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김승환,민신홍,권종원,차봉진,최문상 한국약제학회 1990 Journal of Pharmaceutical Investigation Vol.20 No.1
In case of the slowly disintegrating tablets such as enzyme preparations, disintegration time (DT) may be the important factor in formulating those preparations. The effects of tablet hardness, lubricants and disintegrants on DT were investigated in this approach. Disintegration time was significantly affected by disintegrants, moderately by lubricants, but not by tablet hardness. The effect was in the order of magnesium stearate >talc, PEG, sodium benzoate in case of lubricants, and of Ac-Di-Sol>LHPC > Primogel > Kollidon in case of disintegrants. Because lubricants and disintegrants influenced the tablet hardness and DT profile showed complicated pattern, it should be remembered that all factors mentioned above should be simultaneously considered in the formulation of enzyme tablets.
김승환(Seung Hwan Kim),최문상(Moon Sang Choi),민신홍(Shin Hong Min) 한국약제학회 1988 Journal of Pharmaceutical Investigation Vol.18 No.4
In case of the slowly disintegrating tablets such as enzyme preparations, disintegration time(DT) may be the important factor in formulating those preparations. The effects of tablet hardness, lubricants, disintegrants on DT were investigated in this approach. Disintegration time was significantly affected by disintegrants and lubricants, but not by tablet hardness. The effect was in the order of mag. stearate>talc>PEG, sodium benzoate in case of lubricants, and of cross-linked Na-CMC, L-HPC>sodium starch glycolate>cross-linked PVP in case of disintegrants. Because lubricants and disintegrants had effect on the tablet hardness and DT profile showed complicated pattern, it should be remembered all factors mentioned above should be simultaneouly considered in the formulation of enzyme tablets.