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쌀, 조 수수, 및 콩의 식이가 흰쥐의 성장 및 혈액 성상에 미치는 영향을 조사하기 위하여, 평균체중 180g의 Sprague-Dawley계 rat(♂) 각 5마리씩을 대조군(T_(0)), 쌀(T_(1)), 조(T_(2)), 수수(T_(3)), 콩(T_(4))급이군등 5개군으로 나누어 실온에서 6주간 사육하면서 사료섭취량, 급수량, 증체량과 6주후의 혈액상의 변화틀 조사하였다. 사료 섭취량은 대조군이 각 처리 실험군보다 높았으며 물의 급수량도 동일한 결과이었으며 그 순위는 쌀, 조, 콩, 수수 순으로 감소하였으며, 각 처리군의 증체량은 대조군 보다 낮았으며, 특히 수수는 초기보다 감소하였고, 각 처리군의 사료효율은 대조군보다 낮았으며 특히 수수처리군이 타 처리군보다 낮았다. 연액성상의 변희는 대조군에서는 큰 변화가 없으나 수수군에서 BUN, HOT지 다른군보다 높았으며 쌀의 처리군은 creatinine치가 높았고 조에서는 혈당치가 낮았으며, 콩에서는 LDH는 높았고, HGB, HCT, PI.T, RBC가 낮았고, 특히 콩 수수에서는 혈액상의 변화가 가장 컸으며 다른 실험군과 비교하였을 때 통계적인 유의성이 인정되었다. This study was conducted to investigate the effects of rice, millet, sorghum and soybean diet on the growth rate, daily intake feed ratio and change in hematology of male rats. The experimental male rats of 180g average weight were fed on control (T_(0)), rice (T_(1)), millet (T_(2)), sorghum (T_(3)) and soybean diet (T_(4)) for 6 weeks. The amount of daily feed and water intake supply in each diet group is higher than that of control group to as shown in the following order: rice, millet, soybean, sorghum. The growth ratio of each diet group is lower than that of control group. Especially, sorghum made each diet group reduce the weight even more than the initial weight. Control group is lower than each diet group in regard to the effective ratio of feed. Especially, the sorghum group is lower than other groups. Control group remained same in the change of hematology, however, sorghum group is higher than other groups for BUN, HCT. Rice group is higher in creatinine and millet group is lower in glucose content of serum than any other groups. Soybean group is higher in LDH but lower in HGB, HCT, PLT, RBC than control group. Especially, the soybean and sorghum groups showed a big change in hematology and had the statistic significance in comparison to other groups.
최근 생산현장의 흐름은 우수한 품질의 제품을 출하하는 단계를 넘어서, 시장진입의 경쟁시대라고 해도 과언이 아닐 것이다. 동일한 제품을 생산하고 있는 경쟁사들은 하루라도 앞서 제품을 시장에 출하함으로써 선점권을 갖기 위해 제품개발의 초기단계에서부터 제품의 시장출하를 앞당기기 위한 경쟁은 시작되었다고 볼 수 있다. 이에 본 연구는 제품의 시장출하가 지연됨으로써 발생하는 수익의 손실을 평가해 볼 수 있는 분석모델을 수리화 하였다. 제품개발의 초기단계에서부터 제품을 생산할 수 있는 라인구축의 검토도 동시에 진행하면서 현재의 설비를 가지고 제품을 출하하는 것이 수익상 유리한지, 아니면 자본을 투자해 새로운 라인을 구축해서라도 제품의 출하시기를 앞당기는 것이 유리한지에 대한 의사결정수단을 제공한다.
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The best way to eradicate the operation of overloaded vehicles is that those related to cargo transport should abide by prescribed regulations, but if they are not observed well, road managers have responsibilities and duties to preserve the road facilities constructed by the taxes of the people from a handful groups pursuing illegal profits by restricting illegal operation and imposing punishments. According to rapid economic growth since 1970s. our country has deeply recognized adverse effects of operation of overloaded vehicles starting with the activation of cargo distribution, each road manager has cracked down operation restricted vehicles, but they has not reached such extent as completely eliminate the operation of overloaded vehicles by the lack of crackdown personnel and facilities. This article aimed at draw out the problems in the existing crackdown system and presenting the reform plans to bring forth the countermeasures to eradicate the operation of overloaded vehicles in the national road.
There is a correlation between obesity and the amount of brown adipose tissue; however, the molecular mechanism of brown adipogenic differentiation has not been as extensively studied. In this study, we performed a protein tyrosine phosphatase (PTP) profiling analysis during the brown adipogenic differentiation of mouse primary brown preadipocytes. Several PTPs, including PTPRF, PTPRZ, and DUSP12showing differential expression patterns were identified. In the case of DUSP12, the expression level is dramatically downregulated during brown adipogenesis. The ectopic expression of DUSP12 using a retroviral expression system induces the suppression of adipogenic differentiation, whereas a catalytic inactive DUSP12 mutant showed no effect on differentiation. These results suggest that DUSP12 is involved in brown adipogenic differentiation and may be used as a target protein for the treatment or prevention of obesity by the regulation of brown adipogenic differentiation.
The epithelial cell adhesion molecule (EpCAM, also known as CD326) is a transmembrane glycoprotein that is specifically detected in most adenocarcinomas and cancer stem cells. In this study, we performed a Cell systematic evolution of ligands by exponential enrichment (SELEX) experiment to isolate the aptamers against EpCAM. After seven round of Cell SELEX, we identified several aptamer candidates. Among the selected aptamers, EP166 specifically binds to cells expressing EpCAM with an equilibrium dissociation constant (Kd) in a micromolar range. On the other hand, it did not bind to negative control cells. Moreover, EP166 binds to J1ES cells, a mouse embryonic stem cell line. Therefore, the isolated aptamers against EpCAM could be used as a stem cell marker or in other applications in both stem cell and cancer studies.
Abnormal differentiation of muscle is closely associated with aging (sarcopenia) and diseases such as cancer and type II diabetes. Thus, understanding the mechanisms that regulate muscle differentiation will be useful in the treatment and prevention of these conditions. Protein lysine acetylation and methylation are major post-translational modification mecha-nisms that regulate key cellular processes. In this study, to elucidate the relationship between myogenic differentiation and protein lysine acetylation/methylation, we performed a PCR array of enzymes related to protein lysine acetylation/methylation during C2C12 myoblast differentiation. Our results indicated that the expression pattern of HDAC11 was substantially increased during myoblast differentiation. Fur-thermore, ectopic expression of HDAC11 completely inhibited myoblast differentiation, concomitant with reduced expression of key myogenic transcription factors. However, the catalytically inactive mutant of HDAC11 (H142/143A) did not impede myoblast differentiation. In addition, wild-type HDAC11, but not the inactive HDAC11 mutant, suppressed MyoD-induced promoter activities of MEF2C and MYOG (Myogenin), and reduced histone acetylation near the E-boxes, the MyoD binding site, of the MEF2C and MYOG promoters. Collectively, our results indicate that HDAC11 would suppress myoblast differentiation via regulation of MyoD-dependent transcription. These findings suggest that HDAC11 is a novel critical target for controlling myoblast differentiation.
Although brown adipose tissue is important with regard to energy balance, the molecular mechanism of brown adipocyte differentiation has not been extensively studied. Specifically, regulation factors at the level of protein modification are largely unknown. In this study, we examine the changes in the expression level of enzymes which are involved in protein lysine methylation during brown adipocyte differentiation. Several enzymes, in this case SUV420H2, PRDM9, MLL3 and JHDM1D, were found to be up-regulated. On the other hand, Set7/9 was significantly down-regulated. In the case of SUV420H2, the expression level increased sharply during brown adipocyte differentiation, whereas the expression of SUV420H2 was marginally enhanced during the white adipocyte differentiation. The knock-down of SUV420H2 caused the suppression of brown adipocyte differentiation, as compared to a scrambled control. These results suggest that SUV420H2, a methyltransferase, is involved in brown adipocyte differentiation, and that the methylation of protein lysine is important in brown adipocyte differentiation.
Microfluidics can provide unique experimental tools to visualize the development of neural structures within a microscale device, which is followed by guidance of neurite growth in the axonal isolation compartment. We utilized microfluidics technology to monitor the differentiation and migration of neural cells derived from human embryonic stem cells (hESCs). We co-cultured hESCs with PA6 stromal cells, and isolated neural rosette-like structures, which subsequently formed neurospheres in suspension culture. Tuj1-positive neural cells, but not nestin- positive neural precursor cells (NPCs), were able to enter the microfluidics grooves (microchannels), suggesting that neural cell-migratory capacity was dependent upon neuronal differentiation stage. We also showed that bundles of axons formed and extended into the microchannels. Taken together, these results demonstrated that microfluidics technology can provide useful tools to study neurite outgrowth and axon guidance of neural cells, which are derived from human embryonic stem cells.