VLSI 설계와 관련된 Steiner 트리 문제에 대한 연구

최윤경 배화여자대학 1999 培花論叢 Vol.18 No.-

We consider generalized versions of Steiner's problem, motivated by the wire routing phase in physical VLSI design. A Steiner tree with maximum-weight edge minimized is called a Steiner min-max tree (SMMT) or a bottleneck Steiner tree. A rectilinear Steiner tree with minimum number of vias is called a via-minimized rectilinear Steiner tree (VRST), where via means the point at which horizontal and vertical line segments of the VRST meet. The class Steiner tree problem or the group Steiner tree problem is a generalized Steiner tree problem where we are given several subsets(classes) of vertices in a weighted graph, and the goal is to find a minimum-weight connected subgraph containing at least one vertex from each class. We survey these generalized Steiner tree problems and consider their applications in VLSI design area.

Role of Carbon Monoxide in Neurovascular Repair Processing

최윤경 한국응용약물학회 2018 Biomolecules & Therapeutics(구 응용약물학회지) Vol.26 No.2

Carbon monoxide (CO) is a gaseous molecule produced from heme by heme oxygenase (HO). Endogenous CO production occurring at low concentrations is thought to have several useful biological roles. In mammals, especially humans, a proper neurovascular unit comprising endothelial cells, pericytes, astrocytes, microglia, and neurons is essential for the homeostasis and survival of the central nervous system (CNS). In addition, the regeneration of neurovascular systems from neural stem cells and endothelial precursor cells after CNS diseases is responsible for functional repair. This review focused on the possible role of CO/HO in the neurovascular unit in terms of neurogenesis, angiogenesis, and synaptic plasticity, ultimately leading to behavioral changes in CNS diseases. CO/HO may also enhance cellular networks among endothelial cells, pericytes, astrocytes, and neural stem cells. This review highlights the therapeutic effects of CO/HO on CNS diseases involved in neurogenesis, synaptic plasticity, and angiogenesis. Moreover, the cellular mechanisms and interactions by which CO/HO are exploited for disease prevention and their therapeutic applications in traumatic brain injury, Alzheimer’s disease, and stroke are also discussed.

경계선 성격장애의 하위유형에 따른 아동기 성 피해 경험과 충동성

최윤경 한국임상심리학회 2009 Korean Journal of Clinical Psychology Vol.28 No.2

The purpose of the present study was to achieve a better understanding of the features of borderline personality disorder, especially those involving self-destructive behavior, such as self-injury, suicide attempts, and sexual deviance including promiscuity. The subjects were 31 patients with a diagnosis of borderline personality disorder. All were interviewed to assess the incidence and severity of childhood sexual abuse (CSA), and they also completed a self-report measure of impulsivity (Barratt Impulsiveness Scale). The subjects were then categorized into three groups based on the nature of their self-destructive symptoms: self-injurious or suicidal behavior (N=11), sexual deviance (N=8), and both type of symptoms (N=12). CSA was assessed to have occurred in 27.3% of the self-injury group, in 50.0% in the sexual deviance group, and in 83.3% of the mixed-symptom group. A between group comparisons was subsequently conducted using ANCOVA with gender and age as covariates. The results showed that, compared with the self-injury group, the mixed-symptom group reported more severe CSA, and the sexual deviance group perceived themselves as being more impulsive. The findings were discussed in terms of sexual revictimization and traumatic sexualization (Finkelhor & Browne, 1985). 본 연구의 목적은 경계선 성격장애의 특징, 특히 자해나 자살 시도, 성적 난잡성을 포함한 성 이탈 행동을 이해하기 위한 것이다. 이러한 목적을 위해 경계선 성격장애로 진단된 31명의 연구 참여자들에게 면담을 실시하여 아동기 성 피해 경험의 유무와 심각도를 평가하였고, Barratt 충동성 검사를 시행하였다. 연구 참여자들은 자기 파괴적 증상의 특성에 기초하여 세 집단, 즉 자해나 자살시도를 경험한 집단, 성 이탈 행동을 보이는 집단, 그리고 두 가지를 모두 보이는 복합 증상 집단으로 분류되었다. 자해/자살시도 집단(N=11)의 27.3%, 성 이탈 집단(N=8)의 50.0%, 그리고 복합 증상 집단(N=12)의 83.3%가 아동기 성 피해 경험을 보고하였다. 성별과 연령을 공변인으로 통제하여 공분산분석을 시행한 후 집단간 비교를 실시한 결과, 복합 증상 집단은 자해/자살시도 집단에 비해 아동기 성 피해가 더 심각하였고, 성 이탈을 경험한 피험자들은 자해/자살시도 집단에 비해 스스로를 더 충동적인 것으로 지각하였다. 이러한 결과는 성적 재희생화와 외상적 성애화(Finkelhor & Browne, 1985)의 측면에서 논의되었다.

한국인의 반복자연유산 환자에서 Thymidylate Synthase Enhancer Region (TSER) 돌연변이형의 혈중 호모시스테인 양과의 관련성

최윤경,강명서,김남근,김선희,최동희,안명옥,이수만,Choi, Yoon-Kyung,Kang, Myung-Seo,Kim, Nam-Keun,Kim, Sun-Hee,Choi, Dong-Hee,An, Myung-Ok,Lee, Su-Man 대한생식의학회 2004 Clinical and Experimental Reproductive Medicine Vol.31 No.3

Objectives: Methylenetetrahydrofolate reductase (MTHFR) mutation are commonly associated with hyperhomocysteinemia, and through their defects in homocysteine metabolism, they have been implicated as a risk factor for recurrent spontaneous abortion. Recent report describe that 28-bp tandem repeat polymorphism in thymidylate synthase enhancer region (TSER) that influence enzyme activity would affect plasma homocysteine level. We have investigated the relationship between TSER genotype and plasma homocysteine level in 54 patients with recurrent spontaneous abortion. Methods: Plasma homocysteine level was measured by fluorescent polarizing immunoassay. MTHFR mutation (C677T and A1298C) was identified by PCR-restriction fragment length polymorphism assay and TSER mutation was analyzed by PCR method. The data were analyzed using the program SAS 8.2 for Windows. Results: Total homocysteine level was significantly higher in MTHFR 677TT genotype ($9.80{\pm}3.87{\mu}mol/L$) than MTHFR 677CC genotype ($8.14{\pm}1.74{\mu}mol/L$) in Korean patients with unexplained recurrent spontaneous abortion (p=0.0143). However, the plasma homocysteine level was not significantly different in the MTHFR 1298AA ($8.42{\pm}2.65{\mu}mol/L$) and 1298CC ($6.09{\pm}0.32{\mu}mol/L$; p=0.2058) and, TSER 2R2R ($8.61{\pm}1.68{\mu}mol/L$) and 3R3R ($8.05{\pm}2.81{\mu}mol/L$; p=0.9319) mutant genotypes, respectively. In this study, we found the combination effects of TSER and MTHFR C677T genotypes. Plasma homocysteine levels were the highest ($11.47{\pm}4.66{\mu}mol/L$) in individuals with TSER 3R3R ($8.05{\pm}2.81{\mu}mol/L$) and MTHFR 677TT ($9.80{\pm}3.87{\mu}mol/L$) genotypes. Individuals with a combination of both TSER 2R2R/2R3R and MTHFR 677CC/CT genotypes ($7.69{\pm}1.77{\mu}mol/L$) had lower plasma homocysteine levels than TSER 2R2R ($8.61{\pm}1.68{\mu}mol/L$) and MTHR 677CC ($8.14{\pm}1.74{\mu}mol/L$) genotypes, respectively. The effect of MTHFR polymorphism in the homocysteine metabolism appears to be stronger than that of TSER polymorphism. Conclusion: Although statistically not significant, we found the elevated level of plasma homocysteine in combined genotypes with TSER and MTHFR (C677T and A1298C) in Korean patients with unexplained habitual abortion. In this study, we reported the possibility that TSER polymorphism is a genetic determinant of plasma homocysteine levels in the Korean patients as well as MTHFR C677T polymorphism. A large prospective study is needed to verify our findings.

주름의 형상으로 본 말라르메의 "책"

최윤경 韓國佛語佛文學會 2004 佛語佛文學硏究 Vol.0 No.59

중국어 읽기 과제가 기억전략 및 인지전략에 미치는 영향

최윤경 한국중국어교육학회 2015 한국중국어교육학회 학술대회 Vol.2015 No.04

트라우마 초점의 인터넷 기반 인지행동치료 개발을 위한 제언

최윤경 한국융합학회 2020 한국융합학회논문지 Vol.11 No.12

트라우마 초점의 인터넷 기반 인지행동치료(internet-based cognitive-behavioral therapy with a trauma focus: iCBT-T)의 개발 및 효과 검증 연구가 서구에서 활발하게 진행되고 있는 것에 비해, 한국 사회에서는 관련 연구 가 최근에야 시작되었다. 본 연구의 목적은 iCBT-T 프로그램 개발과 운영의 고려사항을 제안하는 것이다. 먼저, iCBT-T와 관련된 선행 연구를 고찰한 후, iCBT-T 프로그램을 개발하기 위해 정신건강 지식과 ICT 기술을 융합하는 모형을 제시하였다. 그런 다음, iCBT-T의 초점과 표적 집단, 개입의 유형(오픈 액세스 vs. 안내형), 회기 수, 윤리적 이슈, 전문적 지원 및 이용자의 참여를 포함한 실질적 고려사항을 다루고, iCBT-T에서 인터넷 매체의 한계를 보완하기 위한 방법들을 제안하였다. 트라우마 초점의 인지행동치료와 ICT 기술의 융합 모델이 트라우마 사건을 경험한 많은 이용자들의 정신건강의 향상에 기여할 수 있는 프로그램 개발을 촉진하기를 기대한다. Research on the development and effectiveness of internet-based cognitive-behavioral therapy with a trauma focus (iCBT-T) has been actively conducted in Western societies, but these studies have just begun in Korea. The purpose of this study was to suggest practical considerations to developing and managing the iCBT-T program. After reviewing previous studies on iCBT-T, this author suggested a model of convergence and collaboration between mental health knowledge and information and communication technologies (ICT) to develop the iCBT-T program. This article outlines practical considerations, including focus and target groups of iCBT-T, intervention types of iCBT-T (open access vs. guided), number of sessions, ethical issues, professional support, and degree of user involvement. Methods to complement the limitations of internet as a medium are also proposed in the iCBT-T program. The convergence model of CBT-T and ICT is expected to promote the development of programs that can contribute to improving the mental health of users who experience traumatic events.

음악 수업 설계에서 백워드 모형의 적용

최윤경,강현석 한국교육과정평가원 2008 교육과정평가연구 Vol.11 No.2

Recently, educational policies are presented to grasp the precise reality of regular schooling and to improve the achievement of students. The Ministry of Education Science and Technology demands accountability from each school to improve achievement of students through the opening of achievement after 2010. Since serious problems were raised in US at 1950, the educational system has been continuously reformed. It is important to verify whether the achievement of student reaches the requirement of a nation or a region to improve the achievement of students. Bellwethers of the US educational reform campaign, McTighe and Wiggins, have come into a spotlight since they proposed backward design. In backward design evaluation for verification of the achievement of students is seriously considered. As music curriculum is continuously reformed, evaluation becomes more important and a plan for evaluation-oriented class is asserted. In this study, backward design which firstly considers evaluation is applied to music class. For this study, each step of the template UbD for backward design and the necessity of backward design for music education is studied. Finally, music class is designed using UbD and then suggestion of backward design for music education is presented. 교육과학기술부에서는 2010년부터 학교별 학업성취도 결과를 공개함으로써 학생들의 학력 향상을 위해 각 학교에 책무성을 요구하고 있다. 1980년대 이후 미국에서도 학생들의 학력 저하가 심각한 문제점으로 제기되면서 교육 개혁 운동이 지속적으로 이루어지고 있다. 학생들의 학력을 향상시키기 위해서는 국가나 지역이 요구하는 성취 기준에 학생들이 얼마나 도달하였는지의 여부를 확인하는 것이 관건이다. 미국 교육 개혁 운동의 선두자 중의 두 사람인 McTighe와 Wiggins는 학생들이 성취 기준에 도달하였는지를 확인하기 위해 평가를 중요하게 고려하는 백워드 모형(backward design)을 구안함으로써 크게 주목을 받고 있다. 음악교육에서도 교육과정에 제시된 음악 성취 기준에 대한 학생들의 성취 수준이 낮다는 문제점이 제기되고 있고 음악교육 평가 방식 개선에 대한 논의가 활발하다. 학생들의 음악 성취 수준을 높이기 위해서는 음악과 교육과정에 제시된 성취 기준이 음악 수업에 직접적으로 반영되어야 하고, 학생들이 성취 기준에 도달하였는지를 확인하기 위한 평가가 중요하게 고려되어야 한다. 이에 본 연구에서는 수업 설계에서 성취 기준에의 도달과 그 여부를 확인하기 위해 평가를 중요하게 고려하고 있는 백워드 모형을 음악 수업 설계에 적용하였다. 이를 위해 백워드 모형 설계의 템플릿인 UbD의 각 단계와 음악교육에서 백워드 모형의 필요성을 고찰하였다. 그리고 UbD를 적용하여 음악 수업을 설계한 후 백워드 모형이 음악교육에 주는 시사점을 제시하였다.

고추 잎에 처리된 농약의 내우성

최윤경,유주현,임희경,전재철,조광연 한국토양비료학회 2001 한국토양비료학회 학술발표회 초록집 Vol.2001 No.5

제1회 간호현장 에피소드공모전 최우수상수상작-약속

최윤경,Choe, Yun-Gyeong 대한간호협회 2007 대한간호 Vol.46 No.3