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RISS 인기검색어
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Lipopolysaccharide (LPS)에 의해 유도된 염증에 대한 건조 고등어 추출물의 항염증 효과
김광혁(Kwang-Hyuk Kim),최명원(Myoung Won Choi),최향미(Hyang Mi Choi),임선영(Sun-Young Lim) 한국생명과학회 2013 생명과학회지 Vol.23 No.9
본 연구에서는 건조 고등어 추출물 및 분획물들에 의한 nitric oxide 생성에 미치는 영향을 살펴보았고 건조 고등어 85% aq. MeOH 분획물을 중심으로 면역과정의 생물학적 작용과 대사적 변화를 유도하는 IL-6, IFN-γ 및 TNF-α 같은 pro-inflammatory 사이토카인의 생성을 측정하여 건조 고등어 추출물에 의한 항염증 효과에 대하여 검토하였다. 건조 고등어 추출물과 각 분획물은 control보다 낮은 nitric oxide 생성량을 나타내었으며, 특히 85% aq. MeOH 및 n-hexane 분획물에 의한 저해효과가 높았다. 건조 고등어 분획물은 Con-A 보다는 LPS에 의해 자극된 IL-6, TNF-α 및 IFN-γ의 생성을 감소시키는데 더 효과적이었다. IL-6 및 TNF-α의 생성은 배양시간 6시간 후 건조 고등어 85% aq. MeOH 분획물의 모든 첨가농도(1, 3 및 10 μg)에서 감소되었다(p<0.05). IFN-γ의 경우, 건조 고등어 85% aq. MeOH 분획물을 LPS와 함께 처리했을 때 특히 72시간 배양 IFN-γ의 생성량이 농도 의존적으로 감소하였고 Con-A에 의해 자극된 IFN-γ의 생성량은 6 및 24시간 배양 후 유의적으로 감소하였다(p<0.05). 이상의 결과로부터 건조 고등어 85% aq. MeOH 분획물은 nitric oxide 생성과 pro-inflammatory 사이토카인(IL-6, TNF-α, and IFN-γ)을 감소시켜 염증반응을 예방할 것으로 기대된다. The effect of dried mackerel extract on the production of nitric oxide (NO) and cytokines, including interleukin-6 (IL-6), tumor necrosis factor-α (TNF-α), and interferon-γ (IFN-γ), was investigated. All extracts and fractions from dried mackerel significantly reduced NO production induced by lipopolysaccharide (LPS). Among the extracts, acetone+methylene chloride (A+M), n-hexane, and 85% aqueous methanol (MeOH) showed the strongest inhibitory effects. The 85% aqueous MeOH fraction at a concentration of 10 μg significantly decreased LPS-induced IL-6 and TNF-α production after 6 hr of incubation. In the case of LPS-induced IFN-γ production, the 85% aqueous MeOH fraction decreased the production of IFN-γ afer 6, 24, and 72 hr of incubation in a dose-dependent manner. The results show that an 85% aqueous MeOH fraction inhibits the production of NO and proinflammatory cytokines (IL-6, TNF-α, IFN-γ), suggesting that this fraction acts as a potent immunomodulator.
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참치 추출물의 일산화질소 및 사이토카인 생성에 미치는 영향
김광혁(Kwang-Hyuk Kim),최명원(Myoung Won Choi),최향미(Hyang Mi Choi),임선영(Sun-Young Lim) 한국식품과학회 2013 한국식품과학회지 Vol.45 No.3
The effect of tuna extracts on the production of nitric oxide (NO) and cytokines including interleukin-6 (IL-6), tumor necrosis factor-α (TNF-α), and interferon-γ (IFN-γ), was investigated. All extracts and fractions from tuna significantly reduced NO production induced by lipopolysaccharide (LPS). The acetone+methylene chloride (A+M) extract, n-hexane and 85% aqueous methanol (MeOH) fractions had stronger inhibitory effects among them. The 85% aqueous MeOH fraction at a 10-㎍ concentration significantly decreased LPS-induced IL-6 and TNF-α productions at 6 h of incubation. In the case of LPS-induced IFN-γ production, the 85% aqueous MeOH fraction at a 3-㎍ concentration showed significantly higher levels at 48 h of incubation. These results show that the 85% aqueous MeOH fraction inhibited the production of NO and pro-inflammatory cytokines (IL-6, TNF-α), suggesting that this fraction acts as a potent immunomodulator.
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문태섭 ( Tae-sup Moon ),하재홍 ( Jae-hong Ha ),최명원 ( Myoung-won Choi ),박해식 ( Hae-sik Park ),조현길 ( Hyun-gil Cho ),강동효 ( Dong-hyo Kang ) 한국환경기술학회 2009 한국환경기술학회지 Vol.10 No.4
본 연구에서는 2013년 음식물폐기물의 해양투기가 금지됨에 따라 적정 처리방안 검토의 일환으로 부산시 민간업체 P사와 S사에서 발생되는 음식물폐기물 탈리액(이하 음폐수)의 녹산하수처리장에서 하수와 병합처리시 생물학적 처리 가능성을 평가하고자 하였다. 이를 위해, 호흡율 분석을 통해 음폐수의 생분해도가 평가되었고, 녹산 하수처리장과 유사한 운전모드로 회분식 실험 수행을 통해, 음폐수가 유출수에 미치는 영향이 평가되었다. 호흡율 분석 결과, P사와 S사의 음폐수 내 용존성 난분해성 유기물 함량은 2.1%, 2.9%로 확인되었고, 그 결과 음폐수 유입 시 유출 COD<sub>Mn</sub> 농도는 약 2.2mg/L 증가될 것으로 예상되었으며, 회분식 실험 결과 음폐수 유입으로 인해 실제 현장에 비해 COD<sub>Mn</sub>과 T-N 농도는 1.12mg/L, 1.37mg/L 증가가 되고, T-P 농도는 0.10mg/L 감소한다는 것이 확인되었다. 그리고, 음폐수 병합 처리시 예상되는 염분농도는 문헌에서 제시하는 저해농도보다 상당히 낮은 값으로 생물학적 처리공정의 저해는 발생하지 않을 것으로 판단되었다. The Ocean dumping of foodwaste will be prohibited from 2013. At this point, as one of method to treat the foodwaste, the possibility was estimated if the supernatant of foodwaste from P & S company after separation of solid and liquid could be biologically treated with sewage in Noksan WWTP of Busan in this study. First of all, biodegradability of supenatant of foodwaste fro, P & S company was estimated through OUR test. And then, the effect of supernatant from foodwaste on effluent of Noksan WWTP was estimated therough the operation of bacth reactor by similar operation mode with Noksan WWTP. As result of OUR test, it was observed that the percentage of soluble inert substrate among COD was 2.1% for P company`s supernatant and 2.9% for S company`s supernatant. Based on this, it was expected that the supernatant from foodwaste would increase the effluent COD<sub>Mn</sub> of Noksan WWTP by about 2.2mg/L. As result of batch experiment, due to the enter of supernatant from foodwaste, it was observed effluent COD<sub>Mn</sub> and T-N woluld be increased by 1.12mg/L and 1.37mg/L, effluent T-P would be decreased by 0.10 mg/L as compared to the Noksan WWTP that supernatant was not entered.
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김창원,한기백,최광수,최명원 부산대학교 공과대학 1993 工大論文集 Vol.46 No.-
To overcome the current problems of wastewater treatment systems new technologies have to be developed. A promising system is the air-lift reactor. The aim of these experiments is to investigate the effect of air flow rate and volumetric loading rate on the performance of reactors. To achieve this purpose, two identical bench-scale air-lift biofilm reactors were installed. The ratio of reactor height to reactor diameter(H/D) was 14.8 and the ratio of cross sectional area of riser to down-comer was 0.096. By using this type of reactors, three sets of experiments were conducted under the following conditions. The carrier material was basalt and the diameter and density of the carrier was 0.18mm-0.25mm and 2.53 g/ml, respectively. Operating temperature was 20±1℃ and pH was 6-7. The major difference in operating conditions among RUN #1, RUN #2 and RUN #3 was the hydraulic loading rate. And the difference in operating conditions between Reactor A and B in each run was the air flow rate. The wastewater was synthetic with nominal COD of 600, 1200 mg/l. Waste activated sludge was withdrawn from the clarifer twice every day. In the same clarifier design, the more air flow rate, the more substrate removal efficiency. The maximum substrate removal efficiency(91%) was obtained in the Reactor B of RUN #2 which hydraulic loading rate was 9.61 kg COD/㎥-day and MLVSS was about 9,000 mg/l. In the RUN #3, MLVSS was reached about 20,000 mg/l, but substrate removal rate was only 58.52%.
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