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교회학교 교사의 온정적합리주의리더십이 회복탄력성에 미치는 영향: 활동몰입과 소명의식의 순차적 매개효과
최현덕,연지연,최은수 한국성인교육학회 2024 Andragogy Today : International Journal of Adult & Vol.27 No.3
본 연구는 교회학교 교사의 온정적합리주의리더십이 회복탄력성에 미치는 영향과 그 과정에서 활동몰입과 소명의식의 순차적 매개효과를 검증하고자 하였다. 이를 위해 한국 개신교 교회의 교회학교 교사 234명을 대상으로 온라인 설문조사를 실시하였다. 연구 결과, 교회학교 교사의 온정적합리주의리더십은 회복탄력성에 직접적인 정적 영향을 미쳤으며, 활동몰입과 소명의식을 매개로 간접적인 영향도 미치는 것으로 나타났다. 또한, 활동몰입과 소명의식의 순차적 매개효과가 유의한 것으로 확인되었다. 이러한 결과는 교회학교 교사의 회복탄력성 향상을 위해 온정적합리주의리더십 개발과 함께 활동몰입과 소명의식 강화가 필요함을 시사한다. 본 연구는 성인교육 측면에서 자원봉사 기반의 성인 학습자인 교회학교 교사들의 리더십 발달과 역량 강화에 대한 통찰을 제공하고, 이를 통해 교회학교 교사 교육 프로그램 개발에 실질적인 기여를 할 수 있을 것으로 기대된다. This study aimed to examine the impact of compassionate rationalism leadership on the resilience of church school teachers and the sequential mediating effects of flow and sense of calling in this process. An online survey was conducted with 234 church school teachers from Korean Protestant churches. The results showed that compassionate rationalism leadership had a direct positive effect on resilience and an indirect effect mediated by flow and sense of calling. Furthermore, the sequential mediating effects of flow and sense of calling were found to be significant. These findings suggest that to enhance the resilience of church school teachers, it is necessary to develop compassionate rationalism leadership along with strengthening flow and sense of calling. This study provides insights into the leadership development and capacity building of church school teachers as adult learners based on volunteerism from an adult education perspective. It is expected to make a practical contribution to the development of educational programs for church school teachers.
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최현덕,김광연,박광일,김상헌,Park Sul-Gi,Yu Sun-Nyoung,김영우,김동섭,정경태,안순철 대한독성 유전단백체 학회 2021 Molecular & cellular toxicology Vol.17 No.1
Background Pharbitis nil (L.) Choisy (PN) is used as a traditional herb in East Asia and exhibits anti-parasitic, purgative, diuretic, anti-inflammatory, and anti-cancer activities. However, the molecular mechanisms underlying the anti-cancer activity are not well understood. Objective This study aims to elucidate the effects of reactive oxygen species (ROS), generated after treatment with the compound PN, on the induction of apoptosis and autophagy, which are pathways that underly the mechanisms of cell death and cell survival in human prostate cancer cells. Results The MTT assay and western blot analysis were used to assess the effects of compound PN on cell viability and the expression of apoptosis- and autophagy-related proteins in prostate cancer PC-3 cells. The effects of PN on apoptosis (via annexin V/propidium iodide staining), autophagy (via acridine orange staining), and ROS (via DCFH-DA staining) were investigated using flow cytometry. Compound PN induced the production of intracellular and mitochondrial ROS leading to increased apoptosis and autophagy in PC-3 cells. Interestingly, pretreatment with N-acetyl-L-cysteine (NAC), an intracellular ROS scavenger, enhanced compound PN-induced apoptosis, but reduced levels of autophagy. In contrast, pretreatment with diphenyleneiodonium (DPI), an inhibitor of mitochondrial ROS, reduced compound PN-induced apoptosis and enhanced autophagy. Inhibition of autophagy led to acceleration of apoptosis in a PN-induced ROS-dependent manner. Compound PN-induced ROS production from two different sources, an intracellular source and mitochondrial source. ROS production in these differing locations had different effects on apoptosis and autophagy. They acted either by promoting cell death or cell survival through regulating autophagy to either escape or enhance apoptotic cell death. Conclusion This crosstalk between ROS-activated signals in apoptosis and autophagy induction by PN provides new insights into the molecular mechanisms of this compound and suggests that PN may be a potential therapy for prostate cancer treatment. Background Pharbitis nil (L.) Choisy (PN) is used as a traditional herb in East Asia and exhibits anti-parasitic, purgative, diuretic, anti-inflammatory, and anti-cancer activities. However, the molecular mechanisms underlying the anti-cancer activity are not well understood. Objective This study aims to elucidate the effects of reactive oxygen species (ROS), generated after treatment with the compound PN, on the induction of apoptosis and autophagy, which are pathways that underly the mechanisms of cell death and cell survival in human prostate cancer cells. Results The MTT assay and western blot analysis were used to assess the effects of compound PN on cell viability and the expression of apoptosis- and autophagy-related proteins in prostate cancer PC-3 cells. The effects of PN on apoptosis (via annexin V/propidium iodide staining), autophagy (via acridine orange staining), and ROS (via DCFH-DA staining) were investigated using flow cytometry. Compound PN induced the production of intracellular and mitochondrial ROS leading to increased apoptosis and autophagy in PC-3 cells. Interestingly, pretreatment with N-acetyl-L-cysteine (NAC), an intracellular ROS scavenger, enhanced compound PN-induced apoptosis, but reduced levels of autophagy. In contrast, pretreatment with diphenyleneiodonium (DPI), an inhibitor of mitochondrial ROS, reduced compound PN-induced apoptosis and enhanced autophagy. Inhibition of autophagy led to acceleration of apoptosis in a PN-induced ROS-dependent manner. Compound PN-induced ROS production from two different sources, an intracellular source and mitochondrial source. ROS production in these differing locations had different effects on apoptosis and autophagy. They acted either by promoting cell death or cell survival through regulating autophagy to either escape or enhance apoptotic cell death. Conclusion This crosstalk between ROS-activated signals in apoptosis and autophagy induction by PN provides new insights into the molecular mechanisms of this compound and suggests that PN may be a potential therapy for prostate cancer treatment.
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