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최명규,Choi, Myung-Kyu 한국과학기술정보연구원 과학기술정보센터 1996 Journal of Information Science Theory and Practice Vol.27 No.2
본 연구는 데이터베이스 기술분류의 표준시안을 제시하기 위하여 1차년도(1994년) 연구 결과에 대한 관점을 체계화하고 구체화시켜 수정, 보완하는 형식으로 이루어졌다. 분류관점을 정보와 이를 지원하는 시스템 측면으로 크게 나누어, 데이터베이스 일반, 정보유통, 정보검색, 데이터베이스 시스템, 주변 관련주제를 분류기준으로 하는 표준 시안의 모형이 제시되었다.
바이오오일 가스화 반응에 대한 CFD 전산해석 및 공정해석 연구
최명규(Myung Kyu Choi),최동혁(Dong Hyuk Choi),황재규(Jae Gyu Hwang),최항석(Hang Seok Choi) 한국열환경공학회 2020 한국열환경공학회 학술대회지 Vol.2020 No.춘계
인류의 지속 가능한 발전을 위한 신재생 에너지원으로써 바이오에너지는 최근 주목을 받고 있다. 그 중 바이오매스의 급속 열분해를 통해 생성된 바이오오일은 바이오매스에 비해 에너지 밀도가 높고 저장과 수송에 편리한 이점을 가지고 있다. 또한 바이오오일을 가스화하여 생산된 합성 가스는 수소를 이용한 연료전지 발전과 같은 여러 산업 분야에 활용 가능하다. 바이오오일은 바이오매스의 직접 가스화에 비해 타르와 촤의 생성이 적기 때문에 가스화 공정을 통해 고품질의 합성가스를 생산할 수 있으며, 불순물의 양이 적기 때문에 후단 정제 공정이 필수적이지 않은 장점을 가지고 있다. 따라서 본 연구에서는 바이오오일의 가스화 반응을 해석하기 위하여 CFD 전산해석과 공정해석을 수행하였다. CFD 전산해석과 공정해석은 상용 프로그램인 Star-ccm+와 gPROMS를 사용하여 각각 수행하였다. 가스화 반응 조건으로 반응 온도, 바이오오일에 따른 공기 당량비(equivalence ratio)를 설정하여 CFD 전산해석을 먼저 수행하였으며, 도출된 최적 조건으로 공정해석을 수행하였다. 최종적으로, 바이오오일 가스화 반응으로 인해 생성된 합성가스의 조성과 그에 따른 냉-가스 효율, H2/CO 비율 등을 실제 실험 결과와 비교하였다.


증례3 : Omeprazole 투여로 호전된 위식도역류를 동반한 호두까기 식도증 1예
최명규(Myung Gyu Choi),문성배(Sung Bae Moon),김보경(Bo Kyoung Kim),최황(Hwang Choi),김재광(Jae Kwang Kim),정규원(Kyu Won Chung),선희식(Hee Sik Sun),나종순(Jong Soon Na),김병욱(Byung Wook Kim),정인식(In Sik Chung) 대한소화기기능성질환·운동학회 1998 Journal of Neurogastroenterology and Motility (JNM Vol.4 No.2
Gastroesophageal reflux disease (GERD) is thought to be caused by an incompetent lower esophageal sphincter, either because of a chronic hypotonia or an increased frequency of transient lower esophageal sphincter relaxation. Thus, it seems paradoxical under nutcracker esophagus to consider gastroesophageal reflux as a possible diagnosis, particularly in the patient presenting with chest pain. Current therapy in nutcracker esophagus is aimed at reducing the high amplitude peristaltic contractions characteristic of this disorder. Treatment directed at reducing contraction can decrease lower esaphageal sphincter pressure and may exacerbate gastroesophageal reflux. It is not easy to treat a case of nutcracker esophagus associated with GERD. We report a 38-year-old male with nutcracker esophagus associated with GERD who lost the diagnostic features of nutcracker esophagus after 6 week of antireflux therapy. (Korean Joumal of Gastrointestinal Motility 1998;4:127-132)


최명규(Myung Gyu Choi),문성배(Sung Bae Moon),김보경(Bo Kyoung Kim),최황(Hwang Choi),김재광(Jae Kwang Kim),정규원(Kyu Won Chung),선희식(Hee Sik Sun),박두호(Doo Ho Park),김형태(Hyung Tae Kim),조승호(Seung Ho Cho) 대한소화기기능성질환·운동학회 1998 Journal of Neurogastroenterology and Motility (JNM Vol.4 No.2
Background/Aims: The aim of our study was to evaluate the role of gastroesophageal reflux in patients with chronic laryngeal symptoms. Methods: Fourty-four patients with chronic laryngeal symptoms had not responded to empirical therapies of otolaryngologist, mean age 44.3 years, were studied. They were evaluated with esophageal manometry and 24 hour ambulatory pH monitoring with 2 channel antimony probe. The pathologic reflux was defined as the percentage of total time that the pH was below 4.0 exceeded 4.0%. Results: 1) Chronic laryngeal symptoms were sorethroat (57%), horeseness (50%), globus sensation (14%). 2) Six of the 44 patients had the pathologic reflux at t he lower esophagus, four had the pathologic reflux at the upper esophagus. 3) Three (50%) of the 6 patients with pathologic reflux at the lower esophagus were upright refluxer, two (33%) were supine refluxer, and one (16%) was mixed refluxer. Three (75%) of the 4 patients with pathologic reflux at the upper esophagus were uprght refluxer, and one (25%) was supine refluxer. 4) Eleven of the 44 patients had symptoms of heartbum and chest pain. Seven of the ll patients were more than 50% of the symptam index at the upper esophagus, Eight were at lower esophagus. Six (13.6%) of the 44 patients with positive symptom index did not have pathologic reflux. In summary, chronic laryngeal symptoms were related to acid reflux in twelve (27.2%) of the 44 patients. Conclusion: We suggest that some patients with chronic laryngeal symptoms in Korean may have abnormal gastroesophageal reflux. (Korean Joumal of Gastrointestinal Motility 1998;4:105-111)


한국인의 기능성 소화불량증 환자에서의 증상관찰, 아형분류 및 이에 대한 시사프리드의 효과
최명규 ( Myung Gyu Choi ),최규완 ( Kyu Wan Choi ),김나영 ( Na Young Kim ),임선희 ( Seon Hee Lim ),이계희 ( Kye Heui Lee ),김성국 ( Sung Kook Kim ),최용환 ( Yong Hwan Choi ),송치욱 ( Chi Wook song ),김혜랑 ( Heu Rang Kim ),임창영 ( 대한소화기기능성질환·운동학회 1998 Journal of Neurogastroenterology and Motility (JNM Vol.4 No.1
Background/Aims : The aims of this study were to determine subgoups of functional dyspesia and to evaluate the short-term effect of cisapride in patients with functional dyspepsia in Korea. Methods . 1025 patients, with a mean age of 42.6 years, with symptoms of functional dyspepsia, were recruited consecutively and upper gastrointestinal symptoms were investigated by interview in 41 hospitals in Korea. In an open, multicenter trial, 1025 patients received Smg of cisapride three times a day (TID) for at least .2 weeks for the treatment of symptoms of functional dyspepsia. When necessary, the dose of cisapride was increased to 10mg TID and the duration of therapy was extended to 4 weeks. Results . The most frequently reported symptoms of functional dyspepsia were epigastric discomfort or fullness (85%), bloating (70%), belching (53%), early satiety (52%) and epigastric pain (46%) retrospectively. Subgroups of functional dyspepsia were as follows; dysmotility-like 73.5%, ulcer-like 39.7%, reflux-like 13.0%, and unspecified dyspepsia 14.0%. However, 33.2% of subjects with functional dyspepsia could be classified into more than one subgroup. Upper gastrointestinal symptoms were decreased to average 50.3% (range; 42.2 to 59.2%) after 2 weeks of cisapride treatment and to 25% (19.2 to 29.9%) after 4 weeks. cisapride therapy resulted in good or excellent improvement in 59.0% of the patients after two weeks, in 75% of patients after 4 weeks. Adverse events were occurred in 52 patients (5.8% of all patients), most commonly, loose stools or diarrhea (3.5%), abdominal pain (1.1%), and dizziness (0.3%). The majority of adverse events was mild and transient in nature and led to premature discontinuation of treatment in 4 patients. Conclusions . Although the majorities of patients with functional dyspepsia have dysmotility like symptoms in Korea, there is such overlap among the dyspepsia subgroups. Most patients responded well to a short therapeutic trial with cisapride without significant side effects.

Itopride가 정상 성인에서 상부 위긴장도와 위감각능에 미치는 영향
최명규(Myung Gyu Choi),추교영(Kyo Young Choo),김병욱(Byung Wook Kim),최황(Hwang Choi),박수헌(Soo Heon Park),오정환(Jung Hwan Oh),한석원(Sok Won Han),김재광(Jae Kwang Kim),정인식(In Sik Chung),정규원(Kyu Won Chung),선희식(Hee Sik Sun 대한소화기학회 2000 대한소화기학회지 Vol.36 No.3
Background/Aims : Itopride is a newly developed prokinetic agent and has antidopaminergic and anti- acetylcholine esterase activities. Our aim was to evaluate the effect of itopride on proximal gastric tone and visceral perception. Methods: Fifteen healthy subjects participated in two experiments with 7 days interval. Randomized double blinded cross-over design with 3 days pretreatment of placebo or itopride was followed by itopride or placebo treatment. After overnight fasting, itopride was given prior to barostat study. Sensory function was assessed by scoring the perception for nausea, fullness, and abdominal discomfort/pain during random-order distensions of 4, 8, and 12 mmHg above minimal intragastric distending pressure (MDP). Effect of distensions was studied three times. Results : Compliance was not different after pretreatment of itopride or placebo. Itopride has no effect on visceral perception at MDP+4 mmHg (92.5±45.3 vs. 79.1±30.2), 8 mmHg (117.7±41.1 vs. 118.9±41.5) and at MDP+12 mmHg (159.8±43.9 vs. 149.9±53.5). MDP and fasting tone were not different between the two experimental groups. After itopride pretreatment, significantly increased intragastric volume were recorded in 60 min postprandial period (p<0.05). Conclusions: Itopride enhances the gastric accommodation to meal. This observation suggests that itopride may provide benefits to patients with impaired postprandial relaxation of proximal stomach. (Kor J Gastroenterol 2000;36:293 - 301)