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2010년 일개 회사에서 집단발생한 바실루스 세레우스 식중독에 관한 역학조사
최금발,임현술,이관,하경임,정광현,손창규,Choi, Kum-Bal,Lim, Hyun-Sul,Lee, Kwan,Ha, Gyoung-Yim,Jung, Kwang-Hyun,Sohn, Chang-Kyu 대한예방의학회 2011 Journal of Preventive Medicine and Public Health Vol.44 No.2
Objects: In July 2 2010, a diarrhea outbreak occurred among the workers in a company in Gyeungju city, Korea. An epidemiological investigation was performed to clarify the cause and transmission route of the outbreak. Methods: We conducted a questionnaire survey among 193 persons, and we examined 21 rectal swabs and 6 environmental specimens. We also delegated the Daegu Bukgu public health center to examine 3 food service employees and 5 environmental specimens from the P buffet which served a buffet on June 30. The patient case was defined as a worker of L Corporation and who participated in the company meal service and who had diarrhea more than one time. We also collected the underground water filter of the company on July 23. Results: The attack rate of diarrhea among the employees was 20.3%. The epidemic curve showed that a single exposure peaked on July 1. The relative risk of attendance and non-attendance by date was highest for the lunch of June 30 (35.62; 95% CI, 2.25 to 574.79). There was no specific food that was statistically regarded as the source of the outbreak. $Bacillus$ $cereus$ was cultured from two of the rectal swabs, two of the preserved foods and the underground water filter. We thought the exposure date was lunch of June 30 according the latency period of $B.$ $cereus$. Conclusions: We concluded the route of transmission was infection of dishes, spoons and chopsticks in the lunch buffet of June 30 by the underground water. At the lunch buffet, 50 dishes, 40 spoons, and chopsticks were served as cleaned and wiped with a dishcloth. We thought the underground water contaminated the dishes, spoons, chopsticks and the dishcloth. Those contaminated materials became the cause of this outbreak.
Helicobacter pylori 감염 환자에서 Western blot 법에 의한 혈청내 세포독성 유전자의 발현에 관한 연구
김대인,이구,서정일,이창우,김정란,하경임,이규춘,남경수,양창헌,Kim, Dae-In,Lee, Goo,Shu, Jung-Ill,Lee, Chang-Woo,Kim, Jung-Ran,Ha, Gyoung-Yim,Lee, Kyu-Chun,Nam, Kyung-Soo,Yang, Chang-Heon 한국생명과학회 2000 생명과학회지 Vol.10 No.6
The gastric pathogen Helicobacter pylori(H. pylori) establishes long-term chronic infection that can lead to atrophic gastritis, intestinal metaplasia, and gastric cancer. H. pylori, which express cytotoxic genes is now recohnized as a cause of peptic ulcer and is also a major risk factor for the development of gastric adenocarcinoma. We performed this study 1) to assess the detection rate of H. pylori according to direct investigation of bacteria of gastric biopsy specimen and two serologic tests of GAP test and Helico blot 2.0 system in the symptomatic and non-symptomatic group 2) to evaluate and compare the efficacy of two serologic tests of GAP test and Helico blot 2.0 system for the diagnosis of H. pylori infection. Forty-nine patients were positive for H pylori infection based on direct investigation of bacteria by histology. The detection rates of H. pylori infection based on direct investigation of bacteria by histology. The detection rates of H. phlori were significantly lower in gastric cancer than in other gastroduodenal disease(p<0.05). The concordance of two serologic tests of GAP test and Helico blot 2.0 system is poor. There was no statistically significant difference between the expression rate of CagA and VacA in the symptomatic and non-symptomatic group. Although Helico blot 2.0 system may not displace GAP test, it was a very sensitive serologic test for the diagnosis of H. pylori infection and it was used to detect IgG antibodies to H. pylori-specific antigens, including CagA, VacA and the various urease subunit. Our data suggest that further investigation is needed to determine whether or not the serologic expression of cytotoxic gene may be clinical usefulness of diagnostic methods in the gastroduodenal disease.
경주시에서 발생한 세균성이질 확진자에 대한 유행기전 분석
정철(Cheoll Jung),임현술(Hyun-Sul Lim),하경임(Gyoung Yim Ha),김희수(Hee Su Kim) 한국역학회 2004 Epidemiology and Health Vol.26 No.1
Purpose This study was earned out to investigate the sources of infection and modes of transmission of an 107 (54 males, 53 females) confirmed shigellosis in Gyeongju from Sept 24 to Oct 24, 1998 Methods We reviewed hospital records of all confirmed shigellosis Thirty-two stains of Shigella sonnet isolated were analyzed in order to trace the source of infections by plasmid profile, antimicrobial drug resistance pattern, biotyping and pulsed-field gel electrophoresis (PFGE) Results The first source of Infection was estimated to be contaminated underground water and simple piped water caused by leakage from the cess pool Antimicrobial drug resistance pattern showed that all strains were multi-resistant All Isolates had the same XbaI and SfiI PFGE patterns, indicating the epidemiological relationship of the outbreaks strains in this area The major characteristics of diarrhea were watery (84.2%) in nature The clinical symptoms among the diarrheal cases included abdominal pain (86.1%), fever (83.2%), headache (78.2%), chill (45.5%) and tenesmus (41.6%) Six cases were asymptomatic From initial manifestation to admission were 6.2±1 .6 (median 6) days, so It could be transmitted to others in this infective period Duration of admission were 5.5±2.4 (median 6) days We can find familial mean secondary attack rate were 38.5% Conclusion It's transmission to other areas were certified by contaminated water and contact with shigellosis, and unknown cases were estimated to be transmitted by contacts with inapparent infection By plasmid profile and PFGE, the epidemiological relationship of the outbreaks Strains in this area seemed to be the same micro-organisms.
Fonsecaea pedrosoi에 의한 색소 분아 진균증
서무규 ( Moo Kyu Suh ),성열오 ( Yeol Oh Sung ),윤기성 ( Ki Seong Yoon ),하경임 ( Gyoung Yim Ha ),김정란 ( Jung Ran Kim ) 대한피부과학회 1996 대한피부과학회지 Vol.34 No.5
We report a case of chromoblastomycosis caused by Fonsecaea(F.) pedrosoi in a 58-year old fe- male, who showed a 2 *1.5cm sized, scply erythematous plaque on the left wrist for 7 months. Histopathologically, chronic granulomatous inflammation and sclerotic cells were observed. Fungal culture grew out th typical black colonies of F. pedrosoi. The patient had been treated with weekly intralesional injections of amphotericin B for 3 months. We observed a good response without evidence of recu~rrence. (Kor J Dermatol 1996;34(5): 832-836)
매독을 동반한 Human Immunodeficiency Virus 감염
서무규(Moo Kyu Suh),어경윤(Kyung Yoon Eur),하경임(Gyoung Yim Ha) 대한피부과학회 1994 대한피부과학회지 Vol.32 No.3
We report a case of HIV, infection associated with syphilis. A 40-year-old heterosexual man presented with headache, malaise, and a cutaneous lesion consisting of a whitish patch and petechiae on the hard palate. The serum VDRL titer wss positive at 1:64 and the cerebrospinal fluid VDRL titer was negative. Anti-HIV antibodies were detected in the patient sera by particle agglutination test and confirmed by Western blot test. (Kor J Dermatol 1994; 32(3): 498-502)
Paecilomyces Lilacinus에 의한 국소 피부감염증
고우태 ( Woo Tae Ko ),김수호 ( Soo Ho Kim ),서무규 ( Moo Kyu Suh ),하경임 ( Gyoung Yim Ha ),김정란 ( Jung Ran Kim ) 대한피부과학회 2007 대한피부과학회지 Vol.45 No.9
Paecilomyces (P.) lilacinus is a saprophytic filamentous fungus, mostly found in soil and very rarely pathogenic to humans. Although it has been reported to cause endophthalmitis, endocarditis and pulmonary infection, localized skin infection due to P. lilacinus has been rarely reported. We report a case of localized skin infection by P. lilacinus in an 83-year-old man. The lesion was manifested by a 7.0×5.0 cm-sized erythematous plaque on the left wrist. The fungal culture from the biopsy specimen on Sabouraud`s dextrose agar showed velvety whitish pink colonies of P. lilacinus. The patient was treated with 200 mg of itraconazole daily for 3 months. The skin lesion was completely cured and recurrence has not been observed to date. (Korean J Dermatol 2007;45(9):930∼933)
최진혁(Jin Hyouk Choi),서무규(Moo Kyu Suh),하경임(Gyoung Yim Ha) 대한피부과학회 2002 대한피부과학회지 Vol.40 No.10
N/A Backgroun :There have been few clinical and mycological studies of superficial cutaneous candidiasis in Korea. Objective : The purpose of the study was to investigate the recent clinical and mycological features of superficial cutaneous candidiasis and correlation between underlying diseases and candidiasis. Methods : Among 233 patients, 233 strains of Candida(C.) species were isolated and identified by Sabouraud`s dextrose agar culture, germ tube test and sugar assimilation test using API 20C kit. Results and Conclusion : 1. The incidence of superfical cutaneous candidiasis was 4.0% out of a total of 5,809 out-patients. 2. The ratio of male to femal patients was 1.1:1. 3. Among the age groups, the incidence rate was high in the first decade and above sixth decade. 4. Candidal intertrigo was the most common type of infection(56.7%), 5. Among 233 Candida species C, albicans(90.6%), C. parapsilosis(4.7%), C, guilliermondii(2.1%), C. tropicalis(l.7%), C. glabrata(0.9%) were identified. 6. Neurological disease was the most common underlying disease(56.4%)