Silymarin과 작약감초탕 병용투여의 C57BL/6 마우스 간조직 지질축적 및 염증 억제효과

최정원,조수정,신미래,박해진,Choi, Jeong Won,Cho, Su-Jung,Shin, Mi-rae,Park, Hae-Jin 대한본초학회 2022 大韓本草學會誌 Vol.37 No.5

Objective : The aim of the present study is to examine hepatic lipid-lowering and anti-inflammatory effects of silymarin combined with Jakyakgamcho-tang on non-alcoholic fatty liver disease in a high fat diet-induced obese mice model. Methods : C57BL/6 mice were divided into four dietary groups: (1) Normal, (2) Control (60% high-fat diet), (3) Control + silymarin 50 mg/kg/day (Silymarin), (4) Control + Silymarin 50 mg/kg/day + Jakyakgamcho-tang 100 mg/kg/day (SPG). After 12 weeks administration, mice were sacrificed and lipids and inflammation-related biomarkers were analyzed liver and plasma. Results : Silymarin and SPG treatments significantly lowered body and liver weights compared to the Control. Serumlipids (triglyceride (TG), total cholesterol) and pro-inflammatory cytokines (tumor necrosis factor alpha, interleukin 1𝛽, and IL-6) concentrations were significantly lowered in the Silymarin and SPG groups than the Control group. Silymarin and SPG treatments suppressed hepatic TG level and hepatic lipid droplets compared to the Control. Theses two treatments significantly increased hepatic kinase B1 and AMP-activated protein kinase protein levels, and significantly decreased hepatic key lipogenic enzymes (acetyl-CoA carboxylase, fatty acid synthase and stearyl coenzyme A desaturase 1) protein levels than the Control. SPG also significantly increased hepatic fatty acid oxidation-related protein (peroxisome proliferator-activated receptor alpha and uncoupling protein 2) levels than the Control. Conclusions: Silymarin and SPG suppressed hepatic lipid accumulation by regulating hepatic protein expression, and lowered blood pro-inflammatory cytokines concentrations though the synergic effect of silymarin and Jakyakgamchotang was not clear.

칼시토닌 고분자 미립자 투여에 따른 골다공증 유발 쥐의 골밀도 변화

최정원(Jeong won Choi),정제순(Je soon Jung),이상건(Sang Gun Lee),백두진(Doo Jin Paik),박일규(Il Kyu Park),박용구(Yong Goo Park),김미정(Mi Jung Kim) 대한임상노인의학회 2003 대한임상노인의학회지 Vol.4 No.4

Objective: To evaluate bone protective effects of salmon calcitonin microspheres against cancellous bone loss in ovariectomized rats. Method: Thirty five osteoporosis-induced Sprague-Dawley rats were randomly divided into five groups (high dose calcitonin group (112 U/kg), low dose calcitonin group (56 U/kg), free calcitonin group, only ovariectomy group, control group). Ovariectomized rats were injected s.c. with salmon calcitonin microspheres(l12 U/kg or 56 U/kg) weekly, and free salmon calcitonin on alternate days. control rats and the remaining ovariectomized rats were injected s.c. on alternate days with saline vehicle. The effects and side effects in each group were assessed by the bone mineral density and bone histomorphomeσy. Results: 1. At four months after the ovariectomy, the bone mineral densities in high dose calcitonin group were 0.1640±0.0156 grn/㎠, the bone mineral densities in low dose calcitonin group were 0.1600±0.0114 gm/㎠, the bone mineral densities in calcitonin group were 0.1531±0.0168 gm/㎠, the bone mineral densities in ovariectomy group were 0.1404±0.0070 gm/㎠, the bone mineral densities in control group were 0.1896±0.0163 gm/㎠. The bone mineral densities of the femur in ovrariectomy groups compared with control group were decreased with time. The difference of the bone mineral densities between high and low dose calcitonin group and ovariectomy groups was significant (p<0.05). 2. We found that the bone trabeculi in bone histomophometry were more maintained in high dose calcitonin group compared with ovariectomy group. Conclusion: 1. Bone mineral densities of salmon calcitonin microsphere injected rats was higher than only ovariectomized rats in femur. 2. Bone mineral densities of salmon calcitonin microsphere injected rats had no significant differences than only ovariectomized rats in L5 vertebra. 3. In histologic examination, salmon calcitonin microsphere and free salmon calcitonin injected rats showed more prominent bony trabeculae than ovariectomized rats.

보문 : 과시적 소비성향과 콜레보레이션 패션제품 구매동기, 선택기준 및 만족도에 관한 연구

최정원 ( Jung Won Choi ),장미순 ( Mi Soon Chang ) 한국의류학회 2010 한국의류학회지 Vol.34 No.4

알랭 바디우의 예술론을 통해 본 김은숙의 작품세계

최정원(Choi, Jung won) 한국아동문학학회 2009 한국아동문학연구 Vol.- No.16

이 논문은 김은숙의 반세기 가까운 작품 활동 기간의 업적을 돌아보고 그동안 발표된 작품들을 관통하는 저자의 욕망은 무엇인지 살펴보는 것이 주목적이다. 김은숙은 환상적인 작품을 통해 主體로서의 자신을 자각하기 시작한 어린이들이 주체를 확립하는 모험을 떠나게 하고 자립적인 사람이 되도 록 이끌어주는 인도자이다. 그들이 同一視를 통해 만나는 주인공들은 상상계로의 진입을 가능하게 해 주는, 거울에 비친 완성된 자신의 모습, 대타자의 모습이다. 또 그 계기를 마련하는 소재로 꽃이 자주 등장하는데 그녀의 작품에서 나타나는 꽃은 등장인물들의 욕망의 대상이며 대타자이다. 김은숙은 바디우적 여성성의 작가이다. 그녀의 대표작들을 살펴보면 주인공들이 보다 가치 있는 무엇인가를 찾아 자신이 살던 곳을 떠난다. 이는 진리의 구도여행을 하는 바디우적 여성과 일치한다. 그들은 사건의 도래를 통해 진리를 찾아 여행을 떠나며 그들이 찾은 진리는 바디우가 주장한 하나, 둘, 무한이라는 사랑의 공식과도 일맥상통한다. 따라서 김은숙은 환타지, 우화 혹은 역사동화의 모습으로 어린이들의 눈앞에 사랑이라는 진리의 형상을 그려주려고 시도하는 바디우적 진리 전도사이다. 한 마디로 김은숙은 글쓰기를 통해 “사랑”이라는 인류의 팔루스, 바디우적 사랑을 찾아 환상의 세계로 떠나는 무한의 작가, 사랑의 작가이다. The purpose of this study is for considering Kim, Eunsooks achievements through her half-century career and her desire which holds its course. She is a pharos for children to realize themselves as a Subject and to be an independent ens by means of her works. The protagonist created by her is an ideal type for children, that is the Objet A by Lacan, which can help them to enter the imaginary. She takes use of flowers as a subject matter in her works, theysymbolize the object of Desire, namely Object A of Lacan for her Characters. Kim, Eunsook is an author faithful to the cultural theory of Badiou, that is, the one of the Feminine. Considering her works, we can find out that her protagonists wander for seeking for something eternal. They correspond to the concept, The Feminineof Badiou. After some Event arriving, they wander seeking for the truth and the truth they discover coincides that of Badiou, Love. Reading her works we find out her doctrine that we can get the state of Infinity when the One loves the One and succeeds to make the Two, as is insisted by Badiou. So, we can say that she is an evangelist of the truth, Love same as Badiou, by means of her own fantastic stories, fables or historical novels. In short, Kim, Eunsook is the author of infinity and love on a journey for the truth, as is love or infinity that Badiou has insiste d, as is the Phallus that the human race has desired.

선학초 (짚신나물) 복강주사의 항암효과 탐색 및 약물 대사효소의 변화

최정원(Jung-Won Choi),장보형(Bo-Hyung Jang),이주아(Ju-Ah Lee),고호연(Ho-Yeon Ko),정희(Hee Jung),전찬용(Chan-Yong Jun),박종형(Jong-Hyung Park),김지혜(Ji-Hye Kim),고성규(Seong-Gyu Ko),최유경(You-Kyung Choi) 대한한의학회 2009 대한한의학회지 Vol.30 No.4

재벌총수의 자신감이 소속 기업의 재무의사결정에 미치는 영향 연구

최정원(Jung-won Choi),오세경(Sekyung Oh) 한국경영학회 2017 한국경영학회 통합학술발표논문집 Vol.2017 No.08

혁신적인 경영자에게 자신감은 중요한 요소지만, 경영자의 자신감이 지나쳐 자기과신으로 이어질 경우 합리적인 기업 재무의사결정을 저해하는 요인으로 작용할 수 있다. 본 연구는 국내기업의 경우 재벌총수를 실질적인 기업의 의사결정을 수행하는 주체로 정의하고, 재벌총수의 자신감이 소속기업의 재무의사결정과 재무성과에 미치는 영향을 분석하였다. 이를 위하여 우선 재벌총수 및 기업에 대한 미디어 기사를 텍스트마이닝기법으로 분석하여 자신감을 계량화된 변수로 측정하였다. 이후 측정된 자신감 지표를 패널 모형에 설명변수로 활용하여 주요 재무지표와의 관계를 계량적으로 실증 분석하였다. 연구결과, 자신감이 높은 재벌총수는 부채 등의 자본을 추가적으로 조달하여 투자를 확대하는 적극적인 재무의사결정을 수행한다는 가설을 지지하였다. 또한 성장가치와 수익성 지표의 경우 시차를 두고 음(-)의 관계가 산출되었다. 이는 경영자의 지나친 자신감이 기업가치 및 재무성과에 악영향을 초래할 수 있음을 지지하는 결과이다. Confidence of CEO is an important factor, but over-confidence of CEO can result in adverse effects on corporate financial decision makings. The study aims to analyze the impact of CEO confidence on corporate financial decisions and financial performance in Korean Chaebols. First, we measure ‘CEO confidence’ by analyzing media articles about both CEOs and corporations of Korean Chaebols with a text mining technique. Second, we use the CEO confidence as an explanatory variable in panel regression model to analyze its effects on key financial variables. We find the results supporting the hypothesis that CEOs with higher confidence in Korean Chaebols make active financial decisions to expand investments. In addition, we find that debt ratio also rises when CEOs show a higher confidence if previous (t-1) debt level is included as an independent variable. On the other hand, we find that future value of growth opportunity (Tobin’s Q) and profitability (both are one year ahead) will deteriorate when CEOs show a higher confidence.

과학관 서비스 품질이 고객만족도 및 재방문 의도에 미치는 영향 분석

최정원(Choi, Jung won),남태우(Nam, Tae woo),조재민(Cho, Jae min) 한국전시산업융합연구원 2017 한국과학예술융합학회 Vol.27 No.-

우리나라의 과학관수는 2008년 72개에서 2016년 128개로 양적 팽창을 이루었다. 본 연구는 많은 예산을 투입하여 과학관을 건립하지만, 하루 평균 관람객 수가 50명 이하의 과학관이 1/4 이상으로 비효율적인 기관이 많다는 점에서 시작되었다. 과학관 운영의 효율성을 높이기 위해 관람객 수는 중요한 요소이다. 본 연구의 목적은 과학관 서비스 품질과 고객만족도 및 재방문 의도와의 관계를 분석하여, 더 많은 관람객을 유인하기 위해 과학관에서는 어떠한 노력을 집중해야 하는지 알아보는 것이다. 국립과천과학관의 전시, 교육, 문화 분야로 각각 설문지를 작성하여 서비스 접점별 고객을 대상으로 설문조사를 실시하였다. 그 결과를 빈도분석, 신뢰도 분석, 요인분석, 다중회귀분석 등으로 도출하였다. 연구결과 및 내용은 다음과 같다. 첫째, 전시분야에서 전시 시설물에 대한 품질은 고객만족도 및 재방문 의도에 영향을 미칠 것으로 예상했지만 유의미한 관계를 얻지 못했다. 둘째, 교육분야는 서비스 품질(운영 및 내용, 강사, 교육시설 및 환경) 모든 요소에서 고객 만족도와 재방문 의도에 영향을 미치는 것으로 결과가 도출되었다. 셋째, 문화(행사)분야에서는 문화프로그램의 질이 관람객 만족도에 영향을 미치지만 재방문 의도에는 영향을 미치지 않는 것으로 나타났다. 과학관은 과학과 예술 등의 융복합 활동이 이루어져 관람객에게 만족을 줄 수 있다. 결과를 바탕으로 향후 국립과학관 전체에 대한 융복합 연구가 진행되어 관람객 만족도와 재방문을 높일 수 있도록 노력이 필요하다. The number of science museums in Korea has expanded quantitatively from 72 in 2008 to 128 in 2016. This study started with the fact that the government puts a lot of budget into building a science museum, but there are more than one quarter of science museums with less than 50 spectators per day and many inefficient institutions. The number of visitors is an important factor in improving the efficiency of the science museum operation. The purpose of this study is to analyze the relation between the service quality of the science museum and the customer satisfaction and the intention to revisit and to find out what kind of effort should be concentrated in the science museum to attract more visitors. Questionnaires were written in the exhibition, education, and culture fields of the Gwacheon National Science Museum. The results were derived by frequency analysis, reliability analysis, factor analysis, and multiple regression analysis. The results and contents of the study are as follows. First, in the field of exhibition, the quality of exhibition facilities was expected to affect customer satisfaction and intention to return, but did not have a meaningful relationship. Second, the education sector has been found to affect customer satisfaction and return intention in all aspects of service quality (operation and contents, instructors, educational facilities and environment). Third, in the field of culture (event), the quality of the cultural program influences the visitor satisfaction, but it does not affect the intention to revisit. The science museum can provide satisfaction to visitors by combining activities such as science and arts. Despite the limitations, it is necessary to make efforts to improve the visitor satisfaction and revisit by proceeding with the convergence research on the entire National Science Museum in the future.

반려동물을 위한 스마트 종합 기기 ‘키플’ 개발에 대한 연구

최정원(Jung-Won Choi),백기협(Gi-Hyub Baek),엄희도(Hee-Do Eom),이동우(Dong-Woo Lee),신정활(Jung Hwal Shin) 대한기계학회 2019 대한기계학회 춘추학술대회 Vol.2019 No.5

정신장애를 가진 부모의 자녀(Children of Parents with a Mental Illness, COPMI)에 대한 설명 모델과 심리사회적 개입에 대한 고찰

최정원 ( Jung Won Choi ) 한국정신병리진단분류학회 2020 精神病理學 Vol.24 No.1

This review provides the mechanism of transgenerational transmission of mental disorder (TTMD), the factors involved in them, and the psychosocial interventions in the Children of Parents with a Mental Illness (COPMI). The TTMD is a combination of biological risk factors and various psychological risk factors including parent-related factors, family condition, child-related factors and social-environmental factors. Interventions in the COPMI consist of peer support programs, parent education, family intervention, professional education, and community networking. Evidence on the effectiveness of intervention programs is accumulating. Policies and researches are needed to strengthen medical and social support in Korea to reduce social losses from TTMD.

광범위한 뇌연수막 파종으로 나타난 역형성 성상세포종의 특이 발현 Temozolomide를 기초로 치료한 두 증례 보고

최정원 ( Jung Won Choi ),김인아 ( In A Kim ),최기영 ( Ghee Young Choe ),김재용 ( Chae Yong Kim ) 대한뇌종양학회·대한신경종양학회·대한소아뇌종양학회 2008 대한뇌종양학회지 Vol.7 No.2

We describe two unusual cases of diffuse leptomeningeal seeding as the initial manifestation of a subtle brain mass lesion. At first, they were misdiagnosed as tuberculous encephalitis because there was no obvious mass lesion in magnetic resonance(MR) images of the brain and the cerebrospinal fluid profile was highly suggestive of an infective process. The MR images showed only ill-defined lesions in the basal ganglia. Anaplastic astrocytomas were finally diagnosed following stereotactic brain biopsies. Whole-spine MR images from these two patients revealed diffuse leptomeningeal enhancing lesions that affected the whole spine. We planned aggressive multimodal treatment including concurrent chemoradiation therapy using temozolomide. One patient died from disease progression eight months after the initial diagnosis. The second patient was treated more aggressively. She survived for more than thirteen months after diagnosis. Biopsy and aggressive treatment must be considered in cases of ill-defined lesions with clinical manifestation indicating unusual encephalitis.