Cetyl Myristoleate를 주성분으로 하는 식물성 복합 지방산의 퇴행성 슬관절염 환자에 대한 통증 감소 효과

하태국,강주형,이인범,안철수,이치훈,이상철,강승완 대한가정의학회 2010 Korean Journal of Family Medicine Vol.31 No.1

Background: Previous study suggested that beef tallow extract including cis-9-cetylmyristoleate was a safe and effective treatment for patients with osteoarthritis. We used extract of vegetable oils containing cetyl myristoleate. This study assessed the effect of this supplementation on knee pain and function in patients with osteoarthritis. Methods: The 70 patients who manifested the symptoms and signs of osteoarthritis of knee were randomly assigned to placebo (36) and plant-fatty acids complex (FAC) group (34). Two capsules of placebo (corn starch 350 mg) and plant-FAC (12% cetyl myristoleate in 350 mg) were orally administered to placebo and plant-FAC group three times a day for 60 day, respectively. Visual analogue scale (VAS) and Korean version of Western Ontario and McMaster’s Universities Osteoarthritis Index (KWOMAC) were assessed before and after the intervention and we monitored any adverse effects. Results: The 6 of 36 patients (16.7%) in the placebo and the 5 of 34 patients (14.7%) in the plant-FAC group were missed due to low compliance. In the plant-FAC group, the VAS score was improved by mean 0.76 (P = 0.03) but the improvement was lower than that of placebo group. The KWOMAC was improved by mean 8.90 and 8.13 in the plant-FAC and placebo group, respectively. But the independent t-test showed no statistical signifi cance (P = 0.47). Conclusion: We failed to show the superiority of plant-FAC to placebo on the pain and function of patients with osteoarthritis of the knee. 연구배경: Cetyl myristoleate를 주성분으로 한 쇠기름 추출 복합지방산(fatt y aicd complex, FAC)이 퇴행성 슬관절염의 통증조절에 효과적이라는 보고가 있었다. 본 연구는 식물에서 cetyl myristoleate를 함유한 복합지방산을 추출하여, 이 보충제가 슬관절염 환자의 통증 감소 및 관절기능 향상에 효과적인지 알아보고자 하였다. 방법: 퇴행성 슬관절염으로 진단된 46-77세의 피험자 70명을 이중맹검 무작위 할당 방식으로 식물성 FAC군(N=34) 및위약군(N=36)에 배정하였다. 식물성 FAC군은 2정의 FAC (350 mg 중 cetyl myristoleate 12% 함유)를, 위약군은 동일 제형의 위약 2정을 각각 하루 3회 총 60일간 복용하였다. 관절통증 척도로서 visual analogue scale (VAS)과 관절기능 척도로서 Korean version of Western Ontario and McMaster’s Universities Osteoarthritis Index (KWOMAC)를 투약기간 전후로 측정하였다. 결과: 위약군 36명 중 6명(16.7%), 식물성 FAC군 34명 중 5명(14.7%)이 탈락하여 결과 분석에는 위약군 및 식물성 FAC군각각 30명, 29명이 포함되었다. 위약군에서 VAS 변화량은 평균 1.01점(6.18→5.17)으로 16.34% 감소하였다. 식물성 FAC군에서 VAS 변화량은 평균 0.76점(5.45→4.69)으로 13.94% 감소하였으나(P=0.03), 위약군보다 낮은 감소를 보였다. KWOMAC은식물성 FAC군 및 위약군에서 각각 평균 8.90점(40.83→31.93)및 8.13점(45.63→37.50) 감소하였으나, 독립표본 t-검정 결과 통계적으로 유의한 차이를 보이지 않았다(P=0.47). 결론: Cetyl myristoleate를 주성분으로 하는 식물에서 추출한복합지방산은 슬관절염 환자의 관절통증 및 관절기능 향상에있어서 위약보다 나은 효과를 보이지 않았다.

보완대체의학에 대한 국내 일차진료의사와 대학 병원 근무 의사의 지식, 태도, 경험에 관한 설문조사

강승완,하태국,조병희,이상철,한동석,이경미,한서경 대한의사협회 2011 대한의사협회지 Vol.54 No.2

Despite the recent increase in the use of complementary and alternative medicine (CAM)among the general population and patients, little is known about Korean physicians’attitudes about and interest in CAM. We conducted a web-based survey of knowledge, attitude,and experience in CAM among primary care physicians (PCPs) and academic physicians (APs)in Korea. A total of 826 physicians (341 PCPs and 485 APs) responded. Respondents in both groups felt that they were not sufficiently knowledgeable about CAM. PCPs, however, had a significantly higher composite index score in CAM knowledge than that of APs. Although APs were more skeptical about the scientific evidence of CAM than PCPs, both groups had a positive attitude toward CAM. The level of experience in utilizing CAM in their practice was 23.2% among PCPs, which was much higher than that among APs (2.7%). Experience rates of referring patients to CAM were 11.7% in PCPs and 4.5% in APs (P<0.001). Despite the discrepant rates in CAM education between the two groups (58.7% in PCPs and 26.0% in APs, P<0.001), the majority of doctors in both groups (85.0% in PCPs and 70.0% in APs) expressed an intention to participate in authorized CAM coursework. In conclusion, despite the lack of scientific evidence,both PCPs and APs have an interest in incorporating CAM into their conventional medical practices. To meet physicians' increasing needs for CAM the Korean medical societies should promote education and research about CAM in the conventional medical system.

Twisting된 Bi-2223 선재의 제조, 미세조직 관찰 및 임계 특성평가

임준형,지봉기,박형상,주진호,장미혜,고태국,이상진,하홍수,오상수 한국전기전자재료학회 2000 전기전자재료학회논문지 Vol.13 No.3

We fabricated Bi-2223 multi-filaments superconductor tape and evaluated the effect of twisting on the microstructural evolution and critical current. Twist pitches of the tapes are in the range of 70- 8mm and uniformly deformed. It was observed that grain size and the degree of texture decreased as decreasing pitch probably due to the formation of the irregular interface between Ag and filaments. In addition critical current of the tapes decreased to 6.5 A with decreasing pitch to 8mm, showing 48% of degradation compared to the untwisted tapes decreased to 6.5 A with decreasing pitch to 8mm, showing 48% of degradation compared to the untwisted tape(12.5 A). These reduction of critical current may be related to the interface irregularity smaller grain size worse texture and the presence of cracks due to the induced strain during twisting processing.

BSCCO(2223) 단심 초전도 선재를 이용한 다심 초전도 선재의 접합공정 연구

김규태,김정호,장석헌,주진호,강형구,고태국,하홍수,오상수 한국전기전자재료학회 2003 전기전자재료학회논문지 Vol.16 No.10

We jointed Bi(Pb)-Sr-Ca-Cu-O multifilament tapes and evaluated their electrical and mechanical properties. In order to improve connectivity of multifilaments, one or two single-filament tape was inserted between two multifilament tapes. The critical current ratio(CCR) and n-value of the jointed tapes were evaluated as a function of uniaxial pressure. It was observed that critical current ratio and n-value were 24.8-29.0% and 2.5-2.8 for MM lap-jointed tape. On the other hand, the corresponding values were improved to 24.7-53.9% and 3.1-4.2 for MSM jointed tape, and 63.4-76.0% and 3.4-5.1 for double MS:vr lap-jointed tape, respectively. The highest electrical properties of double MSM lap-jointed tape are considered to be owing to the presence of single core, causing better interconnections of multifilaments between the two tapes. The mechanical property of jointed tape was evaluated and correlated to the microstructural evolution. The strength of jointed tapes was 44-64% less than that of the unjoined tape. The strain tolerance of jointed tape was also reduced compared to that of the unjoined tape. These lower mechanical properties of jointed tape are probably due to the induced nonuniform microstructure such as the existence of cracks and Ag-intrusion in the joined region.

숲활동 중재가 암환자의 불안, 우울, 기분상태 및 희망에 미치는 영향

김영규(Kim, Young-Guy),이상희(Lee, Sang-Hee),김윤희(Kim, Youn-Hee),엄재옥(Eum, Jae-Ouk),임영란(Yim, Young-Ran),하태국(Ha, Tae-Guk),신창섭(Shin, Chang-Seob) 한국산림휴양복지학회 2015 한국산림휴양학회지 Vol.19 No.1

& & 본 연구는 숲활동 중재가 암환자의 불안과 우울, 기분상태 및 희망에 어떤 영향을 미치는지 알아보고자 수행하였다. 서울과 경기도에 위치한 암 전문 요양병원의 환자 53명을 대상으로 수행 되었으며, 연구 대상은 실험집단과 비교집단으로 구분하였고, 두 집단은 사전-사후 측정방법을 사용하여 연구를 진행하였다. 자료는 2014년 8월부터 11월까지 수집하였고 수집된 자료는 SPSS 18.0를 이용하여 t-검정 분석을 실시하였다. 분석 결과, 숲활동 중재를 받은 실험군이 숲활동 중재를 받지 않은 대조군보다 불안과 우울이 개선되었다. 기분상태의 경우 활기 요인을 제외하고 긴장, 우울, 분노, 피로, 혼돈의 5개 하위요소는 개선되었으며, 종합감정장애(TMD)도 개선된 것으로 나타났다. 희망은 통계적으로 유의하지 않았으나 실험후 평균값 비교 결과 숲활동 중재를 받은 실험군의 희망 평균이 대조군보다 높게 나타났다. 그러므로 암환자에게 적용한 숲활동 중재가 암환자의 불안과 우울, 기분상태 및 희망 개선에 효과적이라고 볼 수 있다. & & This study is a research into what effect the forest activity intervention can affect anxiety·depression, profile of mood states(POMS) and hope of cancer patients. The subject of the study was 53 cancer patients of the care hospital that treats cancer patients in Seoul and Gyeonggi-do. The subject was divided into two groups, or an experimenting group and a comparing group, and was performed by using the method of measuring the results before and after the researching process. The data were collected from august to november in 2014, and collected data were analyzed using SPSS 18.0 through independent t-test. After analyzing the research data, it was revealed that the anxiety and depression was improved the level(p<.05) which experimenting group who participate in the forest activity intervention was better than control group who didn’t, and that POMS was improved the level of tension, depression, anger, fatigue, confusion and total mood disturbance(TMD) except vigor factor. There were not statistically significant differences in hope, but the experimental group which received forest activity intervention was higher mean level of hope than the control group which not received. Therefore, it was revealed that forest activity intervention applying to cancer patients could be an effective method for improving anxiety, depression, POMS and hope of cancer patients.