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임플란트 표면처리 기술: 마이크로 아크 산화법과 그 응용
한철민,이은정,이해형,김해원 한국생체재료학회 2013 생체재료학회지 Vol.17 No.3
Titanium (Ti) and its alloys are currently popularly used for dental and orthopedic implants, due to their merits, including corrosion resistance, mechanical properties, chemical stability and biocompatibility. Accumulated studies have also demonstrated that osseointegration of the Ti-based implants could be significantly improved by the surface modifications. Micro-arc oxidation (MAO) is one promising electrochemical modification technique for osseointegration of implants, enabling the deposition of a rough and thick oxide layer which containing calcium and phosphorous ions via one-step process. Here we briefly review recent studies on the MAO-modified Ti-based implant materials and their future applications.
Recent alternative approaches of vascular drug-eluting stents
한철민,박광숙,정윤기 한국약제학회 2018 Journal of Pharmaceutical Investigation Vol.48 No.2
Vascular stent is tubular shaped medical device designed to treat occluded circulatory or digestive systems by opening the blocked vascular sites. Originally stents were made of bare metals, such as stainless steel and cobalt–chromium alloys, due to their inherent corrosion resistance and good mechanical properties. Damage of intimal layer during expansion of stent, however, have caused neointimal hyperplasia resulting in in-stent restenosis which is one of main complications of vascular stent treatment. Drug-eluting stents (DESs) were introduced to alleviate this restenosis by local delivery of anti-proliferative drugs to the implanted or inserted site. The DES systems have been developed over the years by making changes in its main component, namely, drug, polymeric coating layer and expandable scaffold. Nevertheless, late thrombosis caused by drugs themselves and polymeric coating layer still remains as a serious problem of DES systems. Numerous studies, therefore, consistently focus on more advanced DES systems to solve the current issues. In this mini review article, we cast an opinion on how to improve the potential of DES system by means of (i) summarizing the history of DES system developed so far and (ii) updating current advances for the future generation of DES system.
한철민,이유진,최슬기,Tarek M. Bedair,이영재,박우람,한동근,손준식,정윤기 한국공업화학회 2018 Journal of Industrial and Engineering Chemistry Vol.67 No.-
In this study, a polydioxanone (PDO) and poly(L-lactic acid) (PLLA) sheath-core biphasic monofilament was designed to develop an esophageal stent with improved mechanical properties and controlled biodegradability. The radial force of PDO/PLLA sheath-core stent was 10.24 N, while that of PDO stent was 5.64 N. Deteriorations of tensile strength, elastic modulus and elongation during degradation test were also delayed on PDO/PLLA group. Hyaluronic acid–dopamine conjugate and BaSO4/PDO conjugate coating layers provided improved tissue adhesion strength and reasonable X-ray contrast, respectively. Taken all together, the sheath-core filaments with tissue adhesive and radiopaque properties will be useful in designing esophageal stents.