http://chineseinput.net/에서 pinyin(병음)방식으로 중국어를 변환할 수 있습니다.
변환된 중국어를 복사하여 사용하시면 됩니다.
Oxytetracycline/Tiamulin 복합제제의 병원성 미생물에 대한 항균작용과 돼지에서의 약물동태학적 연구
박승춘,윤효인,허원,최양웅,이원준,오태광 충남대학교 대학원 1994 論文集 Vol.14 No.-
The study was carried out to characterize the pharmacokinetic values after intravenous (iv, 20 mg/kg) and oral (po, 100 mg/kg) administration as mixture Oxytetracycline (OTC)/Tiamulin (TIA)in healthy pigs and to determine interaction between OTC and TIA against pig pathogenic bacteria. The results obtained through the experiment were summarized as follows: 1. The antibacterial effects of a combination of TIA and oxytetracycline OTC in vitro against Klebsiella pneumonia, Bordetella bronchoseptica, pasteurella multocida A, pasteurella multocida D,Actinobacillus pneumonia 2 type, Actinobacillus pnenmonia 5 type, Salmonella typhimurium,staphylococcus aureus were examined. There was a marked synergism between the two antibiotics against the test pathogenic organisms. 2. The pharmacokinetic profiles of OTC and TIA were best described with a two compartment open model (OTCl :C=11.93^e-0.76 t+4.446 ^e-0.09 t, TIA: C=27.97e^-2.06t +8.10e ^0.2t). 3. Following (20mg/kg, OTC/TIA) administration, a rapid distribution (OTC: t_(1/2)a 0.91±0.071, TIA:0.45±0.23) was predominant, and then more slow elimination phase ensued (t_(1/2)B, OTC:6.90±1.22시간 , TIA: 3.74±1.21). Other pharmacokinetic parameters calculated by computer programe were as follows ; [CI:170 ml/kg/h(OTC), 180 ml/kg/h(TIA)], [AUC:59.5 mg.h/L(OTC), 53.02 mg.h/L(TIA)]. 4. After po 100 mg/kg administration, the pharmacokinetic model was confirmed to two compartment open model the absorption was very rapid[K_10(h):0.33± 0.01(OTC), 0.26±0.056(TIA)] followed by a biexponential fashion. The time of peak blood level was calculated [Tmax 1.54±0.02 h (OTC), 4.22±0.14 h (TIA)].The peak levels (Cmax) at corresponding time were 4.10±0.01 ug/ml (OTC), 27.12±0.13 ug/m (TIA), respectively.
ICR계 마우스에서 Enrofloxacin과 Colistin 복합체의 단회 경구 및 정맥투여시 급성독성
김민규,박승춘,윤효인,오태광,최양웅,Kim, Min-Kyu,Park, Seung-Chun,Yun, Hyo-In,Oh, Tae-Kwang,Choi, Yang-Woong 한국독성학회 1998 Toxicological Research Vol.14 No.3
The study was carried out to evaluate the acute toxicity of enrofloxacin-colistin combination via a single oral(p.o.)and intravenous(i.v.) administration in ICR mice. All procedures of the test were performed by the established regulation of Korean National Institute of Safety Research (1994. 4.14). The maximal dose of oral and intravenous routes was 5,000mg/kg and 90mg/kg, consisting with each 6 groups including control of male and female, respectively. As the results, $LD_{50}$m}'s of the combinations showed 3,075mg/kg (f)and 2,564mg/kg(m) after oral administrations, together with 48mg/kg(f) and 40mg/kg(m) after intravenous administration. These facts indicated that acute toxicitiy of enrofloxacin-colistin combination were different depending on the administration routes and sexes in ICR mice. In conclusion, the route of enrofloxacin-colistin combination must not choose as i.v. route administration in terms of acute toxicity based on $LD_{50}$.
Enrofloxacin과 colistin의 복합제(Enroco)의 아급성 독성시험
윤효인,김민규,박승춘,장범수,이내경,최양웅 충남대학교 수의과대학 동물의과학연구소 1997 動物醫科學硏究誌 Vol.5 No.-
The study was carried out to evaluate toxicity of enrofloxacin and colistin complex (Enroco) with a dose of 10 ㎎/㎏/day, 20 ㎎/㎏/day and 40 ㎎/㎏/day via oral administration for 3 weeks in ICR mice. All procedures of the test were performed by the established regulation of Korean National Institute of Safety Research (1994. 4. 14). Appearance, behavior, mortality and food consumption of treated groups were not affected during the experimental periods. No significant does-related changes of the combined antibacterials were found in urinalysis, eye examination, hematology, serum chemistry, and organ weight. No histopathological lesions were observed in both control and treatment groups. Our results strongly suggested that no toxic changes were found in mice treated orally with enrofloxacin-colistin complex for 3 weeks.
옥수수 - 대두박 사료내 미생물 Phytase 의 첨가가 브로일러의 생산능력에 미치는 영향
손광수,권관,권찬호,장재익,주종철,유문일,최양웅 한국축산학회 1999 한국축산학회지 Vol.41 No.5
This experiment was conducted to evaluate the effects of a domestic phytase originated from bacterial source on performance of starter and Bower broiler chicks. It was basically designed to meet NRC requirement for the contents of calcium and phosphorus when the contents of Ca and P in the feeds were met to 100%(Control; C) and 80%(P0) of the NRC requirement. Three different bacterial phytase(0, 300, 500PU) were supplemented to basal diet and compared it's effect on growth performance, nutritional digestibility, fecal N and P excretion, tibial Ca and P content. A total 200 broiler chicks were assigned to 4 treatments with 5 replications per treatment, 10 chicks of each replication. The weight gain(1,581.6g) in control treatment(C) was slightly higher than that of P0(1,557.7g). Although phytase treatments(P300 and P500) tended to show higher weight gain as compared to treatments without phytase, there were no significant differences among the treatments. No differences were observed among dietary treatments for feed efficiency although broiler chicks fed control diet (1.94) tended to show slightly better feed efficiency than those fed P0 diet(1.99). The excretion of P per kg weight gain tended to be decreased by 17% when 300PU of bacterial phytase was fed to starter and by 10% when 500PU was fed to Bower. However, there were no statistical significances among the treatments. It was concluded that the addition of phytase had neither affects in improving of utilization efficiencies of dry matter, crude protein, and crude fat, nor efficiencies of Ca and P. The supplemental of phytase at the level of 500 ppm for both stages of broiler chick diets was assumed to appropriate.