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최훈,윤석철,Cui, Xun,Yoon, Suk-Chul 대한동의생리학회 2005 동의생리병리학회지 Vol.19 No.3
Perspiration is the product of metabolism and the resin comes out through the hole of skin. And it keeps constant with heart and blood. So, it has great meaning in the clinical medicine and it is closely connected with the qi, blood, body fluid and viscera in our body. In the oriental medicine it is said that when our body is attacked with the evil qi and it locates in the surface of our body, we must induce the perspiration and it is called 'Method of Perspiration'. If we use that method we should refer the contraindication, and historical doctors stressed the need of deliberate use. However, the moderns have the misunderstandings about the perspiration. When they have alcoholic trouble and feel fatigue, they wring out the sweat. And they think that doing has good results. They even sweat off their surplus fat. But, that doing is rashly as that is an energy-consuming behavior and it shorten one's span of life because of the running dry of the resin. Therefore, we must use very carefully the 'Method of Perspiration' and not wring out the sweat rashly.
십전대보탕(十全大補湯)이 혈관신생(血管新生) 억제(抑制)에 미치는 효과(效果)
최훈,강희,심범상,김성훈,최승훈,안규석,Cui, Xun,Kang, Hee,Shim, Bum-Sang,Kim, Sung-Hoon,Choi, Seung-Hoon,Ahn, Kyoo-Seok 대한암한의학회 2006 大韓癌韓醫學會誌 Vol.11 No.1
Shiquandabutang is very famous prescription for tonifying vital energy. We examined the anti-metatstastic effect of Shiquandabutang with in vitro invasion assay model. We performed the following experiments and the results are listed below:Cell viability assay was carried to determine the dose of Shiquandabutang. At lower dose under 200 ${\mu}g/m{\ell}$ (89.6%) viability was very high. But, viability downed as dose grows. At the dose of 600 ${\mu}g/m{\ell}$ (54.2%) viability was almost half of that of control. And at high dose of 1000 ${\mu}g/m{\ell}$ (15.8%) viability was very pure. In BrdU incorporation assay, Shiquandabutang treated groups showed the decreased DNA synthesis rate compared with control group.(200 ${\mu}g/m{\ell}$ (64.4%), 400 ${\mu}g/m{\ell}$ (7.3%)) The results of gelatinase assay showed that Shiquandabutang decreases the gelatinolytic activity of MMP-9. We examined tube formation assay and the result was that Shiquandabutang ihhibits the tube formation at the dose of 200 ${\mu}g/m{\ell}$ and 400 ${\mu}g/m{\ell}$. We examined rat aortic ring assay and the result was that Shiquandabutang ihhibits the angiogenesis of the rat aortic ring at the dose of 400 ${\mu}g/m{\ell}$. From our research, part of the mechanism underlying anti-metastastic effect of Shiquandabutang was proven in vitro. Moreover, we knew that Shiquandabutang is more effectively inhibits the angiogenesis at high dose.
폐열(肺熱)을 치료(治療)하는 약물의 기미론(氣味論)적 약리분석(藥理分析)에 대한 고찰(考察)
최훈 ( Xun Cui ),이청학 ( Cheong Hak Lee ) 한약응용학회 2010 한약응용학회지 Vol.10 No.2
In Traditional Oriental Medicine, the drug treatment has been explained by the thoery of "Qiweilun(氣味論)". So we studied on the drug treatment of drugs to treat FeiRe(肺熱) by "Qiweilun(氣味論)" When FeiRe(肺熱) was caused by "Wai Gan Feng Re(外感風熱)", we make a conclusion that use Mori Folium, Lonicerae Flos, Gypsum Fibrosum. And when FeiRe(肺熱) was caused by "Shi Re(實熱)", we make a conclusion that use Gardeniae Fructus, Scutellariae Radix, Fritillariae Bulbus, Anemarrhenae Rhizoma, Asparagi Radix. When FeiRe(肺熱) was caused by "Fei Zhong Fu Huo(肺中伏火)", we make a conclusion that use Adenophorae Radix, Trichosanthis Semen, Lilii Herba. When FeiRe(肺熱) was caused by "Xu Re(虛熱)", we make a conclusion that use Ophiopogonis Radix, Trichosanthis Radix.
김윤경,김정숙,최훈,Kim, Yun-Kyung,Kim, Chung-Seok,Cui, Xun 한국한의학연구원 2004 한국한의학연구원논문집 Vol.10 No.2
The decocting method of herbal medicines is various with a prescription or herbal medicine's characteristics. But it has common principles by which effective elements can be easily extracted with synergistic actions of herbs and which the therapeutic effect of a medicine is amplified. When decocting a herbal medicine, the volume of water is an important factor. Fire for decocting drugs and decocting time are also important factors. The excessive water and unproper decocting time and temperature can reduce the effect of the decoction. Besides a better decoction can be obtained by squeeze. According to herbal medicine's characteristics and prescription, there are herbs that should be treated after a specific method. For example, decoct first and decoct later. It also affects the therapeutic if a right taking method is not carried out. Methods of taking drugs include both the time and the method. We can confirm these decocting and taking methods in the ancient medical literatures of herbal medicine. This article deals with these things in detail.