탄광부 진폐증자의 혈액 중 납, 철 및 아연 농도

최호춘,정호근,김해정,Choi, Ho-Chun,Chung, Ho-Keun,Kim, Hae-Jeong 대한예방의학회 1989 예방의학회지 Vol.22 No.4

Lead, iron, and zinc concentrations in whole blood were determined by atomic absorption spectrophotometry, using a simple one-step dilution procedure, which were measured in 3 groups, 98 officers unexposed to dust or to metal, 58 coal miners without pneumoconiosis, and 113 coal workers' pneumoconiosis (CWP) patients. The results were as follows : 1. The precisions (C. V.%) of lead, iron, and zinc in blood were $12.65{\pm}6.95%,\;1.47{\pm}1.25%\;and\;6.35{\pm}3.34%$, respectively. 2. Lead and zinc in blood showed the log-normal distribution unlike iron in blood which showed normal distribution. 3. Lead, iron, and zinc concentrations in blood of 3 groups were follows : There was significant difference of concentration for zinc in blood by groups statistically. 4. The difference of lead, iron, and zinc concentrations in blood was not significant (p>0.05) by profusion on chest radiographs.

정상인과 도금업 근로자의 요 및 혈청중 크롬 및 니켈 농도

최호춘 한국산업위생학회 1995 한국산업보건학회지 Vol.5 No.1

The exposure levels of chromium and nickel for chromeplating workers were evaluated. Chromium and nickel concentrations in urine and serum from 82 exposed workers and 69 controls, who were not exposed occupationally to metals, were analyzed by flameless atomic absorption spectrophotometry. The results were as follows: 1. Chromium concentrations in urine of exposed group and control were 3.491±1.83g/g of creatinine, 5.59±2.83g/g of creatinine, and in serum were 0.69±0.30g/ℓ, 2.31±1.16g/ℓ respectively. There were significant difference of concentrations for chromium in urine and serum by group respectively. 2. Nickel concentrations in urine of exposed group and control were 0.92±0.23g/g of creatinine, 2.20±1.93g/g of creatinine, and serum concentrations were 0.52±0.34g/ℓ, 1.41 ±0.74g/ℓ respectively. There were significant difference of concentrations for nickel in serum by groups statistically. 3. Chromium and nickel concentrations in urine and serum of exposed groups were not significant by workplaces(grinding, electroplants, packaging).

Gas Chromatograph 에 의한 Arylmethy Halides 의 정량

최호춘,오도석 한국산업위생학회 1994 한국산업보건학회지 Vol.4 No.1

Arylmethyl halides(benzyl chloride, BZYC; benzal chloride, BZYA; benzotrichloride, BZTC) and related compounds(benzyl alcohol, BZYA; benzoyl chloride, BZOC) were determined by GC using capillary column. Detailed results are as follows. 1. Stability In methanol benzotrichloride slowly transferred to benzoyl chloride by hydrolysis(ca. 7.5% for 5 days), but the others were stable, Therefore, benzotrichloride solution should be prepared just before analysis. 2. GC analysis Tenax-GC was used to absorbent and desorption solvents were CCl₄ and MeOH. Arylmethyl halides were analyzed within 7.5min without interference with related compounds. The calibration curve(ca. 15-80 ppm in soln), repeatability(n=10) and the desorption efficiency were good. Limit of detection by NIOSH method was about 0.003 ppm for arylmethyl halide, respectively. To analyze arylmethyl halides and related compounds in working places GC using capillary column is anticipated to be used effectively.

고체상 추출과 GC/MSD를 이용한 금속가공유중 다핵 방향족 탄화수소류 및 그 유도체의 분석

최호춘,김강윤,안선희,문형중 한국산업위생학회 2003 한국산업보건학회지 Vol.13 No.1

This study was performed to confirm an analytical method for polyunclear aromatic hydrocarbons (PAHs) in metalworking fluids(MWFs) which were used in metalworking factories. To ensure the analysis with accuracy and precision the fesults of PAHs in MMFs, this study was tried to use solid phase extraction(SPE) and gas chromatography/mass selective detector(GC/MSD). Also, this study was examined the concentrations of PAHs in MMF bulks and the qualitative analysis polycyclic aromatic compounds(PACs)excluding PAHs. 21 bulk samples were sampled in 7 metalworking factories. 21 bulk samples were 18 cutting oil(13 straight oils and 5 soluble oils) and 3 others(lubricating oil, discharge oil. compresses oil). 6 SPE cartridges were used to analyze PAH in MMFs and GC/MSD(satum 2000, Varian, U.S.A). Among the the 6 SPE cartridgesm this study was selected strong cation exchanger(SCX, aromatic benzene sulfonic acid functional group) cartridge for PAHs extraction in MMFs. Also the recovery test was performed. 1. The appropriated cartridge of SPE for analysis of PAHs in MWFs was found to be SCX. 2. The detected PAHs in MWFs were naphthalene(n=2). acenaphthylene(n=1). phenanthree(n=1), anthracene(n=2), fluoranthene(=7), pyrene(n=11) benzo[b]fluoranthene(n=1), chrysene(n=1), benzo[k]fluoranthene(n=1), benzo[k]fluoranthene(n=1).benzo[a]pyrene(n=1), dibenz[a,h]anthracene(n=2) and benzo[ghi] perylene(n=8). Total PAH(n=12) concentrations range were lower than LOD-270.03ug/ml. 3. The component of the PACs excluding PAHs were naphthalenes, acenaphthenes, chrysenes, anthracenes, indenes, fluoranthenes, fluorenes, pyrenes, benzopyrenes, phenantherenes and others volitile organic compounds(VOCs)were amines, phenols, aldehydes and others. For the results, SCX cartridge was better than other 5 SPE cartridges. 13 of 16 PAHs components were detected in MWFs. However recovry rate in this study should be improved analytical techniques on PAHs in MWFs. Also this study was need for further investigation for more MWFs samples and environmental monitoring and evaluation of MWFs exposed workers.

요중 마뇨산 정도관리 시료의 비색법과 고속액체크로마토그래프법과의 비교

최호춘,이선주,Choe, Ho-Chun,Lee, Seon-Ju 대한산업보건협회 1995 산업보건 Vol.84 No.-

일부 합성피혁 근로자들의 Dimethylformamide, Methyl Ethyl Ketone, Toluene 노출에 따른 요중 대사물질

최호춘,김강윤,안선희,이영자,정규철 한국산업위생학회 2001 한국산업보건학회지 Vol.11 No.2

This study was performed to measure airborne dimethyl-formamide(DMF), methyl ethyl ketone(MEK) and toluene and their urinary metabolites concentrations and to determine the relationship between airborne and urinary concentration. Air-borne samples and their urinary metabolites were measured 98male workers who work for 8 synthetic leather factories in a portion of Kyoung-in area. Urine samples were collected at end-of-shift to estimate the exposure levels. 1. The concentration of airborne DMF by process was 8.81 ppm for wet-mixing, 15.05 ppm for wet-coating, 6.03 ppm for dry-mixing, 5.58 ppm for dry-coating, 5.37 ppm for printing, and 9.03 ppm for total. There was statistically significant difference by process. Urinary NMF concentrations of wet-mixing, Wet-coasting, Dry-mixing, dry-coating and printing were 90.55㎎/, 79.80㎎/ℓ, 39.86㎎/ℓ, 25.23㎎/ℓ, and 38.15㎎/ℓ, respec-tively, and total geometric mean was 56.24㎎/ℓ. There was statistically significant difference by process. 2. The concentration of airborne MEK by process was 1.89 ppm for wet-mixing, 1.96 ppm for wet-coating, 10.33 ppm for dry-mixing, 29.24 ppm for dry-coating, 14.98 ppm for printing, and 4.87 ppm for total. There was statistically significant difference by process. Urinary MEK concentrations of wet-mxing, wet-coating, dry-mixing, dry-coating and printing were 0.93㎎/ℓ, 0.70㎎/ℓ, 3.29㎎/ℓ, 3.29㎎/ℓ, and 1.06㎎/ℓ, res-pectively, and total geometric mean was 1.25㎎/ℓ, There was statistically significant difference by process. Urinary MEK 3.The concentration of airborne toluene by process was 0.35ppm for wet-mixing, 0.42ppm for wet-coating, 2.95ppm for dry-mixing, 11.67ppm for dry-coating, 4.88ppm for printing, 1.24ppm for total. There was statistically significant difference by process. Urinary hippuric acid concentrations of wet-mixing, wet-coating, dry-mixing, dry-coating and printing were 0.24g/g creatinine, 0.21g/g creatinine, 0.34g/g creatinine, 0.52g/g cre-atinine, and 0.29g/g creatinine, respctively and total geometric mean was 0.28g/g creatinine. There was statistically signifi-cant difference by process. 4. No. of exceeded KPEL was 40 workers(40.8%) for DMF(10ppm), 1 worker(1.0%) for MEK(200ppm), and no worker for toluene(100ppm). No. of exceeded KBEI was 62 workers(63.3%) for urinary NMF(40㎎/ℓ), 29 workers (29.6%) for uri-nary MEK, 1 worker(1.0%) for urinary hippuric acid. 5. The regression equations were Log(MMF)=0.4094* Log(DMF)+1.3587(r=0.4516) for DMF, Log(MEKU)=0.1859* Log(MEK)-0.0324(r=0.3303) for MEK, Log(HA)=0.2106* Log(Toluene)-0.5685 (r=4497) for toluene. Synthetic leather factory workers expose to 3 kinds of organic solvents which are DMF, MEK and toluene. Their Uri-nary NMF and MEK levels were higher than their concentration levels through respiratory. It seems that the urinary levels were affected skin absorption for working habit and alcohol intake.

태백 및 강릉지역 석탄광의 호흡성 분진과 석영농도에 관한 조사

최호춘,천용희,윤영노,김해정,Choi, Ho-Chun,Cheon, Yong-Hee,Yoon, Young-No,Kim, Hae-Jeong 대한예방의학회 1987 Journal of Preventive Medicine and Public Health Vol.20 No.2

In order to investigate working conditions of underground coal mines, this work was undertaken to evaluate the respirable dust and the concentration of quartz in Taeback and Kangneung areas. The concentration of quartz was determined by Fourier Transform Infrared Spectrophotometry. The results were as follows; 1) The concentration of respirable dust of drilling and coal face in Taeback and Kangneung areas were as followed; Arithmetic $Mean{\pm}S.D.(mg/m^3)$ Taeback Drilling: $2.00{\pm}1.56$ Taeback Coal Face: $3.74{\pm}3.14$ Kangneung Drilling: $4.55{\pm}4.51$ Kangneung Coal Face: $5.77{\pm}4.53$ Geometric $Mean{\pm}S.D.(mg/m^3)$ Taeback Drilling: $1.34{\pm}2.81$ Taeback Coal Face : $2.55{\pm}2.61$ Kangneung Drilling : $2.44{\pm}3.63$ Kangneung Coal Face: $4.24{\pm}2.37$ 2) Distribution of respirable dust was well fitted to the log-normal distribution and geometric mean value was $log^{-1}\;0.37{\pm}log^{-1}\;0.47(2.34{\pm}2.95)mg/m^3$. 3) The difference of respirable dust concentrations in Taeback and Kangneung areas was not significant statistically (p>0.05). 4) The concentration of quartz of drilling and coal face in Taeback and Kangneung areas were as followed; Arithmetic $Mean{\pm}S.D.(%)$ Taeback Drilling: $6.18{\pm}5.52$ Taeback Coal Face: $1.89{\pm}1.54$ Kangneung Drilling: $3.54{\pm}2.12$ Kangneung Coal Face: $2.05{\pm}3.37$ Geometric $Mean{\pm}S.D.(%)$ Taeback Drilling: $4.24{\pm}2.59$ Coal Face: $1.39{\pm}2.22$ Kangneung Drilling : $2.55{\pm}3.08$ Kangneung Coal Face : $1.24{\pm}2.33$ 5) Distribution of quartz concentrations was well fitted to the log-normal distribution and geometric mean value was $log^{-1}\;0.33{\pm}log^{-1}\;0.45(2.14{\pm}2.82)%$. 6) The difference of quartz concentrations in Taeback and Kangneung areas was not significant (p>0.05), but significant at drilling sites and coal faces (p<0.05).

1,3-부타디엔 제조 및 취급 근로자의 노출특성에 관한 연구

최호춘,안선희,이현석,박영욱,김경순 한국산업위생학회 2009 한국산업보건학회지 Vol.19 No.4

1,3-butadiene is classified as suspected human carcinogen, group A2(American Conference of Governmental Industrial Hygienists, ACGIH). In Korea, 1,3-butadiene has been used as a raw material; monomer, homopolymer, polybutadiene latex, acrylonitrile-butadiene-styrene(ABS) and styrene-butadiene rubber(SBR), in the petrochemistry and precision chemistry industry. As petrochemistry industry in Korea has been developed, the potential exposure possibility of 1,3-butadiene to workers can be increased. Therefore the purpose of this study is to evaluate airborne 1,3-butadiene concentration and workers' exposure levels in the workplace using 1,3-butadiene. Air samples were collected with 4-tert-butyl catechol(TBC) charcoal tube(100 ㎎/50 ㎎) and were analyzed by gas chromatograph/flame ionization detector(GC/FID) according to the Choi's method(2002). Geometric mean (GM) and arithmetic mean (AM) of total 59 workers' exposure concentrations to airborne 1.3-butadiene were 0.042 ppm and 1.51 ppm, respectively. Although most samples were lower than 1ppm, 2 samples(21.5ppm and 33.1ppm as 8hr-TWA) were exceeded the Korean standard(2ppm) over 10 times at the repair process in synthetic rubber and resin manufacture industry. 14 samples(41%) of total 34 short-term air samples were exceeded the Korean standard(10ppm as STEL) of Ministry Labor. 1,3-butadiene concentration(GM) in the synthetic rubber and resin manufacture industry(7.87ppm) was significantly higher than that in the monomer manufacure industry (0.35ppm)(p<0.05). Also in the sampling and repair process, each GM(range) was 1.39ppm(N.D.-469.6ppm) and 7.85ppm(N.D.-410.2ppm). In conclusion, it depends on the industry and process, 1,3-butadiene can be exposed to workers as high concentration for short-term.

정도관리

최호춘,Choe, Ho-Chun 대한산업보건협회 2007 산업보건 Vol.233 No.-

생물학적 노출지표 검사별 신구 분석방법 고찰 (pp.169-175)

최호춘 대한직업환경의학회 2010 대한직업환경의학회 학술대회 논문집 Vol.45 No.-