Combined chemotherapy and intra-arterial chemotherapy of retinoblastoma

최새롬,한정우,김효선,김범식,김동준,이성철,유철주 대한소아청소년과학회 2013 Clinical and Experimental Pediatrics (CEP) Vol.56 No.6

Purpose: Retinoblastoma (RB) is the most common primary malignant intraocular tumor in children. Although systemic chemotherapy has been the primary treatment, intra-arterial chemotherapy (IAC)represents a new treatment option. Here, we performed alternate systemic chemotherapy and IAC and retrospectively reviewed the efficacy and safety of this approach. Methods: Patients diagnosed with intraocular RB between January 2000 and December 2011 at Severance Children’s Hospital, Yonsei University, were reviewed. Before February 2010, the primary treatment for RB was chemotherapy (non-IAC/CTX). Since February 2010, the primary treatment for RB has been IAC (IAC/CTX). External beam radiotherapy or high-dose chemotherapy were used as “last resort” treatments just prior to enucleation at the time of progression or recurrence during primary treatment. Enucleation-free survival (EFS) and progression-free survival were assessed. Results: We examined 19 patients (median age, 11.9 months; range, 1.4 to 75.6 months) with a sum of 25eyes, of which, 60.0% were at advanced Reese Ellsworth (RE) stages. The enucleation rate was 33.3%at early RE stages and 81.8% at advanced RE stages (P =0.028). At 36 months, EFS was significantly higher in the IAC/CTX group than in the non-IAC/CTX group (100% vs. 40.0%, P=0.016). All 5 patients treated with IAC achieved eye preservation, although most patients were at advanced RE stages (IV–V). Conclusion: Despite the limitation of a small sample size, our work shows that an alternative combined approach using IAC and CTX may be safe and effective for eye preservation in advanced RB.

궤양성 대장염의 한약치료에 대한 국내 연구동향 분석 - 오아시스 검색을 중심으로

최새롬,이지윤,박상민,신재욱,백지훈,이민주,이은지 대한한방내과학회 2023 大韓韓方內科學會誌 Vol.44 No.6

Objectives: This study analyzes domestic research trends on herbal medicine treatments for ulcerative colitis (UC) by examining 28 selected domestic papers using the Oriental Medicine Advanced Searching System (OASIS) as the main search source. Methods: A total of 28 domestic papers were selected on the OASIS platform as the main search source using the keywords “(궤양성 대장염) or (궤양성 대장병)" and “(한약) or (한의학)”. Results: There were 11 case report studies and 17 case-control studies published from 2002 to 2022. All the case-control studies only dealt with mice and did not include human subjects. The most common pathologies were damp heat and Changpung. Hwangryunhaedok-tang was the most frequently prescribed herbal formula, and Coptidis Rhizoma was the most commonly used herb across all studies. The results showed that many studies demonstrated the significant effects of herbal treatment. Conclusion: Herbal medicine may exhibit therapeutic effects on various aspects of UC. However, evidence-based studies, such as clinical trials involving human subjects, are needed.

Proton-Pump Inhibitor-Induced Hypocalcemia and Hypomagnesemia

최새롬,변정희,권아름,김예진,김용혁,채현욱,김호성 대한소아내분비학회 2012 Annals of Pediatirc Endocrinology & Metabolism Vol.17 No.4

A 7-day-old female neonate who visited emergency depar tment due to generalized tonic seizure. Laboratory test results showed hypocalcemia (5.7 mg/dL),hypomagnesemia (0.55 mmol/L), low parathyroid hormone (7.5 pg/mL), and normal 25(OH) vitamin D3. Symptom and metabolic abnormalities were normalized with intravenous calcium gluconate and magnesium sulfate. Discharged with supplement of oral calcium, vitamin D, phenobarbital, and lansoprazol, she was re-admitted with hypocalcemia (4.8 mg/dL) with normal level of parathyroid hormone (12.3 pg/mL). Hypocalcemia was resolved with discontinuation of proton pump inhibitor. We report a case of recurrent hypocalcemia and hypomagnesemia due to proton-pump inhibitor.

Changes in Cytomegalovirus Seroprevalence in Korea for 21 Years: a Single Center Study

최새롬,KyungRanKim,Dong Sub Kim,강지만,Sun Ja Kim,Jong Min Kim,Soo-young Oh,Choel-In Kang,Doo Ryeon Chung,Kyong Ran Peck,Eun-Suk Kang,김예진 대한소아감염학회 2018 Pediatric Infection and Vaccine Vol.25 No.3

Purpose: Cytomegalovirus (CMV) infection is mostly asymptomatic but can be detrimental to certain hosts. We investigated changes of CMV seroprevalence in Koreans before and after the year 2000. Methods: We reviewed laboratory values of patients who were tested for CMV immunoglobulin G (IgG) at Samsung Medical Center, Seoul, Korea, from January 1995 to December 2015. Changes in seroprevalence were analyzed by gender, age, region, and tested year period (period 1, 1995–2005 vs. period 2, 2006–2015). Results: Overall CMV seropositivity was 94.1% (10,900/11,584). There was no significant difference for CMV seropositivity among the two periods (94.2% vs. 94.1%) ( P =0.862). CMV seropositivity in the 11 to 20-year age group in period 2 (78.8%) was significantly lower than that of period 1 (89.9%) ( P =0.001). The seropositivity of individuals aged 31–40 years (97.4%) was significantly higher than that of younger age groups ( P <0.001) and lower than that of older age groups ( P <0.001). Of 2,441 females of reproductive age (from 15 to 49), CMV seropositivity was 97% (2,467/2,441). The seropositivity in women aged 20–24-years was higher than that of men in the same age group (97.6% vs. 85.6%, P =0.003). No significant difference was observed among different regions. Conclusions: Overall CMV seropositivity of Koreans was estimated to be 94% and the average seropositivity of reproductive women was 97%. Monitoring of the changes in seroprevalence including the reproductive age group is needed in the future.

장애 특성과 정도에 따른 보완·대체 의사소통 도구 사용자 인터페이스의 구성요소 및 관리

최새롬(Saerom Choi),홍기형(Ki-Hyung Hong),박기태(Kitae Bak) 한국HCI학회 2012 한국HCI학회 학술대회 Vol.2012 No.1

의사소통 요구를 충족시키는데 도움을 주는 보완·대체 의사소통(Augmentative and Alternative Communication, 이하 AAC) 도구를 필요로 하는 장애인구가 점점 증가하고 다양해지는 현대 사회에서 장애의 특성과 정도에 맞추어 개별적으로 사용하기 위해서는 맞춤형 사용자 인터페이스(User Interface, 이하 UI)와 컨텐츠가 필요하다. 본 논문에서는 맞춤형 AAC 도구의 인터페이스에 필요한 구성요소와 관리방안에 대해 제안하였다. With the increased population using Augmentative and Alternative Communication(AAC) devices to meet communication needs and diverse characteristics of modern society, it is necessary to provide the efficient way to customize user interface(UI) and contents according to individual's disability characteristics and levels of severity. This study suggests basic components for customized AAC UI and their management strategies.

의료기관 간호사에 대한 수혈관련 교육 시행 효과 분석

임진숙,최새롬,송치은,박유미,임영애,김준년,권계철 대한수혈학회 2020 大韓輸血學會誌 Vol.31 No.3

Background: Nurses play a central role in the process of blood transfusion because they have the closest interactions with patients. Providing nurses with the appropriate knowledge and competency through education can help ensure transfusion safety. This study investigated the effectiveness of the first nationwide transfusion-related education for nurses by analyzing questionnaires for a self-assessment of competency on transfusion-related knowledge before and after the education and general evaluation for the educational program. Methods: The education program was composed of four lectures and was conducted in seven regions in South Korea. One hundred and ninety-two nurses participated, and the questionnaires for 170 nurses were analyzed. Results: The participants consisted of 90 nurses (53.0%) from tertiary hospitals, 23 (13.5%) from general hospitals, and 57 (33.5%) from other hospitals. The majority of the participants (103/170, 60.6%) were from hospitals with ≥500 beds, and 69.4% had a work period of ≥10 years. The scores for pre-/post-education self-assessment of competency were as follows: blood components, 3.03/3.73; pretransfusion testing, 2.86/3.64; management of transfusion, 3.18/3.84; and transfusion reactions, 3.11/3.78. In all categories, there was a significant increase in the score after the education program. The majority of participants (99.4%) provided a positive response regarding the necessity of a transfusion-related education program. Conclusion: South Korea’s first attempt at transfusion-related education for nurses showed a strong positive effect by improving participants’ transfusion-related competency. Considering the important role of nurses in blood transfusion, the educational program should continue and be expanded in the future. (Korean J Blood Transfus 2020;31:222-229)

Effect of Sodium Citrate on Growth of Bacteria in Blood Culture

이동현,고은하,최새롬,김선주,김동훈,이남용 대한임상미생물학회 2013 Annals of clinical microbiology Vol.16 No.4

Background: This study compared the growth of Staphylococcus aureus, Escherichia coli, Pseudomonas aeruginosa, Streptococcus pneumoniae, and Haemophilus influenzae in blood culture bottles containing anticoagulants, sodium polyanethol sulfonate (SPS)and sodium citrate. Methods: One hundred and fifty colony forming units of five different bacterial species were inoculated into standard aerobic (SA) and standard anaerobic (SN)bottles and were combined with 5 mL of human blood in solution with SPS or sodium citrate. Time to detection (TTD) was then monitored using the BacT/Alert 3D system (bioMerieux Inc.). Results: Compared to the bacteria-only controls, cultures containing S. aureus, E. coli, P. aeruginosa,and S. pneumoniae plus SPS blood or citrated blood trended toward reduced TTD in both SA and SN bottles;however, there was no significant difference in TTD between SPS and sodium citrate anticoagulant. Although H. influenzae showed a remarkable difference in TTD between SPS (SA 14.8 h, SN 15.0 h)and sodium citrate (SA 23.5 h, SN 18.3 h), this difference was not statistically significant (P=0.10). Conclusion: Addition of blood enhanced growth of bacteria. All experimental bacteria except H. influenzae showed similar TTD in SPS blood and citrated blood. These results support the usefulness of sodium citrate anticoagulant for artificial inoculation in blood culture bottles.

Measurement of Shear Strength according to Shear Height of the Electro-Plated Sn and SnAg Micro Bump

나창연,전병민,최새롬,박화선,조성민,김종욱,정운석 한국표면공학회 2021 한국표면공학회 학술발표회 초록집 Vol.2021 No.12

Bronchiectasis and Recurrent Respiratory Infections with a De Novo STAT1 Gain-of-Function Variant: First Case in Korea

허희재,전병우,최새롬,김예진,윤선애,Eliel Nham,공태환,기창석,고원중 연세대학교의과대학 2018 Yonsei medical journal Vol.59 No.8

Bronchiectasis is a chronic disease characterized by airway infection and inflammation, leading to permanent dilation of the bronchi. Evaluation of underlying etiology is important in managing young bronchiectasis patients with recurrent infections caused byunusual pathogens. The signal transducer and activator of transcription 1 (STAT1) protein plays a key role in STAT signaling andimmune system regulation. Heterozygotes for gain-of-function (GOF) alleles of the STAT1 gene usually display autosomal dominantchronic mucocutaneous candidiasis (CMC) and a wide range of clinical features, such as bronchiectasis. Here, we report on apatient with CMC and bronchiectasis with various types of infections who carried a pathogenic variant of the STAT1 gene. The24-year-old female presented with recurrent respiratory bacterial and nontuberculous mycobacterial infections complicated by severebronchiectasis and CMC. Whole-exome sequencing revealed a c.800C>T (p.Ala267Val) heterozygous mutation in the STAT1gene. Further analysis by Sanger sequencing of STAT1 from the patient and her parents revealed the patient had a de novo occurrenceof the variant. This is the first report of a Korean patient with a GOF pathogenic variant in STAT1. Physicians should be awareof the existence of this variant as a genetic factor associated with CMC and bronchiectasis complicated by recurrent infection.

우리나라 국가 수혈가이드라인 인지도 및 활용도에 관한 조사 연구

김형석,조현정,최새롬,김준년,김솔잎,엄태현 대한수혈학회 2016 大韓輸血學會誌 Vol.27 No.2

Background: Transfusion guidelines play an important role for the appropriate use and quality assurance of blood and transfusion services. The Korean national transfusion guideline was developed in 2009 and went under full amendment in 2016. The purpose of this study was to investigate the awareness and practicality of the transfusion guideline in Korea. Methods: Questionnaires about the Korean national transfusion guideline were sent by traditional mail or e-mail to a total of 1,179 clinicians, 32 academic societies, and 6 institutions. Results: Three hundred and seventy-four answers were received; a response rate of 30.7%. The proportion of respondents with good awareness of the guideline was 23.3%, which is a significant increase compared with 10.9% in 2008. Respondents with good awareness were more dependent on the transfusion guideline when making transfusion decisions. Conclusion: There was a considerable increase in the awareness of the national transfusion guideline in Korea. 배경: 수혈가이드라인의 제정 및 활용은 적정수혈 및 수혈서비스의 질 향상에 중요한 역할을한다. 2009년에 처음 발간된 국가 수혈가이드라인은 2016년에 전면 개정 작업을 진행하고 있다. 본 연구에서는 국가 수혈가이드라인의 인지도 및활용도에 대해 조사하고자 하였다. 방법: 임상의사 1,179명, 학회 32곳, 수혈관련기관 6곳에 우편 및 전자우편으로 설문조사를 의뢰하였다. 결과: 374건의 응답을 받아 최종 회신율은 30.7% 로 집계되었다. 수혈가이드라인을 잘 알고 있다고대답한 비율은 23.3%로 2008년의 10.9%에 비해서 상당히 증가하였다. 한편, 수혈가이드라인 인지도가 높은 군에서 낮은 군보다 수혈에 대한 판단 시 가이드라인을 중시한다는 비율이 높았다. 결론: 국가 수혈가이드라인의 인지도는 상당히 증가되었음을 확인하였다.