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김우현,배웅진,박중우,최진봉,김수진,조혁진,하유신,홍성후,이지열,황성연,김세웅 대한남성과학회 2016 The World Journal of Men's Health Vol.34 No.2
Purpose: We compared a transperineal ligation model and a transperitoneal ligation model in male rats to determine which animal model of overactive bladder (OAB) was more useful based on cystometrography, estimations of oxidative stress, and measurements of pro-inflammatory cytokine levels.Materials and Methods: Male rats were randomly divided into three groups (n=15 in each): the control group, the transperineal ligation group, and the transperitoneal ligation group. Four weeks after the ligation procedure, cystometrography was performed and oxidative stress, pro-inflammatory cytokine levels, and histologic changes were evaluated. Oxidative stress was assessed by measuring 8-hydroxy-20-deoxyguanosine and superoxide dismutase, and pro-inflammatory cytokine activity was investigated by measuring levels of interleukin (IL)-6, IL-8, and tumor necrosis factor-α.Results: The transperineal model led to results similar to those observed for the transperitoneal model, namely (1) increased voiding frequency and reductions in the non-voiding contraction interval and the maximal vesical pressure, (2) increased levels of oxidative stress markers, (3) increased pro-inflammatory cytokine levels, and (4) fibrotic changes in the bladder tissue.Conclusions: We suggest that the transperineal procedure can be used as an alternative OAB model in male rats.
신장질환에서의 Lactate Dehydrogenase 및 그의 Isoenzyme 활성도 변화
하종영(Chong Y . Ha),박성광(Sung K . Park),강성귀(Sung K . Kang),김우현(Uh . H . Kim) 대한내과학회 1989 대한내과학회지 Vol.37 No.2
N/A The analysis of the 5 different isoenzymes of lactate dehydrogenase(LDH) is of great value in the differential diagnosis of various diseases. In order to investigate the change of LDH isoenzymes in several renal diseases, 44 patients with Korean hemorrhagic fever(KHF), 10 patients with chronic renal failure(CRF), 10 patients with nephrotic syndrome(NS), and 15 healthy subjects were studied, The isoenzymes of LDH were determined by the Helena LDH isoenzyme electrophoresis procedure which is a modification of that of Paston and his associates. Results showed that LDH1 was 22.3±2.8, LDH2 29.4±5.1, LDH3 20.8±4.5, LDH4 9.0±2.7 and LDH5 8.8±3.2 mu/ml in healthy subjects. In patients in the oliguric stage of KHF, LDH1 was 63.4±28.5, LDH2 99.7±40.7, LDH3 107.5±39.0, LDH4 41.9±32.8, and LDH5 37.2±26.3mu/ml, while LDH1 was 23.8±11.7, LDH2 38.9±14.6, LDH3 35.9±18.7, LDH4 13.8±8.0, and LDH5 12.7±7.6mu/ml in non-oliguric patients. In patients with CRF, LDH1 was 33.2±10.8, LDH2 41.9±13.3, LDH3 27.7±8.5, LDH4 12.1±6.2, and LDH5 12.3±5.8 mu/ml. In patients with NS, LDH1 was 25.1±4.3, LDH2 33.5±4.9, LDH3 23.1±6.2, LDH4 8.4±3.7 and LDH5 58.4±3.4 mu/ml. In summary, LDH3 activity was elevated in the oliguric stage of Korean hemorrhagic fever and LDH2 was elevated in chronic renal failure and those correlated with the BUN level.