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Piperlongumine 유도체 합성과 Aflatoxin B1 생성 억제 효과
이성은 ( Lee Seong Eun ),최원식 ( Choe Won Sig ),이현상 ( Lee Hyeon Sang ),이영행 ( Lee Yeong Haeng ),박병수 ( Park Byeong Su ) 한국응용생명화학회 2003 Applied Biological Chemistry (Appl Biol Chem) Vol.46 No.4
Anti-aflatoxigenic studies on synthetic pyridione alkaloids were conducted. Seven derivatives uring piperlongumine as a leading compound were prepared from 3,4,5-trimethoxycinnamic acid (TMCA). These derivatives were analyzed for their structural confrmation and purity by HPLC, GC, GCMS and ³H-NMR. 1-pjperidin-1-yl-3-(3,4,5-trimethoxyphenyl)propenone (1) reaction with piperidine: 1-morpholin-4-yl-3-(3,4,5-trimethoypenyl)propenone (2) with morpholine ; 1-(3,5-dimethylpiperidin-1-yl)-3-(3,4,5-trimethoxyphenyl)propenone (3) with 3,5-dimethylpiperdine; 1-(2-methylpiperidine-1-yl)-3-(3,4,5-trimethoxyphenyl)propenone (4) with 2-methylpiperidine ; 1- (3-hydroxypiperidin-1-yl )-3-(3,4,5-trimethoxyphenyl)propenone (5) with 3-hydroxypiperidine hydrochloride; 1-[3-(3,4,5-trimethoxyphenyl)acryloyl]piperidin-2-one (6) with δ-valerolactam; and ethyl 1-[3-(3,4,5-trimethoxyphenyl)acyloyl]piperidine-4-carboxylate (7) with ethyl isonipectotate were synthesized respectively. All derivatives showed an inhibitory activity on aflatoxin B₁ production. In conclusion, we believe that they might be an agent for the control of mycotoxin in agricultural commodities.