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Leukocytes as a Prognostic Factor for Patients with Pulmonary Embolism
최원일,조준연,최원일,권용식,이진욱,전영준 대한결핵 및 호흡기학회 2012 대한결핵 및 호흡기학회 추계학술대회 초록집 Vol.114 No.-
Background: Hemodynamic status and cardiac function are major pulmonary embolism (PE) prognostic factors. Although inflammation is considered a risk factor for deep vein thrombosis, the prognostic significance of the systemic inflammatory response syndrome (SIRS) and leukocytosis has not been well studied. Objective: This study evaluates PE prognostic factors, including SIRS and leukocytes. Patients/Methods: This retrospective cohort study included 667 PE patients. Risk evaluation included SIRS and leukocytosis. A prediction model was developed based on independent predictors of 30-day mortality. Results and Conclusions: Fifty-seven patients (8.5%) died within 30 days. Multivariate analysis showed that SIRS satisfying the WBC criteria (odds ratio [OR], 3.4; 95% confidence interval [CI], 1.6-7.1), altered mental status (OR, 2.9; 95% CI, 1.2-7.4), and right-to-left ventricle diameter ratio (OR, 2.0; 95% CI, 1.1-3.7) were associated with 30-day mortality. SIRS criteria including body temperature (OR, 4.6; 95% CI, 1.4-14.8), heart rate (OR, 2.0; 95% CI, 1.1-3.6), respiratory rate (OR, 2.5; 95% CI, 1.4-4.6), and WBC count (OR, 1.9; 95% CI, 1.2-3.5) predicted short-term mortality in PE. The area under the receiver operating characteristic curve for the prognostic model`s prediction performance was 0.76 (95% CI, 0.66-0.85), and for pulmonary embolism severity index (PESI) and PESI + WBC count were 0.72 (95% CI, 0.68-0.75) and 0.76 (95% CI, 0.72-0.79, P<0.01 versus PESI), respectively. Leukocytoes and SIRS are important factors in determining short-term outcomes.
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최원일,Yoon Jae-Hyun,Choi Seo-Hyun,Jeon Bu-Nam,Kim Hail,Hur Man-Wook 생화학분자생물학회 2021 Experimental and molecular medicine Vol.53 No.-
Zbtb7c is a proto-oncoprotein that controls the cell cycle and glucose, glutamate, and lipid metabolism. Zbtb7c expression is increased in the liver and white adipose tissues of aging or high-fat diet-fed mice. Knockout or knockdown of Zbtb7c gene expression inhibits the adipocyte differentiation of 3T3-L1 cells and decreases adipose tissue mass in aging mice. We found that Zbtb7c was a potent transcriptional repressor of SIRT1 and that SIRT1 was derepressed in various tissues of Zbtb7c -KO mice. Mechanistically, Zbtb7c interacted with p53 and bound to the proximal promoter p53RE1 and p53RE2 to repress the SIRT1 gene, in which p53RE2 was particularly critical. Zbtb7c induced p53 to interact with the corepressor mSin3A-HADC1 complex at p53RE. By repressing the SIRT1 gene, Zbtb7c increased the acetylation of Pgc-1α and Pparγ, which resulted in repression or activation of Pgc-1α or Pparγ target genes involved in lipid metabolism. Our study provides a molecular target that can overexpress SIRT1 protein in the liver, pancreas, and adipose tissues, which can be beneficial in the treatment of diabetes, obesity, longevity, etc.
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A Study on the Community of Xylophagous Beetles in Korean White Pine, Pinus koraiensis, Forests
최원일,김경민,고상현,남영우,Choi, Won IL,Kim, Kyung-Min,Koh, Sang-Hyun,Nam, Youngwoo Korean Society of Applied Entomology 2017 한국응용곤충학회지 Vol.56 No.1
2007년에 잣나무림에서 하늘소과, 바구미과, 나무좀아과에 속하는 천공성 딱정벌레 군집을 말레이즈 트랩을 활용하여 조사하였다. 하늘소류 15종 184 개체, 바구미류 17종 185개체, 6종 1,246개체의 총 1,615개체 천공성 딱정벌레가 채집되었고 우점종은 왕녹나무좀이었다. 개체수에 따라 순위를 매겼을 때, 잣나무림에서 천공성 해충과 나무좀류 군집은 나무좀아과의 한 종에 의해 우점되어 생물다양성이 낮은 것으로 나타났다. 잣나무림에서 간벌은 나무좀과 암브로시아좀류의 풍부도에 영향을 미쳐 특정 임분에서의 개체군들은 간벌 1년 후 밀도가 증가했으나 그 후 감소하였다. The community of xylophagous beetles belonging to Cerambycidae, Curculionidae and Scolytinae in Korean white pine, Pinus koraiensis Siebold & Zuccarini, forests was surveyed using Malaise traps in 2007. A total of 1,615 xylophagous beetles were collected, including 184 cerambycids from 15 species, 185 curculionids from 17 species, and 1,246 scolytid beetles from 6 species, of which the dominant species was the ambrosia beetle Xyleborus mutilatus Blandford. Ranked by order of population size, the wood-boring and bark beetle community in Korean white pine showed high dominance by one species of Scolytinae, suggesting the community had low biological diversity. Thinning in Korean white pine forests influenced on the abundance of bark and ambrosia beetles, whose populations in particular stands increased 1 year after thinning, and then decreased the following year.
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최원일,김상조 기술경영경제학회 1998 Journal of Technology Innovation Vol.6 No.1
A continuous development of new products is the lifeblood for firms that hope to maintain competency in competitive environments. Ongoing success in these environments is dependent on whether the management can choose or can't chose the proper mix of new product development strategy, new product development process, and organizational structure. Rather than considering the interrelationship among these success factors, however, most previous studies of new products development have examined these issues individually. Moreover, because past research has been unidimensional in nature, there is a lack of knowledge about how new product development strategy, process, and structure could be linked up each other. Consequently, we have no complete perspective of the linkage among new product development strategy, process, structure, and performance. The purpose of this study is to examine the new product development strategy, process, and structure of firms, and explore the effect of each on performance as well as linkage among strategy, process, strategy and structure.
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MBA(Muscat Bailey A) 와인의 오크통 숙성에 따른 품질 특성
최원일,박정미,박혜진,Choi, Wonil,Park, Jung-Mi,Park, Hyejin 한국식품영양학회 2021 韓國食品營養學會誌 Vol.34 No.1
This study was conducted in order to investigate the quality characteristics of MBA wine resulting from treatment with different oak barrel maturation methods. This study focused on the maturation of wine in five different types of barrels, including a stainless-steel maturation barrel, a foreign medium-toasted oak barrel, and domestic light, medium and heavy toasted oak barrels, and looked at the resulting differences in quality characteristics between the wines. All oak barrels used for this study had a capacity of 100 liters. The results of the study revealed that the pH content increased by up to 3.86~3.93% after 9 months, and then decreased after this point. The total anthocyanin content increased up to 152.52~174.95 mg/L during a 6 month maturation period, and thereafter began decreasing in concentration, with overall anthocyanin levels tending to be higher after maturation in foreign oak barrels. Overall, functional elements tended to measure higher after maturation in foreign oak barrels as opposed to maturation in domestic oak barrels. Therefore, these results indicate that it is necessary to improve the production of domestic oak barrels in the future in order to reliably produce wines with higher levels of functional elements.
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골수기질세포와 진피섬유모세포의 이식이 교원질 합성에 미치는 영향
최원일,한승규,이병일,김우경 대한성형외과학회 2007 Archives of Plastic Surgery Vol.34 No.2
Purpose: In the previous in vitro studies the bone marrow stromal cells(BSCs) have shown the superior effect for wound healing activity than fibroblasts, which includes cell proliferation, type I collagen synthesis, and the production of bFGF, VEGF and TGF-β in chronic wound healing. The aim of this study is to compare the effects of BSCs and fibroblasts on wound healing activity in vivo, especially on collagen synthesis.Methods: The fibroblasts and BSCs were harvested from patients and cultured. The cultured cells were infiltrated into the pores of polyethylene discs. These discs were divided into three groups according to the mixed cells. In groups I, II and III the discs were loaded with no cells, fibroblasts and BSCs, respectively. Twelve discs per group(total 36 discs) were made for this study. After creating 6 pockets in the back of each rats, each discs was implanted into each pockets. At three time intervals from 1 to 3 weeks, the implanted discs were harvested for the histological and quantitative analysis. The amount of collagen produced was evaluated using ELISA. Statistical comparisons were made using the Mann-Whitney U-test.Results: There was great difference in the collagen synthesis among the three groups by the 1st and 2nd weeks. The BSC group showed highest collagen level, followed by fibroblast group and no cell group(p<0.05). The 3rd week specimens also showed greater collagen amount in BSC and fibroblast groups compared to those of no cell group(p<0.05). However, there was little difference between BSC and fibroblast groups.Conclusion: This result demonstrates that BSC has superior effect on stimulating wound healing than fibroblast, which is currently used for wound healing.
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