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Suspected Unilateral Renal Dysplasia in a Cat with Intermittent Hematuria
한재익,나기정 한국임상수의학회 2015 한국임상수의학회지 Vol.32 No.1
A 6-month-old, castrated male, Korean short-haired cat was referred with intermittent hematuria. Physical and laboratory examination including complete blood count and serum biochemistry profiles showed no specific findings. Ultrasonography revealed a cystic lesion of the mid-abdomen, which was approximately 2 × 2 cm in size. FNA cytology of cystic fluid showed numerous cholesterol crystals of varying size and shape and granulomatous inflammation. CT examination showed fluid-filled large cystic lesion in the left side of the abdomen. Taken together, this case was diagnosed as unilateral (left) renal dysplasia and cystic inflammation led by cholesterol crystallization in the left kidney.
Extreme Leukemoid Reaction in a Dog with Pyometra
한재익,장혜진,전귀호,강현구,나기정 한국임상수의학회 2009 한국임상수의학회지 Vol.26 No.6
Leukemoid reaction has been rarely encountered in dogs. This report describes a case of leukemoid reaction showing extremely elevated leukocyte count. A 10-year-old female Maltese dog was presented with purulent and bloody vaginal discharge. The CBC revealed severe leukemoid reaction (976 × 109 cells/l, reference range 6 to 17 × 109 cells/ l) and mild non-regenerative anemia. On the blood smear, elevated leukocytes consist of numerous neutrophils and monocytes only. Radiographic and ultrasonographic examinations revealed generalized enlargement of the uterus, which was filled with a complex fluid. After ovariohysterectomy, Escherichia coli was isolated from the uterine fluid. To author’s knowledge, it is the new record of extreme leukemoid reaction caused by local bacterial infection in dogs.
한재익,장혜진,김근형,장동우,나기정 한국임상수의학회 2010 한국임상수의학회지 Vol.27 No.2
A 2-year-old female Pomeranian dog was referred with multiple pelvic fractures. The surgical correction was performed for the fractures. However, after the surgery, purulent exudation was occurred in the surgical site. Antibiotic susceptibility test revealed that the isolated bacteria are resistant to penicillins, cephalosporins, aminoglycosides,quinolones, and trimethoprim/sulfamethoxazole. Bacterial identification and extended-spectrum β-lactamase (ESBL) confirming test indicated that the isolated bacteriae is ESBL-producing Klebsiella pneumoniae. Minimum inhibitory concentration (MIC) and maximum bactericidal concentration (MBC) tests revealed that meropenem, one of carbapenems, is the only effective antibiotic. The patient was treated with meropenem for 5 days. After 10 days,the exudation was disappeared and the infection was cured. The molecular typing of the ESBL revealed that TEM-1 ESBL is present in the bacteria isolated from the patient. The bacteria isolated from the owner’s palm also revealed that TEM-1 and SHV-1 ESBLs are present.
High Prevalence of Lipid-Dependent Malassezia Infections in Dogs
한재익,조상희,나기정 한국임상수의학회 2010 한국임상수의학회지 Vol.27 No.2
Malassezia (M.) is a member of normal mycobiota in warm-blooded vertebrates. Increased humidity is likely to be crucial in this infection. We studied the proportion of the species infected in dog during summer of Korea. Fifty samples were analyzed by PCR-RFLP and direct sequencing from June 2006 to October 2006. The study showed that lipid-dependent species was main pathogen (M. furfur; 86%, M. obtusa; 10%) while M. pachydermatis (4%) has only small portion. This result suggests that Malassezia infection has endemic characters that can be affected by the climate (temperature and humidity) in dogs.
애완 미니 돼지의 Malassezia furfur에 의한 외이도염 증례
한재익,나기정 한국임상수의학회 2009 한국임상수의학회지 Vol.26 No.3
A 7-month-old, female miniature pig was presented with excessive cerumen and pruritus. Greasy brown cerumen in both exteranal ear canal and sporadic head shaking were observed in the physical examination. Numerous budding yeasts in the cerumen were examined on microscopic examination. For species identification, PCR-RFLP using incubated colony on modified Dixon’s medium was performed and finally, causative yeast was identified as M. furfur.
Increased Expression of MET and RON Receptor Tyrosine Kinases in Canine Cutaneous Melanotic Tumor
한재익,나기정,김대용 한국임상수의학회 2009 한국임상수의학회지 Vol.26 No.5
Aberrant translocation of β-catenin can be induced by the dissociation of cadherin-catenin complex, which is mediated by the activation of receptor tyrosine kinases (RTKs). We examined the expression levels of MET/RON RTKs in tissue samples of canine cutaneous melanotic tumor. The activation of MET/RON RTKs was observed in 28% of the examined samples. Our results indicate the possibility that the activated MET/RON RTKs are implicated in the dissociation of cadherin-catenin complex in canine cutaneous melanotic tumor.
한재익,나기정 한국임상수의학회 2008 한국임상수의학회지 Vol.25 No.3
This report describes a case of severe and prolonged dermatophytosis in a hedgehog that was diagnosedby PCR-RFLP, a rapid and usefulnes technique for identification of many causative agents and hereditary characters.A 5-month-old female hedgehog was presented with grade 2 facial pruritus, scaling, encrustation and hemorrhage.Cytology of exudates on the face showed a suspected fungal infection. A culture and tape imprint test of the culturedcolony showed many hyphae and microcornidia, suspected to belong to the Trichophytonwith MvaI and HinfI, Trichophyton mentagrophytes var. erinacei was finally identified as a causative agent. The patientcompletely recovered after application of nystatin cream for 17 days.
한재익,나기정 한국임상수의학회 2015 한국임상수의학회지 Vol.32 No.2
A 7-year-old castrated male Korean Shorthair cat was referred with lethargy and anorexia. Laboratory examination revealed moderate degenerative changes of peripheral neutrophils on blood smear examination and decreased levels of free and total thyroxine (T4) as well as bacterial growth on blood culture. Molecular analyses of the 16S ribosomal RNA gene and heat shock protein 60 gene confirmed the bacterium as Enterobacter cloacae. A minimal inhibitory concentration test showed multidrug resistance of the bacterium against 16 antibiotics. Polymerase chain reaction (PCR) and subsequent sequencing specifically for blaTEM, blaSHV, blaCTX-M, and plasmid-mediated ampC genes revealed positive results to blaTEM-1, blaCTX-M-15, and plasmid-mediated blaACT-1 genes, indicating that the isolated bacterium contains plasmids containing genes encoding extended-spectrum beta-lactamase and plasmid-mediated ampC beta-lactamase. After 1 month of treatment with antibiotics and levothyroxine, the cat’s condition improved; both the thyroid function test and the blood culture showed no abnormalities. This is the first report of community-acquired multidrug-resistant E. cloacae-induced euthyroid sick syndrome in a cat. By the prompt diagnostic procedures and properly selected antibiotic therapy, the cat was recovered from the multidrug-resistant bacterium-induced septicaemia.
Enteritis Caused by Type A Clostridium perfringens Producing α-Toxin in a Dog
한재익,장혜진,천행복,김지혜,김근형,장동우,나기정 한국임상수의학회 2010 한국임상수의학회지 Vol.27 No.2
A 6-year-old, female, Siberian husky was referred with mucous diarrhea. On fecal examination, numerous clustered and individual large epithelial cells and rod-shaped, spore-forming bacteria were examined. By bacterial culture and molecular typing, the bacteria was identified as Clostridium perfringens (C. perfringens), and by toxin analysis of C. perfringens, production of α-toxin was confirmed. Based on these results, the dog was diagnosed as enteritis caused by C. perfringens producing α-toxin, and was treated with amoxicillin/clavulanate. After 1 week, the diarrhea was disappeared and no spore-forming bacteria were examined on fecal examination. This report shows that the rapid and exact diagnosis keeps a effective treatment for enteritis caused by C. perfringens producing α-toxin in dogs.
Pulmonary Candidiasis in a Dog Receiving Long-term Management for Atopic Dermatitis
한재익,이창민,김태우,이인,최수영,박희명 한국임상수의학회 2015 한국임상수의학회지 Vol.32 No.3
A canine patient exhibited partial anorexia and sudden respiratory distress. Diagnostic imaging and cytology of tracheal-lavage fluids revealed fungal pneumonia. Molecular identification and phylogenetic analysis detected Candida catenulata. Treatment with oral itraconazole for 3 weeks was effective. This is the first report of C. catenulata infection in a dog.