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장선일,김형진,황기명,권태오,제갈승주,김윤철,배현옥,최병민,심재석,곽준수,정헌택,윤용갑,Jang S.I.,Kim H.J.,Hwang K.M.,Kwon T.O.,JeKal S.J.,Kim Y.C.,Pae H.O.,Choi B.M.,Shim J.S.,Kwak J.S.,Chung H.T.,Yun Y.G. 대한한의학방제학회 2002 大韓韓醫學方劑學會誌 Vol.10 No.2
The inhibitory effects of Injinseulki including extracts of melanian snail plus phytomedicinal plants on $CCl_4$-induced fibrosis, $IFN-{\gamma}$ plus LPS-induced production of NO, PMA-stimulated production $O_2$, and tacrine-induced hepatic injury were investigated in rats, RAW 264.7 or HepG2 cells. The ethanol extracts of melanian snail significantly inhibited tarcrine-induced inury of HepG2 cells. Injinseulki inhibited the production of NO and $O_2$ in a dose-dependent manner in activated RAW 264.7 macrophages. Injinseulki significantly inhibited chemical-induced fibrosis in Rats. These results show that Injinseulki including extracts of melanian snail plus phytomedicinal plants may explain some known biological activities of Injinseulki including their anti-inflammatory and anti-fibrotic effect, and is of considerable benefit in the treatment for live diseases.