해양심층수와 γ-Aminobutyric Acid (GABA) 함유 배양액의 결정화를 이용한 GABA함유 소금의 제조

최부영 ( Bu Young Choi ),조석철 ( Seok Cheol Cho ) 한국산업식품공학회 2015 산업 식품공학 Vol.19 No.4

γ-Aminobutyric acid (GABA)-containing salt was prepared by crystallization of a mixture of salt water from deep sea and fermentation broth by lactic acid bacteria that contained GABA converted from glutamic acid. Salt from deep sea water has a lower sodium content but higher calcium, potassium and magnesium contents than commercial salt. Instead of monosodium glutamate (MSG), glutamic acid was used for solving the residual MSG problem. Fermentation by a lactic acid bacterium converted 90% of added glutamic acid (5%, w/v) to GABA, and continuous production of colorless fermentation broth containing more than 3% (w/v) GABA was achieved by using an activated carbon. Mixtures of salt water and fermentation broths with various GABA concentrations were co-crystallized and the GABA content was analyzed. This analysis showed that more than 90% of GABA from broth was adsorbed to salt. The appearance and surface of this prepared GABA-containing salt were examined with an image analyzer and scanning electron microscope. No difference was found with commercial sun-dried salt and no separated particles were detected, which indicates that the co-crystallization process used is suitable for the production of GABAcontaining salt.

여대생의 체형인식과 비만지식 및 비만스트레스 조사

최부영 ( Bu Young Choi ),최미옥 ( Mee Ok Choi ) 한국미용학회 2008 한국미용학회지 Vol.14 No.4

The purpose of this study is to know about real body shape and ideal body shape and to examine fatness knowledge and fatness stress. In order to examine general characteristics, frequency analysis was conducted. To know about gap between body shape recognition and ideal body shape, fatness knowledge and fatness stress index, t-test and One-Wey ANOVA. The subjects were 344 college woman being in K-woman`s university in Kwang-ju and their questionaire survey was the final analysis data. Study results were summarized as follows; The difference between recognition of real body shape and ideal body shape was meaningless. Fatness knowledge also showed no difference. Self cathexis express dissatisfaction. The fatter the body shape recognition, the higher the fatness stress index And also the higher the fatness knowledge, the higher the fatness stress.

비만여대생의 등경락마사지 후 근체형 변화 연구

최부영 ( Bu Young Choi ),서승희 ( Seung Hee Seo ),최미옥 ( Mee Ok Cho ) 한국미용학회 2009 한국미용학회지 Vol.15 No.4

The purpose of this study was to determine effects of back meridian massage on changes in the body type among obese female college students Subjects` BMI was over 23 and conducted a total of 24 sessions of back meridian massage, two sessions per week, for 12 weeks from May 19 to August 15, 2008, and analyzed changes in the muscular type. This study analysed by SPSSWIN 12.0 program. As for changes in the muscular type, there were significant differences in changes in horizontality of the upper scapula(X, Y, Z1) There were significant differences in changes in horizontality of the lower scapula(X, Y, Z2) among all the measurements twelve weeks after the (p<0.01 p<0.05). There were significant difference in changes in horizontality of the waist part(X, Y, Z3) in X and Z3 (p<0.001), Changes in Y4 for horizontality of the upper hips (X, Y, Z4), changes in X and Z4 according to the time of experiment was significant(p<0.001). The effects of back meridian massage on changes in the muscular body type were positive, therefore it is expected to be used as body type management programmed also to be used as basic data for marketing in the beauty industry or obesity and body type management programs.

천연 생약에서 추출한 지표성분들의 모발 성장에 미치는 영향

최부영(Bu Young Choi) 한국유산균프로바이오틱스학회 2023 Current Topic in Lactic Acid Bacteria and Probioti Vol.9 No.2

Many people around the world are stressed by hair loss, and drug-based therapies (minoxidil, finasteride) are available for the treatment of alopecia, but they have several side effects. Therefore, in order to reduce the side effects of anti-hair loss drugs, the use of new treatments using products developed from natural extracts has been emphasized. In this study, we focused on the mechanisms underlying the hair growth-promoting effects of marker compounds of natural herbal extracts. The 32 marker compounds of natural herbal (10 μM) were used to evaluate the growth of human hair follicle dermal papilla cells, the expression of mRNA genes, and the signaling transcription factor activities of Wnt and JAKs. Seven marker compounds were selected that induced equal or greater growth than minoxidil or tofacitinib in cell growth. For the seven marker compounds, we evaluated the expression of mRNA genes and the transcriptional activities of Wnt/β-catenin and IL-4/JAK3-STAT6, which are major signaling pathways that regulate hair growth. As a result of the evaluation, it was scientifically proven that the 4 marker compounds (honokiol, isoalantolactone, broussochalcone A, and 3-deoxysappanone B) induce hair growth. I have suggested the possibility of developing a natural product for improving hair loss with 4 marker compounds.

STAT3 활성 억제를 유도하는 resveratrol의 호르몬 불응성 전립선 암 예방 효과

조석철(Seok-Cheol Cho),최부영(Bu Young Choi) 한국식품과학회 2014 한국식품과학회지 Vol.46 No.4

전립선암은 발병률이 높은 암종 중에 하나이다. 전립선 치료제인 flutamide는 androgen 수용체의 호르몬 치료제로서 내성효과에 대한 기본 메커니즘은 명확하지 않다. 본 연구에서는 flutamide에 의해 유도되는 호르몬 불응성 전립선 암세포 성장에서 포도 성분인 resveratrol의 억제효과를 조사하였다. 본 연구의 결과를 통해 호르몬 비의존적인 신호전달의 전환으로 유발되는 호르몬 불응성 전립선 암에서 resveratrol은 예방 및 항암효과에 기여할 것이라 판단된다. The mechanisms underlying the refractory effects of flutamide, a first-line oral anti-androgen drug, have not been entirely elucidated. In the present study, we investigated the mechanism of flutamide-induced hormone-refractory prostate cancer cell growth and its modulation by resveratrol, a phytoalexin present in grapes. Resveratrol significantly attenuated interleukin 6 (IL-6)-induced signal transducer and activator of transcription 3 (STAT3) transcriptional activity and dihydrotestosterone (DHT) or IL-6-induced prostate-specific antigen (PSA) transcriptional activity. Furthermore, compared to treatment with DHT or IL-6 alone, combination treatment of cells significantly increased PSA transcriptional activity, and resveratrol markedly diminished DHT plus IL-6-induced STAT3 and PSA transcriptional activities. Thus, the inhibitory effects of resveratrol on IL-6-, DHT-, and flutamide-induced hormone-refractory prostate cancer cell growth are partly mediated by the suppression of STAT3 reporter gene activity, suggesting that resveratrol represents a promising therapy for prostate cancer.

유행선도력에 따른 신체만족도 및 체형관리행동의 상관관계분석

서승희(Seung Hee Seo),최부영(Bu Young Choi),최미옥(Mee Ok Choi) 한국인체미용예술학회 2010 한국인체미용예술학회지 Vol.11 No.1

The purpose of this study was to investigate female college students' body satisfaction and body type management behavior by fashion leadership. The survey was conducted with female students at a university in Gwangju for about two weeks from April 28 to May 10, 2008. Data analysis was carried out through descriptive statistical analysis, t-test, one-way ANOVA, correlation analysis, and Duncan's multiple range test. As a result, the mean of general fashion leadership was found to be 3.38. The mean of body satisfaction was found to be 2.94. The mean of general body type management behavior was found to be 1.69. As for differences in body satisfaction according to fashion leadership, the higher fashion leadership, the higher body satisfaction (p<O.OO1). As for correlation among fashion leadership, body satisfaction, and body type management behavior, there was significant positive correlation between fashion leadership and body satisfaction (r=.248, p<O.OO1), while there was no significant correlation with body type management behavior. Correlation between body satisfaction and body type management behavior was also insignificant.

Tumor suppressor p16^(INK4a) in Cancer

이미현(Mee-Hyun Lee),최부영(Bu-Young Choi),서영준(Young-Joon Surh) 한국환경성돌연변이발암원학회 2005 한국환경성돌연변이·발암원학회지 Vol.25 No.3

p16^(INK4a) is a tumor suppressor that belongs to the INK4 family of the cyclin D-dependent kinases (cdk) inhibitors. It plays regulatory roles in cell proliferation and in tumorigenesis by interacting with Rb signaling. Abnormally elevated p16^(INK4a) protein expression causes cell cycle arrest (G1/S transition) and loss of cyclincdk activity. In many cancers, p16^(INK4a) is altered by mutation, deletion, and promoter methylation. This review summarizes the function of p16 as an important regulator of cancer pathobiology and a promising target for developing cancer therapeutic and chemopreventive agents.

하둡 분산 파일 시스템을 위한 효율적인 데이터 분산 저장 기법

최성진(Sung-Jin Choi),전대석(Dae-Seuk Jeon),배대극(Dae-Keuk Bae),최부영(Bu-Young Choi) 한국정보과학회 2011 한국정보과학회 학술발표논문집 Vol.38 No.1D

클라우드 컴퓨팅이란 인터넷 기술을 활용하여 모든 인프라 자원(소프트웨어, 서버, 스토리지, 네트워크 등)을 서비스화(as a Service)하여, 언제, 어디서든, 장치에 독립적으로 네트워크를 통해 사용하고, 사용한 만큼 비용을 지불하는 컴퓨팅으로써, 대표적인 서비스 업체로는 구글과 아마존이 있다. 최근 아파치 재단에서는 구글의 GFS와 동일 또는 유사한 시스템을 만들기 위해 HDFS 오픈소스 프로젝트를 진행하고 있다. HDFS는 빈번한 하드웨어 고장에도 원본 데이터를 복구할 수 있는 가용성을 보장하기 위해 파일 데이터를 블록 단위로 나누어, 다시 datanode에 복제하여 저장한다. 이 기법은 복제가 많아 질수록 가용성은 높아지나 스토리지가 증가한다는 단점을 가지고 있다. 따라서 본 논문에서는 이러한 문제점을 해결하기 위해 행렬의 특성을 이용한 새로운 분산 저장 기법을 제안한다.

스마트그리드 환경을 위한 오픈 소스 소프트웨어 기반의 통합시설관제시스템

이지훈(Ji-Hoon Lee),최성진(Sung-Jin Choi),배대극(Dae-Keuk Bae),최부영(Bu-Young Choi) 한국정보과학회 2011 한국정보과학회 학술발표논문집 Vol.38 No.1D

스마트그리드는 기존의 전력 생산, 운반, 소비의 과정에 정보통신 기술을 접목하여 에너지 절감 및 전기 품질 향상 등을 제공하는 차세대 전력망으로써 스마트 미터 중심의 AMI, 에너지 관리 시스템, 전기 자동차 및 충전소, 재생에너지, 양방향 정보통신 기술, 배전 자동화 시스템 등으로 구성된다. 이중 미터기, 수용가 전력기기, 근거리 통신기술, 데이터 관리 시스템 등은 “제주도 실증단지 구축”사업의 핵심 요소로써, 국내 기업들의 활발한 연구가 이루어지고 있다. 하지만 국내에서 연구되고 있는 스마트그리드 구축과 관련된 소프트웨어들은 외산 솔루션에 기반하고 있거나 자체개발을 통해 이루어지고 있어 기술 지원 부재 및 개발 소요 시간이 길다는 문제점을 가지고 있다. 따라서 본 논문에서는 이러한 문제점을 해결하기 위해 오픈 소스 소프트웨어 기반의 스마트그리드 통합시설관제시스템을 제안하고, 구축하도록 한다.

유체내 전기선폭발에 의한 그래핀-은 나노유체 제조 및 특성

전종훈(Jong-Hoon Jeon),김지혜(Ji-Hye Kim),최부영(Bu-Young Choi),노정필(Jung-Pil Noh),허선철(Sun-Chul Huh) 대한기계학회 2017 대한기계학회 춘추학술대회 Vol.2017 No.11

A graphene-silver nanofluid was prepared by using an electric wire explosion method to coat the graphene particles with silver nanoparticles. The number of times of explosion was set as a variable and the concentration of silver nanoparticles was made different. The properties of graphene - silver nanofluid were confirmed by using thermal conductivity and TEM and SEM. As a result, it was confirmed that graphene grains were attached to silver nanoparticles, and the change in thermal conductivity was confirmed based on distilled water.