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사상(四象) 처방(處方)으로 치료한 여드름 환자 81례의 임상보고(臨床報告)
탁미진,탁명림,윤화정,고우신,Tak, Mi-Jin,Tark, Myoung-Rim,Yoon, Hwa-Jung,Ko, Woo-Shin 대한한방안이비인후피부과학회 2009 한방안이비인후피부과학회지 Vol.22 No.2
Objectives : This study is to investigate the effect of the sasang constitutional prescription with peeling and MTS on Acne patients. Methods : We treated 81 acne patients with sasang constitutional prescription with peeling and MTS. After treatments we compared the before and after photos, and estimated by Korean Acne Grading System. Results & Conclusions : 1. Patients were comprised of 59 females and 22 males. And there were 30 adolescent and 51 postadolescent acne patients. Out of 81 acne patients, there were many 41 postadolescent female acne patients. 2. Sasang constitutional distribution was comprised of 74 Soyangin, 5 Soeumin and 2 Taeeumin 3. Yangkyuksanhwa-tang(48.1%) and Yangdokbackho-tang(40.7%) were used much in 81 acne patients. 4. Before the treatment, 92.3% of Yangkyuksanhwa-tang group and 63.6% of Yangdokbackho-tang group had mild acne symptom and acne grade mean of Yangdokbackho-tang group was higher than another groups. 5. Peeling times mean of 81 acne patients was 2.54 times and MTS times mean was 4.57 times. Acne grade was improved when peeling times were higher. 6. Before the treatment, 81 acne patients were comprised of 81.5% mild symptom and 18.5% severe symptom patients and acne grade mean was 2.75. After the treatment. there were only mild symptom patients and acne grade mean was 1.04.
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양격산화탕(凉膈散火湯)의 항염증(抗炎症) 효과에 대한 연구
탁미진,탁명림,강경화,고우신,윤화정,Tak, Mi-Jin,Tark, Myoung-Rim,Kang, Kyoung-Hwa,Ko, Woo-Shin,Yoon, Hwa-Jung 대한한방안이비인후피부과학회 2010 한방안이비인후피부과학회지 Vol.23 No.1
Objective: Yang Geouk San Hwa - Tang (YGSHT) has been widely used in Sasang Constitutional Medicine of Korea for treatment of acute inflammatory symptom, such as palatine tonsillitis, polydipsia, headache, papule, pimple however, the mechanism of its anti-inflammatory activity has not been clarified. In this study, therefore, we investigated the mechanism of the inhibitory effect of YGSHT on LPS-induced inflammation. Materials and methods: The effect of YGSHT was analyzed by ELISA, RT-PCR and Western blotting in LPS-stimulated RAW264.7 cells. Results: We found that YGSHT suppressed not only the production of pre-inflammatory cytokines (IL-$1{\beta}$ and TNF-$\alpha$), the generation of nitric oxide (NO) and prostaglandin E (PGE)2, but also the mRNA expression of pre-inflammatory cytokines, inducible nitric oxide synthase (iNOS), and cyclooxygenase (COX)-2. Furthermore, YGSHT was shown to inhibit the phosphorylation of ERK1/2 and JNK1/2 and the activation and translocation of NF-kB from cytosol to nuclear in LPS-stimulated RAW264.7 cells. Conclusions: These results suggest that YGSHT exerts an anti-inflammatory effect through the regulation of the ERK1/2 and JNK1/2 pathway and NF-kB pathway, thereby decreasing production of pre-inflammatory cytokines, NO, and PGE2.
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