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한희동,구무길,차상덕,문효군 中央醫學社 1974 中央醫學 Vol.27 No.6
This 10 months old female was admitted to Ok Cheon St. Mary's Hospital on Aug., 1974, because of growth failure, multiple bony anomalies of the extremities and blue sclera. She was a product of 3rd baby with spontaneous normal delivery at home. During pregnancy her mother had no history of drug ingestion and exposure of radiation and also family problems were not detected. During admission, ophthalmologic findings showed blue sclera, however, hearing disturbances could not be evaluated and laboratory tests were within normal limits except for anemia. X-ray findings revealed multiple healed fractures with bowing of the left forearm, bowing of the femurs, tibias and fibulas, wormian bone and egg-shell appearance of the skull. The diagnosis was established by above clinical findings and multiple bony fractures on x-ray pictures and then this case was presented with a brief review of the literature.
Dual Functional Gd(III)-DOTA Liposomes for Cancer Therapy and Diagnosis as a Theragnostic Carrier
한희동,정석현,성하수,조선항,신병철 대한화학회 2013 Bulletin of the Korean Chemical Society Vol.34 No.1
Development of dual functional liposome has been studied for cancer theragnostics. Therefore, we focused on ultrasound-sensitive liposomes with doxorubicin (DOX) and gadolinium (Gd) as a theragnostic carrier having a potential for cancer therapy and diagnosis. In this study, Gd(III)-DOTA-modified sonosensitive liposomes (GL) was developed using chemically synthesized Gd(III)-DOTA-DPPE lipid. Sonosensitivity of GL to 1 MHz ultrasound induced 25% of DOX release. The relaxivities (r1) of GL were 7.33-10.34 mM−1s−1, which was higher than that of MR-bester®. Intracellular delivery of DOX from GL by ultrasound irradiation was evaluated according to ultrasound intensity, resulting in increase of uptake of DOX released from ultrasoundtriggered GLs compared to GL3 or Doxil® without ultrasound. Taken together, this study shows that the paramagnetic and sonosensitive liposomes, GL, is a novel and highly effective delivery system for drug with the potential for broad applications in human disease.
타원곡선 상에서 겹선형사상을 이용한 ID 기반 암호시스템
한희동,신기영,이영환 대전대학교 기초과학연구소 2006 自然科學 Vol.16 No.-
본 연구의 목적은 타원곡선 상에서 겹선형사상을 이용한 새로운 ID기반 암호 시스템을설계하고 구현하는 것이다. 우리가 제안한 암호 프로토콜은 기존의 ID기반 암호 시스템보다 연산의 수와 매개변수의 개수를 줄인 효율적인 암호시스템이며 윈도우 환경에서 실행되도록 구현하였다 . 또한 이 암호 프로토콜의 안정성은 BOH 문제로 귀착된다 .