A single IM injection of Fe-dextran resulted in significant changes in weight of heart, spleen and adrenals but liver, kidneys and thyroid gland weights were not affected significantly by Fe-dextran treatment.

      • SCOPUSKCI등재

        한국 정상 소아의 혈청 교질 삼투압

        함태수,김성덕,임승운 대한마취과학회 1991 Korean Journal of Anesthesiology Vol.24 No.4

        We measured serum colloid oncotic pressure(COP) in ll3 children in good physical state (ASA class 1), admitted to Seoul National University Children's Hospital for elective operations. After adequate NPO time for each age group, they were transferred to the operating room. Immediately after induction of anesthesia, we sampled 4 to 5 ml of blood from femoral artery and measured serum COP. The mean COP was 20.4±2.2 mmHg. No significant difference were found between male and female. Compared with Previous Kims report, COP in children under 12 years old was lower than that of adults, The younger the children are, the lower the COPs are(Key Words: COP, normal children, Korea).

      • KCI등재후보

        고비중 0.5% Bupivacaine의 척추마취 후에 발생된 지속적인 신경손상 -증례 보고-

        함태수,고저스틴상욱,진현승 대한마취통증의학회 2010 Anesthesia and pain medicine Vol.5 No.2

        Persistent neurologic injury is a rare but feared complication of neuroaxial anesthesia.Local anesthetics are believed to be an important cause.A 68-year-old man with an ASA physical status of 2 was scheduled to undergo elective knee arthroplasty.He had no clinical evidence of neurological deficits before the operation. Spinal anesthesia was administered using 10 mg of 0.5% bupivacaine and 20μg of fentanyl without difficulty or complications during the procedure.On the second postoperative day, the patient complained of bilateral weakness in his lower extremities. The neurological examination revealed a sensorimotor impairment consistent with cauda equina syndrome.The neurotoxicity of bupivacaine might have been the cause of this neurological deficit.

      • Dexamethasone 및 ACTH의 投與가 Rat의 卵巢 및 副腎에 미치는 影響

        咸泰守,邊明大 영남대학교 자원문제연구소 1984 資源問題硏究 Vol.3 No.-

        The present study was conducted to determine the effects of dexamethasone and ACTH on the ovaries and adrenal glands of mature female rats. One hundred and twenty rats were assigned randomly in equal numbers to three groups and were treated as follows: (1) Control rats (c) were injested subcutaneously with 0.5ml of physiological saline twice daily for 10 days. (2) Dexamethasone treated rats were injected subcutaneously with a suspension of 250㎍ of dexamethasone in 0.5ml of saline twice daily for 10 days. (3) ACTH treated rats were injected subcutaneously with 20 unit of corticotropin. The ovarian, uterine and adrenal gland weights as well as body growth were measured following each injections. Also the histological changes of ovaries and adrenal glands were observed with light microscope. The results obtained in this experiment were summarized as follows : 1. Body weight of rats treated with dexamethasone and ACTH was significantly (p<0. 01) lower than that observed in both control and ACTH treated groups. 2. The dexamethasone and ACTH treatments reduced the mean overian weight to 27.6±1.4mg and 41.2±2.3mg respectively, compared 57.3±1.3mg in the control rats (p<0.01).The ovarian weights of rats treated with dexamethasone were significantly (p<0.01) decreased as compared to those of ACTH treated groups. 3. Uterine weight of rats treated with dexamethasone were significantly (p<0.01) less than those treated with ACTH or the control but there was no significant difference between the control and ACTH treated rats in weight of uteri. 4. The weight of a adrenal gland was greatly reduced (p<0.01) in the dexamethasone treated rats but in the ACTH treated rats were significantly (p<0.01) increased as compared to those of control group.

      • KCI등재

        Risk Factors for an Intraoperative Arrhythmia during Esophagectomy

        함태수,이정진,양미경,김지애 연세대학교의과대학 2007 Yonsei medical journal Vol.48 No.3

        Purpose: Arrhythmias after an esophagectomy (most commonly atrial fibrillation) are a significant contributing factor to patient morbidity. However, the significance of an intraoperative arrhythmia is not completely understood. The aim of this retrospective study was to determine the occurrence and risk factors for developing intraoperative arrhythmias in patients undergoing an esophagectomy. Materials and Methods: We reviewed the records of 427 patients who underwent a transthoracic esophagectomy between 2001 and 2005. Variables such as age, sex, hypertension, diabetes, cardiac disease, preoperative pulmonary function test (PFT) results, cancer level, combined radiochemotherapy, intrathoracic cavity adhesions and anastomosis site, hemoglobin, central venous pressure (CVP), fluid balance, serum potassium level, dose of vasopressors, temperature, and combined general and epidural anesthesia were analyzed as risk factors for the occurrence of an arrhythmia. We defined this arrhythmia as one not originating from the sinus node. Results: The incidence of intraoperative arrhythmia in this subset of patients was 17.1%, with a 37.2% reoccurrence rate during the first three postoperative days. Univariate and multivariate analysis revealed the presence of heart disease, poor PFTs, cervical anastomosis, elevated CVP, and higher ephedrine doses to be independent predictors of the development of an intraoperative arrhythmia. Conclusion: The incidence of intraoperative arrhythmia during esophagectomy was 17.1% with a 37.2% of reoccurrence rate.

      • KCI등재

        The Effect of 2 Hz and 100 Hz Electrical Stimulation of Acupoint on Ankle Sprain in Rats

        함태수 대한의학회 2007 Journal of Korean medical science Vol.22 No.2

        The electrical stimulation of acupoint (ESA) releases several endogenous neuropeptides, which play important roles in management of pain and inflammation. ESA with low and high frequencies has been shown to release different neuropepides, suggesting its various therapeutic effects. Pain and edema are major problems for ankle sprain. However, there have been few reports on the effects of ESA for ankle sprain. We aimed to investigate that ESA can reduce pain and edema resulting from ankle sprain, and whether there is a difference in therapeutic effects between low and high frequency ESA. To induce ankle sprain in Sprague-Dawley rats, the ankle of right hindpaw was overextended in direction of simultaneous inversion and plantar flexion. Stepping force and edema in the paw of the sprained ankle were measured by electronic balance and plethysmometer, respectively. In both 2 and 100 Hz ESA groups, stepping force was increased significantly in similar degrees (p< 0.05). Only 2 Hz ESA produced the significant rapid decrease in ankle edema. This study demonstrates that ESA of 2 Hz and 100 Hz shows comparable analgesic effects, but only 2 Hz ESA can facilitate the reduction of edema caused by ankle sprain.

      • 한국재래산양에 있어서 흡유 및 GnRH의 처리가 혈장 호르몬 및 뇌하수체의 성선자극호르몬 함량에 미치는 영향

        함태수,변명대 영남대학교 자원문제연구소 1998 資源問題硏究 Vol.17 No.-

        This study was conducted to examine the effects of suckling or exogenous gonadotropin releasing hormone(GnRH) in hormone levels and pituitary gonadotropins content in Korean native goats. At parturition, 24 goats were divided into suckled(n= 12) or nonsuckled(n= 12) groups and were injected daily with 1 doses of 150㎍ GnRH from the day of kidding until d 36 postpartum. Jugular blood samples were collected by venipuncture at 6 day intervals from d 12 to 36 after parturition for assail of progesterone, LH and FSH. Concentrations of LH, PSH and prolactin in the pituitaries were measured at day 12, 24, 30 and 36 after parturition and determined after 24 and 36 d of GnRH treatment in the goats. Concentrations of progesterone in plasma samples after treatment with GnRH did not differ between suckled and nonsuckled goats. Plasma concentrations of LH in suckled goats after GnRH were increased gradually until 24 day after parturition. Afterward, the levels declined to basal values by d 36. The concentrations of plasma LH after GnRH treatment were greater in suckled than in non-suckled goats. However, Concentrations of LH in suckled and nonsuckled goats were similar for the 18 day after GnRH treatment. The concentration of plasma FSH at each sample time after GnRH treatment was considerably greater in suckled than in nonsuckled goats. Goats slanghtered at days 12, 30 and 36 had less pituitary LH than goats slanghtered after day 24(1.12±0.01, 1.37±0.05, 1.38±0.09 and 1.89±0.03 mIU/mg fresh tissue, respectively) Concentrations of FSH and PRL in pituitaries tended to increased slightly with the interval after parturition. Pituitary concentrations of LH and prolactin after GnRH treatment were slightly greater in suckled than in nonsuckled goats at days 24 and 36 postpartum. The concentration of FSH in pituitary glands of nonsuckled goats were slightly greater than the concentration in pituitary from suckled goats. The rsults indicate that factors controlling the synthesis of LH may be responsible for resumption of ovarian cycles after parturition.

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