알쯔하이머의 고찰

최봉근,Choe, Bong-Keun 한국생명보험의학회 2004 保險醫學會誌 Vol.23 No.-

뇌졸중(腦卒中) 환자(患者)의 사상체질별(四象體質別) 특성(特性)에 관(關)한 연구(硏究)

황민우,이수경,최봉근,송일병,고병희,Hwang, Min-Woo,Lee, Soo-Kyung,Choe, Bong-Keun,Song, Il-Byung,Koh, Byung-Hee 사상체질의학회 2005 사상체질의학회지 Vol.17 No.1

1. Objectives The purpose of this research is to find out the Constitutional characters of Stroke inpatients. 2. Methods Stroke inpatients admitted into KyungHee Oriental Medical Center from January 2000 to April 2004, were divided into 2 group, cerebral infarction 493 inpatients and cerebral hemorrhage 83 inpatients. This research investigated the distribution of Sasasng Constitution, the gender, the age decade, the period of admission, the elapse of the time after onset, the course of admission, the frequency of Sasang Constitutional Herb-medicine, the past history of hypertension and diabetes mellitus, the obesity, the prevalence rate of hypertension and diabetes mellitus, EKG abnormality and hyperlipidemia. 3. Results & Conclusions The Sasang Constitutional distribution of cerebral infarction 493 inpatients was 0.4% of Taeyangin, Soyangin 34.1%, Taeurnin 56.4%, Soeumin 9.1%. The Sasang Constitutional distribution of cerebral hemorrhage 83 inpatients was Taeyangin 1.2%, Soyangin 47.9%, Taeurnin 43.4%, Soeumin 9.6%. Stroke incidence rate of Taeumin and Soyangin inpatients was high. Sasang Constitution had significant relations with the prevalence of the obesity and hypertension in cerebral infarction inpatients, the prevalence of obesity, diabetes mellitus and ECG abnormality in cerebral hemorrhage inpatients.

여성 신체형장애의 신체증상 호소와 부족한 산후조리

박용철,송지영,최봉근,박종학,오동재,임옥근,김종우,Park, Yong-Chul,Song, Ji-Young,Choe, Bong-Keun,Park, Jong-Hack,Oh, Dong-Jae,Lim, Ok-Geun,Kim, Jong-Woo 한국정신신체의학회 2008 정신신체의학 Vol.16 No.2

Background : It was not uncommon authors as psychiatrists faced women patients with somatoform disorders who expresses their symptoms has been started after the poor adherence to 'Doing the month' practices (DMP). DMP is known as a traditional ritual for Korean postpartum women. Aims : This study is an cultural approach to explore the practices of Korean women during the postpartum period are related with the formation of somatoform disorders. Methods : 41 multipara women with somatoform disorders diagnosed by DSM-IV criteria and 91 healthy normal control were enrolled. Subjects were given scales of SOM scale of SCL-90R, Somatic Symptom Scale-Korean version, Korean 'Doing the month' practices Scale(40 items), Postpartum Sick Scale(14 items), Beck Depression Scale and State Anxiety Scale. Results : 1) The period of DMP less than one week were prevalent in the patients group(43.9%) compared to the control group(7.9%, p<0.01). 2) The period of DMP after the abortions showed no difference between two groups. 3) Subjective rate for their poor DMP was significantly high in the patients group(73.2%) compared to the control group(33.0%), and the patients group showed high score in Postpartum Sick Scale as well(4.1, 1.6 respectively). 4) Poor DM was negatively correlated with SOM scale of SCL-90R(correlation coefficient r=-0.47, p<0.01). Conclusion : Poor DMP may make a crucial role for their heath condition after the deliveries and which would be one of the major factors of the somatoform disorders in Korean women. And postpartum physical symptoms after the poor DMP could be last long enough to be diagnosed as somatoform disorders. By understanding the cultural nature of the somatization phenomena the doctor-patient relationship could be enhanced. 연구목적 : 신체형 장애를 가진 한국 여성에서, 과연 산후조리를 잘 못한 것이 신체화 형성의 요인이 되는지를 알아보고자 하였다. 방법 : 대상자에게 반구조화된 설문지를 통하여 산후 조리와 관련된 내용에 대해 직접 면담하고, 이와 동시에 자가 평가 질문지를 작성하도록 하였다. 자가 평가도구로는 산후조리 평가지, SCL-90R의 SOM척도, 한국판 신체 증상목록, 산후병증상 평가지, Beck depression Inventory(BDI), State trait anxiety inventory(STAI), Visual analogue scale(VAS)을 사용하였다. 결과 : 환자군이 대조군에 비해 산후조리 기간이 짧았으며, 산후조리 평가 점수(K-DMP)가 낮았으며 본인이 평가한 산후조리의 만족도도 낮았다. 현재의 신체증상에 대한 이유에 대해 환자군에서는 43.9%, 대조군에서는 33.3%가 산후조리 때문이라고 답하였다. 산후조리 점수(K-DMP)와 신체화척도(SOM) 사이에는 유의미한 부적 상관관계를 보였다(Pearson correlation : r=-0.476, p<0.01). 다변량 회기 분석에서 현재 신체증상(SOM)에 대해 과거 산후 풍 정도와 산후조리 점수, 이 2가지 요인이 영향력을 가짐이 나타났다. 결론 : 부족한 산후조리는 이후의 신체화 형성과정에 영향을 주는 요인인 것으로 보인다.

씀바귀 약침이 RAW 264.7 대식세포에서 tumor necrosis factor alpha 생성에 미치는 영향 연구

정경희 ( Kyung Hee Jung ),최봉근 ( Bong Keun Choe ),홍승제 ( Seung Jae Hong ),반주연 ( Joo Yean Ban ),엄윤경 ( Yoon Kyung Uhm ) 대한경락경혈학회 2007 Korean Journal of Acupuncture Vol.24 No.3

목적: 약침으로서 씀바귀의 염증 효과를 알아보기 위해 RAW 264.7 대식세포에서 Tnf 생성을 확인하였다. 방법: 씀바귀를 RAW 264.7 대식세포에 미리 처치한 후 LPS로 염증 반응을 유도하였다. ELISA, Western blotting, RT-PCR, 그리고 EMSA을 통해 Tnf의 생성과 발현에 대한 효과를 평가하였다. 결과: LPS 유도된 세포에서 씀바귀 1, 5, 10, 50 μg/ml의 농도는 각각 23.7, 37.8, 66.4, 86.1% Tnf 생성을 억제한 것을 ELISA 통해 확인되었다. LPS로 유도된 대식세포에서 Tnf 생성은 농도에 따라 감소하였고, Western blotting, RT-PCR 분석에서는 씀바귀 5과 50μg/ml가 LPS로 유도된 대식세포에서 Tnf의 mRNA와 단백질 발현을 저해 하는 것으로 관찰되었다. 또한 EMSA에서도 씀바귀 5과 50μg/ml가 LPS로 유도된 Nf-κB를 감소시키는 것을 확인하였다. 고찰: 이런 결과는 씀바귀가 Nf-κB를 저해하면서 LPS로 유발된 Tnf 생성을 감소시킨다는 것을 보여주었고, 이는 더 나아가 염증 질환에서 씀바귀가 약침으로써의 치료적 효과를 나타낼 수 있을 것으로 사료된다.

일부 대학 학생들의 보건소 이용에 관한 인식과 태도

최중명 ( Joong Myung Choi ),최봉근 ( Bong Keun Choe ),윤태영 ( Tai Young Yoon ),박순영 ( Soon Young Park ) 한국보건정보통계학회 (구 한국보건통계학회) 2004 보건정보통계학회지 Vol.29 No.1

우리나라 청소년의 신체활동과 사회경제적 변수와의 관련성

오인환,이고은,오창모,최경식,최봉근,최중명,윤태영,Oh, In-Hwan,Lee, Go-Eun,Oh, Chang-Mo,Choi, Kyung-Sik,Choe, Bong-Keun,Choi, Joong-Myung,Yoon, Tai-Young 대한예방의학회 2009 예방의학회지 Vol.42 No.5

Objectives : The physical activity of Korean adolescents and its distribution based on social characteristics have not yet been fully assessed. This study intends to reveal the distribution of physical activity by its subgroups and offer possible explanatory variables. Methods : The 3rd Korea Youth Risk Behavior Web-based Survey was analyzed for this study. The appropriateness of physical activity was defined by Korea s Health Plan 2010 and physical inactivity was assessed independently. Family affluence scale, parents education levels, subjective economic status, grade, and school location were considered explanatory variables. All statistical analysis was conducted using SAS ver. 9.1. Results : The proportion of participants engaging in vigorous physical activity was high in males (41.6%), at a low grade (38.5%), within the high family affluence scale group (35.5%). The distribution of participants engaging in moderate physical activity showed similar patterns, but the overall proportion was lower (9.8%). Low family affluence and students with lower subjective economic status reported a higher prevalence of physical inactivity. In multiple logistic regression analysis for physical activity, significant factors included family affluence scale (p<0.05). For physical inactivity, family affluence scale, parents education levels, and subjective economic status were included as significant factors (p<0.05). Conclusions : The results suggest that the physical activity and inactivity of adolescents may be affected by socioeconomic variables, such as family affluence scale. This implies the need to take proper measures to address these socio-economic inequalities.

한국인(韓國人)의 사상인(四象人) 분포(分布)에 관한 연구(硏究)

이태규,황민우,함통일,이수경,최봉근,고병희,송일병,Lee, Tae-Gyu,Hwang, Min-Woo,Ham, Tong-Il,Lee, Soo-Kyung,Choe, Bong-Keun,Koh, Byung-Hee,Song, Il-Byung 사상체질의학회 2005 사상체질의학회지 Vol.17 No.3

1. Objectives Though the distributional rate of Sasangin was mentioned in ${\ulcorner}$Dongyi Suse Bowon${\lrcorner}$, there were few studies on the distributional rate of Sasangin in Korea. So, this study was conducted to estimate the distributional rate of Sasangin in Korea. 2. Methods The medical records of 1,423 subjects who have taken diagnosis of Sasang constitution from January 2003 to June 2003 at a health examination center of a hospital in Seoul were reviewed. Then distributional rate of Sasang constitution were analyzed and age sex-adjusted standardized distributional rate were estimated by direct standardization using a reference population of 2000 aged from 20 to 70 years. 3. Results and Conclusions (1) The total number of subjects were 1,423(Males : 704(49.5%) / Females : 719(50.5%)). And the mean age of the subjects was $46.3{\pm}11.4$ years(males : $45.4{\pm}11.3$ / females $47.1{\pm}11.4$). (2) Among the 1,423 subjects, distributional rate of Taeumin, Soyangin, and Soeumin were 46.9%, 29.1% and 24.0%(Male : Taeumin 48.2%, Soyangin 37.9%, Soeumin 13.9% / Female: Taeumin 45.6%, Soyangin 20.4%, Soeumin 33.9%). (3) Age sex-adjusted standardized distributional rate of Taeumin, Soyangin, and Soeumin were 45.4%, 28.2% and 26.4%(Male : Taeumin 50.8%, Soyangin 35.1%, Soeumin 14.1% / Female: Taeumin 39.5%, Soyangin 21.0%, Soeumin 39.4%) (4) The rate of Soeumins was higher than that mentioned in ${\ulcorner}$Dongyi Suse Bowon${\lrcorner}$,and the distributional rate of Sasangin according to sex was different. (5) So it was thought that the distributional rate of Sasangin in Korea was different from that mentioned in ${\ulcorner}$Dongyi Suse Bowon${\lrcorner}$.

일부 지역 주민에서 고혈압이환과 비만지표와의 관련성

손락성,윤태영,최중명,박순영,유동준,최봉근,Son, Lack-Seong,Yoon, Tai-Young,Choi, Joong-Myung,Park, Soon-Young,Lew, Dong-Joon,Choe, Bong-Keun 대한예방의학회 1999 예방의학회지 Vol.32 No.4

Objective: To examine the relationship between hypertension prevalence and the four commonest anthropometric measurements for obesity(body mass index(BMI), wasit-hip ratio(WHR), waist circumference(WC) and body fat in Korean adults. Methods: We studied the cross-sectional association of the anthropometric indices and blood pressure in 1,197 individuals(who were participants in the population-based cohort study). Hypertension was defined as blood pressure $\geq160/95\;mmHg$ or current use of antihypertensive medication. Informations on life-style factors were obtained from personal interview. Results: There were close associations between BMI, WHR and WC with blood pressure in both men and women. After age adjustment, BMI and WC showed significantly positive correlation with systolic and diastolic blood pressure levels in both men and women. Odds ratio(ORs) of being hypertensive were estimated comparing the highest to the lowest quantile, adjusting for age, smoking status, alcohol intake levels, education attainment. The simultaneously adjusted ORs of being hypertensive, comparing the highest vs the lowest categories, was for BMI 2.0(95% confidence interval(CI)=0.9-3.2) in men and 3.2 (95% CI=1.7-6.1) in women, for WC 2.1(95% CI=1.0-4.4) in men and 3.1 (95% CI=1.6-5.9) in women, for fat(%) 4.2(95% CI=1.9-9.5) in men and 2.1(95% CI=1.2-3.6) in women. Conclusion: In addition to measures of overall obesity(BMI) as well as central obesity(WHR, WC), body fat(%) was independently associated with prevalence of hypertension. Among obesity indices, body fat was the most predictor variable in hypertensive state in male and BMI was in female.

열 화학적 환원 처리를 이용한 절연체 12CaO·7Al₂O₃의 전도체로의 전환

정준호,은종원,오동근,김광진,홍태의,정성민,최봉근,심광보,Chung, Jun-Ho,Eun, Jong-Won,Oh, Dong-Keun,Kim, Kwang-Jin,Hong, Tae-Ui,Jeong, Seong-Min,Choe, Bong-Geun,Shim, Kwang-Bo 한국결정성장학회 2010 한국결정성장학회지 Vol.20 No.4

마이크로 웨이브 연소합성법(microwave-assistant combustion method)를 이용하여 $12CaO{\cdot}7Al_2O_3$(C12A7) 분말을 성공적으로 제작하였고, $H_2$ 가스 분위기에서의 후열처리를 통하여 C12A7:H 제작에 성공하였다. 분말의 합성 여부 와 결정성 확인 및 분말 하소 시 온도에 따른 반응 분석을 위하여 X-ray diffraction(XRD) 및 TG-DSC 분석을 시행하였다. 또한, 후 열처리 후 C12A7 cage 내부의 자유산소 이온이 수소 이온으로 치환되었는지 확인하기 위하여 TG-MS 분석을 시행하였고, $289.5^{\circ}C$에서 H와 $H_2$ 가스가 방출되는 것이 확인되었으므로, H 이온이 cage 내부로 치환된 것을 확인시켜준다. 성공적으로 치환된 C12A7:H 를 홀 측정기(Hall measurement)를 이용하여 전도성을 측정하여 본 결과 $1000^{\circ}C$, Ar/H=8:2의 분위기에서 8h 이상 처리된 C12A7:H의 경우 상온(300 K)에서 $10^2{\Omega}{\cdot}cm$의 비저항 값을 나타내었다. The $12CaO{\cdot}7Al_2O_3$(C12A7) powders were successfully synthesized using combustion method with microwave-assistant and C12A7:H were fabricated by post-annealed process in Ar/H atmosphere. X-ray diffraction patterns and TGDSC were used for investigating to the precursors of crystalline and reaction depending on temperature. C12A7:H that was treated post-annealed process were investigated TG-MS and Hall-measurement for confirming H ions doping and checking electrical resistivity of C12A7:H. H ion substituted to $O^{2-}$ ions in the C12A7 cages were confirmed at $289.5^{\circ}C$ by TG-MS and C12A7:H calcined at $1000^{\circ}C$ in Ar/H=8:2 atmosphere for 8~10 h has low electrical resistivity about $10^2{\Omega}{\cdot}cm$ at room temperature.

사상체질에 따른 대사증후군의 유병률과 위험인자에 대한 연구

이태규(Tae-Gyu Lee),황민우(Min-Woo Hwang),이수경(Soo-Kyung Lee),최봉근(Bong-Keun Choe),고병희,송일병(Il-Byung Song) 대한한의학회 2006 대한한의학회지 Vol.27 No.2